DE69133349D1 - Ein nicht-mitogener kompetitiver hgf-antagonist - Google Patents

Ein nicht-mitogener kompetitiver hgf-antagonist

Info

Publication number
DE69133349D1
DE69133349D1 DE69133349T DE69133349T DE69133349D1 DE 69133349 D1 DE69133349 D1 DE 69133349D1 DE 69133349 T DE69133349 T DE 69133349T DE 69133349 T DE69133349 T DE 69133349T DE 69133349 D1 DE69133349 D1 DE 69133349D1
Authority
DE
Germany
Prior art keywords
hgf
present
mitogenic
relates
hgf antagonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69133349T
Other languages
English (en)
Other versions
DE69133349T2 (de
Inventor
S Rubin
M-L Chan
A Aaronson
P Bottaro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Government Of Usa As Represented By Th
Original Assignee
United States Department of Commerce
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United States Department of Commerce, US Department of Health and Human Services filed Critical United States Department of Commerce
Publication of DE69133349D1 publication Critical patent/DE69133349D1/de
Application granted granted Critical
Publication of DE69133349T2 publication Critical patent/DE69133349T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69133349T 1990-09-14 1991-09-10 Ein nicht-mitogener kompetitiver hgf-antagonist Expired - Fee Related DE69133349T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58206390A 1990-09-14 1990-09-14
US65550291A 1991-02-15 1991-02-15
PCT/US1991/006368 WO1992005184A1 (en) 1990-09-14 1991-09-10 A non-mitogenic competitive hgf antagonist

Publications (2)

Publication Number Publication Date
DE69133349D1 true DE69133349D1 (de) 2004-01-29
DE69133349T2 DE69133349T2 (de) 2004-10-07

Family

ID=27078485

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69133349T Expired - Fee Related DE69133349T2 (de) 1990-09-14 1991-09-10 Ein nicht-mitogener kompetitiver hgf-antagonist

Country Status (7)

Country Link
EP (1) EP0571387B1 (de)
JP (2) JP3438888B2 (de)
AT (1) ATE256736T1 (de)
AU (1) AU650292B2 (de)
CA (1) CA2091700C (de)
DE (1) DE69133349T2 (de)
WO (1) WO1992005184A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5871959A (en) * 1989-12-27 1999-02-16 The United States Of America As Represented By The Department Of Health And Human Services Method of producing hepatocycte growth factor/scatter factor and related cell lines
US6566098B1 (en) 1990-09-14 2003-05-20 The United States Of America As Represented By The Department Of Health And Human Services DNA encoding truncated hepatocyte growth factor variants
DK0642580T3 (da) * 1992-05-18 2002-12-23 Genentech Inc Hepactocytvækstfaktorvarianter
US5328837A (en) * 1992-05-18 1994-07-12 Genentech, Inc. Hepatocyte growth factor protease domain variants
US5316921A (en) * 1992-05-18 1994-05-31 Genentech, Inc. Single-chain hepatocyte growth factor variants
AU693767B2 (en) * 1992-08-10 1998-07-09 Cambridge Neuroscience, Inc. Inhibitors of cell proliferation, their preparation and use
EP0662130B1 (de) * 1992-09-18 1997-11-26 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Eine Methode zur Herstellung von Hepatozytwachstumsfaktor und eine Zelllinie
US6214344B1 (en) 1995-06-02 2001-04-10 Genetech, Inc. Hepatocyte growth factor receptor antagonists and uses thereof
US5686292A (en) 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
US5646036A (en) * 1995-06-02 1997-07-08 Genentech, Inc. Nucleic acids encoding hepatocyte growth factor receptor antagonist antibodies
NZ315769A (en) 1995-08-29 1999-05-28 Sumitomo Pharma Lioposomal composition containing hepatocyte growth factor (hgf)
US6855685B2 (en) 1995-10-24 2005-02-15 Toshikazu Nakamura Anti-cancer agent
JP2001505995A (ja) * 1996-11-05 2001-05-08 スミスクライン・ビーチャム・コーポレイション 肝細胞成長因子アンタゴニスト
JP2003517007A (ja) * 1999-12-15 2003-05-20 エントレメッド インコーポレイテッド 内皮細胞増殖阻害組成物および方法
MX2007001470A (es) 2004-08-05 2007-03-26 Genentech Inc Antagonistas anti-cmet humanizados.
ZA200710599B (en) 2005-04-15 2009-08-26 Genentech Inc HGF Beta chain variants
SG183190A1 (en) 2010-03-10 2012-09-27 Genmab As Monoclonal antibodies against c-met
EP2726098A1 (de) 2011-06-30 2014-05-07 F.Hoffmann-La Roche Ag Anti-c-met-antikörperformulierungen
KR20160137599A (ko) 2014-03-24 2016-11-30 제넨테크, 인크. C-met 길항제로의 암 치료 및 이것과 hgf 발현과의 상관관계

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3750197D1 (de) * 1986-04-22 1994-08-18 Salk Inst For Biological Studi Antagonisten des Fibroblasten-Wachstumsfaktors.
NZ232813A (en) * 1989-03-10 1992-08-26 Snow Brand Milk Products Co Ltd Human fibroblast glycoprotein, cell differentiation, blood vessel endothelial cell growth factor, cellular immunology inforcing factor of 78 or 74 thousand daltons plus or minus two thousand daltons

Also Published As

Publication number Publication date
JPH06504189A (ja) 1994-05-19
JP2003102488A (ja) 2003-04-08
JP3438888B2 (ja) 2003-08-18
EP0571387B1 (de) 2003-12-17
WO1992005184A1 (en) 1992-04-02
AU650292B2 (en) 1994-06-16
AU8659591A (en) 1992-04-15
EP0571387A4 (en) 1994-07-13
EP0571387A1 (de) 1993-12-01
ATE256736T1 (de) 2004-01-15
CA2091700A1 (en) 1992-03-15
CA2091700C (en) 2002-11-19
DE69133349T2 (de) 2004-10-07

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: THE GOVERNMENT OF THE U.S.A., AS REPRESENTED BY TH

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee