ES2099158T3 - Tratamiento del rechazo de trasplantes o de enfermedades autoinmunitarias y complejo de la formula general x-pro-y-boropro asociada al mismo. - Google Patents
Tratamiento del rechazo de trasplantes o de enfermedades autoinmunitarias y complejo de la formula general x-pro-y-boropro asociada al mismo.Info
- Publication number
- ES2099158T3 ES2099158T3 ES91908724T ES91908724T ES2099158T3 ES 2099158 T3 ES2099158 T3 ES 2099158T3 ES 91908724 T ES91908724 T ES 91908724T ES 91908724 T ES91908724 T ES 91908724T ES 2099158 T3 ES2099158 T3 ES 2099158T3
- Authority
- ES
- Spain
- Prior art keywords
- boropro
- pro
- general formula
- transplants
- rejection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE PRESENTAN INHIBIDORES DEL TIPO IV DE LA DIPEPTIDILAMINOPEPTIDASA QUE TIENEN LA SIGUIENTE FORMULA GENERAL: X-PRO-YBOROPRO, EN DONDE X E Y ESTAN ESCOGIDAS ENTRE CUALQUIER AMINOACIDO (INCLUYENDO LA PROLINA).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51027490A | 1990-04-14 | 1990-04-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2099158T3 true ES2099158T3 (es) | 1997-05-16 |
Family
ID=24030067
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91908724T Expired - Lifetime ES2099158T3 (es) | 1990-04-14 | 1991-04-12 | Tratamiento del rechazo de trasplantes o de enfermedades autoinmunitarias y complejo de la formula general x-pro-y-boropro asociada al mismo. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0528858B1 (es) |
JP (3) | JPH05508624A (es) |
AT (1) | ATE148130T1 (es) |
CA (1) | CA2080474A1 (es) |
DE (1) | DE69124371T2 (es) |
DK (1) | DK0528858T3 (es) |
ES (1) | ES2099158T3 (es) |
GR (1) | GR3023233T3 (es) |
WO (1) | WO1991016339A1 (es) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5288707A (en) * | 1990-08-13 | 1994-02-22 | Sandoz Ltd. | Borolysine peptidomimetics |
CA2121369C (en) * | 1991-10-22 | 2003-04-29 | William W. Bachovchin | Inhibitors of dipeptidyl-aminopeptidase type iv |
US6825169B1 (en) | 1991-10-22 | 2004-11-30 | Trustees Of Tufts College | Inhibitors of dipeptidyl-aminopeptidase type IV |
MX9206628A (es) * | 1991-11-22 | 1993-05-01 | Boehringer Ingelheim Pharma | Ester de prolinaboronato y metodo para su preparacion. |
IL111785A0 (en) * | 1993-12-03 | 1995-01-24 | Ferring Bv | Dp-iv inhibitors and pharmaceutical compositions containing them |
US5965532A (en) | 1996-06-28 | 1999-10-12 | Trustees Of Tufts College | Multivalent compounds for crosslinking receptors and uses thereof |
US6011155A (en) * | 1996-11-07 | 2000-01-04 | Novartis Ag | N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV |
US6040145A (en) | 1997-05-07 | 2000-03-21 | Tufts University | Potentiation of the immune response |
US6100234A (en) | 1997-05-07 | 2000-08-08 | Tufts University | Treatment of HIV |
KR100458403B1 (ko) | 1997-09-29 | 2004-11-26 | 포인트 써러퓨틱스, 인크. | 생체외 조혈세포의 자극방법 |
BR9910251A (pt) | 1998-05-04 | 2001-01-02 | Point Therapeutics Inc | Estimulação hematopoiética |
DE19823831A1 (de) | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
AU765370B2 (en) | 1998-06-05 | 2003-09-18 | Point Therapeutics, Inc. | Cyclic boroproline compounds |
DE19828113A1 (de) | 1998-06-24 | 2000-01-05 | Probiodrug Ges Fuer Arzneim | Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV |
DE19828114A1 (de) | 1998-06-24 | 2000-01-27 | Probiodrug Ges Fuer Arzneim | Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV |
US6979697B1 (en) | 1998-08-21 | 2005-12-27 | Point Therapeutics, Inc. | Regulation of substrate activity |
AU5480199A (en) * | 1998-08-21 | 2000-03-14 | Point Therapeutics, Inc. | Regulation of substrate activity |
CO5150173A1 (es) * | 1998-12-10 | 2002-04-29 | Novartis Ag | Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv |
GB9906715D0 (en) | 1999-03-23 | 1999-05-19 | Ferring Bv | Compositions for promoting growth |
GB9906714D0 (en) | 1999-03-23 | 1999-05-19 | Ferring Bv | Compositions for improving fertility |
US6890904B1 (en) | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
US6110949A (en) * | 1999-06-24 | 2000-08-29 | Novartis Ag | N-(substituted glycyl)-4-cyanothiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV |
US6172081B1 (en) | 1999-06-24 | 2001-01-09 | Novartis Ag | Tetrahydroisoquinoline 3-carboxamide derivatives |
US6617340B1 (en) | 1999-07-29 | 2003-09-09 | Novartis Ag | N-(substituted glycyl)-pyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV |
DE19940130A1 (de) | 1999-08-24 | 2001-03-01 | Probiodrug Ges Fuer Arzneim | Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung |
US7132104B1 (en) | 2000-10-27 | 2006-11-07 | Probiodrug Ag | Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders |
US6890905B2 (en) | 2001-04-02 | 2005-05-10 | Prosidion Limited | Methods for improving islet signaling in diabetes mellitus and for its prevention |
US20030130199A1 (en) | 2001-06-27 | 2003-07-10 | Von Hoersten Stephan | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents |
DE10150203A1 (de) | 2001-10-12 | 2003-04-17 | Probiodrug Ag | Peptidylketone als Inhibitoren der DPIV |
US7368421B2 (en) | 2001-06-27 | 2008-05-06 | Probiodrug Ag | Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis |
US6844316B2 (en) | 2001-09-06 | 2005-01-18 | Probiodrug Ag | Inhibitors of dipeptidyl peptidase I |
AU2002360453C1 (en) | 2001-11-26 | 2009-06-18 | The Brigham And Women's Hospital, Inc. | Methods for treating autoimmune disorders, and reagents related thereto |
SI1480961T1 (sl) | 2002-02-28 | 2007-06-30 | Prosidion Ltd | Inhibitorji dpiv na osnovi glutaminila |
US7371871B2 (en) | 2003-05-05 | 2008-05-13 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
CN101837127A (zh) | 2003-05-05 | 2010-09-22 | 前体生物药物股份公司 | 谷氨酰胺酰基和谷氨酸环化酶效应物的应用 |
DE10337074A1 (de) | 2003-08-12 | 2005-03-17 | Keyneurotek Ag | Verwendung der Inhibitoren von Enzymen mit Aktivitäten der Aminopeptidase N und/oder der Dipeptidylpeptidase IV und pharmazeutischen Zubereitungen daraus zur Therapie und Prävention von chronischen neurodegenerativen Erkrankungen |
CN102302781A (zh) | 2003-10-15 | 2012-01-04 | 前体生物药物股份公司 | 谷氨酰胺酰基环化酶效应物和谷氨酸环化酶效应物的应用 |
US7317109B2 (en) | 2003-11-12 | 2008-01-08 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
ES2524916T3 (es) | 2003-11-12 | 2014-12-15 | Sino-Med International Alliance, Inc. | Compuestos heterocíclicos de ácido borónico |
US7576121B2 (en) | 2003-11-12 | 2009-08-18 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
US7767828B2 (en) | 2003-11-12 | 2010-08-03 | Phenomix Corporation | Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
AU2005267093B2 (en) | 2004-07-23 | 2009-10-01 | Nuada Llc | Peptidase inhibitors |
DOP2006000008A (es) | 2005-01-10 | 2006-08-31 | Arena Pharm Inc | Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1 |
US7825139B2 (en) | 2005-05-25 | 2010-11-02 | Forest Laboratories Holdings Limited (BM) | Compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
PE20071221A1 (es) | 2006-04-11 | 2007-12-14 | Arena Pharm Inc | Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas |
EP2108960A1 (en) | 2008-04-07 | 2009-10-14 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY |
AR077642A1 (es) | 2009-07-09 | 2011-09-14 | Arena Pharm Inc | Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo |
JP2013523819A (ja) | 2010-04-06 | 2013-06-17 | アリーナ ファーマシューティカルズ, インコーポレイテッド | Gpr119レセプターのモジュレーターおよびそれに関連する障害の処置 |
KR101871011B1 (ko) | 2010-09-22 | 2018-06-25 | 아레나 파마슈티칼스, 인크. | Gpr119 수용체의 조절제 및 그와 관련된 장애의 치료 |
WO2012135570A1 (en) | 2011-04-01 | 2012-10-04 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2012145361A1 (en) | 2011-04-19 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2012145604A1 (en) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
US20140038889A1 (en) | 2011-04-22 | 2014-02-06 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2013055910A1 (en) | 2011-10-12 | 2013-04-18 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2014074668A1 (en) | 2012-11-08 | 2014-05-15 | Arena Pharmaceuticals, Inc. | Modulators of gpr119 and the treatment of disorders related thereto |
CA2979033A1 (en) | 2015-03-09 | 2016-09-15 | Intekrin Therapeutics, Inc. | Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy |
US11253508B2 (en) | 2017-04-03 | 2022-02-22 | Coherus Biosciences, Inc. | PPARy agonist for treatment of progressive supranuclear palsy |
CN110452258B (zh) * | 2019-09-03 | 2021-01-01 | 上海馨远医药科技有限公司 | 一种二肽缬氨酸硼脯氨酸盐的制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4935493A (en) * | 1987-10-06 | 1990-06-19 | E. I. Du Pont De Nemours And Company | Protease inhibitors |
-
1991
- 1991-04-12 WO PCT/US1991/002519 patent/WO1991016339A1/en active IP Right Grant
- 1991-04-12 CA CA002080474A patent/CA2080474A1/en not_active Abandoned
- 1991-04-12 EP EP91908724A patent/EP0528858B1/en not_active Expired - Lifetime
- 1991-04-12 AT AT91908724T patent/ATE148130T1/de not_active IP Right Cessation
- 1991-04-12 JP JP91508358A patent/JPH05508624A/ja not_active Ceased
- 1991-04-12 DE DE69124371T patent/DE69124371T2/de not_active Expired - Fee Related
- 1991-04-12 ES ES91908724T patent/ES2099158T3/es not_active Expired - Lifetime
- 1991-04-12 DK DK91908724.7T patent/DK0528858T3/da active
-
1997
- 1997-04-22 GR GR970400898T patent/GR3023233T3/el unknown
-
2006
- 2006-06-19 JP JP2006169314A patent/JP2006241173A/ja active Pending
-
2007
- 2007-05-15 JP JP2007129910A patent/JP2007204497A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
GR3023233T3 (en) | 1997-07-30 |
EP0528858A4 (en) | 1993-04-28 |
CA2080474A1 (en) | 1991-10-15 |
EP0528858A1 (en) | 1993-03-03 |
ATE148130T1 (de) | 1997-02-15 |
DE69124371D1 (de) | 1997-03-06 |
JPH05508624A (ja) | 1993-12-02 |
DK0528858T3 (da) | 1997-07-28 |
DE69124371T2 (de) | 1997-06-12 |
JP2006241173A (ja) | 2006-09-14 |
JP2007204497A (ja) | 2007-08-16 |
EP0528858B1 (en) | 1997-01-22 |
WO1991016339A1 (en) | 1991-10-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2099158T3 (es) | Tratamiento del rechazo de trasplantes o de enfermedades autoinmunitarias y complejo de la formula general x-pro-y-boropro asociada al mismo. | |
IL148079A0 (en) | Human ctla-4 antibodies and compositions containing the same | |
BR0114390A (pt) | éteres de 7-desmetilrapamicina | |
MX9101869A (es) | Ciclosporinas, composicion farmaceutica que las contiene y procedimiento para la produccion de las mismas | |
DK0951473T3 (da) | Cyclosporinderivat, fremstilling af dette og farmaceutiske præparater indeholdende dette | |
DK0705100T3 (da) | Terapeutiske substituerede guanidiner | |
DE69435303D1 (de) | Er behandlung von krankheiten bei denen eine cytok | |
ATE165511T1 (de) | Behandlung von organtransplantatsabstossung | |
ATE298741T1 (de) | Polyaromatische verbindungen zur behandlung von herpes-infektionen | |
NO873699D0 (no) | Polypeptid som er egnet til dempning, behandling og diagnosering av autoimmune lidelser saasom leddbetennelser. | |
DE69131200D1 (en) | Herpes simplex virus vp16 impfstoffe | |
ATE335499T1 (de) | Zusammensetzungen zur behandlung von staphylococcus aureus infektionen | |
AU8216691A (en) | Autobiotics and their use in eliminating nonself cells in vivo | |
FR2491334B1 (es) | ||
GR3018304T3 (en) | Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4h-pyran-4-ones. | |
ATE199321T1 (de) | Anti idiotypische antikörper gegen gonococcen und diese verwendende verfahren und zusammensetzungen. | |
EP0387802A3 (en) | 5-substituted-1,4-dihydro-4-oxonaphthyridine-3-carboxylate antibacterial agents | |
HU9603312D0 (en) | Novel elastase inhibitors | |
ATE81467T1 (de) | Immunosuppression bei der auf immunotoxin basierten behandlung von menschen. | |
ES2159287T3 (es) | Peptidos hemorreguladores. | |
DE3769497D1 (de) | Mittel zur bekaempfung von phytopathogenen mikroben. | |
ATE212839T1 (de) | Hämoregulatorische verbindungen | |
FR2657609B1 (fr) | Nouveaux derives de pyrimidine oxyde-3 halogenes, leur utilisation pour le traitement et la prevention de la chute des cheveux et pour stimuler leur repousse. | |
FI942505A (fi) | Antibakteriella aemnen | |
SU1602007A1 (ru) | 6-(4,5-Дифенилтиенил-2)-3-тиа-1,2,4-триазин-5-он, проявляющий противовоспалительную и антимикробную активность |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 528858 Country of ref document: ES |