DE3750197D1 - Antagonisten des Fibroblasten-Wachstumsfaktors. - Google Patents

Antagonisten des Fibroblasten-Wachstumsfaktors.

Info

Publication number
DE3750197D1
DE3750197D1 DE3750197T DE3750197T DE3750197D1 DE 3750197 D1 DE3750197 D1 DE 3750197D1 DE 3750197 T DE3750197 T DE 3750197T DE 3750197 T DE3750197 T DE 3750197T DE 3750197 D1 DE3750197 D1 DE 3750197D1
Authority
DE
Germany
Prior art keywords
antagonists
arg
growth factor
fibroblast growth
fgf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3750197T
Other languages
English (en)
Inventor
Andrew Jacques Baird
Nicholas Chai-Kwan Ling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Application granted granted Critical
Publication of DE3750197D1 publication Critical patent/DE3750197D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE3750197T 1986-04-22 1987-04-21 Antagonisten des Fibroblasten-Wachstumsfaktors. Expired - Lifetime DE3750197D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85484386A 1986-04-22 1986-04-22

Publications (1)

Publication Number Publication Date
DE3750197D1 true DE3750197D1 (de) 1994-08-18

Family

ID=25319659

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3750197T Expired - Lifetime DE3750197D1 (de) 1986-04-22 1987-04-21 Antagonisten des Fibroblasten-Wachstumsfaktors.

Country Status (6)

Country Link
US (1) US5132408A (de)
EP (1) EP0246753B1 (de)
JP (1) JPS62259598A (de)
AT (1) ATE108459T1 (de)
AU (1) AU7180787A (de)
DE (1) DE3750197D1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252718A (en) * 1986-04-22 1993-10-12 The Salk Institute For Biological Studies Fibroblast growth factor antagonists
US5852177A (en) * 1987-02-24 1998-12-22 Takeda Chemical Industries, Ltd. Basic fibroblast growth factor (bFGF) muteins
AU650292B2 (en) * 1990-09-14 1994-06-16 United States of America, as represented by the Secretary, U.S. Department of Commerce, The A non-mitogenic competitive HGF antagonist
US5821223A (en) 1990-09-14 1998-10-13 The United States Of America As Represented By The Department Of Health And Human Services Method of stimulating cell growth with a novel broad spectrum human lung fibroblast-derived mitogen
US6566098B1 (en) 1990-09-14 2003-05-20 The United States Of America As Represented By The Department Of Health And Human Services DNA encoding truncated hepatocyte growth factor variants
US5206354A (en) * 1990-11-23 1993-04-27 American Cyanamid Company Dna sequence encoding active fragment of fibroblast growth factor, hbf-2
AU1052492A (en) * 1991-01-31 1992-08-06 Farmitalia Carlo Erba S.R.L. Synergistic composition comprising a fibroblast growth factor and a sulfated polylsaccharide, for use as antiviral agent
WO1992013958A1 (en) * 1991-02-06 1992-08-20 Georgetown University Receptor blocking peptides of fibroblast growth factor receptor
US5688768A (en) * 1991-02-19 1997-11-18 Cor Therapeutics, Inc. Recombinant thrombin receptor and related pharmaceuticals
US7119182B1 (en) 1991-02-19 2006-10-10 The Regents Of The University Of California Recombinant thrombin receptor and related pharmaceuticals
EP0505108B1 (de) * 1991-03-21 1995-10-18 The Procter & Gamble Company Mittel zur Kontrolle von Hautfalten, die die Arg-Ser-Arg-Lys-Sequenzen enthalten
US5492894A (en) * 1991-03-21 1996-02-20 The Procter & Gamble Company Compositions for treating wrinkles comprising a peptide
US5326695A (en) * 1992-05-15 1994-07-05 Ludwig Institute For Cancer Research Platelet derived growth factor agonists
US5444151A (en) * 1992-05-15 1995-08-22 Ludwig Institute For Cancer Research Platelet derived growth factor antagonists
JPH08500246A (ja) * 1992-08-10 1996-01-16 ケンブリッジ ニューロサイエンス インコーポレーテッド 細胞増殖の阻害剤，その調製および用途
IL108367A0 (en) * 1993-01-27 1994-04-12 Hektoen Inst For Medical Resea Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells
US5571787A (en) 1993-07-30 1996-11-05 Myelos Corporation Prosaposin as a neurotrophic factor
WO1996039509A1 (en) * 1995-06-05 1996-12-12 Human Genome Sciences, Inc. Fibroblast growth factor 15
US5773252A (en) * 1995-06-05 1998-06-30 Human Genome Sciences, Inc. Fibroblast growth factor 15
US6271196B1 (en) 1996-03-05 2001-08-07 Regents Of The University Of Ca Methods of alleviating neuropathic pain using prosaposin-derived peptides
US6849602B1 (en) 1996-03-05 2005-02-01 The Regents Of The University Of California Compositions for alleviating neuropathic pain with prosaposin receptor agonists
AU722626B2 (en) * 1996-05-20 2000-08-10 Abburi Ramaiah Cosmetic preparation
US6143723A (en) * 1996-05-20 2000-11-07 Ramaiah; Abburi Pigmentory agent
US6214795B1 (en) 1996-11-12 2001-04-10 Praecis Pharmaceuticals, Inc. Peptide compounds useful for modulating FGF receptor activity
EP0979238A4 (de) * 1997-03-05 2000-08-23 Univ California Methode zur heilung neuropathischer schmerzen
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
US6548634B1 (en) 1998-09-30 2003-04-15 Chiron Corporation Synthetic peptides having FGF receptor affinity
ITRM20010088A1 (it) * 2001-02-21 2002-08-21 Idi Irccs Peptide in grado di inibire l'attivita' del fattore di crescita derivato dalle piastrine (pdgf-bb) e del fattore di crescita derivato dai fi
EP2489363A3 (de) * 2005-09-13 2012-12-05 Abburi Ramaiah Agonist Peptide des basischen Fibroblasten-Wachstumsfaktor (bFGF) und Verfahren zur Verminderung von Falten auf der Haut, Haare und Verdunkelung der Beschleunigung der Wundheilung
JP5360738B2 (ja) * 2008-03-03 2013-12-04 国立大学法人 奈良先端科学技術大学院大学 細胞増殖促進活性を有するペプチド
JP2012518657A (ja) 2009-02-25 2012-08-16 オーエスアイ・ファーマシューティカルズ，エルエルシー 併用抗癌治療
JP2012519281A (ja) 2009-02-27 2012-08-23 オーエスアイ・ファーマシューティカルズ，エルエルシー 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法
WO2010099138A2 (en) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
JP2012519282A (ja) 2009-02-27 2012-08-23 オーエスアイ・ファーマシューティカルズ，エルエルシー 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法
JP5767314B2 (ja) 2010-04-16 2015-08-19 ソーク インスティチュート フォー バイオロジカル スタディーズ Ｆｇｆを用いて代謝障害を処置するための方法
CN102212568A (zh) * 2011-03-22 2011-10-12 深圳大学 用酶催化合成药物l-多巴的方法
EP2702173A1 (de) 2011-04-25 2014-03-05 OSI Pharmaceuticals, LLC Verwendung von emt-gensignaturen bei der entdeckung von krebswirkstoffen, -diagnostika und -behandlungen
AU2012251699A1 (en) * 2011-05-02 2013-05-09 Baxter Healthcare S.A. FGF based fibrin binding peptides
US9475856B2 (en) 2012-03-02 2016-10-25 New York University Chimeric FGF21 proteins with enhanced binding affinity for β-klotho for the treatment of type II diabetes, obesity, and related metabolic disorders
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
US9657075B2 (en) 2012-06-07 2017-05-23 New York University Chimeric fibroblast growth factor 23 proteins and methods of use
US9474785B2 (en) 2012-06-07 2016-10-25 New York University Chimeric fibroblast growth factor 19 proteins and methods of use
US9464126B2 (en) 2012-06-07 2016-10-11 New York University Chimeric fibroblast growth factor 21 proteins and methods of use
WO2014130659A1 (en) 2013-02-22 2014-08-28 New York University Chimeric fibroblast growth factor 23 proteins and methods of use
JP6621752B2 (ja) 2013-10-21 2019-12-18 ソーク インスティテュート フォー バイオロジカル スタディーズ 変異した線維芽細胞増殖因子（ｆｇｆ）１および使用方法
WO2015061331A1 (en) 2013-10-21 2015-04-30 Salk Institute For Biological Studies Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use
WO2017075260A1 (en) 2015-10-30 2017-05-04 Salk Institute For Biological Studies Treatment of steroid-induced hyperglycemia with fibroblast growth factor (fgf) 1 analogs
US11542309B2 (en) 2019-07-31 2023-01-03 Salk Institute For Biological Studies Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose
CN112110988A (zh) * 2020-08-21 2020-12-22 温州医科大学 一种具有毛发生长作用的多肽类似物及制备方法和应用
CN117886917B (zh) * 2024-01-17 2024-07-23 南通大学附属医院 一种VEGF和bFGF的模拟肽片段组合及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444760A (en) * 1983-06-17 1984-04-24 Merck & Co., Inc. Purification and characterization of a protein fibroblast growth factor
EP0248819B2 (de) * 1985-09-12 2000-08-30 Scios Inc. Rekombinanter fibroblast-wachstumsfaktor

Also Published As

Publication number Publication date
AU622708B2 (en) 1992-04-16
AU7180787A (en) 1987-10-29
US5132408A (en) 1992-07-21
EP0246753A3 (en) 1989-06-07
EP0246753A2 (de) 1987-11-25
AU4235089A (en) 1990-01-18
ATE108459T1 (de) 1994-07-15
JPS62259598A (ja) 1987-11-11
EP0246753B1 (de) 1994-07-13

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