DE3789530D1 - Klonierung und Expression des sauren Fibroblastenwachstumsfaktors. - Google Patents

Klonierung und Expression des sauren Fibroblastenwachstumsfaktors.

Info

Publication number
DE3789530D1
DE3789530D1 DE87306066T DE3789530T DE3789530D1 DE 3789530 D1 DE3789530 D1 DE 3789530D1 DE 87306066 T DE87306066 T DE 87306066T DE 3789530 T DE3789530 T DE 3789530T DE 3789530 D1 DE3789530 D1 DE 3789530D1
Authority
DE
Germany
Prior art keywords
cloning
expression
growth factor
fibroblast growth
acidic fibroblast
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE87306066T
Other languages
English (en)
Other versions
DE3789530T2 (de
Inventor
David L Linemeyer
Linda J Kelly
Kenneth A Thomas
Guillermo Gimenez-Gallego
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3789530D1 publication Critical patent/DE3789530D1/de
Publication of DE3789530T2 publication Critical patent/DE3789530T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE3789530T 1986-07-11 1987-07-09 Klonierung und Expression des sauren Fibroblastenwachstumsfaktors. Expired - Lifetime DE3789530T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88446086A 1986-07-11 1986-07-11
US5499187A 1987-06-04 1987-06-04

Publications (2)

Publication Number Publication Date
DE3789530D1 true DE3789530D1 (de) 1994-05-11
DE3789530T2 DE3789530T2 (de) 1994-09-15

Family

ID=26733717

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3789530T Expired - Lifetime DE3789530T2 (de) 1986-07-11 1987-07-09 Klonierung und Expression des sauren Fibroblastenwachstumsfaktors.

Country Status (12)

Country Link
EP (1) EP0259953B1 (de)
JP (2) JPH0714347B2 (de)
KR (1) KR960009725B1 (de)
AU (1) AU614262B2 (de)
DE (1) DE3789530T2 (de)
DK (1) DK175786B1 (de)
ES (1) ES2062982T3 (de)
FI (1) FI98915C (de)
IE (1) IE62101B1 (de)
IL (1) IL83062A (de)
NZ (1) NZ220917A (de)
PT (1) PT85306B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0593065B1 (de) * 1985-09-12 2002-08-21 Scios Inc. Rekombinante Fibroblasten-Wachstums-Faktoren
DE3721081A1 (de) * 1987-06-26 1989-01-19 Progen Biotechnik Gmbh Dna-sequenz, die codiert fuer ein zellteilungsfoerderndes polypeptid, sowie ein plasmid, ein wirtsorganismus und ein verfahren zur gewinnung dieses polypeptids
US5175147A (en) * 1988-08-19 1992-12-29 Takeda Chemical Industries, Ltd Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract
US5656458A (en) * 1988-11-04 1997-08-12 Chiron Corporation Expression and processing of amino terminus acetylated FGF's in yeast
EP0441886B1 (de) * 1988-11-04 1996-08-21 Chiron Corporation EXPRESSION UND PROZESSIERUNG VON ACETYLIERTEN FGFs IN HEFEN
EP0392605A1 (de) * 1989-04-13 1990-10-17 Merck & Co. Inc. Methode zur Steigerung der Expression des sauren Fibroblast-Wachstumsfaktors
EP0406738A3 (en) * 1989-07-03 1991-08-14 Takeda Chemical Industries, Ltd. Production of acidic fgf protein
JPH0343088A (ja) * 1989-09-29 1991-02-25 Takeda Chem Ind Ltd ａＦＧＦ蛋白質の製造法
US5126323A (en) * 1989-11-16 1992-06-30 Genetics Institute, Inc. Homogeneous purified k-fgf and compositions containing the same
US5726152A (en) 1990-09-21 1998-03-10 Merck & Co., Inc. Vascular endothelial cell growth factor II
EP0506477B1 (de) 1991-03-28 1999-06-23 Merck & Co. Inc. Untereinheit-C des vaskulären endothelialen Zellwachstumsfaktors
US5348941A (en) * 1992-04-01 1994-09-20 Merck & Co., Inc. Stabilizers for fibroblast growth factors
US6746859B1 (en) 1993-01-15 2004-06-08 Genetics Institute, Llc Cloning of enterokinase and method of use
AU675506B2 (en) * 1993-01-15 1997-02-06 Genetics Institute, Llc Cloning of enterokinase and method of use
FR2724665B1 (fr) * 1994-09-16 1996-12-20 Rhone Poulenc Rorer Sa Procede de production de proteines recombinantes, plasmides et cellules modifiees
JP2014193870A (ja) * 2014-04-23 2014-10-09 Eu Sol Biotech Co Ltd ヒト酸性繊維芽細胞増殖因子の改変ペプチド

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444760A (en) * 1983-06-17 1984-04-24 Merck & Co., Inc. Purification and characterization of a protein fibroblast growth factor
EP0593065B1 (de) * 1985-09-12 2002-08-21 Scios Inc. Rekombinante Fibroblasten-Wachstums-Faktoren
US4935352A (en) * 1985-10-21 1990-06-19 Takeda Chemical Industries, Ltd. Expression vector for animal cell line and use thereof
US4868113A (en) * 1986-03-03 1989-09-19 Rorer Biotechnology, Inc. Recombinant DNA vector encoding human endothelial cell growth factor

Also Published As

Publication number Publication date
FI873033A (fi) 1988-01-12
DE3789530T2 (de) 1994-09-15
FI98915C (fi) 1997-09-10
KR960009725B1 (ko) 1996-07-23
JPH0714347B2 (ja) 1995-02-22
NZ220917A (en) 1991-05-28
IE871871L (en) 1988-01-11
PT85306B (pt) 1990-03-30
FI98915B (fi) 1997-05-30
DK175786B1 (da) 2005-02-21
JPS6394991A (ja) 1988-04-26
EP0259953A1 (de) 1988-03-16
EP0259953B1 (de) 1994-04-06
AU7554487A (en) 1988-01-14
IL83062A0 (en) 1987-12-31
KR880001817A (ko) 1988-04-27
PT85306A (en) 1987-08-01
DK358787A (da) 1988-01-12
ES2062982T3 (es) 1995-01-01
AU614262B2 (en) 1991-08-29
JPH07224096A (ja) 1995-08-22
IE62101B1 (en) 1994-12-14
FI873033A0 (fi) 1987-07-08
JP2565666B2 (ja) 1996-12-18
DK358787D0 (da) 1987-07-10
IL83062A (en) 1993-07-08

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