DK358787A - Vaekstfaktor, nucleotidsekvens kodende for vaekstfaktoren ekspressionsplasmid omfattende nucleotidsekvensen,vaert indeholdende plasmidet protein fremstillet af vaerten, fremgangsmaade til fremstilling af vaekstfaktoren og farmaceutisk praeparat indeholdendevaekstfaktoren - Google Patents

Vaekstfaktor, nucleotidsekvens kodende for vaekstfaktoren ekspressionsplasmid omfattende nucleotidsekvensen,vaert indeholdende plasmidet protein fremstillet af vaerten, fremgangsmaade til fremstilling af vaekstfaktoren og farmaceutisk praeparat indeholdendevaekstfaktoren

Info

Publication number
DK358787A
DK358787A DK358787A DK358787A DK358787A DK 358787 A DK358787 A DK 358787A DK 358787 A DK358787 A DK 358787A DK 358787 A DK358787 A DK 358787A DK 358787 A DK358787 A DK 358787A
Authority
DK
Denmark
Prior art keywords
nucleotide sequence
growth factor
preparation
production
plasmid
Prior art date
Application number
DK358787A
Other languages
English (en)
Other versions
DK358787D0 (da
DK175786B1 (da
Inventor
David L Linemeyer
Guillermo Gimenez-Gallego
Linda J Kelly
Jr Kenneth A Thomas
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK358787D0 publication Critical patent/DK358787D0/da
Publication of DK358787A publication Critical patent/DK358787A/da
Priority to DK199801023A priority Critical patent/DK175856B1/da
Application granted granted Critical
Publication of DK175786B1 publication Critical patent/DK175786B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK198703587A 1986-07-11 1987-07-10 Kloning og ekspression af sur fibroblastvækstfaktor DK175786B1 (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK199801023A DK175856B1 (da) 1986-07-11 1998-08-11 Nukleotid sekvens, ekspressionsplasmid og fremgangsmåde til oprensning af aFGF

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US88446086A 1986-07-11 1986-07-11
US88446086 1986-07-11
US5499187A 1987-06-04 1987-06-04
US5499187 1987-06-04

Publications (3)

Publication Number Publication Date
DK358787D0 DK358787D0 (da) 1987-07-10
DK358787A true DK358787A (da) 1988-01-12
DK175786B1 DK175786B1 (da) 2005-02-21

Family

ID=26733717

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198703587A DK175786B1 (da) 1986-07-11 1987-07-10 Kloning og ekspression af sur fibroblastvækstfaktor

Country Status (12)

Country Link
EP (1) EP0259953B1 (da)
JP (2) JPH0714347B2 (da)
KR (1) KR960009725B1 (da)
AU (1) AU614262B2 (da)
DE (1) DE3789530T2 (da)
DK (1) DK175786B1 (da)
ES (1) ES2062982T3 (da)
FI (1) FI98915C (da)
IE (1) IE62101B1 (da)
IL (1) IL83062A (da)
NZ (1) NZ220917A (da)
PT (1) PT85306B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE105868T1 (de) * 1985-09-12 1994-06-15 Scios Nova Inc Rekombinanter fibroblast-wachstumsfaktor.
DE3721081A1 (de) * 1987-06-26 1989-01-19 Progen Biotechnik Gmbh Dna-sequenz, die codiert fuer ein zellteilungsfoerderndes polypeptid, sowie ein plasmid, ein wirtsorganismus und ein verfahren zur gewinnung dieses polypeptids
US5175147A (en) * 1988-08-19 1992-12-29 Takeda Chemical Industries, Ltd Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract
US5656458A (en) * 1988-11-04 1997-08-12 Chiron Corporation Expression and processing of amino terminus acetylated FGF's in yeast
WO1990005184A1 (en) * 1988-11-04 1990-05-17 Chiron Corporation Expression and processing of authentic fgf's in yeast
EP0392605A1 (en) * 1989-04-13 1990-10-17 Merck & Co. Inc. Method of enhancing acidic fibroblast growth factor expression
JPH0343088A (ja) * 1989-09-29 1991-02-25 Takeda Chem Ind Ltd ａＦＧＦ蛋白質の製造法
EP0406738A3 (en) * 1989-07-03 1991-08-14 Takeda Chemical Industries, Ltd. Production of acidic fgf protein
US5126323A (en) * 1989-11-16 1992-06-30 Genetics Institute, Inc. Homogeneous purified k-fgf and compositions containing the same
US5726152A (en) * 1990-09-21 1998-03-10 Merck & Co., Inc. Vascular endothelial cell growth factor II
EP0506477B1 (en) 1991-03-28 1999-06-23 Merck & Co. Inc. Vascular endothelial cell growth factor C subunit
US5348941A (en) * 1992-04-01 1994-09-20 Merck & Co., Inc. Stabilizers for fibroblast growth factors
US6746859B1 (en) 1993-01-15 2004-06-08 Genetics Institute, Llc Cloning of enterokinase and method of use
ATE242330T1 (de) * 1993-01-15 2003-06-15 Inst Genetics Llc Klonierung von enterokinase und verfahren zu deren verwendung
FR2724665B1 (fr) * 1994-09-16 1996-12-20 Rhone Poulenc Rorer Sa Procede de production de proteines recombinantes, plasmides et cellules modifiees
JP2014193870A (ja) * 2014-04-23 2014-10-09 Eu Sol Biotech Co Ltd ヒト酸性繊維芽細胞増殖因子の改変ペプチド

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444760A (en) * 1983-06-17 1984-04-24 Merck & Co., Inc. Purification and characterization of a protein fibroblast growth factor
ATE105868T1 (de) * 1985-09-12 1994-06-15 Scios Nova Inc Rekombinanter fibroblast-wachstumsfaktor.
US4935352A (en) * 1985-10-21 1990-06-19 Takeda Chemical Industries, Ltd. Expression vector for animal cell line and use thereof
US4868113A (en) * 1986-03-03 1989-09-19 Rorer Biotechnology, Inc. Recombinant DNA vector encoding human endothelial cell growth factor

Also Published As

Publication number Publication date
FI98915B (fi) 1997-05-30
KR880001817A (ko) 1988-04-27
JP2565666B2 (ja) 1996-12-18
JPH07224096A (ja) 1995-08-22
JPS6394991A (ja) 1988-04-26
NZ220917A (en) 1991-05-28
KR960009725B1 (ko) 1996-07-23
FI98915C (fi) 1997-09-10
FI873033A (fi) 1988-01-12
IL83062A0 (en) 1987-12-31
IL83062A (en) 1993-07-08
DE3789530D1 (de) 1994-05-11
DK358787D0 (da) 1987-07-10
IE871871L (en) 1988-01-11
DE3789530T2 (de) 1994-09-15
EP0259953B1 (en) 1994-04-06
PT85306B (pt) 1990-03-30
AU7554487A (en) 1988-01-14
JPH0714347B2 (ja) 1995-02-22
ES2062982T3 (es) 1995-01-01
AU614262B2 (en) 1991-08-29
IE62101B1 (en) 1994-12-14
DK175786B1 (da) 2005-02-21
EP0259953A1 (en) 1988-03-16
FI873033A0 (fi) 1987-07-08
PT85306A (en) 1987-08-01

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PUP Patent expired