JP2012525853A5 - - Google Patents
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- JP2012525853A5 JP2012525853A5 JP2012510022A JP2012510022A JP2012525853A5 JP 2012525853 A5 JP2012525853 A5 JP 2012525853A5 JP 2012510022 A JP2012510022 A JP 2012510022A JP 2012510022 A JP2012510022 A JP 2012510022A JP 2012525853 A5 JP2012525853 A5 JP 2012525853A5
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- JP
- Japan
- Prior art keywords
- seq
- antibody
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- agent
- hvr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 38
- 239000003795 chemical substances by application Substances 0.000 claims description 26
- 239000004037 angiogenesis inhibitor Substances 0.000 claims description 25
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 24
- 206010028980 Neoplasm Diseases 0.000 claims description 20
- 229910052757 nitrogen Inorganic materials 0.000 claims description 20
- 239000003814 drug Substances 0.000 claims description 19
- 230000033115 angiogenesis Effects 0.000 claims description 15
- 230000001575 pathological effect Effects 0.000 claims description 14
- 229910052717 sulfur Inorganic materials 0.000 claims description 13
- 230000002401 inhibitory effect Effects 0.000 claims description 11
- 201000011510 cancer Diseases 0.000 claims description 10
- 206010029113 Neovascularisation Diseases 0.000 claims description 9
- 229960000397 bevacizumab Drugs 0.000 claims description 9
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 230000001613 neoplastic effect Effects 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 230000002708 enhancing effect Effects 0.000 claims description 7
- 230000002062 proliferating effect Effects 0.000 claims description 7
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims description 6
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 6
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 206010055665 Corneal neovascularisation Diseases 0.000 claims description 5
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims description 5
- 208000010412 Glaucoma Diseases 0.000 claims description 5
- 206010038933 Retinopathy of prematurity Diseases 0.000 claims description 5
- 206010038934 Retinopathy proliferative Diseases 0.000 claims description 5
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 5
- 210000002987 choroid plexus Anatomy 0.000 claims description 5
- 201000000159 corneal neovascularization Diseases 0.000 claims description 5
- 206010012601 diabetes mellitus Diseases 0.000 claims description 5
- 201000011190 diabetic macular edema Diseases 0.000 claims description 5
- 208000035475 disorder Diseases 0.000 claims description 5
- 208000002780 macular degeneration Diseases 0.000 claims description 5
- 201000003142 neovascular glaucoma Diseases 0.000 claims description 5
- 230000035699 permeability Effects 0.000 claims description 5
- 229960003876 ranibizumab Drugs 0.000 claims description 5
- 230000002207 retinal effect Effects 0.000 claims description 5
- 229940127089 cytotoxic agent Drugs 0.000 claims description 4
- 230000010412 perfusion Effects 0.000 claims description 4
- 206010006187 Breast cancer Diseases 0.000 claims description 3
- 208000026310 Breast neoplasm Diseases 0.000 claims description 3
- 206010009944 Colon cancer Diseases 0.000 claims description 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 201000005202 lung cancer Diseases 0.000 claims description 3
- 208000020816 lung neoplasm Diseases 0.000 claims description 3
- 206010005003 Bladder cancer Diseases 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 230000000202 analgesic effect Effects 0.000 claims description 2
- 230000003474 anti-emetic effect Effects 0.000 claims description 2
- 239000002111 antiemetic agent Substances 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- 229940022399 cancer vaccine Drugs 0.000 claims description 2
- 238000009566 cancer vaccine Methods 0.000 claims description 2
- 239000003246 corticosteroid Substances 0.000 claims description 2
- 239000000430 cytokine receptor antagonist Substances 0.000 claims description 2
- 231100000433 cytotoxic Toxicity 0.000 claims description 2
- 239000002254 cytotoxic agent Substances 0.000 claims description 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 2
- 230000001472 cytotoxic effect Effects 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 201000004101 esophageal cancer Diseases 0.000 claims description 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 2
- 229960003444 immunosuppressant agent Drugs 0.000 claims description 2
- 230000001861 immunosuppressant effect Effects 0.000 claims description 2
- 239000003018 immunosuppressive agent Substances 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000651 prodrug Substances 0.000 claims description 2
- 229940002612 prodrug Drugs 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 102100032031 Epidermal growth factor-like protein 7 Human genes 0.000 claims 1
- 101000921195 Homo sapiens Epidermal growth factor-like protein 7 Proteins 0.000 claims 1
- 230000001772 anti-angiogenic effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 229910052727 yttrium Inorganic materials 0.000 description 11
- 229910052739 hydrogen Inorganic materials 0.000 description 8
- 229910052698 phosphorus Inorganic materials 0.000 description 6
- 229910052799 carbon Inorganic materials 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17681709P | 2009-05-08 | 2009-05-08 | |
| US61/176,817 | 2009-05-08 | ||
| PCT/US2010/034097 WO2010129904A1 (en) | 2009-05-08 | 2010-05-07 | Humanized anti-egfl7 antibodies and methods using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012232771A Division JP2013055944A (ja) | 2009-05-08 | 2012-10-22 | ヒト化抗ｅｇｆｌ７抗体とその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012525853A JP2012525853A (ja) | 2012-10-25 |
| JP2012525853A5 true JP2012525853A5 (enExample) | 2012-12-06 |
| JP5383905B2 JP5383905B2 (ja) | 2014-01-08 |
Family
ID=42333507
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510022A Expired - Fee Related JP5383905B2 (ja) | 2009-05-08 | 2010-05-07 | ヒト化抗ｅｇｆｌ７抗体とその使用方法 |
| JP2012232771A Withdrawn JP2013055944A (ja) | 2009-05-08 | 2012-10-22 | ヒト化抗ｅｇｆｌ７抗体とその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012232771A Withdrawn JP2013055944A (ja) | 2009-05-08 | 2012-10-22 | ヒト化抗ｅｇｆｌ７抗体とその使用方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (8) | US8404811B2 (enExample) |
| EP (1) | EP2427493A1 (enExample) |
| JP (2) | JP5383905B2 (enExample) |
| KR (1) | KR20120005021A (enExample) |
| CN (3) | CN102875677A (enExample) |
| AR (1) | AR076662A1 (enExample) |
| AU (1) | AU2010245739B2 (enExample) |
| BR (1) | BRPI1007706A2 (enExample) |
| CA (2) | CA2838400A1 (enExample) |
| CL (1) | CL2011002784A1 (enExample) |
| CO (1) | CO6450619A2 (enExample) |
| CR (1) | CR20110576A (enExample) |
| EC (1) | ECSP11011430A (enExample) |
| IL (1) | IL216115A0 (enExample) |
| MA (1) | MA33551B1 (enExample) |
| MX (1) | MX2011010570A (enExample) |
| NZ (1) | NZ595641A (enExample) |
| PE (1) | PE20120902A1 (enExample) |
| RU (1) | RU2011149798A (enExample) |
| SG (1) | SG175891A1 (enExample) |
| TW (2) | TW201422237A (enExample) |
| UA (1) | UA105386C2 (enExample) |
| WO (1) | WO2010129904A1 (enExample) |
| ZA (1) | ZA201207484B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003057881A1 (en) * | 2001-12-28 | 2003-07-17 | Chugai Seiyaku Kabushiki Kaisha | Method of stabilizing protein |
| ES2699077T3 (es) | 2009-06-12 | 2019-02-07 | Sunovion Pharmaceuticals Inc | Apomorfina sublingual |
| EA031156B1 (ru) | 2010-12-16 | 2018-11-30 | Суновион Фармасьютикалз Инк. | Сублингвальные пленки |
| EP2670437A2 (en) * | 2011-02-02 | 2013-12-11 | F. Hoffmann-La Roche AG | Dosing for treatment with anti-egfl7 antibodies |
| WO2013061112A1 (en) | 2011-10-24 | 2013-05-02 | Centre National De La Recherche Scientifique | Use of egfl7 modulators for promoting or inhibiting migration of immune cells across vascular endothelium |
| WO2013142961A1 (en) * | 2012-03-27 | 2013-10-03 | London Health Sciences Centre Research Inc. | Egfl7 targeting and/or binding polypeptides and methods for inhibiting angiogenesis |
| BR112015001451B1 (pt) | 2012-07-23 | 2022-03-29 | Zealand Pharma A/S | Composto, construção de ácido nucleico, vetor de expressão, célula hospedeira, composição farmacêutica, utilização de um composto ou de seu sal ou solvato farmaceuticamente aceitável |
| AU2014216959A1 (en) * | 2013-02-15 | 2015-10-01 | Perseus Proteomics Inc. | Anti-CDH3 humanized antibody, drug conjugate thereof, and use thereof |
| AU2013201383B2 (en) | 2013-03-01 | 2015-07-02 | Royal Melbourne Institute Of Technology | Atomisation apparatus using surface acoustic wave generaton |
| US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
| MX368436B (es) | 2013-10-17 | 2019-10-03 | Zealand Pharma As | Analogos de glucagon acilados. |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| PL3283507T3 (pl) | 2015-04-16 | 2020-05-18 | Zealand Pharma A/S | Acylowany analog glukagonu |
| KR102538348B1 (ko) | 2015-09-17 | 2023-05-31 | 삼성전자 주식회사 | 전자 장치 및 전자 장치의 동작 제어 방법 |
| WO2017117464A1 (en) | 2015-12-30 | 2017-07-06 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
| JP6971319B2 (ja) | 2016-12-28 | 2021-11-24 | グリーン・クロス・ラブ・セル・コーポレイション | キメラ抗原受容体及びそれを発現するナチュラルキラー細胞 |
| CA3061505A1 (en) | 2017-04-24 | 2018-11-01 | Ohio State Innovation Foundation | Recombinant egfl7, egfl7 antibodies, and uses thereof |
| US11649294B2 (en) | 2017-11-14 | 2023-05-16 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
| EP3712178A4 (en) | 2017-11-14 | 2021-08-11 | Green Cross Lab Cell Corporation | ANTI-HER2 ANTIBODIES OR ANTIGIBODY FRAGMENT THEREOF AND CHIMERAIR ANTIGEN RECEPTOR WITH IT |
| BR112020017872A2 (pt) | 2018-03-02 | 2020-12-22 | Kodiak Sciences Inc. | Anticorpos de il-6 e construtos de fusão e conjugados dos mesmos |
| WO2021072265A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| US20240197635A1 (en) * | 2021-03-03 | 2024-06-20 | Veramorph Llc | Dissociating polymer matrix compositions of fulvestrant and methods of their making and use |
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-
2010
- 2010-05-07 WO PCT/US2010/034097 patent/WO2010129904A1/en not_active Ceased
- 2010-05-07 BR BRPI1007706-5A patent/BRPI1007706A2/pt not_active IP Right Cessation
- 2010-05-07 CN CN2012103669827A patent/CN102875677A/zh active Pending
- 2010-05-07 AR ARP100101570A patent/AR076662A1/es not_active Application Discontinuation
- 2010-05-07 PE PE2011001927A patent/PE20120902A1/es not_active Application Discontinuation
- 2010-05-07 NZ NZ595641A patent/NZ595641A/xx not_active IP Right Cessation
- 2010-05-07 TW TW102143561A patent/TW201422237A/zh unknown
- 2010-05-07 CA CA2838400A patent/CA2838400A1/en not_active Abandoned
- 2010-05-07 AU AU2010245739A patent/AU2010245739B2/en not_active Ceased
- 2010-05-07 CN CN201310664213.XA patent/CN103772500A/zh active Pending
- 2010-05-07 US US12/776,259 patent/US8404811B2/en not_active Expired - Fee Related
- 2010-05-07 TW TW099114730A patent/TWI428142B/zh not_active IP Right Cessation
- 2010-05-07 KR KR1020117026520A patent/KR20120005021A/ko not_active Ceased
- 2010-05-07 CA CA2760246A patent/CA2760246A1/en not_active Abandoned
- 2010-05-07 RU RU2011149798/02A patent/RU2011149798A/ru not_active Application Discontinuation
- 2010-05-07 SG SG2011081304A patent/SG175891A1/en unknown
- 2010-05-07 JP JP2012510022A patent/JP5383905B2/ja not_active Expired - Fee Related
- 2010-05-07 MX MX2011010570A patent/MX2011010570A/es not_active Application Discontinuation
- 2010-05-07 CN CN2010800301704A patent/CN102459338A/zh active Pending
- 2010-05-07 EP EP10717462A patent/EP2427493A1/en not_active Withdrawn
- 2010-07-05 UA UAA201114544A patent/UA105386C2/uk unknown
-
2011
- 2011-10-26 CO CO11144908A patent/CO6450619A2/es not_active Application Discontinuation
- 2011-11-01 EC EC2011011430A patent/ECSP11011430A/es unknown
- 2011-11-03 IL IL216115A patent/IL216115A0/en unknown
- 2011-11-07 CR CR20110576A patent/CR20110576A/es unknown
- 2011-11-07 CL CL2011002784A patent/CL2011002784A1/es unknown
- 2011-12-06 MA MA34426A patent/MA33551B1/fr unknown
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2012
- 2012-10-05 ZA ZA2012/07484A patent/ZA201207484B/en unknown
- 2012-10-22 JP JP2012232771A patent/JP2013055944A/ja not_active Withdrawn
- 2012-11-02 US US13/668,086 patent/US20130129749A1/en not_active Abandoned
- 2012-11-02 US US13/668,054 patent/US20140051120A1/en not_active Abandoned
- 2012-11-02 US US13/668,064 patent/US20130129733A1/en not_active Abandoned
- 2012-11-02 US US13/668,129 patent/US8574576B2/en not_active Expired - Fee Related
- 2012-11-02 US US13/668,028 patent/US20130149307A1/en not_active Abandoned
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2013
- 2013-06-17 US US13/919,629 patent/US20130287779A1/en not_active Abandoned
- 2013-07-17 US US13/944,538 patent/US20130324704A1/en not_active Abandoned