JP2017530691A5 - - Google Patents
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- JP2017530691A5 JP2017530691A5 JP2017501231A JP2017501231A JP2017530691A5 JP 2017530691 A5 JP2017530691 A5 JP 2017530691A5 JP 2017501231 A JP2017501231 A JP 2017501231A JP 2017501231 A JP2017501231 A JP 2017501231A JP 2017530691 A5 JP2017530691 A5 JP 2017530691A5
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- Prior art keywords
- cancer
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- antibody
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 37
- 238000000034 method Methods 0.000 claims 36
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 33
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 33
- 239000005557 antagonist Substances 0.000 claims 32
- 206010028980 Neoplasm Diseases 0.000 claims 29
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 26
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 26
- 239000000523 sample Substances 0.000 claims 19
- 238000011319 anticancer therapy Methods 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 8
- 210000001519 tissue Anatomy 0.000 claims 8
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 7
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 6
- 210000002865 immune cell Anatomy 0.000 claims 6
- 210000004881 tumor cell Anatomy 0.000 claims 6
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 5
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 5
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 108091006020 Fc-tagged proteins Proteins 0.000 claims 4
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 4
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 4
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000004064 dysfunction Effects 0.000 claims 4
- 208000026278 immune system disease Diseases 0.000 claims 4
- 238000010166 immunofluorescence Methods 0.000 claims 4
- 238000003364 immunohistochemistry Methods 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 208000014018 liver neoplasm Diseases 0.000 claims 4
- 229960003301 nivolumab Drugs 0.000 claims 4
- 229960002621 pembrolizumab Drugs 0.000 claims 4
- 238000011282 treatment Methods 0.000 claims 4
- 238000002965 ELISA Methods 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 229950009791 durvalumab Drugs 0.000 claims 3
- 238000000684 flow cytometry Methods 0.000 claims 3
- 238000003119 immunoblot Methods 0.000 claims 3
- 201000007270 liver cancer Diseases 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 2
- 208000032612 Glial tumor Diseases 0.000 claims 2
- 206010018338 Glioma Diseases 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 208000037581 Persistent Infection Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 206010061934 Salivary gland cancer Diseases 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 208000009956 adenocarcinoma Diseases 0.000 claims 2
- 229950002916 avelumab Drugs 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 201000003914 endometrial carcinoma Diseases 0.000 claims 2
- 230000002357 endometrial effect Effects 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
- 230000036039 immunity Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 201000002628 peritoneum cancer Diseases 0.000 claims 2
- 201000003804 salivary gland carcinoma Diseases 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- 229950007213 spartalizumab Drugs 0.000 claims 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 2
- 210000002536 stromal cell Anatomy 0.000 claims 2
- 201000002510 thyroid cancer Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- 208000012991 uterine carcinoma Diseases 0.000 claims 2
- 201000005102 vulva cancer Diseases 0.000 claims 2
- 208000010667 Carcinoma of liver and intrahepatic biliary tract Diseases 0.000 claims 1
- 206010073069 Hepatic cancer Diseases 0.000 claims 1
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 206010047741 Vulval cancer Diseases 0.000 claims 1
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 229960003852 atezolizumab Drugs 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000003966 growth inhibitor Substances 0.000 claims 1
- 230000002440 hepatic effect Effects 0.000 claims 1
- 102000048776 human CD274 Human genes 0.000 claims 1
- 229940127121 immunoconjugate Drugs 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 201000002250 liver carcinoma Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000005296 lung carcinoma Diseases 0.000 claims 1
- 201000005243 lung squamous cell carcinoma Diseases 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 239000012188 paraffin wax Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021212093A JP2022061983A (ja) | 2014-07-11 | 2021-12-27 | 抗ｐｄ－ｌ１抗体及びその診断上の使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462023741P | 2014-07-11 | 2014-07-11 | |
| US62/023,741 | 2014-07-11 | ||
| PCT/US2015/033395 WO2016007235A1 (en) | 2014-07-11 | 2015-05-29 | Anti-pd-l1 antibodies and diagnostic uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021212093A Division JP2022061983A (ja) | 2014-07-11 | 2021-12-27 | 抗ｐｄ－ｌ１抗体及びその診断上の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017530691A JP2017530691A (ja) | 2017-10-19 |
| JP2017530691A5 true JP2017530691A5 (enExample) | 2018-07-12 |
| JP7032929B2 JP7032929B2 (ja) | 2022-03-09 |
Family
ID=53373660
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017501231A Active JP7032929B2 (ja) | 2014-07-11 | 2015-05-29 | 抗ｐｄ－ｌ１抗体及びその診断上の使用 |
| JP2021212093A Pending JP2022061983A (ja) | 2014-07-11 | 2021-12-27 | 抗ｐｄ－ｌ１抗体及びその診断上の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021212093A Pending JP2022061983A (ja) | 2014-07-11 | 2021-12-27 | 抗ｐｄ－ｌ１抗体及びその診断上の使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US20160009805A1 (enExample) |
| EP (2) | EP3309174B1 (enExample) |
| JP (2) | JP7032929B2 (enExample) |
| KR (1) | KR102360693B1 (enExample) |
| CN (1) | CN106604933B (enExample) |
| AU (1) | AU2015288232B2 (enExample) |
| BR (1) | BR112017000497B1 (enExample) |
| CA (1) | CA2954868C (enExample) |
| DK (1) | DK3309174T3 (enExample) |
| ES (1) | ES2916923T3 (enExample) |
| IL (1) | IL250032B (enExample) |
| MX (1) | MX384364B (enExample) |
| MY (1) | MY188940A (enExample) |
| RU (1) | RU2715038C2 (enExample) |
| SG (1) | SG11201700207WA (enExample) |
| WO (1) | WO2016007235A1 (enExample) |
| ZA (1) | ZA201700832B (enExample) |
Families Citing this family (148)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2012048113A2 (en) | 2010-10-07 | 2012-04-12 | The General Hospital Corporation | Biomarkers of cancer |
| KR20230070054A (ko) | 2013-03-15 | 2023-05-19 | 제넨테크, 인크. | Pd-1 및 pd-l1 관련 상태를 치료하기 위한 바이오마커 및 방법 |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| US9909167B2 (en) | 2014-06-23 | 2018-03-06 | The Board Of Trustees Of The Leland Stanford Junior University | On-slide staining by primer extension |
| EP3760208B1 (en) | 2014-06-25 | 2024-05-29 | The General Hospital Corporation | Targeting human satellite ii (hsatii) |
| BR112017000497B1 (pt) | 2014-07-11 | 2023-12-26 | Ventana Medical Systems, Inc | Anticorpo isolado, célula hospedeira procariótica, imunoconjugado e método de detecção da presença ou do nível de expressão de pd-l1 |
| EP4279087A3 (en) * | 2015-02-26 | 2024-01-31 | Merck Patent GmbH | Pd-1 / pd-l1 inhibitors for the treatment of cancer |
| EP3268392A2 (en) | 2015-03-13 | 2018-01-17 | CytomX Therapeutics, Inc. | Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof |
| AU2016243120B2 (en) | 2015-03-27 | 2021-09-30 | Immunitybio, Inc. | Genetically modified NK-92 cells and monoclonal antibodies for the treatment of cancer |
| US20180071413A1 (en) * | 2015-04-07 | 2018-03-15 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Non-invasive imaging of tumor pd-l1 expression |
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| KR102689256B1 (ko) | 2015-06-17 | 2024-07-30 | 제넨테크, 인크. | Pd-1 축 결합 길항제 및 탁산을 사용하여 국소적 진행성 또는 전이성 유방암을 치료하는 방법 |
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