JP2017505305A5 - - Google Patents

Info

Publication number

JP2017505305A5

JP2017505305A5 JP2016547908A JP2016547908A JP2017505305A5 JP 2017505305 A5 JP2017505305 A5 JP 2017505305A5 JP 2016547908 A JP2016547908 A JP 2016547908A JP 2016547908 A JP2016547908 A JP 2016547908A JP 2017505305 A5 JP2017505305 A5 JP 2017505305A5

Authority

JP

Japan

Prior art keywords

medicament according

seq

prostate

medicament

antibody

Prior art date

2015-01-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 239000003814 drug Substances 0.000 claims 26
• 210000002307 prostate Anatomy 0.000 claims 7
• 108010052285 Membrane Proteins Proteins 0.000 claims 6
• 102000018697 Membrane Proteins Human genes 0.000 claims 6
• 125000003275 alpha amino acid group Chemical group 0.000 claims 6
• 206010060862 Prostate cancer Diseases 0.000 claims 5
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 5
• 102000001307 androgen receptors Human genes 0.000 claims 5
• 108010080146 androgen receptors Proteins 0.000 claims 5
• 239000003112 inhibitor Substances 0.000 claims 4
• 239000002254 cytotoxic agent Substances 0.000 claims 3
• 229940127089 cytotoxic agent Drugs 0.000 claims 3
• 231100000599 cytotoxic agent Toxicity 0.000 claims 3
• 108010016626 Dipeptides Proteins 0.000 claims 2
• 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 2
• 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 2
• 101710120463 Prostate stem cell antigen Proteins 0.000 claims 2
• 102100036735 Prostate stem cell antigen Human genes 0.000 claims 2
• 239000003080 antimitotic agent Substances 0.000 claims 2
• 108010044540 auristatin Proteins 0.000 claims 2
• 229940127121 immunoconjugate Drugs 0.000 claims 2
• 208000010658 metastatic prostate carcinoma Diseases 0.000 claims 2
• AGGWFDNPHKLBBV-YUMQZZPRSA-N (2s)-2-[[(2s)-2-amino-3-methylbutanoyl]amino]-5-(carbamoylamino)pentanoic acid Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CCCNC(N)=O AGGWFDNPHKLBBV-YUMQZZPRSA-N 0.000 claims 1
• MQLACMBJVPINKE-UHFFFAOYSA-N 10-[(3-hydroxy-4-methoxyphenyl)methylidene]anthracen-9-one Chemical compound C1=C(O)C(OC)=CC=C1C=C1C2=CC=CC=C2C(=O)C2=CC=CC=C21 MQLACMBJVPINKE-UHFFFAOYSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 101710145634 Antigen 1 Proteins 0.000 claims 1
• 108010078791 Carrier Proteins Proteins 0.000 claims 1
• 102100039496 Choline transporter-like protein 4 Human genes 0.000 claims 1
• 108020004414 DNA Proteins 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 108091005804 Peptidases Proteins 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
• 108091007561 SLC44A4 Proteins 0.000 claims 1
• IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 239000000654 additive Substances 0.000 claims 1
• 230000000996 additive effect Effects 0.000 claims 1
• 239000003098 androgen Substances 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 150000007857 hydrazones Chemical class 0.000 claims 1
• 230000003993 interaction Effects 0.000 claims 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 230000001394 metastastic effect Effects 0.000 claims 1
• 206010061289 metastatic neoplasm Diseases 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 230000005937 nuclear translocation Effects 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 229910052717 sulfur Inorganic materials 0.000 claims 1
• 125000004434 sulfur atom Chemical group 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1