JP2020536109A5 - - Google Patents

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JP2020536109A5
JP2020536109A5 JP2020519404A JP2020519404A JP2020536109A5 JP 2020536109 A5 JP2020536109 A5 JP 2020536109A5 JP 2020519404 A JP2020519404 A JP 2020519404A JP 2020519404 A JP2020519404 A JP 2020519404A JP 2020536109 A5 JP2020536109 A5 JP 2020536109A5
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Japan
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antibody
amino acid
use according
seq
human
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JP2020519404A
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Japanese (ja)
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JP2020536109A (ja
JP7274469B2 (ja
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Priority claimed from PCT/EP2018/077217 external-priority patent/WO2019068907A1/en
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JP2020519404A 2017-10-06 2018-10-05 Cd39/cd73軸によるt細胞活性の回復 Active JP7274469B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762568812P 2017-10-06 2017-10-06
US62/568,812 2017-10-06
US201862686143P 2018-06-18 2018-06-18
US62/686,143 2018-06-18
PCT/EP2018/077217 WO2019068907A1 (en) 2017-10-06 2018-10-05 RESTORATION OF T CELL ACTIVITY BY AXIS CD39 / CD73

Publications (3)

Publication Number Publication Date
JP2020536109A JP2020536109A (ja) 2020-12-10
JP2020536109A5 true JP2020536109A5 (enExample) 2021-10-21
JP7274469B2 JP7274469B2 (ja) 2023-05-16

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JP2020519404A Active JP7274469B2 (ja) 2017-10-06 2018-10-05 Cd39/cd73軸によるt細胞活性の回復

Country Status (11)

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US (2) US20190218308A1 (enExample)
EP (1) EP3692068B1 (enExample)
JP (1) JP7274469B2 (enExample)
KR (1) KR102710877B1 (enExample)
CN (1) CN111542539B (enExample)
AU (1) AU2018346447B2 (enExample)
BR (1) BR112020006809A2 (enExample)
CA (1) CA3074588A1 (enExample)
IL (1) IL273414B2 (enExample)
SG (1) SG11202002192QA (enExample)
WO (1) WO2019068907A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3153526B1 (en) 2008-01-31 2020-09-23 INSERM - Institut National de la Santé et de la Recherche Médicale Antibodies against human cd39 and use thereof for inhibiting t regulatory cells activity
GB2545676A (en) * 2015-12-21 2017-06-28 Dublin Inst Of Tech Prediction of therapeutic response using vibrational spectroscopy
AU2018235092B2 (en) 2017-03-16 2024-09-19 Innate Pharma Compositions and methods for treating cancer
SG11202000820PA (en) 2017-07-31 2020-02-27 Tizona Therapeutics Anti-cd39 antibodies, compositions comprising anti-cd39 antibodies and methods of using anti-cd39 antibodies
CN112074541A (zh) 2018-05-03 2020-12-11 上海岸迈生物科技有限公司 Pd-1和lag-3的高亲和力抗体以及由其制备的双特异性结合蛋白
TWI870353B (zh) 2018-06-18 2025-01-21 法商天賜製藥公司 用於治療癌症之組合物及方法
KR20220002959A (ko) 2019-04-23 2022-01-07 이나뜨 파르마 에스.에이. Cd73 차단 항체
WO2020216947A1 (en) 2019-04-24 2020-10-29 Heidelberg Pharma Research Gmbh Amatoxin antibody-drug conjugates and uses thereof
CN115141277A (zh) * 2019-08-21 2022-10-04 和铂医药(上海)有限责任公司 抗cd73抗体及其应用
KR20220050971A (ko) * 2019-08-27 2022-04-25 엘피사이언스 (쑤저우) 바이오파마, 엘티디. 신규 항-cd39 항체
CN110407941B (zh) * 2019-09-25 2020-01-14 上海岸迈生物科技有限公司 Cd39的高亲和力抗体及其用途
US12391756B2 (en) 2019-11-05 2025-08-19 Jacobio Pharmaceuticals Co., Ltd. Binding molecule specific for CD39 and use thereof
EP4076669A4 (en) * 2019-12-19 2024-01-10 Board of Regents, The University of Texas System METHOD FOR TREATING GLIOBLASTOMA
CN114106160A (zh) * 2020-08-28 2022-03-01 安源医药科技(上海)有限公司 抗SARS-CoV-2病毒单克隆抗体及应用
US20220133902A1 (en) * 2020-11-04 2022-05-05 Heidelberg Pharma Research Gmbh Composition Comprising a Combination of Immune Checkpoint Inhibitor and Antibody-Amatoxin Conjugate for Use in Cancer Therapy
AR124906A1 (es) * 2021-02-19 2023-05-17 Janssen Biotech Inc Materiales y métodos para dirigirse a las células t reguladoras para potenciar la vigilancia inmunitaria
TW202302638A (zh) * 2021-02-19 2023-01-16 美商健生生物科技公司 用於靶向調節性t細胞以增強免疫監視之材料及方法
MX2023011031A (es) 2021-03-19 2023-12-14 Heidelberg Pharma Res Gmbh Conjugados de amatoxina y anticuerpo especificos de linfocitos b.
TW202340243A (zh) 2022-03-03 2023-10-16 美商阿克思生物科學有限公司 抗cd39抗體及其用途
CN119403837A (zh) * 2022-06-08 2025-02-07 上海华奥泰生物药业股份有限公司 Cd39/cd73双特异性抗原结合蛋白及其用途
WO2024197020A2 (en) * 2023-03-21 2024-09-26 Beam Therapeutics Inc. Immunosuppressant-resistant modified allogeneic modified immune cells and methods for use thereof
CN120992939B (zh) * 2025-10-27 2025-12-26 苏州旭光科星抗体生物科技有限公司 一种可溶性cd39蛋白含量检测试剂盒及其应用

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
US5776427A (en) 1992-03-05 1998-07-07 Board Of Regents, The University Of Texas System Methods for targeting the vasculature of solid tumors
US6387645B1 (en) * 1998-07-16 2002-05-14 Hyseq, Inc. Methods and materials relating to novel CD39-like polypeptides
EP3530736A3 (en) 2005-05-09 2019-11-06 ONO Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
KR101704734B1 (ko) 2005-07-01 2017-02-09 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
US20090028857A1 (en) 2007-07-23 2009-01-29 Cell Genesys, Inc. Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof
EP3153526B1 (en) 2008-01-31 2020-09-23 INSERM - Institut National de la Santé et de la Recherche Médicale Antibodies against human cd39 and use thereof for inhibiting t regulatory cells activity
PT2242773T (pt) 2008-02-11 2017-09-15 Cure Tech Ltd Anticorpos monoclonais para o tratamento de tumores
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
MX356367B (es) 2008-12-09 2018-05-25 Genentech Inc Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t.
EP3279215B1 (en) 2009-11-24 2020-02-12 MedImmune Limited Targeted binding agents against b7-h1
US8865653B2 (en) * 2010-04-22 2014-10-21 Institut Gustave Roussy Method of treatment for immunogenic treatment resistant cancer
CA2833636A1 (en) 2011-04-20 2012-10-26 Amplimmune, Inc. Antibodies and other molecules that bind b7-h1 and pd-1
BR112014002353B1 (pt) 2011-08-01 2022-09-27 Genentech, Inc Usos de antagonistas de ligação do eixo pd-1 e inibidores de mek, composições farmacêuticas, e kit
JP6405242B2 (ja) * 2012-02-07 2018-10-17 イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. Mica結合剤
FR3011240A1 (fr) 2013-10-01 2015-04-03 Centre Nat Rech Scient Inhibiteurs de 5'-nucleotidases et leurs utilisations therapeutiques
CR20160319A (es) 2013-12-12 2016-11-08 Jiangsu Hengrui Medicine Co Anticuerpo pd-1, fragmento de union al antigeno de este y uso médico de este
EP3134411B1 (en) 2014-04-25 2021-06-30 Boehringer Ingelheim International GmbH Purine derivatives as cd73 inhibitors for the treatment of cancer
WO2016055609A1 (en) * 2014-10-10 2016-04-14 Innate Pharma Cd73 blockade
RS62003B2 (sr) 2014-11-10 2025-01-31 Medimmune Ltd Vezujući molekuli specifični za cd73 i njihove upotrebe
EP3789403A1 (en) * 2014-11-11 2021-03-10 MedImmune Limited Therapeutic combinations comprising anti-cd73 antibodies and a2a receptor inhibitor and uses thereof
JP6805142B2 (ja) 2014-11-21 2020-12-23 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Cd73に対する抗体およびその使用
EP3259288B1 (en) 2015-02-20 2026-07-22 Innate Pharma Cd73 blockade
WO2017064043A1 (en) * 2015-10-12 2017-04-20 Innate Pharma Cd73 blocking agents
EP3380519A1 (en) 2015-11-23 2018-10-03 Innate Pharma Cd39 vascular isoform targeting agents
WO2017098421A1 (en) 2015-12-08 2017-06-15 Glaxosmithkline Intellectual Property Development Limited Benzothiadiazine compounds
CA3007646A1 (en) 2015-12-09 2017-06-15 Bioatla, Llc Humanized anti-cd73 antibodies
LT3399984T (lt) 2016-01-08 2023-11-10 Arcus Biosciences, Inc. 5'-nukleotidazės, ekto moduliatoriai ir jų panaudojimas
WO2017153952A1 (en) 2016-03-10 2017-09-14 Glaxosmithkline Intellectual Property Development Limited 5-sulfamoyl-2-hydroxybenzamide derivatives
CN110022881B (zh) 2016-11-18 2023-05-02 艾库斯生物科学有限公司 Cd73介导的免疫抑制的抑制剂
AU2018235092B2 (en) * 2017-03-16 2024-09-19 Innate Pharma Compositions and methods for treating cancer
IL273440B1 (en) * 2017-11-15 2026-08-01 Innate Pharma Strengthening the effect of ATP release
KR20220002959A (ko) * 2019-04-23 2022-01-07 이나뜨 파르마 에스.에이. Cd73 차단 항체
CN114127121B (zh) * 2019-08-12 2025-04-11 北京恩瑞尼生物科技股份有限公司 用于通过cd39表达细胞的adcc靶向促进和增强t细胞介导的免疫反应的方法和组合物

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