CA3074588A1 - Restoration of t cell activity via the cd39/cd73 axis - Google Patents
Restoration of t cell activity via the cd39/cd73 axis Download PDFInfo
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- CA3074588A1 CA3074588A1 CA3074588A CA3074588A CA3074588A1 CA 3074588 A1 CA3074588 A1 CA 3074588A1 CA 3074588 A CA3074588 A CA 3074588A CA 3074588 A CA3074588 A CA 3074588A CA 3074588 A1 CA3074588 A1 CA 3074588A1
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| PCT/EP2018/077217 WO2019068907A1 (en) | 2017-10-06 | 2018-10-05 | RESTORATION OF T CELL ACTIVITY BY AXIS CD39 / CD73 |
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| EP3153526B1 (en) | 2008-01-31 | 2020-09-23 | INSERM - Institut National de la Santé et de la Recherche Médicale | Antibodies against human cd39 and use thereof for inhibiting t regulatory cells activity |
| GB2545676A (en) * | 2015-12-21 | 2017-06-28 | Dublin Inst Of Tech | Prediction of therapeutic response using vibrational spectroscopy |
| WO2018167267A1 (en) | 2017-03-16 | 2018-09-20 | Innate Pharma | Compositions and methods for treating cancer |
| US11345757B2 (en) | 2017-07-31 | 2022-05-31 | Trishula Therapeutics, Inc. | Anti-CD39 antibodies |
| CN112074541A (zh) | 2018-05-03 | 2020-12-11 | 上海岸迈生物科技有限公司 | Pd-1和lag-3的高亲和力抗体以及由其制备的双特异性结合蛋白 |
| US11377503B2 (en) | 2018-06-18 | 2022-07-05 | Innate Pharma | Antibodies that bind human CD39 and inhibit ATPase activity of a soluble extracellular domain human CD39 polypeptide |
| CN113454121B (zh) * | 2019-08-21 | 2022-03-08 | 和铂医药(上海)有限责任公司 | 抗cd73抗体及其应用 |
| EP3820907A4 (en) * | 2019-08-27 | 2022-05-04 | Elpiscience (Suzhou) Biopharma, Ltd. | NOVEL ANTI-CD39 ANTIBODIES |
| CN110407941B (zh) * | 2019-09-25 | 2020-01-14 | 上海岸迈生物科技有限公司 | Cd39的高亲和力抗体及其用途 |
| TW202118791A (zh) | 2019-11-05 | 2021-05-16 | 大陸商北京加科思新藥研發有限公司 | 對cd39具有特異性的結合分子及其用途 |
| CN115135386A (zh) * | 2019-12-19 | 2022-09-30 | 得克萨斯州大学系统董事会 | 用于治疗胶质母细胞瘤的方法 |
| CN114106160A (zh) * | 2020-08-28 | 2022-03-01 | 安源医药科技（上海）有限公司 | 抗SARS-CoV-2病毒单克隆抗体及应用 |
| US20220133902A1 (en) * | 2020-11-04 | 2022-05-05 | Heidelberg Pharma Research Gmbh | Composition Comprising a Combination of Immune Checkpoint Inhibitor and Antibody-Amatoxin Conjugate for Use in Cancer Therapy |
| CA3211501A1 (en) * | 2021-02-19 | 2022-08-25 | Janssen Biotech, Inc. | Materials and methods for targeting regulatory t cells for enhancing immune surveillance |
| BR112023018189A2 (pt) | 2021-03-19 | 2023-10-24 | Heidelberg Pharma Res Gmbh | Conjugados de anticorpos de amatoxina específicos de linfócitos b, composição famacêutica e uso relacionados |
| AU2023227964A1 (en) | 2022-03-03 | 2024-09-19 | Arcus Biosciences, Inc. | Anti-cd39 antibodies and use thereof |
| US20250361314A1 (en) * | 2022-06-08 | 2025-11-27 | Shanghai Huaota Biopharmaceutical Co., Ltd. | Cd39/cd73 bispecific antigen binding protein and use thereof |
| WO2024197020A2 (en) * | 2023-03-21 | 2024-09-26 | Beam Therapeutics Inc. | Immunosuppressant-resistant modified allogeneic modified immune cells and methods for use thereof |
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| ES2807182T3 (es) | 2014-11-21 | 2021-02-22 | Bristol Myers Squibb Co | Anticuerpos frente a CD73 y sus usos |
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| WO2018167267A1 (en) * | 2017-03-16 | 2018-09-20 | Innate Pharma | Compositions and methods for treating cancer |
| AU2018368541B2 (en) * | 2017-11-15 | 2025-06-12 | Innate Pharma | Potentiating the effect of ATP release |
| CN113784981B (zh) * | 2019-04-23 | 2025-01-28 | 先天制药公司 | Cd73阻断抗体 |
| CA3149494A1 (en) * | 2019-08-12 | 2021-02-18 | Purinomia Biotech, Inc. | Methods and compositions for promoting and potentiating t-cell mediated immune responses through adcc targeting of cd39 expressing cells |
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| EP3692068B1 (en) | 2022-12-07 |
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| AU2018346447A1 (en) | 2020-03-19 |
| EP3692068A1 (en) | 2020-08-12 |
| CN111542539B (zh) | 2023-10-20 |
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