PT642580E - Variantes de factor de crescimento dos hepatocitos - Google Patents

Variantes de factor de crescimento dos hepatocitos

Info

Publication number
PT642580E
PT642580E PT93911339T PT93911339T PT642580E PT 642580 E PT642580 E PT 642580E PT 93911339 T PT93911339 T PT 93911339T PT 93911339 T PT93911339 T PT 93911339T PT 642580 E PT642580 E PT 642580E
Authority
PT
Portugal
Prior art keywords
growth factor
hgf
hepatocytes
variables
mutation
Prior art date
Application number
PT93911339T
Other languages
English (en)
Inventor
Nathalie Lokker
Paul J Godowski
Melanie R Mark
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/885,971 external-priority patent/US5328837A/en
Priority claimed from US07/884,811 external-priority patent/US5316921A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PT642580E publication Critical patent/PT642580E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT93911339T 1992-05-18 1993-05-17 Variantes de factor de crescimento dos hepatocitos PT642580E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/885,971 US5328837A (en) 1992-05-18 1992-05-18 Hepatocyte growth factor protease domain variants
US07/884,811 US5316921A (en) 1992-05-18 1992-05-18 Single-chain hepatocyte growth factor variants

Publications (1)

Publication Number Publication Date
PT642580E true PT642580E (pt) 2003-01-31

Family

ID=27128741

Family Applications (1)

Application Number Title Priority Date Filing Date
PT93911339T PT642580E (pt) 1992-05-18 1993-05-17 Variantes de factor de crescimento dos hepatocitos

Country Status (10)

Country Link
US (1) US5547856A (pt)
EP (1) EP0642580B1 (pt)
JP (2) JPH07508420A (pt)
AT (1) ATE222603T1 (pt)
CA (1) CA2118012A1 (pt)
DE (1) DE69332221T2 (pt)
DK (1) DK0642580T3 (pt)
ES (1) ES2181689T3 (pt)
PT (1) PT642580E (pt)
WO (1) WO1993023541A1 (pt)

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ITMI980179A1 (it) 1998-01-30 1999-07-30 Dompe Spa Proteine ricombinanti derivate da hgf e msp
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EP1695982B1 (en) 2003-12-16 2013-01-23 Toshikazu Nakamura Glycosylation-deficient hepatocyte growth factor
SI1718677T1 (sl) * 2003-12-19 2012-08-31 Genentech Inc Monovalentni protitelesni fragmenti, uporabni kot zdravila
US7807177B2 (en) * 2004-01-27 2010-10-05 Toshikazu Nakamura Segment of glycosylation-deficient HGFalpha-chain
WO2005095449A1 (en) 2004-03-03 2005-10-13 F. Hoffmann-La Roche Ag Method for the purification of an n-terminal fragment of hepatocyte growth factor
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DE602005020799D1 (de) 2004-08-05 2010-06-02 Genentech Inc Humanisierte anti-cmet-antagonisten
US7737115B2 (en) 2005-04-15 2010-06-15 Genetech, Inc. HGF beta chain variants
EP2260056A1 (en) * 2008-03-06 2010-12-15 Genentech, Inc. Combination therapy with c-met and her antagonists
US20130004484A1 (en) 2011-06-30 2013-01-03 Genentech, Inc. Anti-c-met antibody formulations
MX2016012285A (es) 2014-03-24 2017-01-23 Genentech Inc Tratamiento de cáncer con antagonista de c-met y correlación de estos con la expresión de hgf.
WO2019027299A2 (ko) * 2017-08-04 2019-02-07 주식회사 에스엘바이젠 간세포성장인자를 발현하는 중간엽줄기세포를 유효성분으로 포함하는 혈관계 질환 예방 또는 치료용 약학 조성물
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Also Published As

Publication number Publication date
ES2181689T3 (es) 2003-03-01
CA2118012A1 (en) 1993-11-25
WO1993023541A1 (en) 1993-11-25
US5547856A (en) 1996-08-20
EP0642580B1 (en) 2002-08-21
ATE222603T1 (de) 2002-09-15
EP0642580A1 (en) 1995-03-15
DE69332221T2 (de) 2003-04-17
JPH07508420A (ja) 1995-09-21
DE69332221D1 (de) 2002-09-26
DK0642580T3 (da) 2002-12-23
JP2004000236A (ja) 2004-01-08

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