JPS643199A - Monoclonal antibody - Google Patents
Monoclonal antibodyInfo
- Publication number
- JPS643199A JPS643199A JP62159149A JP15914987A JPS643199A JP S643199 A JPS643199 A JP S643199A JP 62159149 A JP62159149 A JP 62159149A JP 15914987 A JP15914987 A JP 15914987A JP S643199 A JPS643199 A JP S643199A
- Authority
- JP
- Japan
- Prior art keywords
- cell growth
- human hepatic
- cells
- antibody
- hepatic cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:An antibody capable of exhibiting specific reactivity to human hepatic cell growth factors. USE:Useful for screening and diagnosing hepatopathy, purifying human hepatic cell growth factors, etc. PREPARATION:A mammal, such as mouse, is initially immunized with a human hepatic cell growth factor as an antigen and splenic cells of the immunized animal are extracted and then fused to mammalian plasmocytoma cells, such as myelomatous cells, using a cell fusion promoter, such as polyethylene glycol, to afford a hybridoma. A strain capable of producing the aimed antibody is searched from the above-mentioned hybridoma and then monocloned. The aforementioned is finally propagated in abdominal cavity, etc., of a mouse to produce the aimed antibody.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62159149A JPS643199A (en) | 1987-06-25 | 1987-06-25 | Monoclonal antibody |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62159149A JPS643199A (en) | 1987-06-25 | 1987-06-25 | Monoclonal antibody |
Publications (3)
Publication Number | Publication Date |
---|---|
JPH013199A JPH013199A (en) | 1989-01-06 |
JPS643199A true JPS643199A (en) | 1989-01-06 |
JPH0560359B2 JPH0560359B2 (en) | 1993-09-02 |
Family
ID=15687329
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP62159149A Granted JPS643199A (en) | 1987-06-25 | 1987-06-25 | Monoclonal antibody |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS643199A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5547856A (en) * | 1992-05-18 | 1996-08-20 | Genentech, Inc. | Hepatocyte growth factor variants |
US5580963A (en) * | 1992-05-18 | 1996-12-03 | Genentech, Inc. | Single-chain hepatocyte growth factor variants |
US5879910A (en) * | 1992-05-18 | 1999-03-09 | Genetech, Inc. | Hepatocyte growth factor protease domain variants |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6045534A (en) * | 1983-08-22 | 1985-03-12 | Otsuka Pharmaceut Co Ltd | Hepatocyte growth factor |
JPS6245530A (en) * | 1985-08-23 | 1987-02-27 | Otsuka Pharmaceut Co Ltd | Proliferation factor for hepatic parenchymal cell |
-
1987
- 1987-06-25 JP JP62159149A patent/JPS643199A/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6045534A (en) * | 1983-08-22 | 1985-03-12 | Otsuka Pharmaceut Co Ltd | Hepatocyte growth factor |
JPS6245530A (en) * | 1985-08-23 | 1987-02-27 | Otsuka Pharmaceut Co Ltd | Proliferation factor for hepatic parenchymal cell |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5547856A (en) * | 1992-05-18 | 1996-08-20 | Genentech, Inc. | Hepatocyte growth factor variants |
US5580963A (en) * | 1992-05-18 | 1996-12-03 | Genentech, Inc. | Single-chain hepatocyte growth factor variants |
US5879910A (en) * | 1992-05-18 | 1999-03-09 | Genetech, Inc. | Hepatocyte growth factor protease domain variants |
Also Published As
Publication number | Publication date |
---|---|
JPH0560359B2 (en) | 1993-09-02 |
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