JPS643199A - Monoclonal antibody - Google Patents

Monoclonal antibody

Info

Publication number
JPS643199A
JPS643199A JP62159149A JP15914987A JPS643199A JP S643199 A JPS643199 A JP S643199A JP 62159149 A JP62159149 A JP 62159149A JP 15914987 A JP15914987 A JP 15914987A JP S643199 A JPS643199 A JP S643199A
Authority
JP
Japan
Prior art keywords
cell growth
human hepatic
cells
antibody
hepatic cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62159149A
Other languages
Japanese (ja)
Other versions
JPH0560359B2 (en
JPH013199A (en
Inventor
Eiichi Aida
Shiyuuichi Hirono
Yasushi Daikuhara
Hisakazu Aoki
Fumio Shimizu
Sadahira Shin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP62159149A priority Critical patent/JPS643199A/en
Publication of JPH013199A publication Critical patent/JPH013199A/en
Publication of JPS643199A publication Critical patent/JPS643199A/en
Publication of JPH0560359B2 publication Critical patent/JPH0560359B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:An antibody capable of exhibiting specific reactivity to human hepatic cell growth factors. USE:Useful for screening and diagnosing hepatopathy, purifying human hepatic cell growth factors, etc. PREPARATION:A mammal, such as mouse, is initially immunized with a human hepatic cell growth factor as an antigen and splenic cells of the immunized animal are extracted and then fused to mammalian plasmocytoma cells, such as myelomatous cells, using a cell fusion promoter, such as polyethylene glycol, to afford a hybridoma. A strain capable of producing the aimed antibody is searched from the above-mentioned hybridoma and then monocloned. The aforementioned is finally propagated in abdominal cavity, etc., of a mouse to produce the aimed antibody.
JP62159149A 1987-06-25 1987-06-25 Monoclonal antibody Granted JPS643199A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62159149A JPS643199A (en) 1987-06-25 1987-06-25 Monoclonal antibody

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62159149A JPS643199A (en) 1987-06-25 1987-06-25 Monoclonal antibody

Publications (3)

Publication Number Publication Date
JPH013199A JPH013199A (en) 1989-01-06
JPS643199A true JPS643199A (en) 1989-01-06
JPH0560359B2 JPH0560359B2 (en) 1993-09-02

Family

ID=15687329

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62159149A Granted JPS643199A (en) 1987-06-25 1987-06-25 Monoclonal antibody

Country Status (1)

Country Link
JP (1) JPS643199A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5547856A (en) * 1992-05-18 1996-08-20 Genentech, Inc. Hepatocyte growth factor variants
US5580963A (en) * 1992-05-18 1996-12-03 Genentech, Inc. Single-chain hepatocyte growth factor variants
US5879910A (en) * 1992-05-18 1999-03-09 Genetech, Inc. Hepatocyte growth factor protease domain variants

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6045534A (en) * 1983-08-22 1985-03-12 Otsuka Pharmaceut Co Ltd Hepatocyte growth factor
JPS6245530A (en) * 1985-08-23 1987-02-27 Otsuka Pharmaceut Co Ltd Proliferation factor for hepatic parenchymal cell

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6045534A (en) * 1983-08-22 1985-03-12 Otsuka Pharmaceut Co Ltd Hepatocyte growth factor
JPS6245530A (en) * 1985-08-23 1987-02-27 Otsuka Pharmaceut Co Ltd Proliferation factor for hepatic parenchymal cell

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5547856A (en) * 1992-05-18 1996-08-20 Genentech, Inc. Hepatocyte growth factor variants
US5580963A (en) * 1992-05-18 1996-12-03 Genentech, Inc. Single-chain hepatocyte growth factor variants
US5879910A (en) * 1992-05-18 1999-03-09 Genetech, Inc. Hepatocyte growth factor protease domain variants

Also Published As

Publication number Publication date
JPH0560359B2 (en) 1993-09-02

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