ES2181689T3 - Variantes del factor de crecimiento de hepatocitos. - Google Patents

Variantes del factor de crecimiento de hepatocitos.

Info

Publication number
ES2181689T3
ES2181689T3 ES93911339T ES93911339T ES2181689T3 ES 2181689 T3 ES2181689 T3 ES 2181689T3 ES 93911339 T ES93911339 T ES 93911339T ES 93911339 T ES93911339 T ES 93911339T ES 2181689 T3 ES2181689 T3 ES 2181689T3
Authority
ES
Spain
Prior art keywords
variants
growth factor
hgf
hepatocits
mutation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93911339T
Other languages
English (en)
Inventor
Paul J Godowski
Nathalie A Lokker
Melanie R Mark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/884,811 external-priority patent/US5316921A/en
Priority claimed from US07/885,971 external-priority patent/US5328837A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ES2181689T3 publication Critical patent/ES2181689T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Abstract

LA INVENCION SE REFIERE A LAS VARIANTES DE LA SECUENCIA AMINOACIDA DEL FACTOR DE DESARROLLO DE HEPATOCITOS (HGF). LAS VARIANTES PREFERIDAS SON RESISTENTES A LA SEGMENTACION PROTEOLITICA POR ENZIMAS CAPACES DE CONVERSION IN VIVO DEL HGF DENTRO DE SU FORMA DE DOS CADENAS Y/O CONTIENEN UNA MUTACION SIN DOMINIO DE PROTEASA DEL HGF.
ES93911339T 1992-05-18 1993-05-17 Variantes del factor de crecimiento de hepatocitos. Expired - Lifetime ES2181689T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/884,811 US5316921A (en) 1992-05-18 1992-05-18 Single-chain hepatocyte growth factor variants
US07/885,971 US5328837A (en) 1992-05-18 1992-05-18 Hepatocyte growth factor protease domain variants

Publications (1)

Publication Number Publication Date
ES2181689T3 true ES2181689T3 (es) 2003-03-01

Family

ID=27128741

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93911339T Expired - Lifetime ES2181689T3 (es) 1992-05-18 1993-05-17 Variantes del factor de crecimiento de hepatocitos.

Country Status (10)

Country Link
US (1) US5547856A (es)
EP (1) EP0642580B1 (es)
JP (2) JPH07508420A (es)
AT (1) ATE222603T1 (es)
CA (1) CA2118012A1 (es)
DE (1) DE69332221T2 (es)
DK (1) DK0642580T3 (es)
ES (1) ES2181689T3 (es)
PT (1) PT642580E (es)
WO (1) WO1993023541A1 (es)

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US5646036A (en) * 1995-06-02 1997-07-08 Genentech, Inc. Nucleic acids encoding hepatocyte growth factor receptor antagonist antibodies
US5686292A (en) * 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
JP3832674B2 (ja) * 1995-10-24 2006-10-11 敏一 中村 抗癌剤
US6855685B2 (en) 1995-10-24 2005-02-15 Toshikazu Nakamura Anti-cancer agent
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JP4006058B2 (ja) * 1997-03-11 2007-11-14 第一三共株式会社 多臓器不全予防及び／又は治療剤
WO1998041230A1 (fr) * 1997-03-14 1998-09-24 Snow Brand Milk Products Co., Ltd. Agent preventif et/ou curatif de la cachexie
GB9709453D0 (en) * 1997-05-10 1997-07-02 Imp Cancer Res Tech Polypedtides and their use in therapy
ITMI980180A1 (it) * 1998-01-30 1999-07-30 Dompe Spa Proteine ricombinanti derivate da hgf e msp
ITMI980179A1 (it) 1998-01-30 1999-07-30 Dompe Spa Proteine ricombinanti derivate da hgf e msp
US20020136721A1 (en) * 1998-02-17 2002-09-26 Schwall Ralph H. Hepatocyte growth factor receptor antagonists and uses thereof
WO2001023598A1 (en) * 1999-09-27 2001-04-05 Human Genome Sciences, Inc. 41 human secreted proteins
US20080241835A1 (en) * 1999-11-01 2008-10-02 Genentech, Inc. Differentially expressed genes involved in angiogenesis, the polypeptides encoded thereby, and methods of using the same
EP1233777A4 (en) * 1999-11-24 2003-07-16 Human Genome Sciences Inc MAJOR INTRINSIC PROTEIN (MIP) -LIKE POLYNUCLEOTIDES, POLYPEPTIDES AND ANTIBODIES
AU7459101A (en) * 2000-06-22 2002-01-02 Nippon Zenyaku Kogyo Ltd Canine liver cell growth factor
EP1234583A1 (en) 2001-02-23 2002-08-28 F. Hoffmann-La Roche Ag PEG-conjugates of HGF-NK4
GB0110430D0 (en) 2001-04-27 2001-06-20 Medical Res Council Protein variants and uses thereof
AU2003278807A1 (en) 2002-03-01 2004-08-13 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
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HUE039154T2 (hu) * 2003-03-03 2018-12-28 Dyax Corp HGF receptort (cMet) specifikusan kötõ peptidek és alkalmazásaik
WO2004093892A2 (en) * 2003-04-16 2004-11-04 Genentech, Inc. Stanniocalcin-1, variant or antagonists thereof for selective modulation of vascularization
JP4716875B2 (ja) 2003-12-16 2011-07-06 敏一 中村 糖鎖欠損型肝細胞増殖因子
US20050227324A1 (en) * 2003-12-19 2005-10-13 Genentech, Inc. Monovalent antibody fragments useful as therapeutics
US7807177B2 (en) * 2004-01-27 2010-10-05 Toshikazu Nakamura Segment of glycosylation-deficient HGFalpha-chain
CA2558740A1 (en) 2004-03-03 2005-10-13 F. Hoffmann-La Roche Ag Method for the purification of an n-terminal fragment of hepatocyte growth factor
JP2007525981A (ja) 2004-03-03 2007-09-13 エフ．ホフマン−ラ　ロシュ　アーゲー 肝細胞成長因子のｎ末端フラグメントを組み換え発現するための方法
US7476724B2 (en) 2004-08-05 2009-01-13 Genentech, Inc. Humanized anti-cmet antibodies
EP1869070B1 (en) 2005-04-15 2013-11-27 Genentech, Inc. Hgf beta chain variants
WO2009111707A1 (en) * 2008-03-06 2009-09-11 Genentech, Inc. Combination therapy with c-met and her antagonists
CN107090038A (zh) 2011-06-30 2017-08-25 霍夫曼-拉罗奇有限公司 抗c‑met抗体配制剂
BR112016021383A2 (pt) 2014-03-24 2017-10-03 Genentech Inc Método para identificar um paciente com câncer que é susceptível ou menos susceptível a responder ao tratamento com um antagonista de cmet, método para identificar um paciente apresentando câncer previamente tratado, método para determinar a expressão do biomarcador hgf, antagonista anti-c-met e seu uso, kit de diagnóstico e seu método de preparo
WO2019027299A2 (ko) * 2017-08-04 2019-02-07 주식회사 에스엘바이젠 간세포성장인자를 발현하는 중간엽줄기세포를 유효성분으로 포함하는 혈관계 질환 예방 또는 치료용 약학 조성물
CN109535243B (zh) * 2019-01-07 2019-09-24 北京诺思兰德生物技术股份有限公司 人肝细胞生长因子突变体及其应用

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Also Published As

Publication number Publication date
JPH07508420A (ja) 1995-09-21
DE69332221T2 (de) 2003-04-17
EP0642580B1 (en) 2002-08-21
DE69332221D1 (de) 2002-09-26
CA2118012A1 (en) 1993-11-25
ATE222603T1 (de) 2002-09-15
JP2004000236A (ja) 2004-01-08
DK0642580T3 (da) 2002-12-23
WO1993023541A1 (en) 1993-11-25
PT642580E (pt) 2003-01-31
EP0642580A1 (en) 1995-03-15
US5547856A (en) 1996-08-20

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