|
US3896111A
(en)
|
1973-02-20 |
1975-07-22 |
Research Corp |
Ansa macrolides
|
|
US4237224A
(en)
|
1974-11-04 |
1980-12-02 |
Board Of Trustees Of The Leland Stanford Jr. University |
Process for producing biologically functional molecular chimeras
|
|
US4151042A
(en)
|
1977-03-31 |
1979-04-24 |
Takeda Chemical Industries, Ltd. |
Method for producing maytansinol and its derivatives
|
|
US4137230A
(en)
|
1977-11-14 |
1979-01-30 |
Takeda Chemical Industries, Ltd. |
Method for the production of maytansinoids
|
|
US4265814A
(en)
|
1978-03-24 |
1981-05-05 |
Takeda Chemical Industries |
Matansinol 3-n-hexadecanoate
|
|
US4307016A
(en)
|
1978-03-24 |
1981-12-22 |
Takeda Chemical Industries, Ltd. |
Demethyl maytansinoids
|
|
JPS5562090A
(en)
|
1978-10-27 |
1980-05-10 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS5566585A
(en)
|
1978-11-14 |
1980-05-20 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
US4256746A
(en)
|
1978-11-14 |
1981-03-17 |
Takeda Chemical Industries |
Dechloromaytansinoids, their pharmaceutical compositions and method of use
|
|
JPS55164687A
(en)
|
1979-06-11 |
1980-12-22 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS55102583A
(en)
|
1979-01-31 |
1980-08-05 |
Takeda Chem Ind Ltd |
20-acyloxy-20-demethylmaytansinoid compound
|
|
JPS55162791A
(en)
|
1979-06-05 |
1980-12-18 |
Takeda Chem Ind Ltd |
Antibiotic c-15003pnd and its preparation
|
|
JPS55164685A
(en)
|
1979-06-08 |
1980-12-22 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS55164686A
(en)
|
1979-06-11 |
1980-12-22 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
US4309428A
(en)
|
1979-07-30 |
1982-01-05 |
Takeda Chemical Industries, Ltd. |
Maytansinoids
|
|
JPS5645483A
(en)
|
1979-09-19 |
1981-04-25 |
Takeda Chem Ind Ltd |
C-15003phm and its preparation
|
|
JPS5645485A
(en)
|
1979-09-21 |
1981-04-25 |
Takeda Chem Ind Ltd |
Production of c-15003pnd
|
|
EP0028683A1
(en)
|
1979-09-21 |
1981-05-20 |
Takeda Chemical Industries, Ltd. |
Antibiotic C-15003 PHO and production thereof
|
|
WO1981001145A1
(en)
|
1979-10-18 |
1981-04-30 |
Univ Illinois |
Hydrolytic enzyme-activatible pro-drugs
|
|
WO1982001188A1
(en)
|
1980-10-08 |
1982-04-15 |
Takeda Chemical Industries Ltd |
4,5-deoxymaytansinoide compounds and process for preparing same
|
|
US4450254A
(en)
|
1980-11-03 |
1984-05-22 |
Standard Oil Company |
Impact improvement of high nitrile resins
|
|
US4315929A
(en)
|
1981-01-27 |
1982-02-16 |
The United States Of America As Represented By The Secretary Of Agriculture |
Method of controlling the European corn borer with trewiasine
|
|
US4313946A
(en)
|
1981-01-27 |
1982-02-02 |
The United States Of America As Represented By The Secretary Of Agriculture |
Chemotherapeutically active maytansinoids from Trewia nudiflora
|
|
JPS57192389A
(en)
|
1981-05-20 |
1982-11-26 |
Takeda Chem Ind Ltd |
Novel maytansinoid
|
|
US4751180A
(en)
|
1985-03-28 |
1988-06-14 |
Chiron Corporation |
Expression using fused genes providing for protein product
|
|
US4935233A
(en)
|
1985-12-02 |
1990-06-19 |
G. D. Searle And Company |
Covalently linked polypeptide cell modulators
|
|
US5182368A
(en)
*
|
1986-06-13 |
1993-01-26 |
Ledbetter Jeffrey A |
Ligands and methods for augmenting B-cell proliferation
|
|
US5247069A
(en)
|
1986-06-13 |
1993-09-21 |
Oncogen |
Ligands and methods for augmenting B-cell proliferation
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
GB8705477D0
(en)
|
1987-03-09 |
1987-04-15 |
Carlton Med Prod |
Drug delivery systems
|
|
US5091513A
(en)
|
1987-05-21 |
1992-02-25 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
US5132405A
(en)
|
1987-05-21 |
1992-07-21 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
US4975278A
(en)
|
1988-02-26 |
1990-12-04 |
Bristol-Myers Company |
Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
CA2026147C
(en)
|
1989-10-25 |
2006-02-07 |
Ravi J. Chari |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
US5151510A
(en)
|
1990-04-20 |
1992-09-29 |
Applied Biosystems, Inc. |
Method of synethesizing sulfurized oligonucleotide analogs
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5264586A
(en)
|
1991-07-17 |
1993-11-23 |
The Scripps Research Institute |
Analogs of calicheamicin gamma1I, method of making and using the same
|
|
ZA932522B
(en)
|
1992-04-10 |
1993-12-20 |
Res Dev Foundation |
Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
|
|
US5397703A
(en)
|
1992-07-09 |
1995-03-14 |
Cetus Oncology Corporation |
Method for generation of antibodies to cell surface molecules
|
|
US6765087B1
(en)
|
1992-08-21 |
2004-07-20 |
Vrije Universiteit Brussel |
Immunoglobulins devoid of light chains
|
|
DK0672142T3
(da)
|
1992-12-04 |
2001-06-18 |
Medical Res Council |
Multivalente og multispecifikke bindingsproteiner samt fremstilling og anvendelse af disse
|
|
DK0698097T3
(da)
|
1993-04-29 |
2001-10-08 |
Unilever Nv |
Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde
|
|
FI961285L
(fi)
|
1993-10-01 |
1996-03-20 |
Immunex Corp |
CD40:n vasta-aineita
|
|
NZ278740A
(en)
*
|
1993-12-23 |
1998-05-27 |
Immunex Corp |
Treating disease characterised by neoplastic cells expressing cd40 using a cd40 binding protein
|
|
US5837458A
(en)
|
1994-02-17 |
1998-11-17 |
Maxygen, Inc. |
Methods and compositions for cellular and metabolic engineering
|
|
US5773001A
(en)
|
1994-06-03 |
1998-06-30 |
American Cyanamid Company |
Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
|
|
GB9425060D0
(en)
|
1994-12-13 |
1995-02-08 |
Univ Birmingham |
Carcinoma treatment
|
|
US5675063A
(en)
|
1995-02-28 |
1997-10-07 |
Loyola University Of Chicago |
Immortalized rabbit hybridoma fusion partner
|
|
AU699291B2
(en)
|
1995-03-01 |
1998-11-26 |
Immunex Corporation |
Method for stimulating an immune response
|
|
US5712374A
(en)
|
1995-06-07 |
1998-01-27 |
American Cyanamid Company |
Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
|
|
US5714586A
(en)
|
1995-06-07 |
1998-02-03 |
American Cyanamid Company |
Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
|
|
WO1999022008A1
(en)
*
|
1997-10-27 |
1999-05-06 |
Sumitomo Electric Industries, Ltd. |
Inducer for production of antigen-specific antibody, expression vector containing gene therefor, and method of inducing production of antigen-specific antibody
|
|
US6051228A
(en)
|
1998-02-19 |
2000-04-18 |
Bristol-Myers Squibb Co. |
Antibodies against human CD40
|
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
KR100301796B1
(ko)
*
|
1998-10-01 |
2001-09-06 |
성재갑 |
면역억제능이 있는 항-씨디40 리간드 모노클로날 항체
|
|
US6680176B2
(en)
|
1999-05-17 |
2004-01-20 |
The United States Of America, As Represented By The Department Of Health And Human Services |
Identification of candidate ligands which modulate antigen presenting cells
|
|
US20030118588A1
(en)
|
1999-05-22 |
2003-06-26 |
Linda Diehl |
Induction of anti-tumor CTL immunity through in vivo triggering of 4-1BB and/or CD40
|
|
US6946129B1
(en)
|
1999-06-08 |
2005-09-20 |
Seattle Genetics, Inc. |
Recombinant anti-CD40 antibody and uses thereof
|
|
CN100490895C
(zh)
|
2000-02-01 |
2009-05-27 |
泛遗传学公司 |
结合cd40的apc激活分子
|
|
EP1274455A1
(en)
*
|
2000-04-19 |
2003-01-15 |
Tanox, Inc. |
Cd40 antagonists for use in treating psoriasis and other inflammatory skin conditions
|
|
US7063845B2
(en)
|
2000-04-28 |
2006-06-20 |
Gemini Science, Inc. |
Human anti-CD40 antibodies
|
|
AU2001261383B2
(en)
|
2000-05-08 |
2004-10-21 |
Celldex Therapeutics, Inc. |
Human monoclonal antibodies to dendritic cells
|
|
JP4025881B2
(ja)
*
|
2001-04-27 |
2007-12-26 |
キリンファーマ株式会社 |
抗cd40モノクローナル抗体
|
|
CA2658221C
(en)
|
2001-04-27 |
2012-11-27 |
Kyowa Kirin Co., Ltd. |
Anti-cd40 monoclonal antibody
|
|
AR039067A1
(es)
*
|
2001-11-09 |
2005-02-09 |
Pfizer Prod Inc |
Anticuerpos para cd40
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
US20080199471A1
(en)
|
2002-03-01 |
2008-08-21 |
Bernett Matthew J |
Optimized cd40 antibodies and methods of using the same
|
|
US20040110226A1
(en)
*
|
2002-03-01 |
2004-06-10 |
Xencor |
Antibody optimization
|
|
US7662925B2
(en)
|
2002-03-01 |
2010-02-16 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
|
US7960512B2
(en)
|
2003-01-09 |
2011-06-14 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
|
EP2368578A1
(en)
|
2003-01-09 |
2011-09-28 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
|
ES2349777T3
(es)
*
|
2003-01-22 |
2011-01-11 |
Glycart Biotechnology Ag |
Constructos de fusión y uso de los mismos para producir anticuerpos con mayor afinidad de unión al receptor de fc y función efectora.
|
|
SG148143A1
(en)
*
|
2003-11-04 |
2008-12-31 |
Novartis Vaccines & Diagnostic |
Antagonist anti-cd40 monoclonal antibodies and methods for their use
|
|
JP2007512846A
(ja)
|
2003-12-04 |
2007-05-24 |
ゼンコー・インコーポレイテッド |
増加した宿主ストリング含有量を有する変異体タンパク質の生成方法およびその組成物
|
|
US20050136055A1
(en)
|
2003-12-22 |
2005-06-23 |
Pfizer Inc |
CD40 antibody formulation and methods
|
|
ES2397631T3
(es)
*
|
2003-12-25 |
2013-03-08 |
Kyowa Hakko Kirin Co., Ltd. |
Mutante antagonista de anticuerpos ANTI-CD40
|
|
ES2426817T3
(es)
|
2004-08-04 |
2013-10-25 |
Mentrik Biotech, Llc |
Regiones Fc variantes
|
|
US7462697B2
(en)
|
2004-11-08 |
2008-12-09 |
Epitomics, Inc. |
Methods for antibody engineering
|
|
US7632497B2
(en)
|
2004-11-10 |
2009-12-15 |
Macrogenics, Inc. |
Engineering Fc Antibody regions to confer effector function
|
|
AU2005325801A1
(en)
|
2005-01-31 |
2006-08-03 |
Ablynx N.V. |
Method for generating variable domain sequences of heavy chain antibodies
|
|
US20060257359A1
(en)
|
2005-02-28 |
2006-11-16 |
Cedric Francois |
Modifying macrophage phenotype for treatment of disease
|
|
EP1871808A2
(en)
|
2005-03-31 |
2008-01-02 |
Xencor, Inc. |
Fc VARIANTS WITH OPTIMIZED PROPERTIES
|
|
PL1889065T3
(pl)
|
2005-05-18 |
2013-12-31 |
Novartis Ag |
Metody diagnostyki i leczenia chorób posiadających składnik autoimmunologiczny i/lub zapalny
|
|
US8337851B2
(en)
|
2005-05-18 |
2012-12-25 |
Novartis Ag |
Methods of monitoring the efficacy of anti-CD40 antibodies in treating a subject for a CD40-expressing cancer
|
|
CA2609269C
(en)
|
2005-05-26 |
2014-08-05 |
Seattle Genetics, Inc. |
Humanized anti-cd40 antibodies and their methods of use
|
|
US7429487B2
(en)
|
2005-07-05 |
2008-09-30 |
Epitomics, Inc. |
Fusion partner for production of monoclonal rabbit antibodies
|
|
KR20080073725A
(ko)
*
|
2005-11-01 |
2008-08-11 |
노파르티스 아게 |
항-cd40 항체의 용도
|
|
CN101351478A
(zh)
|
2005-11-01 |
2009-01-21 |
诺华有限公司 |
抗cd40抗体的应用
|
|
AU2006317242A1
(en)
|
2005-11-28 |
2007-05-31 |
Genmab A/S |
Recombinant monovalent antibodies and methods for production thereof
|
|
BRPI0619586A2
(pt)
*
|
2005-12-09 |
2018-08-28 |
Seattle Genetics Inc |
método para o tratamento ou prevenção de um distúrbio associado com cd40
|
|
WO2008091954A2
(en)
*
|
2007-01-23 |
2008-07-31 |
Xencor, Inc. |
Optimized cd40 antibodies and methods of using the same
|
|
US8062864B2
(en)
|
2007-05-21 |
2011-11-22 |
Alderbio Holdings Llc |
Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
|
|
KR20170036814A
(ko)
|
2007-05-21 |
2017-04-03 |
앨더바이오 홀딩스 엘엘씨 |
신규한 래빗 항체 인간화 방법 및 인간화된 래빗 항체
|
|
US20090238825A1
(en)
|
2007-05-21 |
2009-09-24 |
Kovacevich Brian R |
Novel rabbit antibody humanization methods and humanized rabbit antibodies
|
|
DK2176298T3
(en)
|
2007-05-30 |
2018-02-12 |
Xencor Inc |
Methods and compositions for inhibiting CD32B-expressing cells
|
|
WO2009094391A1
(en)
|
2008-01-23 |
2009-07-30 |
Xencor, Inc. |
Optimized cd40 antibodies and methods of using the same
|
|
RU2539765C2
(ru)
|
2008-07-16 |
2015-01-27 |
Бейлор Рисёч Инститьют |
ВИЧ ВАКЦИНА, ОСНОВАННАЯ НА НАПРАВЛЕННОСТИ МАКСИМИЗИРОВАННЫХ Gag И Nef НА ДЕНДРИТНЫЕ КЛЕТКИ
|
|
CN102170908A
(zh)
|
2008-08-29 |
2011-08-31 |
莱顿大学医学中心附属莱顿教学医院 |
向个体的肿瘤引流淋巴结递送cd40激动剂
|
|
ES2650267T3
(es)
|
2008-12-05 |
2018-01-17 |
Als Therapy Development Institute |
Método para el tratamiento de enfermedades neurodegenerativas
|
|
US9562104B2
(en)
|
2009-03-10 |
2017-02-07 |
Baylor Research Institute |
Anti-CD40 antibodies
|
|
CA2758523C
(en)
|
2009-04-18 |
2019-03-12 |
Genentech, Inc. |
Methods for assessing responsiveness of b-cell lymphoma to treatment with anti-cd40 antibodies
|
|
JP5694921B2
(ja)
|
2009-04-20 |
2015-04-01 |
協和発酵キリン株式会社 |
アミノ酸変異が導入されたIgG2を有する抗体
|
|
MX341925B
(es)
*
|
2010-03-29 |
2016-09-07 |
Zymeworks Inc |
Anticuerpos con funcion efectora suprimida o mejorada.
|
|
PT3178851T
(pt)
|
2010-03-31 |
2020-07-17 |
Boehringer Ingelheim Int |
Anticorpos anti-cd40
|
|
EP2600878A4
(en)
|
2010-08-04 |
2014-06-11 |
Univ Duke |
REGULATORY B-CELLS AND ITS USES
|
|
AR083847A1
(es)
|
2010-11-15 |
2013-03-27 |
Novartis Ag |
Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40
|
|
EP2656073A4
(en)
|
2010-12-20 |
2014-12-17 |
Univ Rockefeller |
Modulating agonistic tnfr antibodies
|
|
AR086360A1
(es)
*
|
2011-04-21 |
2013-12-11 |
Bristol Myers Squibb Co |
Polipeptidos anticuerpos que antagonizan cd40
|
|
WO2012149356A2
(en)
|
2011-04-29 |
2012-11-01 |
Apexigen, Inc. |
Anti-cd40 antibodies and methods of use
|
|
CN104918957B
(zh)
*
|
2012-10-30 |
2018-11-16 |
埃派斯进有限公司 |
抗-cd40抗体及其使用方法
|
|
US9209965B2
(en)
|
2014-01-14 |
2015-12-08 |
Microsemi Semiconductor Ulc |
Network interface with clock recovery module on line card
|