JP2015163068A5 - - Google Patents
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- JP2015163068A5 JP2015163068A5 JP2015042824A JP2015042824A JP2015163068A5 JP 2015163068 A5 JP2015163068 A5 JP 2015163068A5 JP 2015042824 A JP2015042824 A JP 2015042824A JP 2015042824 A JP2015042824 A JP 2015042824A JP 2015163068 A5 JP2015163068 A5 JP 2015163068A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- fragment
- human
- kir
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 101000945371 Homo sapiens Killer cell immunoglobulin-like receptor 2DL2 Proteins 0.000 claims description 8
- 101001027081 Homo sapiens Killer cell immunoglobulin-like receptor 2DL1 Proteins 0.000 claims description 6
- 102100037363 Killer cell immunoglobulin-like receptor 2DL1 Human genes 0.000 claims description 4
- 102100033599 Killer cell immunoglobulin-like receptor 2DL2 Human genes 0.000 claims description 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 12
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 12
- 239000012634 fragment Substances 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 9
- 101000945333 Homo sapiens Killer cell immunoglobulin-like receptor 2DL3 Proteins 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 102000058207 human KIR2DL2 Human genes 0.000 claims 4
- 102000058208 human KIR2DL3 Human genes 0.000 claims 4
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 102100033634 Killer cell immunoglobulin-like receptor 2DL3 Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 102000047041 human KIR2DL1 Human genes 0.000 claims 2
- 210000004408 hybridoma Anatomy 0.000 claims 2
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims 2
- 239000002872 contrast media Substances 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108010043610 KIR Receptors Proteins 0.000 description 1
- 102100033627 Killer cell immunoglobulin-like receptor 3DL1 Human genes 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 230000007910 cell fusion Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48389403P | 2003-07-02 | 2003-07-02 | |
| US60/483,894 | 2003-07-02 | ||
| US54547104P | 2004-02-19 | 2004-02-19 | |
| US60/545,471 | 2004-02-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012087648A Division JP5826697B2 (ja) | 2003-07-02 | 2012-04-06 | Ｎｋ細胞活性を制御するための組成物及び方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018078329A Division JP2018153185A (ja) | 2003-07-02 | 2018-04-16 | Ｎｋ細胞活性を制御するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015163068A JP2015163068A (ja) | 2015-09-10 |
| JP2015163068A5 true JP2015163068A5 (enExample) | 2017-11-16 |
| JP6556465B2 JP6556465B2 (ja) | 2019-08-07 |
Family
ID=33567703
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006515738A Expired - Lifetime JP5015592B2 (ja) | 2003-07-02 | 2004-07-01 | Ｎｋ細胞活性を制御するための組成物及び方法 |
| JP2006516606A Expired - Lifetime JP4871125B2 (ja) | 2003-07-02 | 2004-07-01 | Ｎｋ細胞活性を調節するための組成物および方法 |
| JP2012087648A Expired - Lifetime JP5826697B2 (ja) | 2003-07-02 | 2012-04-06 | Ｎｋ細胞活性を制御するための組成物及び方法 |
| JP2015042824A Expired - Lifetime JP6556465B2 (ja) | 2003-07-02 | 2015-03-04 | Ｎｋ細胞活性を制御するための組成物及び方法 |
| JP2018078329A Pending JP2018153185A (ja) | 2003-07-02 | 2018-04-16 | Ｎｋ細胞活性を制御するための組成物及び方法 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006515738A Expired - Lifetime JP5015592B2 (ja) | 2003-07-02 | 2004-07-01 | Ｎｋ細胞活性を制御するための組成物及び方法 |
| JP2006516606A Expired - Lifetime JP4871125B2 (ja) | 2003-07-02 | 2004-07-01 | Ｎｋ細胞活性を調節するための組成物および方法 |
| JP2012087648A Expired - Lifetime JP5826697B2 (ja) | 2003-07-02 | 2012-04-06 | Ｎｋ細胞活性を制御するための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018078329A Pending JP2018153185A (ja) | 2003-07-02 | 2018-04-16 | Ｎｋ細胞活性を制御するための組成物及び方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9902936B2 (enExample) |
| EP (3) | EP1639013B1 (enExample) |
| JP (5) | JP5015592B2 (enExample) |
| KR (5) | KR20060079180A (enExample) |
| CN (2) | CN103588880B (enExample) |
| AT (1) | ATE490984T1 (enExample) |
| AU (2) | AU2004253630B2 (enExample) |
| BR (2) | BRPI0412153B8 (enExample) |
| CA (2) | CA2530272C (enExample) |
| CY (1) | CY1113394T1 (enExample) |
| DE (1) | DE602004030464D1 (enExample) |
| DK (2) | DK1673397T3 (enExample) |
| ES (2) | ES2393485T3 (enExample) |
| HR (1) | HRP20120845T1 (enExample) |
| IL (3) | IL172613A (enExample) |
| MX (1) | MXPA05013923A (enExample) |
| NO (4) | NO338818B1 (enExample) |
| PL (1) | PL1639013T3 (enExample) |
| PT (1) | PT1639013E (enExample) |
| RU (2) | RU2376315C2 (enExample) |
| WO (2) | WO2005003168A2 (enExample) |
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| CN1997670B (zh) | 2004-07-01 | 2014-04-30 | 诺和诺德公司 | 人类抗-kir抗体 |
| PT2287195T (pt) * | 2004-07-01 | 2019-07-29 | Novo Nordisk As | Anticorpos de recetor de nk de pan-kir2dl e a sua utilização em diagnóstico e terapêutica |
| EP2921500B1 (en) | 2004-07-10 | 2023-08-30 | The Institute for Cancer Research | Genetically modified human natural killer cell lines |
| CA2589034C (en) * | 2004-11-02 | 2016-05-31 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Compositions and methods for treating hyperproliferative disorders |
| EP1835929B8 (en) * | 2005-01-06 | 2016-07-27 | Novo Nordisk A/S | Anti-kir combination treatments and methods |
| EP1835937B1 (en) | 2005-01-06 | 2012-04-11 | Novo Nordisk A/S | Compositions and methods for treating viral infection |
| CN104829720B (zh) | 2005-01-06 | 2019-01-01 | 诺和诺德公司 | Kir结合剂和使用其的方法 |
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