|
US4737462A
(en)
|
1982-10-19 |
1988-04-12 |
Cetus Corporation |
Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
|
|
US4518584A
(en)
|
1983-04-15 |
1985-05-21 |
Cetus Corporation |
Human recombinant interleukin-2 muteins
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
EP0307434B2
(en)
|
1987-03-18 |
1998-07-29 |
Scotgen Biopharmaceuticals, Inc. |
Altered antibodies
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US6172197B1
(en)
|
1991-07-10 |
2001-01-09 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
AU8507191A
(en)
|
1990-08-29 |
1992-03-30 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US6277969B1
(en)
|
1991-03-18 |
2001-08-21 |
New York University |
Anti-TNF antibodies and peptides of human tumor necrosis factor
|
|
ATE255131T1
(de)
|
1991-06-14 |
2003-12-15 |
Genentech Inc |
Humanisierter heregulin antikörper
|
|
PT1696031E
(pt)
|
1991-12-02 |
2010-06-25 |
Medical Res Council |
Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
|
|
GB9325182D0
(en)
|
1993-12-08 |
1994-02-09 |
T Cell Sciences Inc |
Humanized antibodies or binding proteins thereof specific for t cell subpopulations exhibiting select beta chain variable regions
|
|
US6824767B2
(en)
|
1994-11-07 |
2004-11-30 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
WO1996014328A1
(en)
|
1994-11-07 |
1996-05-17 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
US6599719B2
(en)
|
1994-11-07 |
2003-07-29 |
Human Genome Sciences, Inc. |
Nucleic acid molecules encoding tumor necrosis factor-gamma-alpha
|
|
US7820798B2
(en)
|
1994-11-07 |
2010-10-26 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
WO2000066608A1
(en)
|
1999-04-30 |
2000-11-09 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
US20030129189A1
(en)
|
1994-11-07 |
2003-07-10 |
Guo-Liang Yu |
Tumor necrosis factor-gamma
|
|
US20030198640A1
(en)
|
1994-11-07 |
2003-10-23 |
Human Genome Sciences, Inc. |
Methods and compositions for treating inflammatory bowel diseases relating to human tumor necrosis factor-gamma-beta
|
|
US7597886B2
(en)
|
1994-11-07 |
2009-10-06 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
ATE219517T1
(de)
|
1995-08-18 |
2002-07-15 |
Morphosys Ag |
Protein-/(poly)peptidbibliotheken
|
|
US6696248B1
(en)
|
1995-08-18 |
2004-02-24 |
Morphosys Ag |
Protein/(poly)peptide libraries
|
|
US6632976B1
(en)
|
1995-08-29 |
2003-10-14 |
Kirin Beer Kabushiki Kaisha |
Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene
|
|
US7357927B2
(en)
|
1996-03-12 |
2008-04-15 |
Human Genome Sciences, Inc. |
Death domain containing receptors
|
|
ES2375931T3
(es)
|
1997-12-05 |
2012-03-07 |
The Scripps Research Institute |
Humanización de anticuerpo murino.
|
|
US6297367B1
(en)
|
1997-12-30 |
2001-10-02 |
Chiron Corporation |
Polynucleotide encoding TNFL1
|
|
CA2323787A1
(en)
|
1998-03-13 |
1999-09-16 |
Wayne Marasco |
Humanized antibody and uses thereof
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
ATE482275T1
(de)
|
1999-07-02 |
2010-10-15 |
Morphosys Ag |
Erzeugung spezifischer bindungspartner die an von genomischen dns-fragmenten oder ests kodierten (poly)peptiden binden
|
|
US6399857B1
(en)
*
|
1999-09-22 |
2002-06-04 |
Paradigm Genetics, Inc. |
Modified nucleotide sequence encoding a LexA DNA binding domain optimized for arabidopsis species
|
|
US20110131679A2
(en)
|
2000-04-19 |
2011-06-02 |
Thomas La Rosa |
Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
|
|
US6571638B2
(en)
|
2000-06-30 |
2003-06-03 |
Sawtek, Inc. |
Surface-acoustic-wave pressure sensor and associated methods
|
|
WO2002004643A1
(en)
|
2000-07-07 |
2002-01-17 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
US6824989B1
(en)
|
2000-09-01 |
2004-11-30 |
Upstate Biotechnology, Inc. |
Recombinant monoclonal antibody to phosphotyrosine-containing proteins
|
|
US20030017518A1
(en)
*
|
2001-06-26 |
2003-01-23 |
Joseph Lam |
Non-radio-active assay of LPS kinases
|
|
SI1551876T1
(sl)
|
2002-10-16 |
2011-07-29 |
Purdue Pharma Lp |
Protitelesa, ki se vežejo na celično povezan CA 125/0722P, in postopki za njihovo uporabo
|
|
CA2507080C
(en)
*
|
2002-11-27 |
2015-01-06 |
Biogen Idec Ma Inc. |
Humanized antibodies against monocyte chemotactic proteins
|
|
US20050101889A1
(en)
|
2003-11-06 |
2005-05-12 |
Freeman Gary A. |
Using chest velocity to process physiological signals to remove chest compression artifacts
|
|
US20080287309A1
(en)
|
2004-07-10 |
2008-11-20 |
Alexion Pharmaceuticals, Inc. |
Methods for Discovering Antibodies Specific to Cancer Cells and Antibodies Discovered Thereby
|
|
TWI309240B
(en)
|
2004-09-17 |
2009-05-01 |
Hoffmann La Roche |
Anti-ox40l antibodies
|
|
BRPI0611069A2
(pt)
|
2005-05-06 |
2010-11-09 |
Zymogenetics Inc |
anticorpo monoclonal, anticorpo humanizado, fragmento de anticorpo, uso de um antagonista, e, hibridoma
|
|
WO2006122187A2
(en)
|
2005-05-10 |
2006-11-16 |
Biogen Idec Ma Inc. |
Treating and evaluating inflammatory disorders
|
|
WO2006127900A2
(en)
|
2005-05-25 |
2006-11-30 |
Biogen Idec Ma Inc. |
Tl1a in the treatment of disease
|
|
CN103146708A
(zh)
|
2005-06-30 |
2013-06-12 |
Abbvie公司 |
Il-12/p40结合蛋白
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
BRPI0617057A2
(pt)
|
2005-08-30 |
2011-07-12 |
Univ Miami |
anticorpo isolado, toxina especìfica para receptor de fator de necrose tumoral 25 (tnfr25), método para ativar o receptor de fator de necrose tumoral 25 (tnfr25), método para inibir a sinalização do receptor de fator de necrose tumoral 25 (tnfr25) numa célula, vacina antitumoral, método para imunizar um paciente contra tumor, método para tratar cáncer num paciente, método para tratar e/ou prevenir inflamação intestinal, composição terapêutica para a facilitação de um transplante de órgão, método para transplantar um tecido de um doador para um hospedeiro, método para inibir a expressão clonal de uma população de células t cd8 cognatas, método para tratar e/ou prevenir inflamação pulmonar, antagonista de tnfr25 isolado, composição e vetor de expressão
|
|
CN105837690A
(zh)
|
2006-06-12 |
2016-08-10 |
新兴产品开发西雅图有限公司 |
具有效应功能的单链多价结合蛋白
|
|
US7691980B2
(en)
|
2007-01-09 |
2010-04-06 |
Bio-Rad Laboratories, Inc. |
Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
|
|
US9896511B2
(en)
|
2007-01-10 |
2018-02-20 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Antibodies that bind to TL1A and methods of treating inflammatory or autoimmune disease comprising administering such antibodies
|
|
US20110217310A1
(en)
|
2007-01-10 |
2011-09-08 |
Siegel Richard M |
Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology
|
|
US20100190162A1
(en)
*
|
2007-02-26 |
2010-07-29 |
Cedars-Sinai Medical Center |
Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease
|
|
US20100055700A1
(en)
|
2007-02-28 |
2010-03-04 |
Cedars-Sinai Medical Center |
Role of il-12, il-23 and il-17 receptors in inflammatory bowel disease
|
|
MX2010005282A
(es)
|
2007-11-13 |
2010-08-31 |
Teva Pharma |
Anticuerpos humanizados contra tl1a.
|
|
CN101469270B
(zh)
|
2007-12-27 |
2012-08-22 |
牛斌 |
工业连续化塑料裂解器
|
|
US8093364B2
(en)
|
2008-01-18 |
2012-01-10 |
Bio-Rad Laboratories, Inc. |
Enhanced purification of antibodies and antibody fragments by apatite chromatography
|
|
KR101318549B1
(ko)
|
2008-09-29 |
2013-10-16 |
로슈 글리카트 아게 |
인간 ｉｌ17 에 대한 항체 및 이의 용도
|
|
WO2010111180A1
(en)
|
2009-03-24 |
2010-09-30 |
Teva Biopharmaceuticals Usa, Inc. |
Humanized antibodies against light and uses thereof
|
|
DK2462165T3
(en)
|
2009-08-03 |
2016-08-29 |
Univ Miami |
Method for in vivo proliferation of regulatory T cells
|
|
WO2011106707A2
(en)
|
2010-02-26 |
2011-09-01 |
Human Genome Sciences, Inc. |
Antibodies that specifically bind to dr3
|
|
AR082518A1
(es)
|
2010-08-25 |
2012-12-12 |
Hoffmann La Roche |
Anticuerpos contra il-18r1 y usos de los mismos
|
|
CN103249742B
(zh)
|
2010-09-16 |
2017-04-12 |
巴利奥医药股份公司 |
抗人肿瘤坏死因子1型受体抗体
|
|
US8766034B2
(en)
*
|
2010-09-22 |
2014-07-01 |
Cedars-Sinai Medical Center |
TL1A model of inflammation fibrosis and autoimmunity
|
|
JO3375B1
(ar)
|
2010-11-08 |
2019-03-13 |
Regeneron Pharma |
أجسام مضادة بشرية للجين a1 الشبيه بعامل النخر الورمي (tl1a)
|
|
AU2012259312A1
(en)
|
2011-05-20 |
2013-12-12 |
Government Of The United States, As Represented By The Secretary Department Of Health And Human Services |
Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology and antibodies thereof
|
|
PH12013502489B1
(en)
|
2011-06-03 |
2019-04-24 |
Xoma Technology Ltd |
Antibodies specific for tgf-beta
|
|
MX2014003689A
(es)
|
2011-09-30 |
2014-12-05 |
Teva Pharmaceuticals Australia Pty Ltd |
Anticuerpos contra tl1a y sus usos.
|
|
EA201591153A1
(ru)
|
2013-01-02 |
2016-01-29 |
Гленмарк Фармасьютикалс С.А. |
Антитела, связывающиеся с tl1a, и их применение
|
|
PT2970398T
(pt)
*
|
2013-03-13 |
2024-06-07 |
The Us Secretary Department Ofhealth And Human Servic |
Proteínas f de pré-fusão do vsr e sua utilização
|
|
CN105722856B
(zh)
*
|
2013-03-15 |
2019-04-16 |
厦门大学 |
Rsv融合蛋白的表位以及识别其的抗体
|
|
LT3702373T
(lt)
|
2013-09-13 |
2022-11-10 |
Beigene Switzerland Gmbh |
Anti-pd1 antikūnai ir jų naudojimas terapijai ir diagnostikai
|
|
EP3068801A1
(en)
*
|
2013-11-13 |
2016-09-21 |
Pfizer Inc. |
Tumor necrosis factor-like ligand 1a specific antibodies and compositions and uses thereof
|
|
US10392438B2
(en)
|
2014-05-16 |
2019-08-27 |
Pfizer Inc. |
Bispecific antibodies
|
|
US10160805B2
(en)
|
2014-07-11 |
2018-12-25 |
New York University |
Methods of treating inflammatory bowel disease by administering tumor necrosis factor-like ligand 1A or an agonistic death-domain receptor 3 antibody
|
|
MX391388B
(es)
|
2014-11-14 |
2025-03-21 |
Hoffmann La Roche |
Moléculas de unión a antígeno que comprenden un trímero de ligando de la familia de tnf.
|
|
TWI703158B
(zh)
|
2015-09-18 |
2020-09-01 |
美商希佛隆公司 |
特異性結合tl1a之抗體
|
|
US20180319889A1
(en)
|
2015-11-02 |
2018-11-08 |
La Jolla Institute For Allergy & Immunology |
Method and medicament for treating airway and/or lung diseases
|
|
CR20180365A
(es)
|
2015-12-16 |
2018-09-28 |
Amgen Inc |
PROTEÍNAS DE UNIÓN AL ANTÍGENO BISPECÍFICO DE ANTI-TL1A/ANTI-TNF-a Y SUS USOS
|
|
US10968279B2
(en)
|
2016-05-09 |
2021-04-06 |
Bristol-Myers Squibb Company |
TL1A antibodies and uses thereof
|
|
US10274751B2
(en)
*
|
2016-07-05 |
2019-04-30 |
Bausch & Lomb Incorporated |
Prism ballasted contact lens
|
|
US10688412B2
(en)
|
2016-07-25 |
2020-06-23 |
Cehpalon, Inc. |
Affinity chromatography wash buffer
|
|
CN118240830A
(zh)
*
|
2016-10-26 |
2024-06-25 |
西达-赛奈医疗中心 |
中和抗tl1a单克隆抗体
|
|
CN112585165B8
(zh)
*
|
2018-04-25 |
2025-02-14 |
普罗米修斯生物科学公司 |
优化的抗tl1a抗体
|