|
US4737462A
(en)
|
1982-10-19 |
1988-04-12 |
Cetus Corporation |
Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
|
|
US4518584A
(en)
|
1983-04-15 |
1985-05-21 |
Cetus Corporation |
Human recombinant interleukin-2 muteins
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
DE3883899T3
(de)
|
1987-03-18 |
1999-04-22 |
Sb2, Inc., Danville, Calif. |
Geänderte antikörper.
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US6172197B1
(en)
|
1991-07-10 |
2001-01-09 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
DE69133476T2
(de)
|
1990-08-29 |
2006-01-05 |
GenPharm International, Inc., Palo Alto |
Transgene Mäuse fähig zur Produktion heterologer Antikörper
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US6277969B1
(en)
|
1991-03-18 |
2001-08-21 |
New York University |
Anti-TNF antibodies and peptides of human tumor necrosis factor
|
|
AU675916B2
(en)
|
1991-06-14 |
1997-02-27 |
Genentech Inc. |
Method for making humanized antibodies
|
|
ATE408012T1
(de)
|
1991-12-02 |
2008-09-15 |
Medical Res Council |
Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
|
|
GB9325182D0
(en)
|
1993-12-08 |
1994-02-09 |
T Cell Sciences Inc |
Humanized antibodies or binding proteins thereof specific for t cell subpopulations exhibiting select beta chain variable regions
|
|
US7820798B2
(en)
|
1994-11-07 |
2010-10-26 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
US7597886B2
(en)
|
1994-11-07 |
2009-10-06 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
US20030129189A1
(en)
|
1994-11-07 |
2003-07-10 |
Guo-Liang Yu |
Tumor necrosis factor-gamma
|
|
US20030198640A1
(en)
|
1994-11-07 |
2003-10-23 |
Human Genome Sciences, Inc. |
Methods and compositions for treating inflammatory bowel diseases relating to human tumor necrosis factor-gamma-beta
|
|
US6824767B2
(en)
|
1994-11-07 |
2004-11-30 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
US6599719B2
(en)
|
1994-11-07 |
2003-07-29 |
Human Genome Sciences, Inc. |
Nucleic acid molecules encoding tumor necrosis factor-gamma-alpha
|
|
ES2285701T3
(es)
|
1994-11-07 |
2007-11-16 |
Human Genome Sciences, Inc. |
Factor-gamma de necrosis tumoral.
|
|
US6696248B1
(en)
|
1995-08-18 |
2004-02-24 |
Morphosys Ag |
Protein/(poly)peptide libraries
|
|
DE69621940T2
(de)
|
1995-08-18 |
2003-01-16 |
Morphosys Ag |
Protein-/(poly)peptidbibliotheken
|
|
US6632976B1
(en)
|
1995-08-29 |
2003-10-14 |
Kirin Beer Kabushiki Kaisha |
Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene
|
|
US7357927B2
(en)
|
1996-03-12 |
2008-04-15 |
Human Genome Sciences, Inc. |
Death domain containing receptors
|
|
WO1999029888A1
(en)
|
1997-12-05 |
1999-06-17 |
The Scripps Research Institute |
Humanization of murine antibody
|
|
US6297367B1
(en)
|
1997-12-30 |
2001-10-02 |
Chiron Corporation |
Polynucleotide encoding TNFL1
|
|
EP1071458A4
(en)
|
1998-03-13 |
2005-02-16 |
Dana Farber Cancer Inst Inc |
HUMANIZED ANTIBODIES AND CORRESPONDING USES THEREOF
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
AU5124500A
(en)
|
1999-04-30 |
2000-11-17 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
WO2001002588A2
(en)
|
1999-07-02 |
2001-01-11 |
Morphosys Ag |
Generation of specific binding partners binding to (poly)peptides encoded by genomic dna fragments or ests
|
|
US6399857B1
(en)
*
|
1999-09-22 |
2002-06-04 |
Paradigm Genetics, Inc. |
Modified nucleotide sequence encoding a LexA DNA binding domain optimized for arabidopsis species
|
|
US20110131679A2
(en)
|
2000-04-19 |
2011-06-02 |
Thomas La Rosa |
Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
|
|
US6571638B2
(en)
|
2000-06-30 |
2003-06-03 |
Sawtek, Inc. |
Surface-acoustic-wave pressure sensor and associated methods
|
|
WO2002004643A1
(en)
|
2000-07-07 |
2002-01-17 |
Human Genome Sciences, Inc. |
Tumor necrosis factor-gamma
|
|
US6824989B1
(en)
|
2000-09-01 |
2004-11-30 |
Upstate Biotechnology, Inc. |
Recombinant monoclonal antibody to phosphotyrosine-containing proteins
|
|
US20030017518A1
(en)
|
2001-06-26 |
2003-01-23 |
Joseph Lam |
Non-radio-active assay of LPS kinases
|
|
DE60336406D1
(de)
*
|
2002-10-16 |
2011-04-28 |
Purdue Pharma Lp |
Antikörper, die an zellassoziiertes ca 125/0722p binden, und verfahren zu deren anwendung
|
|
EP1567555A4
(en)
|
2002-11-27 |
2006-06-21 |
Biogen Idec Inc |
HUMANIZED ANTIBODIES AGAINST CHEMOTOXIC MONOCYTE PROTEINS
|
|
US20050101889A1
(en)
|
2003-11-06 |
2005-05-12 |
Freeman Gary A. |
Using chest velocity to process physiological signals to remove chest compression artifacts
|
|
US20080287309A1
(en)
|
2004-07-10 |
2008-11-20 |
Alexion Pharmaceuticals, Inc. |
Methods for Discovering Antibodies Specific to Cancer Cells and Antibodies Discovered Thereby
|
|
TWI309240B
(en)
|
2004-09-17 |
2009-05-01 |
Hoffmann La Roche |
Anti-ox40l antibodies
|
|
AU2006244180B2
(en)
|
2005-05-06 |
2012-03-01 |
Zymogenetics, Inc. |
IL-31 monoclonal antibodies and methods of use
|
|
WO2006122187A2
(en)
|
2005-05-10 |
2006-11-16 |
Biogen Idec Ma Inc. |
Treating and evaluating inflammatory disorders
|
|
US20090317388A1
(en)
*
|
2005-05-25 |
2009-12-24 |
Linda Burkly |
Tl1a in treatment of disease
|
|
EP1907421A4
(en)
*
|
2005-06-30 |
2012-03-28 |
Abbott Lab |
IL-12 / P40 BINDING PROTEINS
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
AU2006284922B2
(en)
|
2005-08-30 |
2012-01-19 |
University Of Miami |
Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists and immunotoxins
|
|
NZ596865A
(en)
|
2006-06-12 |
2013-07-26 |
Emergent Product Dev Seattle |
Single-chain multivalent binding proteins with effector function
|
|
US7691980B2
(en)
|
2007-01-09 |
2010-04-06 |
Bio-Rad Laboratories, Inc. |
Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
|
|
US20110217310A1
(en)
|
2007-01-10 |
2011-09-08 |
Siegel Richard M |
Blockade of tl1a-dr3 interactions to ameliorate t cell mediated disease pathology
|
|
US9896511B2
(en)
|
2007-01-10 |
2018-02-20 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Antibodies that bind to TL1A and methods of treating inflammatory or autoimmune disease comprising administering such antibodies
|
|
US20100190162A1
(en)
*
|
2007-02-26 |
2010-07-29 |
Cedars-Sinai Medical Center |
Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease
|
|
WO2008106579A2
(en)
|
2007-02-28 |
2008-09-04 |
Cedars-Sinai Medical Center |
The role of il-12, il-23 and il-17 receptors in inflammatory bowel disease
|
|
EP2500362A3
(en)
*
|
2007-11-13 |
2012-10-24 |
Teva Biopharmaceuticals USA, Inc. |
Humanized antibodies against TL1A
|
|
CN101469270B
(zh)
|
2007-12-27 |
2012-08-22 |
牛斌 |
工业连续化塑料裂解器
|
|
EP2275431A3
(en)
|
2008-01-18 |
2011-05-25 |
Bio-Rad Laboratories, Inc. |
Enhanced fractionation of phosphorylated and nonphosphorylated biomolecules by apatite chromotography
|
|
RU2539029C2
(ru)
|
2008-09-29 |
2015-01-10 |
Роше Гликарт Аг |
Антитела против интерлейкина 17 (ил-17) человека и их применение
|
|
CA2756186A1
(en)
|
2009-03-24 |
2010-09-30 |
Teva Biopharmaceuticals Usa, Inc. |
Humanized antibodies against light and uses thereof
|
|
ES2586837T3
(es)
|
2009-08-03 |
2016-10-19 |
University Of Miami |
Método para la expansión in vivo de linfocitos T reguladores
|
|
WO2011106707A2
(en)
|
2010-02-26 |
2011-09-01 |
Human Genome Sciences, Inc. |
Antibodies that specifically bind to dr3
|
|
RU2013110874A
(ru)
|
2010-08-25 |
2014-09-27 |
Ф.Хоффманн-Ля Рош Аг |
Антитела против il-18r1 и их применения
|
|
KR101871008B1
(ko)
|
2010-09-16 |
2018-06-25 |
발리오팜 아게 |
항-huTNFR1 항체
|
|
US8766034B2
(en)
|
2010-09-22 |
2014-07-01 |
Cedars-Sinai Medical Center |
TL1A model of inflammation fibrosis and autoimmunity
|
|
JO3375B1
(ar)
|
2010-11-08 |
2019-03-13 |
Regeneron Pharma |
أجسام مضادة بشرية للجين a1 الشبيه بعامل النخر الورمي (tl1a)
|
|
EP2709664A4
(en)
|
2011-05-20 |
2015-06-10 |
Us Government |
BLOCKADE OF TL1A-DR3 INTERACTIONS FOR THE TREATMENT OF T-CELL-MEDIATED DISEASES AND ANTIBODIES THEREOF
|
|
CN116333113A
(zh)
|
2011-06-03 |
2023-06-27 |
佐马技术有限公司 |
对TGF-β具有特异性的抗体
|
|
JP2014531210A
(ja)
*
|
2011-09-30 |
2014-11-27 |
テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド |
ＴＬ１ａに対する抗体およびその使用
|
|
TR201815254T4
(tr)
|
2013-01-02 |
2018-11-21 |
Glenmark Pharmaceuticals Sa |
Tl1a'ya bağlanan anti̇korlar ve bunlarin kullanimlari
|
|
EP4421177A3
(en)
*
|
2013-03-13 |
2024-12-18 |
The United States of America, as represented by the Secretary, Department of Health and Human Services |
Prefusion rsv f proteins and their use
|
|
JP6462599B2
(ja)
*
|
2013-03-15 |
2019-01-30 |
シャアメン ユニバーシティ |
Ｒｓｖ融合タンパク質のエピトープ及びそのエピトープを認識する抗体
|
|
EA034666B1
(ru)
|
2013-09-13 |
2020-03-04 |
Бейджин Свитзерланд Гмбх |
Антитело против pd-1 и его применение для лечения рака или вирусной инфекции и фрагмент антитела
|
|
RU2708140C1
(ru)
|
2013-11-13 |
2019-12-04 |
Пфайзер Инк. |
Антитела, специфичные в отношении лиганда 1А, подобного фактору некроза опухолей, и их композиции и применения
|
|
JP6868394B2
(ja)
|
2014-05-16 |
2021-05-12 |
ファイザー・インク |
二重特異性抗体
|
|
US10160805B2
(en)
|
2014-07-11 |
2018-12-25 |
New York University |
Methods of treating inflammatory bowel disease by administering tumor necrosis factor-like ligand 1A or an agonistic death-domain receptor 3 antibody
|
|
SG11201703597TA
(en)
|
2014-11-14 |
2017-06-29 |
Hoffmann La Roche |
Antigen binding molecules comprising a tnf family ligand trimer
|
|
TWI703158B
(zh)
|
2015-09-18 |
2020-09-01 |
美商希佛隆公司 |
特異性結合tl1a之抗體
|
|
WO2017077715A1
(en)
|
2015-11-02 |
2017-05-11 |
La Jolla Institute For Allergy & Immunology |
Method and medicament for treating airway and/or lung diseases
|
|
CR20180365A
(es)
|
2015-12-16 |
2018-09-28 |
Amgen Inc |
PROTEÍNAS DE UNIÓN AL ANTÍGENO BISPECÍFICO DE ANTI-TL1A/ANTI-TNF-a Y SUS USOS
|
|
CN109476742B
(zh)
|
2016-05-09 |
2023-04-14 |
百时美施贵宝公司 |
Tl1a抗体及其用途
|
|
US10274751B2
(en)
*
|
2016-07-05 |
2019-04-30 |
Bausch & Lomb Incorporated |
Prism ballasted contact lens
|
|
MX392628B
(es)
|
2016-07-25 |
2025-03-24 |
Cephalon Inc |
Amortiguador de lavado de cromatografia de afinidad.
|
|
KR20240128132A
(ko)
*
|
2016-10-26 |
2024-08-23 |
세다르스-신나이 메디칼 센터 |
중화 항-tl1a 단일 클론 항체
|
|
CA3098374A1
(en)
*
|
2018-04-25 |
2019-10-31 |
Prometheus Biosciences, Inc. |
Optimized anti-tl1a antibodies
|