JP2018510636A5 - - Google Patents
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- JP2018510636A5 JP2018510636A5 JP2017549507A JP2017549507A JP2018510636A5 JP 2018510636 A5 JP2018510636 A5 JP 2018510636A5 JP 2017549507 A JP2017549507 A JP 2017549507A JP 2017549507 A JP2017549507 A JP 2017549507A JP 2018510636 A5 JP2018510636 A5 JP 2018510636A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- antigen
- cdr3
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000427 antigen Substances 0.000 claims description 100
- 102000036639 antigens Human genes 0.000 claims description 100
- 108091007433 antigens Proteins 0.000 claims description 100
- 239000012634 fragment Substances 0.000 claims description 56
- 101000914326 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 6 Proteins 0.000 claims description 30
- 102100025473 Carcinoembryonic antigen-related cell adhesion molecule 6 Human genes 0.000 claims description 16
- 102000046810 human CEACAM6 Human genes 0.000 claims description 14
- 241000282567 Macaca fascicularis Species 0.000 claims description 10
- 229940125644 antibody drug Drugs 0.000 claims description 10
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 150000007523 nucleic acids Chemical group 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 108010062802 CD66 antigens Proteins 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 4
- 125000000539 amino acid group Chemical group 0.000 claims description 4
- 230000035772 mutation Effects 0.000 claims description 4
- 230000003053 immunization Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 102100024533 Carcinoembryonic antigen-related cell adhesion molecule 1 Human genes 0.000 claims description 2
- 102220470708 Carcinoembryonic antigen-related cell adhesion molecule 6_I63F_mutation Human genes 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 101000914337 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 3 Proteins 0.000 claims description 2
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims description 2
- 102100037850 Interferon gamma Human genes 0.000 claims description 2
- 108010074328 Interferon-gamma Proteins 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 229940039227 diagnostic agent Drugs 0.000 claims description 2
- 239000000032 diagnostic agent Substances 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 210000003527 eukaryotic cell Anatomy 0.000 claims description 2
- 102000055639 human CEACAM3 Human genes 0.000 claims description 2
- 102000047627 human CEACAM5 Human genes 0.000 claims description 2
- 230000003993 interaction Effects 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 210000001236 prokaryotic cell Anatomy 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102220193249 rs1057516144 Human genes 0.000 claims description 2
- 230000028327 secretion Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229940127557 pharmaceutical product Drugs 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15160292 | 2015-03-23 | ||
| EP15160292.7 | 2015-03-23 | ||
| PCT/EP2016/056104 WO2016150899A2 (en) | 2015-03-23 | 2016-03-21 | Anti-ceacam6 antibodies and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020212437A Division JP7185379B2 (ja) | 2015-03-23 | 2020-12-22 | 抗ｃｅａｃａｍ６抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018510636A JP2018510636A (ja) | 2018-04-19 |
| JP2018510636A5 true JP2018510636A5 (enExample) | 2019-02-21 |
| JP6815329B2 JP6815329B2 (ja) | 2021-01-20 |
Family
ID=52692556
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017549507A Active JP6815329B2 (ja) | 2015-03-23 | 2016-03-21 | 抗ｃｅａｃａｍ６抗体およびその使用 |
| JP2020212437A Active JP7185379B2 (ja) | 2015-03-23 | 2020-12-22 | 抗ｃｅａｃａｍ６抗体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020212437A Active JP7185379B2 (ja) | 2015-03-23 | 2020-12-22 | 抗ｃｅａｃａｍ６抗体およびその使用 |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US10584167B2 (enExample) |
| EP (2) | EP3628688A1 (enExample) |
| JP (2) | JP6815329B2 (enExample) |
| KR (1) | KR102749339B1 (enExample) |
| CN (1) | CN107743495B (enExample) |
| AR (1) | AR104047A1 (enExample) |
| AU (1) | AU2016236270B2 (enExample) |
| BR (1) | BR112017020373A2 (enExample) |
| CA (1) | CA2980390A1 (enExample) |
| CY (1) | CY1122627T1 (enExample) |
| DK (1) | DK3274370T3 (enExample) |
| ES (1) | ES2768784T3 (enExample) |
| HR (1) | HRP20192280T1 (enExample) |
| HU (1) | HUE048111T2 (enExample) |
| IL (1) | IL254534B (enExample) |
| LT (1) | LT3274370T (enExample) |
| MX (1) | MX376973B (enExample) |
| PE (1) | PE20171790A1 (enExample) |
| PL (1) | PL3274370T3 (enExample) |
| PT (1) | PT3274370T (enExample) |
| RS (1) | RS59878B1 (enExample) |
| RU (1) | RU2739163C2 (enExample) |
| SG (1) | SG11201707800QA (enExample) |
| SI (1) | SI3274370T1 (enExample) |
| TW (1) | TWI719969B (enExample) |
| WO (1) | WO2016150899A2 (enExample) |
| ZA (1) | ZA201707138B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6815329B2 (ja) | 2015-03-23 | 2021-01-20 | バイエル ファーマ アクチエンゲゼルシャフト | 抗ｃｅａｃａｍ６抗体およびその使用 |
| BR112019000071A2 (pt) | 2016-07-07 | 2019-07-02 | Bolt Biotherapeutics Inc | conjugados adjuvantes de anticorpo |
| KR102580319B1 (ko) | 2016-10-10 | 2023-09-19 | 에이전시 포 사이언스, 테크놀로지 앤드 리서치 | 항 ceacam6 항체 및 사용 방법 |
| SG11201903800XA (en) * | 2016-11-14 | 2019-05-30 | Dinona | ANTIBODY BINDING SPECIFICALLY TO CD66c AND USE THEREOF |
| WO2018128486A1 (ko) * | 2017-01-05 | 2018-07-12 | 한국생명공학연구원 | Ceacam6에 특이적으로 결합하는 항-ceacam6 키메릭 항원 수용체 |
| JP7325045B2 (ja) * | 2017-02-27 | 2023-08-14 | カイロス セラピューティクス， インコーポレイテッド | 癌を処置する抗体コンストラクトおよび方法 |
| KR20190140943A (ko) | 2017-04-24 | 2019-12-20 | 메모리얼 슬로안 케터링 캔서 센터 | 항-cd33 항체 제제 |
| WO2018217459A2 (en) * | 2017-05-23 | 2018-11-29 | Academia Sinica | Conditional internalization of pegylated agents by pretargeting bi-specific peg-binding antibodies for diagnosis and therapy |
| BR112020002636A2 (pt) * | 2017-08-10 | 2020-07-28 | Grifols Diagnostic Solutions Inc. | composições, métodos e/ou kits que compreendem um domínio extracelular recombinante de cd38 humano |
| KR102134954B1 (ko) | 2018-01-08 | 2020-07-16 | 충북대학교 산학협력단 | CEACAM6 발현 억제를 위한 siRNA 및 이를 포함하는 선암 치료제 |
| JP7555270B2 (ja) * | 2018-02-13 | 2024-09-24 | プレシジョン バイオロジックス、インコーポレイテッド | Ｔｒｅｇ細胞を標的とするための方法及び組成物 |
| CN112020516B (zh) * | 2018-03-13 | 2025-01-03 | 塔斯克疗法有限公司 | 用于肿瘤特异性细胞清除的抗-cd25 |
| KR102373502B1 (ko) * | 2018-05-14 | 2022-03-11 | 주식회사 금호에이치티 | 골수유래억제세포 관련 질환의 예방 및 치료 용도 |
| CN112566935B (zh) * | 2018-05-23 | 2024-12-13 | 百济神州有限公司 | 抗ox40抗体和使用方法 |
| CN112566938B (zh) * | 2018-06-03 | 2025-04-01 | 拉姆卡普生物测试有限公司 | 针对ceacam5和cd47的双特异性抗体 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CA3119563A1 (en) * | 2018-11-14 | 2020-05-22 | Bayer Aktiengesellschaft | Pharmaceutical combination of anti-ceacam6 and either anti-pd-1 or anti-pd-l1 antibodies for the treatment of cancer |
| JP7521163B2 (ja) * | 2018-12-19 | 2024-07-24 | ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ | 抗ｃｅａｃａｍ６及びｔｉｍ３抗体の医薬組み合わせ |
| EP3937984A1 (en) | 2019-03-15 | 2022-01-19 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
| TWI844684B (zh) * | 2019-06-04 | 2024-06-11 | 大陸商普米斯生物技術（珠海）有限公司 | 一種抗ceacam5的單殖株抗體及其製備方法和用途 |
| WO2021050799A1 (en) * | 2019-09-13 | 2021-03-18 | Purdue Research Foundation | Compositions and methods for cancer treatment by enhancing antitumor immunity using tannic acid-based nanocapsules |
| US20230115540A1 (en) * | 2020-03-06 | 2023-04-13 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Tumor targeted fluorescence guidance for intraoperative margin assessment |
| CN111533808B (zh) * | 2020-03-10 | 2021-02-09 | 南京医科大学 | 一种可自分泌TLR4 scFv且靶向cMet的嵌合抗原受体修饰的T细胞及其应用 |
| CN113637073B (zh) | 2020-05-11 | 2024-04-12 | 上海赛比曼生物科技有限公司 | Bcma抗体及其制备和应用 |
| CN112457402B (zh) * | 2020-10-21 | 2022-08-30 | 北京纽安博生物技术有限公司 | 抗ceacam6单域抗体、人源化单域抗体及其融合蛋白和应用 |
| WO2022116079A1 (zh) * | 2020-12-03 | 2022-06-09 | 上海吉倍生物技术有限公司 | 一种抗ceacam5的人源化抗体及其制备方法和用途 |
| US20240024317A1 (en) * | 2020-12-11 | 2024-01-25 | Materia Therapeutics Inc. | Cancer treatment using bosentan in combination with a checkpoint inhibitor |
| CA3205463A1 (en) * | 2020-12-18 | 2022-06-23 | Bioardis, Llc | Cea6 binding molecules and uses thereof |
| CN112521509B (zh) * | 2020-12-23 | 2022-07-08 | 姚雪英 | 一种抗ceacam5人源化抗体、其缀合物及其用途 |
| KR20240051162A (ko) * | 2021-09-02 | 2024-04-19 | 도이체스크레브스포르슝스젠트룸스티프퉁데스외펜트리헨레크츠 | 부작용이 감소된 항-cecam6 항체 |
| MX2024011519A (es) | 2022-03-23 | 2024-09-24 | Synaffix Bv | Conjugados de anticuerpos para el direccionamiento contra tumores que expresan el antigeno carcinoembrionario. |
| CN116196415B (zh) * | 2022-12-07 | 2023-08-01 | 浙江省肿瘤医院 | 用于增敏pd-1抗体的混合制剂及其使用方法 |
| CN121152803A (zh) * | 2023-05-25 | 2025-12-16 | 百进公司 | Ceacam6结合抗体和其抗原结合片段 |
| AU2023465316A1 (en) * | 2023-09-17 | 2025-06-19 | Ji Yan Biomedical Co., Ltd | Recombinant antibodies and uses thereof |
| WO2025237329A1 (en) * | 2024-05-15 | 2025-11-20 | Nona Biosciences (Suzhou) Co., Ltd. | Ceacam6-binding protein |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4510245A (en) | 1982-11-18 | 1985-04-09 | Chiron Corporation | Adenovirus promoter system |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US4968615A (en) | 1985-12-18 | 1990-11-06 | Ciba-Geigy Corporation | Deoxyribonucleic acid segment from a virus |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| CA2026147C (en) | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
| US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
| EP0859841B1 (en) | 1995-08-18 | 2002-06-19 | MorphoSys AG | Protein/(poly)peptide libraries |
| GB9603256D0 (en) | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
| JP2002506353A (ja) | 1997-06-24 | 2002-02-26 | ジェネンテック・インコーポレーテッド | ガラクトシル化糖タンパク質の方法及び組成物 |
| CA2307166A1 (en) | 1997-10-31 | 1999-05-14 | Genentech, Inc. | Methods and compositions comprising glycoprotein glycoforms |
| WO1999029888A1 (en) | 1997-12-05 | 1999-06-17 | The Scripps Research Institute | Humanization of murine antibody |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| CA2323757C (en) | 1998-04-02 | 2011-08-02 | Genentech, Inc. | Antibody variants and fragments thereof |
| JP4334141B2 (ja) | 1998-04-20 | 2009-09-30 | グリカート バイオテクノロジー アクチェンゲゼルシャフト | 抗体依存性細胞傷害性を改善するための抗体のグリコシル化操作 |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| EP1423510A4 (en) | 2001-08-03 | 2005-06-01 | Glycart Biotechnology Ag | ANTIBODY GLYCOSYLATION VARIANTS WITH INCREASED ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY |
| US7361740B2 (en) | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| HUE035898T2 (en) | 2002-12-16 | 2018-05-28 | Genentech Inc | Immunoglobulin variants and their applications |
| HUE038955T2 (hu) | 2003-11-05 | 2018-12-28 | Roche Glycart Ag | Antigén-kötõ molekulák fokozott Fc receptor-kötõ affinitással és effektor funkcióval |
| ES2605443T3 (es) | 2003-11-06 | 2017-03-14 | Seattle Genetics, Inc. | Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia |
| CN1961003B (zh) | 2004-03-31 | 2013-03-27 | 健泰科生物技术公司 | 人源化抗TGF-β抗体 |
| EP3530736A3 (en) | 2005-05-09 | 2019-11-06 | ONO Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
| KR101704734B1 (ko) | 2005-07-01 | 2017-02-09 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체 |
| US20080226635A1 (en) | 2006-12-22 | 2008-09-18 | Hans Koll | Antibodies against insulin-like growth factor I receptor and uses thereof |
| PT2170959E (pt) | 2007-06-18 | 2014-01-07 | Merck Sharp & Dohme | Anticorpos para o receptor humano de morte programada pd-1 |
| EA201500417A1 (ru) | 2008-08-25 | 2015-11-30 | Эмплиммьюн, Инк. | Композиции антагонистов pd-1 и способы применения |
| MX356367B (es) | 2008-12-09 | 2018-05-25 | Genentech Inc | Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t. |
| WO2011034660A1 (en) * | 2009-09-16 | 2011-03-24 | Immunomedics, Inc. | Class i anti-cea antibodies and uses thereof |
| EP3279215B1 (en) | 2009-11-24 | 2020-02-12 | MedImmune Limited | Targeted binding agents against b7-h1 |
| US8404812B2 (en) | 2010-02-26 | 2013-03-26 | Dinona Inc. | Epitope of CD66C specific to lung adenocarcinoma and antibody recognizing the same |
| CA2803391C (en) | 2010-06-22 | 2021-11-09 | Neogenix Oncology, Inc. | Npc1 antibodies that bind a muc5ac epitope |
| ES2664989T3 (es) * | 2010-10-01 | 2018-04-24 | National Research Council Of Canada | Anticuerpos ANTI-CEACAM6 y usos de los mismos |
| EP2508525A1 (en) | 2011-04-05 | 2012-10-10 | Bayer Pharma Aktiengesellschaft | Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts |
| BR112014012819B1 (pt) | 2011-11-28 | 2022-08-16 | Merck Patent Gmbh | Anticorpo anti-pd-l1 ou fragmento de ligação ao antígeno do mesmo e composição |
| RU2493166C1 (ru) * | 2012-04-09 | 2013-09-20 | Общество с ограниченной ответственностью "Технофарма" | Наноантитело, специфически связывающее белок сеа, способ его использования для детекции этого белка |
| US9856320B2 (en) | 2012-05-15 | 2018-01-02 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting PD-1/PD-L1 signaling |
| US10131712B2 (en) | 2012-08-14 | 2018-11-20 | Ibc Pharmaceuticals, Inc. | Combination therapy with T-cell redirecting bispecific antibodies and checkpoint inhibitors |
| SMT202300039T1 (it) | 2013-09-13 | 2023-03-17 | Beigene Switzerland Gmbh | Anticorpi anti-pd1 e loro uso come terapia e per diagnostica |
| PL3099717T3 (pl) | 2014-01-31 | 2019-10-31 | Novartis Ag | Cząsteczki przeciwciała dla TIM-3 i ich zastosowanie |
| JP6815329B2 (ja) | 2015-03-23 | 2021-01-20 | バイエル ファーマ アクチエンゲゼルシャフト | 抗ｃｅａｃａｍ６抗体およびその使用 |
| PL3277321T3 (pl) | 2015-04-01 | 2024-11-18 | Anaptysbio, Inc. | Przeciwciała skierowane przeciwko białku 3 immunoglobuliny limfocytów t i mucyny (tim-3) |
| CN116693685A (zh) | 2016-04-12 | 2023-09-05 | 法国施维雅药厂 | 抗tim-3抗体及组合物 |
| KR102543118B1 (ko) | 2016-05-27 | 2023-06-14 | 아게누스 인코포레이티드 | 항-tim-3 항체 및 이의 사용 방법 |
| US20190248893A1 (en) | 2016-07-14 | 2019-08-15 | Bristol-Myers Squibb Company | Antibodies against tim3 and uses thereof |
| JOP20190013A1 (ar) | 2016-08-25 | 2019-01-31 | Lilly Co Eli | أجسام مضادة لـ (تي آي ام -3) |
| SG11201903800XA (en) | 2016-11-14 | 2019-05-30 | Dinona | ANTIBODY BINDING SPECIFICALLY TO CD66c AND USE THEREOF |
| AU2018205401B2 (en) | 2017-01-09 | 2025-01-02 | Tesaro, Inc. | Methods of treating cancer with anti-TIM-3 antibodies |
-
2016
- 2016-03-21 JP JP2017549507A patent/JP6815329B2/ja active Active
- 2016-03-21 AU AU2016236270A patent/AU2016236270B2/en active Active
- 2016-03-21 PL PL16713784T patent/PL3274370T3/pl unknown
- 2016-03-21 PT PT167137843T patent/PT3274370T/pt unknown
- 2016-03-21 TW TW105108621A patent/TWI719969B/zh active
- 2016-03-21 SG SG11201707800QA patent/SG11201707800QA/en unknown
- 2016-03-21 WO PCT/EP2016/056104 patent/WO2016150899A2/en not_active Ceased
- 2016-03-21 HU HUE16713784A patent/HUE048111T2/hu unknown
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