BR112017020373A2 - anticorpos anti-ceacam6 e usos dos mesmos - Google Patents

anticorpos anti-ceacam6 e usos dos mesmos

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Publication number
BR112017020373A2
BR112017020373A2 BR112017020373-1A BR112017020373A BR112017020373A2 BR 112017020373 A2 BR112017020373 A2 BR 112017020373A2 BR 112017020373 A BR112017020373 A BR 112017020373A BR 112017020373 A2 BR112017020373 A2 BR 112017020373A2
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Brazil
Prior art keywords
antibodies
human
nca
binding regions
antigen binding
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BR112017020373-1A
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English (en)
Inventor
Willuda Jörg
Trautwein Mark
Gritzan Uwe
Freiberg Christoph
Dittmer Frank
Schönfeld Dorian
Marius Glück Julian
Pinkert Jessica
Gutierrez Eva-Maria
Golfier Sven
Holton Simon
Beckhove Philip
Ge Yingzi
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Bayer Pharma Aktiengesellschaft
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Publication of BR112017020373A2 publication Critical patent/BR112017020373A2/pt

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464448—Regulators of development
    • A61K39/46445—Apoptosis related proteins, e.g. survivin or livin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464466—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/46448—Cancer antigens from embryonic or fetal origin
    • A61K39/464482—Carcinoembryonic antigen [CEA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • A61K39/0011—Cancer antigens
    • A61K39/00118—Cancer antigens from embryonic or fetal origin
    • A61K39/001182—Carcinoembryonic antigen [CEA]
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
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Abstract

a presente invenção fornece regiões de ligação a antígeno recombinantes e anticorpos e fragmentos funcionais contendo tais regiões de ligação a antígeno que são específicas para ceacam6 (molécula 6 de adesão celular relacionada a antígeno carcinoembrionária, cd66c, antígeno de reação cruzada não específico, nca, nca-50/90) de ser humano e macaca fascicularis e que não reagem de modo cruzado significativamente com a ceacam1 humana, ceacam3 humana e ceacam5 humana estreitamente relacionadas. a invenção fornece adicionalmente métodos para gerar esse tipo de anticorpos. os anticorpos, consequentemente, podem ser usados para tratar câncer e outros distúrbios e afecções associadas à expressão da ceacam6. a invenção também fornece sequências de ácidos nucleicos que codificam os anticorpos anteriores, vetores contendo os mesmos, composições farmacêuticas e kits com instruções para uso.
BR112017020373-1A 2015-03-23 2016-03-21 anticorpos anti-ceacam6 e usos dos mesmos BR112017020373A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15160292.7 2015-03-23
EP15160292 2015-03-23
PCT/EP2016/056104 WO2016150899A2 (en) 2015-03-23 2016-03-21 Anti-ceacam6 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
BR112017020373A2 true BR112017020373A2 (pt) 2018-06-05

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Country Status (28)

Country Link
US (3) US10584167B2 (pt)
EP (2) EP3628688A1 (pt)
JP (2) JP6815329B2 (pt)
KR (1) KR20170128567A (pt)
CN (1) CN107743495B (pt)
AR (1) AR104047A1 (pt)
AU (1) AU2016236270B2 (pt)
BR (1) BR112017020373A2 (pt)
CA (1) CA2980390A1 (pt)
CY (1) CY1122627T1 (pt)
DK (1) DK3274370T3 (pt)
ES (1) ES2768784T3 (pt)
HK (1) HK1246312A1 (pt)
HR (1) HRP20192280T1 (pt)
HU (1) HUE048111T2 (pt)
IL (1) IL254534B (pt)
LT (1) LT3274370T (pt)
MX (1) MX2017012278A (pt)
PE (1) PE20171790A1 (pt)
PL (1) PL3274370T3 (pt)
PT (1) PT3274370T (pt)
RS (1) RS59878B1 (pt)
RU (1) RU2739163C2 (pt)
SG (1) SG11201707800QA (pt)
SI (1) SI3274370T1 (pt)
TW (1) TWI719969B (pt)
WO (1) WO2016150899A2 (pt)
ZA (1) ZA201707138B (pt)

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