PT3274370T - Anticorpos anti-ceacam6 e utilizações dos mesmos - Google Patents
Anticorpos anti-ceacam6 e utilizações dos mesmosInfo
- Publication number
- PT3274370T PT3274370T PT167137843T PT16713784T PT3274370T PT 3274370 T PT3274370 T PT 3274370T PT 167137843 T PT167137843 T PT 167137843T PT 16713784 T PT16713784 T PT 16713784T PT 3274370 T PT3274370 T PT 3274370T
- Authority
- PT
- Portugal
- Prior art keywords
- ceacam6 antibodies
- ceacam6
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464448—Regulators of development
- A61K39/46445—Apoptosis related proteins, e.g. survivin or livin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464466—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/46448—Cancer antigens from embryonic or fetal origin
- A61K39/464482—Carcinoembryonic antigen [CEA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00118—Cancer antigens from embryonic or fetal origin
- A61K39/001182—Carcinoembryonic antigen [CEA]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15160292 | 2015-03-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3274370T true PT3274370T (pt) | 2020-01-30 |
Family
ID=52692556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT167137843T PT3274370T (pt) | 2015-03-23 | 2016-03-21 | Anticorpos anti-ceacam6 e utilizações dos mesmos |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US10584167B2 (pt) |
| EP (2) | EP3628688A1 (pt) |
| JP (2) | JP6815329B2 (pt) |
| KR (1) | KR20170128567A (pt) |
| CN (1) | CN107743495B (pt) |
| AR (1) | AR104047A1 (pt) |
| AU (1) | AU2016236270B2 (pt) |
| BR (1) | BR112017020373A2 (pt) |
| CA (1) | CA2980390A1 (pt) |
| CY (1) | CY1122627T1 (pt) |
| DK (1) | DK3274370T3 (pt) |
| ES (1) | ES2768784T3 (pt) |
| HK (1) | HK1246312A1 (pt) |
| HR (1) | HRP20192280T1 (pt) |
| HU (1) | HUE048111T2 (pt) |
| IL (1) | IL254534B (pt) |
| LT (1) | LT3274370T (pt) |
| MX (1) | MX2017012278A (pt) |
| PE (1) | PE20171790A1 (pt) |
| PL (1) | PL3274370T3 (pt) |
| PT (1) | PT3274370T (pt) |
| RS (1) | RS59878B1 (pt) |
| RU (1) | RU2739163C2 (pt) |
| SG (1) | SG11201707800QA (pt) |
| SI (1) | SI3274370T1 (pt) |
| TW (1) | TWI719969B (pt) |
| WO (1) | WO2016150899A2 (pt) |
| ZA (1) | ZA201707138B (pt) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3274370T3 (da) | 2015-03-23 | 2020-02-17 | Bayer Pharma AG | Anti-ceacam6-antistoffer og anvendelser deraf |
| AU2017292934B2 (en) | 2016-07-07 | 2024-04-04 | Bolt Biotherapeutics, Inc. | Antibody adjuvant conjugates |
| EP3523333B1 (en) * | 2016-10-10 | 2023-12-13 | Singapore Health Services Pte Ltd | Anti-ceacam6 antibodies and methods of use |
| BR112019009771A2 (pt) * | 2016-11-14 | 2019-09-17 | Dinona | ligação de anticorpos especificamente à cd66c e utilização dos mesmos |
| WO2018128486A1 (ko) * | 2017-01-05 | 2018-07-12 | 한국생명공학연구원 | Ceacam6에 특이적으로 결합하는 항-ceacam6 키메릭 항원 수용체 |
| JP7325045B2 (ja) * | 2017-02-27 | 2023-08-14 | カイロス セラピューティクス， インコーポレイテッド | 癌を処置する抗体コンストラクトおよび方法 |
| BR112019021182A2 (pt) * | 2017-04-24 | 2020-06-02 | Memorial Sloan Kettering Cancer Center | Agentes de anticorpo anti-cd33 |
| WO2018217459A2 (en) * | 2017-05-23 | 2018-11-29 | Academia Sinica | Conditional internalization of pegylated agents by pretargeting bi-specific peg-binding antibodies for diagnosis and therapy |
| AU2018313028B2 (en) * | 2017-08-10 | 2023-05-25 | Grifols Diagnostic Solutions Inc. | Compositions, methods and/or kits comprising a recombinant human CD38-extracellular domain |
| KR102134954B1 (ko) | 2018-01-08 | 2020-07-16 | 충북대학교 산학협력단 | CEACAM6 발현 억제를 위한 siRNA 및 이를 포함하는 선암 치료제 |
| BR112020016374A2 (pt) * | 2018-02-13 | 2020-12-15 | Precision Biologics, Inc. | Métodos e composições para direcionar células treg |
| EP3765504A1 (en) * | 2018-03-13 | 2021-01-20 | Tusk Therapeutics Ltd | Anti-cd25 for tumour specific cell depletion |
| KR102373502B1 (ko) * | 2018-05-14 | 2022-03-11 | 주식회사 금호에이치티 | 골수유래억제세포 관련 질환의 예방 및 치료 용도 |
| EP3797123A4 (en) * | 2018-05-23 | 2022-03-02 | BeiGene, Ltd. | ANTI-OX40 ANTIBODIES AND METHODS OF USE |
| WO2019234576A1 (en) * | 2018-06-03 | 2019-12-12 | Lamkap Bio Beta Ltd. | Bispecific antibodies against ceacam5 and cd47 |
| EP3880705A1 (en) | 2018-11-14 | 2021-09-22 | Bayer Aktiengesellschaft | Pharmaceutical combination of anti-ceacam6 and either anti-pd-1 or anti-pd-l1 antibodies for the treatment of cancer |
| US20220089721A1 (en) * | 2018-12-19 | 2022-03-24 | Bayer Aktiengesellschaft | Pharmaceutical combination of anti ceacam6 and tim3 antibodies |
| WO2020190725A1 (en) | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
| TW202100560A (zh) * | 2019-06-04 | 2021-01-01 | 大陸商上海吉倍生物技術有限公司 | 一種抗ceacam5 的單殖株抗體及其製備方法和用途 |
| WO2021178951A1 (en) * | 2020-03-06 | 2021-09-10 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Tumor targeted fluorescence guidance for intraoperative margin assessment |
| CN111533808B (zh) * | 2020-03-10 | 2021-02-09 | 南京医科大学 | 一种可自分泌TLR4 scFv且靶向cMet的嵌合抗原受体修饰的T细胞及其应用 |
| CN113637073B (zh) * | 2020-05-11 | 2024-04-12 | 上海赛比曼生物科技有限公司 | Bcma抗体及其制备和应用 |
| CN112457402B (zh) * | 2020-10-21 | 2022-08-30 | 北京纽安博生物技术有限公司 | 抗ceacam6单域抗体、人源化单域抗体及其融合蛋白和应用 |
| WO2022116079A1 (zh) * | 2020-12-03 | 2022-06-09 | 上海吉倍生物技术有限公司 | 一种抗ceacam5的人源化抗体及其制备方法和用途 |
| CN117015377A (zh) * | 2020-12-11 | 2023-11-07 | 材料治疗公司 | 使用波生坦与检查点抑制剂组合的癌症治疗 |
| US20240052031A1 (en) * | 2020-12-18 | 2024-02-15 | Bioardis, Llc | Cea6 binding molecules and uses thereof |
| CN112521509B (zh) * | 2020-12-23 | 2022-07-08 | 姚雪英 | 一种抗ceacam5人源化抗体、其缀合物及其用途 |
| IL310773A (en) | 2021-09-02 | 2024-04-01 | Deutsches Krebsforschungszentrum Stiftung Des ?Ffentlichen Rechts | Anti-CECAM6 antibodies with reduced side effects |
| WO2023180489A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing carcinoembyronic antigen |
| CN116196415B (zh) * | 2022-12-07 | 2023-08-01 | 浙江省肿瘤医院 | 用于增敏pd-1抗体的混合制剂及其使用方法 |
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| RU2493166C1 (ru) * | 2012-04-09 | 2013-09-20 | Общество с ограниченной ответственностью "Технофарма" | Наноантитело, специфически связывающее белок сеа, способ его использования для детекции этого белка |
| CN113967253A (zh) | 2012-05-15 | 2022-01-25 | 百时美施贵宝公司 | 通过破坏pd-1/pd-l1信号传输的免疫治疗 |
| US10131712B2 (en) | 2012-08-14 | 2018-11-20 | Ibc Pharmaceuticals, Inc. | Combination therapy with T-cell redirecting bispecific antibodies and checkpoint inhibitors |
| HUE049281T2 (hu) | 2013-09-13 | 2020-09-28 | Beigene Switzerland Gmbh | Anti-PD1 antitestek, valamint terapeutikumként és diagnosztikumként történõ alkalmazásuk |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| DK3274370T3 (da) * | 2015-03-23 | 2020-02-17 | Bayer Pharma AG | Anti-ceacam6-antistoffer og anvendelser deraf |
| MA41867A (fr) | 2015-04-01 | 2018-02-06 | Anaptysbio Inc | Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3) |
| PL3443009T3 (pl) | 2016-04-12 | 2022-01-31 | Symphogen A/S | Przeciwciała i kompozycje anty-tim-3 |
| KR102543118B1 (ko) | 2016-05-27 | 2023-06-14 | 아게누스 인코포레이티드 | 항-tim-3 항체 및 이의 사용 방법 |
| CN109757103B (zh) | 2016-07-14 | 2024-01-02 | 百时美施贵宝公司 | 针对tim3的抗体及其用途 |
| JOP20190013A1 (ar) | 2016-08-25 | 2019-01-31 | Lilly Co Eli | أجسام مضادة لـ (تي آي ام -3) |
| BR112019009771A2 (pt) | 2016-11-14 | 2019-09-17 | Dinona | ligação de anticorpos especificamente à cd66c e utilização dos mesmos |
| MA47206A (fr) | 2017-01-09 | 2019-11-13 | Tesaro Inc | Méthodes de traitement du cancer au moyen d'anticorps anti-tim-3 |
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2016
- 2016-03-21 DK DK16713784.3T patent/DK3274370T3/da active
- 2016-03-21 KR KR1020177029946A patent/KR20170128567A/ko not_active Application Discontinuation
- 2016-03-21 CA CA2980390A patent/CA2980390A1/en active Pending
- 2016-03-21 AU AU2016236270A patent/AU2016236270B2/en active Active
- 2016-03-21 EP EP19202632.6A patent/EP3628688A1/en active Pending
- 2016-03-21 ES ES16713784T patent/ES2768784T3/es active Active
- 2016-03-21 TW TW105108621A patent/TWI719969B/zh active
- 2016-03-21 RS RS20200132A patent/RS59878B1/sr unknown
- 2016-03-21 RU RU2017137010A patent/RU2739163C2/ru active
- 2016-03-21 BR BR112017020373-1A patent/BR112017020373A2/pt active Search and Examination
- 2016-03-21 PL PL16713784T patent/PL3274370T3/pl unknown
- 2016-03-21 US US15/561,013 patent/US10584167B2/en active Active
- 2016-03-21 CN CN201680024895.XA patent/CN107743495B/zh active Active
- 2016-03-21 MX MX2017012278A patent/MX2017012278A/es active IP Right Grant
- 2016-03-21 WO PCT/EP2016/056104 patent/WO2016150899A2/en active Application Filing
- 2016-03-21 JP JP2017549507A patent/JP6815329B2/ja active Active
- 2016-03-21 LT LTEP16713784.3T patent/LT3274370T/lt unknown
- 2016-03-21 HU HUE16713784A patent/HUE048111T2/hu unknown
- 2016-03-21 PT PT167137843T patent/PT3274370T/pt unknown
- 2016-03-21 EP EP16713784.3A patent/EP3274370B1/en active Active
- 2016-03-21 SG SG11201707800QA patent/SG11201707800QA/en unknown
- 2016-03-21 PE PE2017001579A patent/PE20171790A1/es unknown
- 2016-03-21 SI SI201630585T patent/SI3274370T1/sl unknown
- 2016-03-22 AR ARP160100772A patent/AR104047A1/es unknown
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2017
- 2017-09-17 IL IL254534A patent/IL254534B/en unknown
- 2017-10-20 ZA ZA2017/07138A patent/ZA201707138B/en unknown
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2018
- 2018-05-02 HK HK18105631.4A patent/HK1246312A1/zh unknown
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2019
- 2019-12-18 HR HRP20192280TT patent/HRP20192280T1/hr unknown
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2020
- 2020-01-29 US US16/776,326 patent/US11773164B2/en active Active
- 2020-01-29 US US16/776,329 patent/US11866495B2/en active Active
- 2020-02-13 CY CY20201100133T patent/CY1122627T1/el unknown
- 2020-12-22 JP JP2020212437A patent/JP7185379B2/ja active Active
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