JP2013528357A5 - - Google Patents
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- JP2013528357A5 JP2013528357A5 JP2013501570A JP2013501570A JP2013528357A5 JP 2013528357 A5 JP2013528357 A5 JP 2013528357A5 JP 2013501570 A JP2013501570 A JP 2013501570A JP 2013501570 A JP2013501570 A JP 2013501570A JP 2013528357 A5 JP2013528357 A5 JP 2013528357A5
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- 229920001184 polypeptide Polymers 0.000 claims 33
- 102000004196 processed proteins & peptides Human genes 0.000 claims 33
- 108090000765 processed proteins & peptides Proteins 0.000 claims 33
- 230000004048 modification Effects 0.000 claims 15
- 238000012986 modification Methods 0.000 claims 15
- 150000001413 amino acids Chemical class 0.000 claims 11
- 230000001225 therapeutic effect Effects 0.000 claims 9
- 108010073807 IgG Receptors Proteins 0.000 claims 7
- 102000009490 IgG Receptors Human genes 0.000 claims 7
- 230000035772 mutation Effects 0.000 claims 4
- 108010021468 Fc gamma receptor IIA Proteins 0.000 claims 3
- 108010021472 Fc gamma receptor IIB Proteins 0.000 claims 3
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 claims 3
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 3
- 101710099301 Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 2
- -1 IgE antibody Proteins 0.000 claims 2
- 102100023123 Mucin-16 Human genes 0.000 claims 2
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 2
- 102100036922 Tumor necrosis factor ligand superfamily member 13B Human genes 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 208000026278 immune system disease Diseases 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 229960003989 tocilizumab Drugs 0.000 claims 2
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 1
- 108010028006 B-Cell Activating Factor Proteins 0.000 claims 1
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 108010008629 CA-125 Antigen Proteins 0.000 claims 1
- 102100024217 CAMPATH-1 antigen Human genes 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
- 108010065524 CD52 Antigen Proteins 0.000 claims 1
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 1
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 1
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims 1
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 1
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 claims 1
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101100165850 Homo sapiens CA9 gene Proteins 0.000 claims 1
- 101001016865 Homo sapiens Heat shock protein HSP 90-alpha Proteins 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 102100032818 Integrin alpha-4 Human genes 0.000 claims 1
- 108010041012 Integrin alpha4 Proteins 0.000 claims 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 1
- 108010002616 Interleukin-5 Proteins 0.000 claims 1
- 102000000743 Interleukin-5 Human genes 0.000 claims 1
- 102000010781 Interleukin-6 Receptors Human genes 0.000 claims 1
- 108010038501 Interleukin-6 Receptors Proteins 0.000 claims 1
- 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 claims 1
- 102100029205 Low affinity immunoglobulin gamma Fc region receptor II-b Human genes 0.000 claims 1
- 102000014128 RANK Ligand Human genes 0.000 claims 1
- 108010025832 RANK Ligand Proteins 0.000 claims 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 1
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 1
- 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 claims 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 1
- 229960002964 adalimumab Drugs 0.000 claims 1
- 229950001863 bapineuzumab Drugs 0.000 claims 1
- 229960004669 basiliximab Drugs 0.000 claims 1
- 229960003270 belimumab Drugs 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
- 229960005395 cetuximab Drugs 0.000 claims 1
- 229960002806 daclizumab Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 229960000598 infliximab Drugs 0.000 claims 1
- 108040006849 interleukin-2 receptor activity proteins Proteins 0.000 claims 1
- 229960005386 ipilimumab Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960005108 mepolizumab Drugs 0.000 claims 1
- 229960001521 motavizumab Drugs 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 229960005027 natalizumab Drugs 0.000 claims 1
- 101150006061 neur gene Proteins 0.000 claims 1
- 229950010203 nimotuzumab Drugs 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229950005751 ocrelizumab Drugs 0.000 claims 1
- 229960002450 ofatumumab Drugs 0.000 claims 1
- 229960000470 omalizumab Drugs 0.000 claims 1
- 229960000402 palivizumab Drugs 0.000 claims 1
- 229960001972 panitumumab Drugs 0.000 claims 1
- 229960002087 pertuzumab Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229960003876 ranibizumab Drugs 0.000 claims 1
- 229960004641 rituximab Drugs 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 claims 1
- 229960005267 tositumomab Drugs 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
- 229950008250 zalutumumab Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31858310P | 2010-03-29 | 2010-03-29 | |
| US61/318,583 | 2010-03-29 | ||
| US201161436584P | 2011-01-26 | 2011-01-26 | |
| US61/436,584 | 2011-01-26 | ||
| PCT/CA2011/000321 WO2011120134A1 (en) | 2010-03-29 | 2011-03-28 | Antibodies with enhanced or suppressed effector function |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017046946A Division JP2017165728A (ja) | 2010-03-29 | 2017-03-13 | 強化又は抑制されたエフェクター機能を有する抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013528357A JP2013528357A (ja) | 2013-07-11 |
| JP2013528357A5 true JP2013528357A5 (enExample) | 2014-05-15 |
Family
ID=44711257
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013501570A Withdrawn JP2013528357A (ja) | 2010-03-29 | 2011-03-28 | 強化又は抑制されたエフェクター機能を有する抗体 |
| JP2013501571A Withdrawn JP2013523098A (ja) | 2010-03-29 | 2011-03-28 | 強化又は抑制されたエフェクター機能を有する抗体 |
| JP2017046946A Pending JP2017165728A (ja) | 2010-03-29 | 2017-03-13 | 強化又は抑制されたエフェクター機能を有する抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013501571A Withdrawn JP2013523098A (ja) | 2010-03-29 | 2011-03-28 | 強化又は抑制されたエフェクター機能を有する抗体 |
| JP2017046946A Pending JP2017165728A (ja) | 2010-03-29 | 2017-03-13 | 強化又は抑制されたエフェクター機能を有する抗体 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20130108623A1 (enExample) |
| EP (2) | EP2552957A4 (enExample) |
| JP (3) | JP2013528357A (enExample) |
| CN (1) | CN102971340A (enExample) |
| AU (1) | AU2011235569B2 (enExample) |
| BR (1) | BR112012024489A2 (enExample) |
| CA (2) | CA2794708C (enExample) |
| MX (1) | MX341925B (enExample) |
| RU (1) | RU2012145183A (enExample) |
| WO (2) | WO2011120134A1 (enExample) |
Families Citing this family (144)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| WO2011149999A2 (en) | 2010-05-27 | 2011-12-01 | Merck Sharp & Dohme Corp. | Method for preparing antibodies having improved properties |
| CA2806252C (en) | 2010-07-29 | 2019-05-14 | Xencor, Inc. | Antibodies with modified isoelectric points |
| RU2604490C2 (ru) | 2010-11-05 | 2016-12-10 | Займворкс Инк. | ДИЗАЙН УСТОЙЧИВОГО ГЕТЕРОДИМЕРНОГО АНТИТЕЛА С МУТАЦИЯМИ В Fc ДОМЕНЕ |
| EP3604330A1 (en) * | 2011-02-25 | 2020-02-05 | Chugai Seiyaku Kabushiki Kaisha | Fcgammariib-specific fc antibody |
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| KR20140059168A (ko) | 2011-04-21 | 2014-05-15 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 시신경 척수염 치료용 조성물 및 치료 방법 |
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2016
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