|
USRE30985E
(en)
|
1978-01-01 |
1982-06-29 |
|
Serum-free cell culture media
|
|
US4657760A
(en)
|
1979-03-20 |
1987-04-14 |
Ortho Pharmaceutical Corporation |
Methods and compositions using monoclonal antibody to human T cells
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
US5206344A
(en)
|
1985-06-26 |
1993-04-27 |
Cetus Oncology Corporation |
Interleukin-2 muteins and polymer conjugation thereof
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
US5567610A
(en)
|
1986-09-04 |
1996-10-22 |
Bioinvent International Ab |
Method of producing human monoclonal antibodies and kit therefor
|
|
ES2058199T3
(es)
|
1987-09-23 |
1994-11-01 |
Bristol Myers Squibb Co |
Heteroconjugados de anticuerpos para la eliminacion de celulas infectadas por el vih.
|
|
EP0435911B1
(en)
|
1988-09-23 |
1996-03-13 |
Cetus Oncology Corporation |
Cell culture medium for enhanced cell growth, culture longevity and product expression
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
WO1990005144A1
(en)
|
1988-11-11 |
1990-05-17 |
Medical Research Council |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
|
|
US5175384A
(en)
|
1988-12-05 |
1992-12-29 |
Genpharm International |
Transgenic mice depleted in mature t-cells and methods for making transgenic mice
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
DE69029036T2
(de)
|
1989-06-29 |
1997-05-22 |
Medarex Inc |
Bispezifische reagenzien für die aids-therapie
|
|
US5225212A
(en)
|
1989-10-20 |
1993-07-06 |
Liposome Technology, Inc. |
Microreservoir liposome composition and method
|
|
US5959177A
(en)
|
1989-10-27 |
1999-09-28 |
The Scripps Research Institute |
Transgenic plants expressing assembled secretory antibodies
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
EP1690935A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US5229275A
(en)
|
1990-04-26 |
1993-07-20 |
Akzo N.V. |
In-vitro method for producing antigen-specific human monoclonal antibodies
|
|
EP0547065B1
(en)
|
1990-06-29 |
2001-08-29 |
Large Scale Biology Corporation |
Melanin production by transformed microorganisms
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
JP2938569B2
(ja)
|
1990-08-29 |
1999-08-23 |
ジェンファーム インターナショナル,インコーポレイティド |
異種免疫グロブリンを作る方法及びトランスジェニックマウス
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
WO1992009690A2
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with altered binding properties
|
|
US5571894A
(en)
|
1991-02-05 |
1996-11-05 |
Ciba-Geigy Corporation |
Recombinant antibodies specific for a growth factor receptor
|
|
JPH06507398A
(ja)
|
1991-05-14 |
1994-08-25 |
リプリジェン コーポレーション |
Hiv感染治療のための異種複合抗体
|
|
CA2103059C
(en)
|
1991-06-14 |
2005-03-22 |
Paul J. Carter |
Method for making humanized antibodies
|
|
GB9114948D0
(en)
|
1991-07-11 |
1991-08-28 |
Pfizer Ltd |
Process for preparing sertraline intermediates
|
|
JP3951062B2
(ja)
|
1991-09-19 |
2007-08-01 |
ジェネンテック・インコーポレーテッド |
少なくとも遊離のチオールとして存在するシステインを有する抗体フラグメントの大腸菌での発現、2官能性F(ab’)2抗体の産生のための使用
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
FI941572L
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
EP1136556B1
(en)
|
1991-11-25 |
2005-06-08 |
Enzon, Inc. |
Method of producing multivalent antigen-binding proteins
|
|
WO1993011794A1
(en)
|
1991-12-13 |
1993-06-24 |
Xoma Corporation |
Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
|
|
US5869619A
(en)
|
1991-12-13 |
1999-02-09 |
Xoma Corporation |
Modified antibody variable domains
|
|
EP1997894B1
(en)
|
1992-02-06 |
2011-03-30 |
Novartis Vaccines and Diagnostics, Inc. |
Biosynthetic binding protein for cancer marker
|
|
US5573905A
(en)
|
1992-03-30 |
1996-11-12 |
The Scripps Research Institute |
Encoded combinatorial chemical libraries
|
|
CA2140280A1
(en)
|
1992-08-17 |
1994-03-03 |
Avi J. Ashkenazi |
Bispecific immunoadhesins
|
|
US5789199A
(en)
|
1994-11-03 |
1998-08-04 |
Genentech, Inc. |
Process for bacterial production of polypeptides
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5840523A
(en)
|
1995-03-01 |
1998-11-24 |
Genetech, Inc. |
Methods and compositions for secretion of heterologous polypeptides
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
DE69637481T2
(de)
|
1995-04-27 |
2009-04-09 |
Amgen Fremont Inc. |
Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8
|
|
EP0823941A4
(en)
|
1995-04-28 |
2001-09-19 |
Abgenix Inc |
HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
|
|
JP2002514895A
(ja)
|
1995-09-28 |
2002-05-21 |
アレクション、ファーマスーティカルズ、インコーポレーテッド |
ブタ細胞相互作用タンパク質
|
|
DE19544393A1
(de)
|
1995-11-15 |
1997-05-22 |
Hoechst Schering Agrevo Gmbh |
Synergistische herbizide Mischungen
|
|
ES2301183T3
(es)
|
1996-12-03 |
2008-06-16 |
Amgen Fremont Inc. |
Anticuerpo completamente humano que se une al receptor del egfr.
|
|
US6040498A
(en)
|
1998-08-11 |
2000-03-21 |
North Caroline State University |
Genetically engineered duckweed
|
|
US6610833B1
(en)
|
1997-11-24 |
2003-08-26 |
The Institute For Human Genetics And Biochemistry |
Monoclonal human natural antibodies
|
|
ATE531812T1
(de)
|
1997-12-05 |
2011-11-15 |
Scripps Research Inst |
Humanisierung von nager-antikörpern
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
EP1222292B1
(en)
|
1999-10-04 |
2005-08-31 |
Medicago Inc. |
Method for regulating transcription of foreign genes in the presence of nitrogen
|
|
US7125978B1
(en)
|
1999-10-04 |
2006-10-24 |
Medicago Inc. |
Promoter for regulating expression of foreign genes
|
|
PT2857516T
(pt)
|
2000-04-11 |
2017-08-28 |
Genentech Inc |
Anticorpos multivalentes e utilizações dos mesmos
|
|
US7064191B2
(en)
|
2000-10-06 |
2006-06-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Process for purifying antibody
|
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
KR100857943B1
(ko)
|
2000-11-30 |
2008-09-09 |
메다렉스, 인코포레이티드 |
인간 항체의 제조를 위한 형질전환 트랜스염색체 설치류
|
|
NZ532526A
(en)
|
2001-10-25 |
2007-01-26 |
Genentech Inc |
Compositions comprising a glycoprotein having a Fc region
|
|
US20040093621A1
(en)
|
2001-12-25 |
2004-05-13 |
Kyowa Hakko Kogyo Co., Ltd |
Antibody composition which specifically binds to CD20
|
|
JPWO2003085118A1
(ja)
|
2002-04-09 |
2005-08-11 |
協和醗酵工業株式会社 |
抗体組成物の製造方法
|
|
WO2003084569A1
(en)
|
2002-04-09 |
2003-10-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Drug containing antibody composition
|
|
JP4628679B2
(ja)
|
2002-04-09 |
2011-02-09 |
協和発酵キリン株式会社 |
Gdp−フコースの輸送に関与する蛋白質の活性が低下または欠失した細胞
|
|
MXPA04009924A
(es)
|
2002-04-09 |
2005-07-01 |
Kyowa Hakko Kogyo Kk |
Celulas de genoma modificado.
|
|
WO2004042072A2
(en)
|
2002-11-01 |
2004-05-21 |
The Regents Of The University Of Colorado, A Body Corporate |
Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry
|
|
EP1891966B1
(en)
|
2002-12-20 |
2012-02-15 |
H. Lundbeck A/S |
Modulation of activity of neurotrophins; screening method
|
|
EP1682170A2
(en)
|
2003-11-07 |
2006-07-26 |
Lay Line Genomics SpA |
Compositions able to prevent neurodegenerative processes and methods of assaying the same
|
|
WO2005097832A2
(en)
|
2004-03-31 |
2005-10-20 |
Genentech, Inc. |
Humanized anti-tgf-beta antibodies
|
|
US20080181888A1
(en)
|
2004-12-31 |
2008-07-31 |
Ambrose Christine M |
Polypeptides That Bind Br3 and Uses Thereof
|
|
US7700099B2
(en)
|
2005-02-14 |
2010-04-20 |
Merck & Co., Inc. |
Non-immunostimulatory antibody and compositions containing the same
|
|
WO2006138343A2
(en)
|
2005-06-14 |
2006-12-28 |
Raptor Pharmaceutical Inc. |
Compositions comprising receptor - associated protein (rap) variants specific for lrp2 and uses thereof
|
|
KR101888321B1
(ko)
*
|
2005-07-01 |
2018-08-13 |
이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. |
예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
|
|
EP1945240B1
(en)
|
2005-09-16 |
2016-12-28 |
Raptor Pharmaceutical Inc |
Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
|
|
FR2896881B1
(fr)
|
2006-01-31 |
2008-04-18 |
Biomerieux Sa |
Procede de dosage du prongf pour le diagnostic in vitro du cancer du sein et utilisation du prongf en therapie
|
|
WO2007106585A1
(en)
|
2006-03-15 |
2007-09-20 |
Alexion Pharmaceuticals, Inc. |
Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement
|
|
EP2016101A2
(en)
|
2006-05-09 |
2009-01-21 |
Genentech, Inc. |
Binding polypeptides with optimized scaffolds
|
|
PL2059533T3
(pl)
|
2006-08-30 |
2013-04-30 |
Genentech Inc |
Przeciwciała wieloswoiste
|
|
WO2008036682A2
(en)
|
2006-09-18 |
2008-03-27 |
Raptor Pharmaceutical Inc. |
Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
|
|
WO2008052016A2
(en)
|
2006-10-23 |
2008-05-02 |
Columbia University |
The sortilin-related receptor sorl1 is functionally and genetically associated with alzheimer's disease
|
|
WO2008076262A2
(en)
*
|
2006-12-15 |
2008-06-26 |
Merck & Co., Inc. |
Receptor for amyloid beta and uses thereof
|
|
DK3225251T3
(da)
|
2006-12-21 |
2020-03-16 |
H Lundbeck As |
Modulering af pro-neurotrofinaktivitet
|
|
UY30776A1
(es)
|
2006-12-21 |
2008-07-03 |
Medarex Inc |
Anticuerpos cd44
|
|
WO2008086452A2
(en)
|
2007-01-10 |
2008-07-17 |
Columbia University |
Treatment and prevention of alzheimer's disease
|
|
CN100592373C
(zh)
|
2007-05-25 |
2010-02-24 |
群康科技(深圳)有限公司 |
液晶显示面板驱动装置及其驱动方法
|
|
US8877688B2
(en)
|
2007-09-14 |
2014-11-04 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
|
CN101855242B
(zh)
|
2007-09-14 |
2014-07-30 |
阿迪马布有限责任公司 |
合理设计的合成抗体文库及其用途
|
|
AU2009204501B2
(en)
|
2008-01-07 |
2015-02-12 |
Amgen Inc. |
Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
|
|
US8377701B2
(en)
*
|
2008-04-27 |
2013-02-19 |
H. Lundbeck A/S |
Specific ligands to sortilin
|
|
US20160359907A1
(en)
|
2015-06-02 |
2016-12-08 |
Vmware, Inc. |
Automatically auditing virtual machines for security hardening compliance
|
|
US9084745B2
(en)
|
2008-05-22 |
2015-07-21 |
H. Lundback A/S |
Modulation of the Vps10p-domain for the treatment of cardiovascular disease
|
|
EP2732823B1
(en)
|
2008-06-25 |
2019-08-07 |
H. Lundbeck A/S |
Modulation of the TrpV : Vps10p-domain receptor system for the treatment of pain
|
|
PL3009449T3
(pl)
*
|
2008-07-16 |
2018-09-28 |
Institute For Research In Biomedicine |
Przeciwciała neutralizujące ludzkie cytomegalowirusy i ich zastosowanie
|
|
US20120039865A1
(en)
*
|
2008-08-19 |
2012-02-16 |
Yale University |
Identification of sortilin as a neuronal receptor for the frontotemporal dementia protein, progranulin
|
|
WO2010028333A2
(en)
|
2008-09-08 |
2010-03-11 |
Mayo Foundation For Medical Education And Research |
Methods and devices for ligating tubular structures
|
|
EP2379593A2
(en)
|
2008-12-19 |
2011-10-26 |
H. Lundbeck A/S |
Modulation of the vps 10-domain receptor family for the treatment of mental and behavioural disorders
|
|
FR2945538B1
(fr)
|
2009-05-12 |
2014-12-26 |
Sanofi Aventis |
Anticorps humanises specifiques de la forme protofibrillaire du peptide beta-amyloide.
|
|
EP2483406A2
(en)
|
2009-09-30 |
2012-08-08 |
President and Fellows of Harvard College |
Methods for modulation of autophagy through the modulation of autophagy-inhibiting gene products
|
|
US20130115222A1
(en)
|
2010-06-15 |
2013-05-09 |
Cornell University |
Methods of limiting microvascular damage following acute myocardial ischemia
|
|
EP3336225B1
(en)
|
2010-07-16 |
2020-02-19 |
Adimab, LLC |
Antibody libraries
|
|
US20130336988A1
(en)
|
2010-11-17 |
2013-12-19 |
New York University |
Methods for treating early stage or mild neurological disorders
|
|
CN103649123B
(zh)
|
2011-06-13 |
2017-05-24 |
Csl有限公司 |
抗g‑csfr抗体及其用途
|
|
WO2014071131A1
(en)
|
2012-11-02 |
2014-05-08 |
The Brigham And Women's Hospital, Inc. |
Sortilin 1 is a novel inducer of vascular calcification
|
|
US10156574B2
(en)
|
2013-04-29 |
2018-12-18 |
Adimab, Llc |
Polyspecificity reagents, methods for their preparation and use
|
|
SI3019240T1
(sl)
|
2013-07-09 |
2024-07-31 |
Annexon, Inc. |
Protitelesa proti komplementnemu faktorju C1q in njihova uporaba
|
|
WO2015119989A1
(en)
|
2014-02-04 |
2015-08-13 |
New York University |
Progranulin (pgrn) and its derivatives for diagnosis and treatment of lysosomal storage diseases
|
|
HK1232289A1
(zh)
|
2014-02-12 |
2018-01-05 |
H. Lundbeck A/S |
分拣蛋白作为针对情感/心境障碍的生物标记的用途
|
|
WO2015144860A1
(en)
*
|
2014-03-26 |
2015-10-01 |
Goran Landberg |
Agents inhibiting granulin for treatment of cancer
|
|
US10603364B2
(en)
|
2014-08-11 |
2020-03-31 |
Shire Human Genetic Therapies, Inc. |
Lysosomal targeting and uses thereof
|
|
US10849992B1
(en)
*
|
2015-04-07 |
2020-12-01 |
Alector Llc |
Methods of screening for sortilin binding antagonists
|
|
JP6999421B2
(ja)
|
2015-04-07 |
2022-02-04 |
アレクトル エルエルシー |
抗ソルチリン抗体及びその使用方法
|
|
US20160331746A1
(en)
|
2015-05-12 |
2016-11-17 |
University Of South Florida |
Sortilin-Binding Small Molecules for Increasing Glucose Uptake
|
|
GB201512215D0
(en)
*
|
2015-07-13 |
2015-08-19 |
Lundbeck & Co As H |
Agents,uses and methods
|
|
WO2017024137A1
(en)
|
2015-08-04 |
2017-02-09 |
New York University |
Progranulin (pgrn) fragments and derivatives for treatment or alleviation of lysosomal storage diseases
|
|
US10085969B1
(en)
|
2016-02-12 |
2018-10-02 |
University Of South Florida |
Sortilin binding compounds, formulations, and uses thereof
|
|
US10894833B2
(en)
|
2017-07-20 |
2021-01-19 |
H. Lundbeck A/S |
Agents, uses and methods for treatment
|
|
US11833187B2
(en)
|
2017-10-23 |
2023-12-05 |
The Brigham And Women's Hospital, Inc. |
Materials and methods for extracellular vessicle-associated diseases
|
|
AU2019288212A1
(en)
|
2018-06-18 |
2020-12-03 |
Denali Therapeutics Inc. |
Fusion proteins comprising progranulin
|
|
PE20210186A1
(es)
|
2018-07-13 |
2021-02-02 |
Alector Llc |
Anticuerpos anti-sortilina y metodos para su uso
|
|
US20220000971A1
(en)
|
2018-08-24 |
2022-01-06 |
Transfert Plus, S.E.C. |
Methods and compounds for targeting sortilin receptors and inhibiting vasculogenic mimicry
|
|
WO2020051624A1
(en)
|
2018-09-11 |
2020-03-19 |
Grophin Pty Ltd |
Methods and compositions for improving recovery from a brain injury
|
|
EP3666281A1
(en)
|
2018-12-14 |
2020-06-17 |
Insusense ApS |
Compositions comprising sortilin-1
|
|
EP3942049A4
(en)
|
2019-03-20 |
2023-10-18 |
President And Fellows Of Harvard College |
ANTISENSE OLIGONUCLEOTIDE BASED PROGRANULIN AUGMENTATION THERAPY FOR NEURODEGENERATIVE DISEASES
|
|
CA3140023A1
(en)
|
2019-06-11 |
2020-12-17 |
Alector Llc |
Anti-sortilin antibodies for use in therapy
|