JP2024009818A5 - - Google Patents
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- JP2024009818A5 JP2024009818A5 JP2023158382A JP2023158382A JP2024009818A5 JP 2024009818 A5 JP2024009818 A5 JP 2024009818A5 JP 2023158382 A JP2023158382 A JP 2023158382A JP 2023158382 A JP2023158382 A JP 2023158382A JP 2024009818 A5 JP2024009818 A5 JP 2024009818A5
- Authority
- JP
- Japan
- Prior art keywords
- siglec
- amino acid
- antibody
- seq
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101000863882 Homo sapiens Sialic acid-binding Ig-like lectin 7 Proteins 0.000 claims 43
- 102100029946 Sialic acid-binding Ig-like lectin 7 Human genes 0.000 claims 41
- 125000003275 alpha amino acid group Chemical group 0.000 claims 41
- 239000003446 ligand Substances 0.000 claims 32
- 210000004027 cell Anatomy 0.000 claims 12
- 238000006467 substitution reaction Methods 0.000 claims 12
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 6
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 6
- 210000004443 dendritic cell Anatomy 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 230000001506 immunosuppresive effect Effects 0.000 claims 4
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 3
- 229930186217 Glycolipid Natural products 0.000 claims 3
- 102000003886 Glycoproteins Human genes 0.000 claims 3
- 108090000288 Glycoproteins Proteins 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 210000002540 macrophage Anatomy 0.000 claims 3
- 210000000822 natural killer cell Anatomy 0.000 claims 3
- 210000000440 neutrophil Anatomy 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 102000050701 human SIGLEC7 Human genes 0.000 claims 2
- 210000000274 microglia Anatomy 0.000 claims 2
- 210000001616 monocyte Anatomy 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 208000037259 Amyloid Plaque Diseases 0.000 claims 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 101000795117 Homo sapiens Triggering receptor expressed on myeloid cells 2 Proteins 0.000 claims 1
- 108090000144 Human Proteins Proteins 0.000 claims 1
- 102000003839 Human Proteins Human genes 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 102100029678 Triggering receptor expressed on myeloid cells 2 Human genes 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000001640 apoptogenic effect Effects 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 210000001130 astrocyte Anatomy 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000004985 myeloid-derived suppressor cell Anatomy 0.000 claims 1
- 210000004498 neuroglial cell Anatomy 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562211656P | 2015-08-28 | 2015-08-28 | |
| US62/211,656 | 2015-08-28 | ||
| US201562265742P | 2015-12-10 | 2015-12-10 | |
| US62/265,742 | 2015-12-10 | ||
| JP2018511133A JP7525980B2 (ja) | 2015-08-28 | 2016-08-26 | 抗Ｓｉｇｌｅｃ－７抗体及びその使用方法 |
| PCT/US2016/049032 WO2017040301A1 (en) | 2015-08-28 | 2016-08-26 | Anti-siglec-7 antibodies and methods of use thereof |
| JP2021167895A JP2022028653A (ja) | 2015-08-28 | 2021-10-13 | 抗Ｓｉｇｌｅｃ－７抗体及びその使用方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021167895A Division JP2022028653A (ja) | 2015-08-28 | 2021-10-13 | 抗Ｓｉｇｌｅｃ－７抗体及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024009818A JP2024009818A (ja) | 2024-01-23 |
| JP2024009818A5 true JP2024009818A5 (enExample) | 2024-08-20 |
Family
ID=56853902
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018511133A Active JP7525980B2 (ja) | 2015-08-28 | 2016-08-26 | 抗Ｓｉｇｌｅｃ－７抗体及びその使用方法 |
| JP2021167895A Pending JP2022028653A (ja) | 2015-08-28 | 2021-10-13 | 抗Ｓｉｇｌｅｃ－７抗体及びその使用方法 |
| JP2023158382A Pending JP2024009818A (ja) | 2015-08-28 | 2023-09-22 | 抗Ｓｉｇｌｅｃ－７抗体及びその使用方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018511133A Active JP7525980B2 (ja) | 2015-08-28 | 2016-08-26 | 抗Ｓｉｇｌｅｃ－７抗体及びその使用方法 |
| JP2021167895A Pending JP2022028653A (ja) | 2015-08-28 | 2021-10-13 | 抗Ｓｉｇｌｅｃ－７抗体及びその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US10590198B2 (enExample) |
| EP (1) | EP3341411B1 (enExample) |
| JP (3) | JP7525980B2 (enExample) |
| KR (1) | KR20180054639A (enExample) |
| CN (2) | CN115960235A (enExample) |
| AU (1) | AU2016316768A1 (enExample) |
| CA (1) | CA2996059A1 (enExample) |
| HK (1) | HK1252696A1 (enExample) |
| WO (1) | WO2017040301A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| ES3040431T3 (en) | 2014-03-12 | 2025-10-31 | Yeda Res & Dev | Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns |
| JP7525980B2 (ja) * | 2015-08-28 | 2024-07-31 | アレクトル エルエルシー | 抗Ｓｉｇｌｅｃ－７抗体及びその使用方法 |
| EP3402516A4 (en) * | 2016-01-12 | 2020-01-08 | Palleon Pharmaceuticals Inc. | USE OF ANTIBODIES DIRECTED AGAINST SIGLEC-7 OR SIGLEC-9 IN THE TREATMENT OF CANCER |
| US11773162B2 (en) | 2016-08-05 | 2023-10-03 | Allakos, Inc. | Anti-Siglec-7 antibodies for the treatment of cancer |
| KR20250158824A (ko) * | 2016-09-10 | 2025-11-06 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | Cns의 질병 또는 손상의 치료를 위한 전신 조절 t 세포 수준 또는 활성 감소 |
| BR112019018429A2 (pt) * | 2017-03-06 | 2020-04-14 | Univ Pennsylvania | anticorpo, métodos para tratar uma doença ou distúrbio mediado pela via do complemento em um indíviduo e para reduzir a atividade de um sistema complemento de um indivíduo, e, célula |
| CN113336849A (zh) * | 2017-03-28 | 2021-09-03 | 礼进生物医药科技（上海）有限公司 | 用于增强肿瘤微环境中免疫应答的治疗剂和方法 |
| JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
| US20200132691A1 (en) * | 2017-04-24 | 2020-04-30 | The General Hospital Corporation | Detection and targeting of tumor-promoting neutrophils |
| US11359014B2 (en) | 2017-05-16 | 2022-06-14 | Alector Llc | Anti-siglec-5 antibodies and methods of use thereof |
| EP3737410A4 (en) * | 2018-01-11 | 2022-04-20 | Allakos, Inc. | Anti-siglec-7 antibodies having reduced effector function |
| US20210395333A1 (en) * | 2018-06-07 | 2021-12-23 | Palleon Pharmaceuticals Inc. | Multimeric proteins for detecting a carbohydrate and/or treating a siglec-mediated disorder |
| CN119841953A (zh) | 2018-06-08 | 2025-04-18 | 艾利妥 | 抗siglec-7抗体及其使用方法 |
| US12060422B2 (en) * | 2018-06-29 | 2024-08-13 | Alector Llc | Anti-SIRP-Beta1 antibodies and methods of use thereof |
| SG11202100555PA (en) | 2018-07-27 | 2021-02-25 | Alector Llc | Anti-siglec-5 antibodies and methods of use thereof |
| JP7653909B2 (ja) | 2018-09-06 | 2025-03-31 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | ヒト化抗ｃ５抗体とその利用 |
| CA3145885A1 (en) * | 2019-07-31 | 2021-02-04 | Jeonghoon Sun | Anti-ms4a4a antibodies and methods of use thereof |
| CN111647084B (zh) * | 2020-06-13 | 2020-12-01 | 广东赛尔生物科技有限公司 | 抗c-MET抗体及其在治疗癌症中的应用 |
| CA3183994A1 (en) | 2020-06-24 | 2021-12-30 | Philip James Dolan Iii | Antibodies recognizing sortilin |
| CN112877394A (zh) * | 2021-01-27 | 2021-06-01 | 南京大学 | B7-h4+单核细胞型mdsc在制备ins激素治疗疗效预测试剂中的应用 |
| IL313812A (en) * | 2021-12-23 | 2024-08-01 | Prothena Biosciences Ltd | Antibodies that recognize SORTILIN |
| JP2025511188A (ja) * | 2022-03-31 | 2025-04-15 | ザ ウィスター インスティテュート オブ アナトミー アンド バイオロジー | ヒトＳｉｇｌｅｃ－７に対する抗体及び免疫療法のためのその使用 |
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2016
- 2016-08-26 JP JP2018511133A patent/JP7525980B2/ja active Active
- 2016-08-26 KR KR1020187008277A patent/KR20180054639A/ko not_active Ceased
- 2016-08-26 WO PCT/US2016/049032 patent/WO2017040301A1/en not_active Ceased
- 2016-08-26 US US15/756,043 patent/US10590198B2/en active Active
- 2016-08-26 EP EP16760335.6A patent/EP3341411B1/en active Active
- 2016-08-26 CA CA2996059A patent/CA2996059A1/en not_active Abandoned
- 2016-08-26 AU AU2016316768A patent/AU2016316768A1/en not_active Abandoned
- 2016-08-26 CN CN202211677231.7A patent/CN115960235A/zh active Pending
- 2016-08-26 HK HK18112005.8A patent/HK1252696A1/zh unknown
- 2016-08-26 CN CN201680059071.6A patent/CN108137702B/zh active Active
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2020
- 2020-02-14 US US16/792,040 patent/US11390680B2/en active Active
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2021
- 2021-10-13 JP JP2021167895A patent/JP2022028653A/ja active Pending
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2022
- 2022-06-02 US US17/831,336 patent/US20220411503A1/en active Pending
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2023
- 2023-09-22 JP JP2023158382A patent/JP2024009818A/ja active Pending
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