JP2018508188A5 - - Google Patents
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- JP2018508188A5 JP2018508188A5 JP2017536356A JP2017536356A JP2018508188A5 JP 2018508188 A5 JP2018508188 A5 JP 2018508188A5 JP 2017536356 A JP2017536356 A JP 2017536356A JP 2017536356 A JP2017536356 A JP 2017536356A JP 2018508188 A5 JP2018508188 A5 JP 2018508188A5
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021038857A JP7177317B2 (ja) | 2015-01-08 | 2021-03-11 | Ｃｄ３およびｃｄ２０に対する二重特異性抗体 |
| JP2022162493A JP7596342B2 (ja) | 2015-01-08 | 2022-10-07 | Ｃｄ３およびｃｄ２０に対する二重特異性抗体 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2015/050276 | 2015-01-08 | ||
| PCT/EP2015/050276 WO2015104346A1 (en) | 2014-01-09 | 2015-01-08 | Humanized or chimeric cd3 antibodies |
| DKPA201500412 | 2015-07-15 | ||
| DKPA201500413 | 2015-07-15 | ||
| DKPA201500412 | 2015-07-15 | ||
| DKPA201500413 | 2015-07-15 | ||
| DKPA201500415 | 2015-07-16 | ||
| DKPA201500416 | 2015-07-16 | ||
| DKPA201500415 | 2015-07-16 | ||
| DKPA201500416 | 2015-07-16 | ||
| PCT/EP2016/050296 WO2016110576A1 (en) | 2015-01-08 | 2016-01-08 | Bispecific antibodies against cd3 and cd20 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021038857A Division JP7177317B2 (ja) | 2015-01-08 | 2021-03-11 | Ｃｄ３およびｃｄ２０に対する二重特異性抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018508188A JP2018508188A (ja) | 2018-03-29 |
| JP2018508188A5 true JP2018508188A5 (enExample) | 2019-02-14 |
| JP6853176B2 JP6853176B2 (ja) | 2021-03-31 |
Family
ID=56355550
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017536356A Active JP6853176B2 (ja) | 2015-01-08 | 2016-01-08 | Ｃｄ３およびｃｄ２０に対する二重特異性抗体 |
| JP2021038857A Active JP7177317B2 (ja) | 2015-01-08 | 2021-03-11 | Ｃｄ３およびｃｄ２０に対する二重特異性抗体 |
| JP2022162493A Active JP7596342B2 (ja) | 2015-01-08 | 2022-10-07 | Ｃｄ３およびｃｄ２０に対する二重特異性抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021038857A Active JP7177317B2 (ja) | 2015-01-08 | 2021-03-11 | Ｃｄ３およびｃｄ２０に対する二重特異性抗体 |
| JP2022162493A Active JP7596342B2 (ja) | 2015-01-08 | 2022-10-07 | Ｃｄ３およびｃｄ２０に対する二重特異性抗体 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10544220B2 (enExample) |
| EP (2) | EP3242682A1 (enExample) |
| JP (3) | JP6853176B2 (enExample) |
| KR (3) | KR102663073B1 (enExample) |
| CN (2) | CN107660214B (enExample) |
| AU (3) | AU2016205967B2 (enExample) |
| CA (1) | CA2973159A1 (enExample) |
| EA (1) | EA201791554A1 (enExample) |
| IL (3) | IL289946B2 (enExample) |
| MX (2) | MX391279B (enExample) |
| SG (1) | SG11201705496SA (enExample) |
| UA (1) | UA120286C2 (enExample) |
| WO (1) | WO2016110576A1 (enExample) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201408646VA (en) | 2012-07-06 | 2015-01-29 | Genmab Bv | Dimeric protein with triple mutations |
| ES2776706T3 (es) | 2013-07-05 | 2020-07-31 | Genmab As | Anticuerpos contra CD3 humanizados o quiméricos |
| JP6449295B2 (ja) | 2013-12-17 | 2019-01-09 | ジェネンテック， インコーポレイテッド | 抗ｃｄ３抗体および使用方法 |
| AU2015314744A1 (en) | 2014-09-12 | 2017-03-02 | Genentech, Inc. | Anti-CLL-1 antibodies and immunoconjugates |
| PT3310814T (pt) | 2015-06-16 | 2023-10-02 | H Hoffnabb La Roche Ag | Anticorpos humanizados e de afinidade amadurecida para fcrh5 e métodos de utilização |
| TW201718647A (zh) | 2015-06-16 | 2017-06-01 | 建南德克公司 | 抗-cll-1抗體及使用方法 |
| JP2018526972A (ja) | 2015-06-16 | 2018-09-20 | ジェネンテック， インコーポレイテッド | 抗ｃｄ３抗体及び使用方法 |
| WO2017009442A1 (en) | 2015-07-15 | 2017-01-19 | Genmab A/S | Humanized or chimeric cd3 antibodies |
| IL319047A (en) | 2015-08-28 | 2025-04-01 | Amunix Operating Inc | Chimeric polypeptide composition and methods for its preparation and use |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| AU2018276419A1 (en) * | 2016-06-02 | 2019-10-17 | F. Hoffmann-La Roche Ag | Type II anti-CD20 antibody and anti-CD20/CD3 bispecific antibody for treatment of cancer |
| EP3252078A1 (en) * | 2016-06-02 | 2017-12-06 | F. Hoffmann-La Roche AG | Type ii anti-cd20 antibody and anti-cd20/cd3 bispecific antibody for treatment of cancer |
| JP7083820B2 (ja) | 2016-09-30 | 2022-06-13 | セントレ ナショナル デ ラ レセルシュ シャンティフィク | 膜マーカー |
| WO2018093821A1 (en) | 2016-11-15 | 2018-05-24 | Genentech, Inc. | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies |
| EP3559034B1 (en) | 2016-12-20 | 2020-12-02 | H. Hoffnabb-La Roche Ag | Combination therapy of anti-cd20/anti-cd3 bispecific antibodies and 4-1bb (cd137) agonists |
| CN113896797B (zh) | 2017-08-01 | 2023-05-09 | Ab工作室有限公司 | 双特异性抗体及其用途 |
| KR102758346B1 (ko) * | 2017-08-04 | 2025-01-24 | 젠맵 에이/에스 | Pd-l1 및 cd137에 결합하는 결합제 및 그의 용도 |
| WO2019034580A1 (en) * | 2017-08-14 | 2019-02-21 | Morphosys Ag | HUMANIZED ANTIBODIES FOR CD3 |
| CN107501412A (zh) * | 2017-10-11 | 2017-12-22 | 深圳精准医疗科技有限公司 | 突变型双特异性抗体及其应用 |
| MA51793A (fr) | 2018-02-08 | 2020-12-16 | Hoffmann La Roche | Molécules bispécifiques de liaison à l'antigène et procédés d'utilisation |
| CN111787948A (zh) * | 2018-02-09 | 2020-10-16 | 健玛保 | 包含针对cd3和cd20的双特异性抗体的药物组合物及其用途 |
| CN120399075A (zh) * | 2018-03-14 | 2025-08-01 | 诺维莫尼公司 | 抗-CD3ε抗体及其应用方法 |
| EP3569617A1 (en) * | 2018-05-18 | 2019-11-20 | Trion Research GmbH | Pharmaceutical preparation for use in treating epstein- barr virus positive patients with reactivation phenomenon- associated diseases |
| CN110540593B (zh) * | 2018-05-29 | 2022-05-17 | 上海药明生物技术有限公司 | 新型的抗cd3/抗cd20双特异性抗体 |
| WO2019244107A1 (en) * | 2018-06-21 | 2019-12-26 | Daiichi Sankyo Company, Limited | Compositions including cd3 antigen binding fragments and uses thereof |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN109836502B (zh) * | 2018-11-12 | 2021-09-07 | 浙江大学 | 一种双特异性抗体及其应用 |
| WO2020159918A2 (en) | 2019-01-28 | 2020-08-06 | Ab Therapeutics, Inc. | Bispecific antibodies and uses thereof |
| CA3131036A1 (en) * | 2019-02-22 | 2020-08-27 | Wuhan Yzy Biopharma Co., Ltd. | Cd3 antigen-binding fragment and application thereof |
| JP7273195B2 (ja) * | 2019-05-13 | 2023-05-12 | エフ． ホフマン－ラ ロシュ アーゲー | 干渉抑制薬物動態イムノアッセイ |
| CN110551221B (zh) * | 2019-07-02 | 2021-03-05 | 广州爱思迈生物医药科技有限公司 | 一种双特异性抗体及其制备方法与应用 |
| AU2020328195A1 (en) * | 2019-08-15 | 2022-03-03 | Genmab A/S | Pharmaceutical compositions comprising bispecific antibodies directed against CD3 and CD20 and their uses |
| CN111100204B (zh) * | 2019-11-26 | 2022-03-11 | 山东立菲生物产业有限公司 | 靶向cd20的抗体、其制备方法和应用 |
| TWI897903B (zh) | 2019-12-13 | 2025-09-21 | 美商建南德克公司 | 抗ly6g6d抗體及其使用方法 |
| JP2023509991A (ja) * | 2020-01-13 | 2023-03-10 | シンアフィックス ビー．ブイ． | 抗体及び免疫細胞エンゲージャーのコンジュゲート |
| CN113402612A (zh) | 2020-03-17 | 2021-09-17 | 西比曼生物科技（香港）有限公司 | 靶向cd19和cd20的联合嵌合抗原受体及其应用 |
| AU2021236906A1 (en) | 2020-03-18 | 2022-08-18 | Genmab A/S | Antibodies binding to B7H4 |
| JP2023524149A (ja) * | 2020-05-08 | 2023-06-08 | ジェンマブ エー／エス | Ｃｄ３およびｃｄ２０に対する二重特異性抗体 |
| US11976120B2 (en) | 2020-06-01 | 2024-05-07 | Boehringer Ingelheim International Gmbh | Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use |
| US10981996B1 (en) * | 2020-06-01 | 2021-04-20 | Abexxa Biologics, Inc. | Antibodies targeting a complex comprising non-classical HLA-I and neoantigen and their methods of use |
| CN112062855B (zh) * | 2020-08-26 | 2024-08-30 | 北京天诺健成医药科技有限公司 | 一种含有衔接器的药物治疗剂的开发和应用 |
| AU2021342342A1 (en) | 2020-09-10 | 2023-04-13 | Genmab A/S | Bispecific antibodies against CD3 and CD20 for treating chronic lymphocytic leukemia |
| CA3192251A1 (en) | 2020-09-10 | 2022-03-17 | Genmab A/S | Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma |
| KR20230066391A (ko) * | 2020-09-10 | 2023-05-15 | 젠맵 에이/에스 | 여포성 림프종을 치료하기 위한 조합 요법에서의 cd3 및 cd20에 대한 이중특이적 항체 |
| US20230312758A1 (en) | 2020-09-10 | 2023-10-05 | Genmab A/S | Bispecific antibody against cd3 and cd20 in combination therapy for treating follicular lymphoma |
| CA3192255A1 (en) * | 2020-09-10 | 2022-03-17 | Brian Elliott | Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma |
| JP2023542092A (ja) * | 2020-09-10 | 2023-10-05 | ジェンマブ エー／エス | びまん性大細胞型ｂ細胞リンパ腫を治療するための併用療法におけるｃｄ３及びｃｄ２０に対する二重特異性抗体 |
| EP4240766A2 (en) | 2020-11-04 | 2023-09-13 | Genentech, Inc. | Subcutaneous dosing of anti-cd20/anti-cd3 bispecific antibodies |
| AU2021374592A1 (en) | 2020-11-04 | 2023-06-01 | Genentech, Inc. | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies |
| CN114656562B (zh) * | 2020-12-23 | 2023-11-03 | 北京天广实生物技术股份有限公司 | 结合人和猴cd3的抗体及其应用 |
| FI4284512T3 (fi) | 2021-01-28 | 2025-05-22 | Regeneron Pharma | Koostumuksia ja menetelmiä sytokiinien vapautumisoireyhtymän hoitamiseksi |
| US20240139322A1 (en) * | 2021-03-10 | 2024-05-02 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Compositions and methods to reduce therapeutic t cell toxicity |
| MX2023010567A (es) * | 2021-03-12 | 2023-09-21 | Genmab As | Variantes de anticuerpos no activadoras. |
| AU2021443318A1 (en) | 2021-04-30 | 2023-09-07 | F. Hoffmann-La Roche Ag | Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate |
| KR20240007171A (ko) | 2021-05-14 | 2024-01-16 | 제넨테크, 인크. | 모수네투주맙 및 폴라투주맙 베도틴을 이용한 cd20 양성 증식성 장애의 치료 방법 |
| MX2024008832A (es) | 2022-01-28 | 2024-07-25 | Genmab As | Anticuerpo biespecifico contra el cumulo de diferenciacion 3 (cd3) y el cumulo de diferenciacion 20 (cd20) en terapia combinada para tratar linfoma difuso de celulas b grandes. |
| JP2025503176A (ja) | 2022-01-28 | 2025-01-30 | ジェンマブ エー／エス | びまん性大細胞型ｂ細胞リンパ腫を治療するための併用療法におけるｃｄ３及びｃｄ２０に対する二重特異性抗体 |
| AU2023254191A1 (en) | 2022-04-11 | 2024-10-17 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for universal tumor cell killing |
| WO2023198839A2 (en) | 2022-04-13 | 2023-10-19 | Genmab A/S | Bispecific antibodies against cd3 and cd20 |
| US11958906B2 (en) | 2022-04-13 | 2024-04-16 | Genentech, Inc. | Pharmaceutical compositions of mosunetuzumab and methods of use |
| WO2024102948A1 (en) | 2022-11-11 | 2024-05-16 | Celgene Corporation | Fc receptor-homolog 5 (fcrh5) specific binding molecules and bispecific t-cell engaging antibodies including same and related methods |
| AU2023398887A1 (en) * | 2022-12-14 | 2025-06-26 | Evolveimmune Therapeutics, Inc. | Bispecific antibody fusion molecules and methods of use thereof |
| EP4665385A2 (en) | 2023-02-17 | 2025-12-24 | Regeneron Pharmaceuticals, Inc. | Induced nk cells responsive to cd3/taa bispecific antibodies |
| AU2024244733B2 (en) | 2023-03-31 | 2025-12-11 | AbelZeta Inc. | Bispecific chimeric antigen receptors targeting cd20 and bcma |
| AU2024255174A1 (en) | 2023-04-13 | 2025-10-09 | Genmab A/S | Methods of treating lymphoma with bispecific antibodies against cd3 and cd20 |
| TW202509073A (zh) | 2023-05-15 | 2025-03-01 | 丹麥商珍美寶股份有限公司 | 高度純化之依可利單抗組成物 |
| TW202508630A (zh) | 2023-05-15 | 2025-03-01 | 丹麥商珍美寶股份有限公司 | 治療表現ｃｄ２０之ｂ細胞癌症之方法 |
| WO2025064890A1 (en) * | 2023-09-20 | 2025-03-27 | Evolveimmune Therapeutics, Inc. | Bispecific antibody fusion molecules targeting cd180 and cd3 and methods of use thereof |
| WO2025109119A1 (en) * | 2023-11-22 | 2025-05-30 | Priothera Sas | Methods of treatment with multispecific antigen-binding proteins in combination with s1p receptor modulators |
| GB2641580A (en) | 2024-06-07 | 2025-12-10 | T Therapeutics Ltd | Tumour-transforming multispecific proteins |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05004022A (es) * | 2002-10-17 | 2005-10-05 | Genmab As | Anticuerpos monoclonales humanos contra cd20. |
| CA2625440C (en) | 2005-10-11 | 2023-06-13 | Micromet Ag | Compositions comprising cross-species-specific antibodies and uses thereof |
| US20100325744A1 (en) | 2007-05-31 | 2010-12-23 | Genmab A/S | Non-glycosylated recombinant monovalent antibodies |
| WO2008145141A1 (en) * | 2007-05-31 | 2008-12-04 | Genmab A/S | Method for extending the half-life of exogenous or endogenous soluble molecules |
| US9322035B2 (en) | 2007-05-31 | 2016-04-26 | Genmab A/S | Recombinant IgG4 monovalent antibodies |
| WO2010037838A2 (en) * | 2008-10-01 | 2010-04-08 | Micromet Ag | Cross-species-specific single domain bispecific single chain antibody |
| TW201109438A (en) | 2009-07-29 | 2011-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| WO2011028952A1 (en) | 2009-09-02 | 2011-03-10 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| US20130089554A1 (en) | 2009-12-29 | 2013-04-11 | Emergent Product Development Seattle, Llc | RON Binding Constructs and Methods of Use Thereof |
| JP6040148B2 (ja) * | 2010-04-20 | 2016-12-07 | ゲンマブ エー／エス | ヘテロ二量体抗体Ｆｃ含有タンパク質およびその産生方法 |
| SG190726A1 (en) * | 2010-11-30 | 2013-07-31 | Chugai Pharmaceutical Co Ltd | Cytotoxicity-inducing therapeutic agent |
| US20140170149A1 (en) * | 2011-04-20 | 2014-06-19 | Genmab A/S | Bispecific antibodies against her2 and cd3 |
| UA115402C2 (uk) | 2011-05-21 | 2017-10-25 | Макродженікс, Інк. | Cd3-зв'язувальна молекула, здатна до зв'язування з cd3 людини і cd3, що не є людським |
| RS56879B1 (sr) | 2011-08-23 | 2018-04-30 | Roche Glycart Ag | Bispecifične molekule koje vezuju antigen za aktiviranje t ćelija |
| SG11201408646VA (en) | 2012-07-06 | 2015-01-29 | Genmab Bv | Dimeric protein with triple mutations |
| JOP20200236A1 (ar) * | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
| CA2896370A1 (en) | 2013-02-26 | 2014-09-04 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
| JP2016512421A (ja) | 2013-02-26 | 2016-04-28 | ロシュ グリクアート アーゲー | 二重特異性ｔ細胞活性化抗原結合分子 |
| ES2776706T3 (es) | 2013-07-05 | 2020-07-31 | Genmab As | Anticuerpos contra CD3 humanizados o quiméricos |
| EP3019622A4 (en) * | 2013-07-12 | 2017-06-14 | Zymeworks Inc. | Bispecific cd3 and cd19 antigen binding contructs |
| JP6449295B2 (ja) * | 2013-12-17 | 2019-01-09 | ジェネンテック， インコーポレイテッド | 抗ｃｄ３抗体および使用方法 |
| TWI754319B (zh) | 2014-03-19 | 2022-02-01 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| AU2015350075B2 (en) | 2014-11-17 | 2021-06-03 | Regeneron Pharmaceuticals, Inc. | Methods for tumor treatment using CD3xCD20 bispecific antibody |
| WO2017210485A1 (en) | 2016-06-01 | 2017-12-07 | Xencor, Inc. | Bispecific antibodies that bind cd20 and cd3 for use in the treatment of lymphoma |
| WO2019034580A1 (en) * | 2017-08-14 | 2019-02-21 | Morphosys Ag | HUMANIZED ANTIBODIES FOR CD3 |
| KR20230066391A (ko) * | 2020-09-10 | 2023-05-15 | 젠맵 에이/에스 | 여포성 림프종을 치료하기 위한 조합 요법에서의 cd3 및 cd20에 대한 이중특이적 항체 |
-
2016
- 2016-01-08 KR KR1020177021738A patent/KR102663073B1/ko active Active
- 2016-01-08 WO PCT/EP2016/050296 patent/WO2016110576A1/en not_active Ceased
- 2016-01-08 EP EP16700133.8A patent/EP3242682A1/en not_active Withdrawn
- 2016-01-08 UA UAA201708112A patent/UA120286C2/uk unknown
- 2016-01-08 AU AU2016205967A patent/AU2016205967B2/en active Active
- 2016-01-08 MX MX2017008875A patent/MX391279B/es unknown
- 2016-01-08 US US15/541,594 patent/US10544220B2/en active Active
- 2016-01-08 EA EA201791554A patent/EA201791554A1/ru unknown
- 2016-01-08 JP JP2017536356A patent/JP6853176B2/ja active Active
- 2016-01-08 IL IL289946A patent/IL289946B2/en unknown
- 2016-01-08 IL IL318350A patent/IL318350A/en unknown
- 2016-01-08 KR KR1020247014333A patent/KR102712786B1/ko active Active
- 2016-01-08 CA CA2973159A patent/CA2973159A1/en active Pending
- 2016-01-08 EP EP25189898.7A patent/EP4678661A2/en active Pending
- 2016-01-08 CN CN201680014755.4A patent/CN107660214B/zh active Active
- 2016-01-08 KR KR1020247032341A patent/KR20240148942A/ko active Pending
- 2016-01-08 SG SG11201705496SA patent/SG11201705496SA/en unknown
- 2016-01-08 CN CN202210117824.1A patent/CN114478792A/zh active Pending
-
2017
- 2017-06-25 IL IL253166A patent/IL253166B/en unknown
- 2017-07-04 MX MX2022004082A patent/MX2022004082A/es unknown
-
2019
- 2019-12-04 US US16/702,996 patent/US20200199231A1/en active Pending
-
2021
- 2021-03-11 JP JP2021038857A patent/JP7177317B2/ja active Active
-
2022
- 2022-02-10 AU AU2022200871A patent/AU2022200871B2/en active Active
- 2022-10-07 JP JP2022162493A patent/JP7596342B2/ja active Active
-
2025
- 2025-08-07 AU AU2025213616A patent/AU2025213616A1/en active Pending
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