CY1122188T1 - Θεραπευτικη αντιμετωπιση της προοδευτικης οστεοποιους ινοδυσπλασιας - Google Patents

Θεραπευτικη αντιμετωπιση της προοδευτικης οστεοποιους ινοδυσπλασιας

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Publication number
CY1122188T1
CY1122188T1 CY20191100972T CY191100972T CY1122188T1 CY 1122188 T1 CY1122188 T1 CY 1122188T1 CY 20191100972 T CY20191100972 T CY 20191100972T CY 191100972 T CY191100972 T CY 191100972T CY 1122188 T1 CY1122188 T1 CY 1122188T1
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CY
Cyprus
Prior art keywords
fibrodysplasia
progressive
acvr2a
acvr1
acvr2b
Prior art date
Application number
CY20191100972T
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English (en)
Inventor
Aris N. Economides
Vincent J. IDONE
Sarah J. HATSELL
Original Assignee
Regeneron Pharmaceuticals, Inc.
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Publication date
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of CY1122188T1 publication Critical patent/CY1122188T1/el

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Microbiology (AREA)
  • Mycology (AREA)
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  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)

Abstract

Παρέχονται μέθοδοι για τη θεραπευτική αντιμετώπιση της Προοδευτικής Οστεοποιούς Ινοδυσπλασίας (FOP). Οι εν λόγω μέθοδοι περιλαμβάνουν τη χορήγηση σε ένα υποκείμενο που πάσχει από FOP ενός αποτελεσματικού σχήματος ενός ανταγωνιστή του υποδοχέα ακτιβίνης τύπου 2Α (ACVR2A) ή/και του υποδοχέα ακτιβίνης τύπου 2Β (ACVR2B) ή ενός ανταγωνιστή του υποδοχέα ακτιβίνης τύπου 1 (ACVR1). Οι ανταγωνιστές συμπεριλαμβάνουν πρωτεΐνες σύντηξης ενός ή περισσότερων εξωκυττάριων τομέων (ECD) των ACVR2A, ACVR2B ή/και ACVR1 και του τομέα Fc μιας βαριάς αλυσίδας της ανοσοσφαιρίνης, καθώς και αντισώματα κατά των ACVR2A, ACVR2B, ACVR1 ή της Ακτιβίνης Α.
CY20191100972T 2014-09-12 2019-09-17 Θεραπευτικη αντιμετωπιση της προοδευτικης οστεοποιους ινοδυσπλασιας CY1122188T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462049869P 2014-09-12 2014-09-12
US201562141775P 2015-04-01 2015-04-01
PCT/US2015/000100 WO2016039796A2 (en) 2014-09-12 2015-09-14 Treatment of fibrodysplasia ossificans progressiva

Publications (1)

Publication Number Publication Date
CY1122188T1 true CY1122188T1 (el) 2020-11-25

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Application Number Title Priority Date Filing Date
CY20191100972T CY1122188T1 (el) 2014-09-12 2019-09-17 Θεραπευτικη αντιμετωπιση της προοδευτικης οστεοποιους ινοδυσπλασιας

Country Status (28)

Country Link
US (3) US20160075772A1 (el)
EP (2) EP3191512B1 (el)
JP (1) JP6560341B2 (el)
KR (1) KR102564079B1 (el)
CN (1) CN107106648B (el)
AU (1) AU2015315829B2 (el)
CA (1) CA2960950C (el)
CL (2) CL2017000603A1 (el)
CY (1) CY1122188T1 (el)
DK (1) DK3191512T3 (el)
ES (1) ES2739605T3 (el)
HR (1) HRP20191929T1 (el)
HU (1) HUE046558T2 (el)
IL (1) IL251063B (el)
LT (1) LT3191512T (el)
MA (1) MA40621B1 (el)
ME (1) ME03541B (el)
MX (1) MX2017003175A (el)
MY (1) MY179654A (el)
NZ (1) NZ730773A (el)
PL (1) PL3191512T3 (el)
PT (1) PT3191512T (el)
RS (1) RS59412B1 (el)
SG (2) SG10201902175RA (el)
SI (1) SI3191512T1 (el)
TW (1) TWI688402B (el)
WO (1) WO2016039796A2 (el)
ZA (1) ZA201702112B (el)

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PT3191512T (pt) 2019-09-26
US20180111983A1 (en) 2018-04-26
KR20170052666A (ko) 2017-05-12
PL3191512T3 (pl) 2020-01-31
JP2017528476A (ja) 2017-09-28
US20160075772A1 (en) 2016-03-17
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LT3191512T (lt) 2019-09-10
WO2016039796A3 (en) 2016-06-16
ME03541B (me) 2020-07-20
BR112017004812A2 (pt) 2017-12-12
CN107106648A (zh) 2017-08-29
HRP20191929T1 (hr) 2020-01-10
CL2018002962A1 (es) 2018-12-28
CA2960950C (en) 2023-03-14
IL251063B (en) 2022-08-01
SG10201902175RA (en) 2019-04-29
AU2015315829B2 (en) 2021-05-27
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SG11201701913SA (en) 2017-04-27
CL2017000603A1 (es) 2017-10-06
US11407822B2 (en) 2022-08-09
KR102564079B1 (ko) 2023-08-08
CN107106648B (zh) 2021-06-11
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US20200115440A1 (en) 2020-04-16
RS59412B1 (sr) 2019-11-29
IL251063A0 (en) 2017-04-30
SI3191512T1 (sl) 2019-09-30
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WO2016039796A2 (en) 2016-03-17
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