JP2011528902A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011528902A5 JP2011528902A5 JP2011519253A JP2011519253A JP2011528902A5 JP 2011528902 A5 JP2011528902 A5 JP 2011528902A5 JP 2011519253 A JP2011519253 A JP 2011519253A JP 2011519253 A JP2011519253 A JP 2011519253A JP 2011528902 A5 JP2011528902 A5 JP 2011528902A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antigen
- antibody
- binding fragment
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims 22
- 102000036639 antigens Human genes 0.000 claims 22
- 108091007433 antigens Proteins 0.000 claims 22
- 239000012634 fragment Substances 0.000 claims 21
- 125000003275 alpha amino acid group Chemical group 0.000 claims 17
- 241000712431 Influenza A virus Species 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 206010022000 influenza Diseases 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 230000002163 immunogen Effects 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000037797 influenza A Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8383808P | 2008-07-25 | 2008-07-25 | |
| US61/083,838 | 2008-07-25 | ||
| US18158209P | 2009-05-27 | 2009-05-27 | |
| US61/181,582 | 2009-05-27 | ||
| PCT/IB2009/006623 WO2010010467A2 (en) | 2008-07-25 | 2009-07-27 | Neutralizing anti-influenza a virus antibodies and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011528902A JP2011528902A (ja) | 2011-12-01 |
| JP2011528902A5 true JP2011528902A5 (enExample) | 2012-09-13 |
Family
ID=41570664
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011519253A Pending JP2011528902A (ja) | 2008-07-25 | 2009-07-27 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
| JP2011519252A Active JP5607620B2 (ja) | 2008-07-25 | 2009-07-27 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
| JP2014174221A Active JP6022515B2 (ja) | 2008-07-25 | 2014-08-28 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011519252A Active JP5607620B2 (ja) | 2008-07-25 | 2009-07-27 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
| JP2014174221A Active JP6022515B2 (ja) | 2008-07-25 | 2014-08-28 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9340603B2 (enExample) |
| EP (2) | EP2313433A2 (enExample) |
| JP (3) | JP2011528902A (enExample) |
| KR (2) | KR20110049802A (enExample) |
| CN (2) | CN102216327A (enExample) |
| AU (2) | AU2009275227A1 (enExample) |
| BR (1) | BRPI0911699B8 (enExample) |
| CA (2) | CA2733218A1 (enExample) |
| CO (1) | CO6341572A2 (enExample) |
| CR (2) | CR20110079A (enExample) |
| EC (1) | ECSP11010823A (enExample) |
| ES (1) | ES2662519T3 (enExample) |
| GT (1) | GT201100023A (enExample) |
| IL (2) | IL210772A0 (enExample) |
| MA (1) | MA32577B1 (enExample) |
| MX (2) | MX2011000768A (enExample) |
| NZ (2) | NZ590891A (enExample) |
| RU (1) | RU2553325C2 (enExample) |
| WO (2) | WO2010010466A2 (enExample) |
| ZA (2) | ZA201101113B (enExample) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2708221C (en) | 2007-12-06 | 2017-07-25 | Wayne A. Marasco | Antibodies against influenza virus and methods of use thereof |
| AU2009275227A1 (en) | 2008-07-25 | 2010-01-28 | Institute For Research In Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
| US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
| EP2545074A4 (en) * | 2010-03-08 | 2014-01-08 | Celltrion Inc | HUMAN MONOCLONAL ANTIBODIES MADE FROM HUMAN B-CELLS WITH NEUTRALIZING EFFECT AGAINST INFLUENZA A-VIRUS |
| CA2839421C (en) * | 2010-06-17 | 2019-12-03 | Trellis Bioscience, Llc | Antibodies useful in passive influenza immunization |
| US9534042B2 (en) * | 2010-09-03 | 2017-01-03 | Fujita Health University | Influenza virus-neutralizing antibody and screening method therefor |
| WO2012045001A2 (en) * | 2010-09-30 | 2012-04-05 | Vanderbilt University | Influenza virus antibodies and immunogens and uses therefor |
| EP2699688A1 (en) | 2011-04-20 | 2014-02-26 | The Trustees Of The University Of Pennsylvania | Regimens and compositions for aav-mediated passive immunization of airborne pathogens |
| US8961978B2 (en) * | 2011-07-14 | 2015-02-24 | Crucell Holland B.V. | Human binding molecules capable of neutralizing influenza A viruses of phylogenetic group 1 and phylogenetic group 2 and influenza B viruses |
| LT3418300T (lt) * | 2011-07-18 | 2021-01-11 | Institute For Research In Biomedicine | Neutralizuojantys antikūnai prieš gripo virusą a ir jų panaudojimas |
| CN107417789A (zh) * | 2011-07-18 | 2017-12-01 | 生物医学学会 | 中和抗甲型流感病毒抗体及其用途 |
| AU2012289926A1 (en) * | 2011-08-03 | 2014-03-13 | Children's Medical Center Corporation | A broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin |
| US9512202B2 (en) | 2011-08-27 | 2016-12-06 | University Of Zurich | Multi-strain-reactive antibodies for therapy and diagnosis of influenza |
| JP5998222B2 (ja) * | 2011-09-30 | 2016-09-28 | セルトリオン・インコーポレイテッド | ヒトｂ細胞で生産されたインフルエンザａウイルス中和活性を持つ結合分子 |
| CA2852474A1 (en) * | 2011-10-18 | 2013-04-25 | Emory University | Antibodies directed against influenza |
| KR20130059721A (ko) * | 2011-11-29 | 2013-06-07 | (주)셀트리온 | 인간 ｂ 세포에서 생산된 인플루엔자 ａ 바이러스 중화 활성을 가지는 결합 분자 |
| SG11201402780UA (en) | 2011-12-02 | 2014-10-30 | Aimm Therapeutics Bv | Influenza a virus specific antibodies |
| BR112014013640A8 (pt) * | 2011-12-05 | 2021-03-16 | Trellis Bioscience Llc | anticorpos úteis em imunização passiva para influenza |
| US20140335507A1 (en) * | 2011-12-12 | 2014-11-13 | Novartis Ag | Assays for influenza virus hemagglutinins |
| KR101749316B1 (ko) | 2011-12-15 | 2017-06-21 | (주) 에이프로젠 | Ｈ１ｎ１―감염된 환자들로부터 유도된 매우 잠재력 있는 넓은-스펙트럼 중화 단일클론 항체 및 이를 포함하는 바이러스의 치료용 조성물 |
| RU2502745C2 (ru) * | 2011-12-30 | 2013-12-27 | Общество с ограниченной ответственностью "Технофарма" | Наноантитело "anti-flu", рекомбинантные вирусные векторы и фармацевтические композиции для профилактики и терапии гриппа типа а |
| AU2013229488B2 (en) * | 2012-03-08 | 2017-12-07 | Janssen Vaccines & Prevention B.V. | Human binding molecules capable of binding to and neutralizing influenza B viruses and uses thereof |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| HK1207970A1 (en) | 2012-05-10 | 2016-02-19 | Massachusetts Institute Of Technology | Agents for influenza neutralization |
| CN103665155B (zh) * | 2012-09-14 | 2016-07-06 | 中国科学院上海生命科学研究院 | 一种抗流感病毒广谱中和性的中和分子1f2 |
| CN103665157B (zh) * | 2012-09-14 | 2016-06-29 | 中国科学院上海生命科学研究院 | 一种抗流感病毒广谱中和性的中和分子1c4 |
| CN103665156B (zh) * | 2012-09-14 | 2016-08-03 | 中国科学院上海生命科学研究院 | 一种抗流感病毒广谱中和性的结合分子3e1 |
| CN103665154B (zh) * | 2012-09-14 | 2016-08-03 | 中国科学院上海生命科学研究院 | 一种抗流感病毒广谱中和性的中和分子3c4 |
| CN104968367B (zh) * | 2012-11-13 | 2018-04-13 | 弗·哈夫曼-拉罗切有限公司 | 抗血凝素抗体和使用方法 |
| IL241552B2 (en) * | 2013-03-14 | 2023-09-01 | Contrafect Corp | Preparation and methods based on neutralizing antibodies administered intranasally for increased therapeutic efficacy |
| KR20140118682A (ko) * | 2013-03-29 | 2014-10-08 | (주)셀트리온 | 2 이상의 인플루엔자 ａ 바이러스 중화 결합 분자를 포함하는 조성물 |
| EP2982691B1 (en) * | 2013-04-02 | 2020-05-06 | Xiamen University | Broad spectrum monoclonal antibody identifying ha1 structural domain of influenza virus hemagglutinin proteins |
| PL3052192T3 (pl) * | 2013-10-02 | 2021-04-06 | Medimmune, Llc | Przeciwciała neutralizujące przeciwko grypie A i ich zastosowania |
| EP3070167A4 (en) * | 2013-11-06 | 2017-06-07 | Osaka University | Antibody having broad neutralizing activity in group 1 influenza a virus |
| AU2015214146B2 (en) | 2014-02-04 | 2020-09-17 | Contrafect Corporation | Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof |
| US10639370B2 (en) | 2014-02-04 | 2020-05-05 | Contrafect Corporation | Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof |
| CN110642944B (zh) * | 2014-03-07 | 2021-06-11 | 神州细胞工程有限公司 | 一种中和人感染h7n9甲型流感病毒的抗体及其用途 |
| HRP20201530T1 (hr) | 2014-05-13 | 2020-12-11 | The Trustees Of The University Of Pennsylvania | Kompozicije koje sadrže aav koji eksprimira konstrukte dvojnih antitijela i njihove primjene |
| JP6495434B2 (ja) * | 2014-07-14 | 2019-04-03 | ザ ペン ステイト リサーチ ファンデーション | サーファクタントタンパク質ａ受容体を標的とする組成物及び方法 |
| CN113563462B (zh) | 2014-07-15 | 2024-08-13 | 免疫医疗有限责任公司 | 中和抗乙型流感抗体及其用途 |
| JPWO2016010160A1 (ja) * | 2014-07-18 | 2017-06-01 | 国立感染症研究所長 | 抗インフルエンザウイルス抗体及びその利用 |
| US20180008702A1 (en) * | 2014-12-05 | 2018-01-11 | Celltrion Inc. | Adjuvant composition containing at least one influenza virus neutralizing and binding molecule and vaccine composition containing same |
| WO2016089181A1 (ko) * | 2014-12-05 | 2016-06-09 | (주)셀트리온 | 1 이상의 인플루엔자 바이러스 중화 결합 분자를 포함하는 애주번트 조성물 및 이를 포함하는 백신 조성물 |
| TWI702229B (zh) * | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
| US11535665B2 (en) | 2015-05-13 | 2022-12-27 | The Trustees Of The University Of Pennsylvania | AAV-mediated expression of anti-influenza antibodies and methods of use thereof |
| LT3303384T (lt) | 2015-06-01 | 2021-10-11 | Medimmune, Llc | Neutralizuojančios surišančios molekulės prieš gripą ir jų naudojimas |
| WO2017083627A1 (en) | 2015-11-13 | 2017-05-18 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| IL304940A (en) | 2016-01-13 | 2023-10-01 | Medimmune Llc | A method for treating type A influenza |
| US20170240617A1 (en) | 2016-02-24 | 2017-08-24 | Visterra, Inc. | Formulations of antibody molecules to influenza virus |
| US12065482B2 (en) * | 2016-08-10 | 2024-08-20 | Celltrion Inc. | Stable liquid pharmaceutical formulation of anti-influenza virus antibody |
| JP2017086068A (ja) * | 2016-10-31 | 2017-05-25 | インスティテュート・フォー・リサーチ・イン・バイオメディシンＩｎｓｔｉｔｕｔｅ Ｆｏｒ Ｒｅｓｅａｒｃｈ Ｉｎ Ｂｉｏｍｅｄｉｃｉｎｅ | Ａ型インフルエンザウイルス中和抗体及びその使用法 |
| RU2671477C2 (ru) * | 2016-12-30 | 2018-10-31 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pBiPr-ABIgA2m1F16-ht ДЛЯ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ИММУНОГЛОБУЛИНА А ИЗОТИПА IGA2m1 |
| RU2664184C2 (ru) * | 2016-12-30 | 2018-08-15 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pBiPr-ABIgA1FI6-Intht ДЛЯ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ИММУНОГЛОБУЛИНА А ИЗОТИПА IgA1 |
| RU2656142C1 (ru) * | 2016-12-30 | 2018-05-31 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pBiPr-ABIgA1FI6-ht ДЛЯ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ИММУНОГЛОБУЛИНА А ИЗОТИПА IGA1 |
| JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
| PT3589730T (pt) | 2017-02-28 | 2024-02-28 | Univ Pennsylvania | Vetor de vírus adenoassociado (aav) de clado f e suas utilizações |
| CN110573523A (zh) | 2017-02-28 | 2019-12-13 | 宾夕法尼亚州大学信托人 | 基于aav载体的流感疫苗 |
| JP7403733B2 (ja) | 2017-09-04 | 2023-12-25 | 国立感染症研究所長 | インフルエンザｈａスプリットワクチンの製造方法 |
| US11685934B2 (en) | 2017-09-18 | 2023-06-27 | Amyris, Inc. | Methods for genomic integration for Kluyveromyces host cells |
| BR112020005154A2 (pt) * | 2017-09-18 | 2020-09-15 | Amyris, Inc. | métodos de integração genômica em pichia e outras células hospedeiras |
| CN109988236B (zh) * | 2017-12-30 | 2022-04-01 | 中国科学院天津工业生物技术研究所 | 一种流感病毒抗体的应用 |
| HRP20220980T1 (hr) * | 2018-01-23 | 2022-11-11 | Janssen Vaccines & Prevention B.V. | Cjepiva protiv virusa influence i njihova uporaba |
| JP6622825B2 (ja) * | 2018-01-25 | 2019-12-18 | インスティテュート・フォー・リサーチ・イン・バイオメディシンＩｎｓｔｉｔｕｔｅ Ｆｏｒ Ｒｅｓｅａｒｃｈ Ｉｎ Ｂｉｏｍｅｄｉｃｉｎｅ | Ａ型インフルエンザウイルス中和抗体及びその使用法 |
| IL275884B2 (en) | 2018-01-26 | 2024-11-01 | Regeneron Pharma | Human antibodies to influenza hemagglutinin |
| TW202011986A (zh) | 2018-07-23 | 2020-04-01 | 公益財團法人日本健康科學振興財團 | 包含流感疫苗之組合物 |
| WO2020160560A2 (en) * | 2019-02-01 | 2020-08-06 | Novarock Biotherapeutics, Ltd. | Anti-claudin 18 antibodies and methods of use thereof |
| MY208974A (en) | 2019-03-04 | 2025-06-14 | Sumitomo Pharma Co Ltd | Method for preparing influenza ha split vaccine |
| US11230593B2 (en) | 2019-03-25 | 2022-01-25 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| JP2020048568A (ja) * | 2019-11-22 | 2020-04-02 | インスティテュート・フォー・リサーチ・イン・バイオメディシンＩｎｓｔｉｔｕｔｅ Ｆｏｒ Ｒｅｓｅａｒｃｈ Ｉｎ Ｂｉｏｍｅｄｉｃｉｎｅ | Ａ型インフルエンザウイルス中和抗体及びその使用法 |
| AU2020403133A1 (en) | 2019-12-11 | 2022-06-23 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| WO2021201677A1 (en) | 2020-04-01 | 2021-10-07 | Kiadis Pharma Intellectual Property B.V. | Compositions and methods targeting influenza |
| CN111825763B (zh) * | 2020-07-15 | 2022-04-19 | 扬州大学 | 流感病毒ha蛋白茎部特异性单克隆抗体及其制备方法和应用 |
| CN114181303B (zh) * | 2020-09-14 | 2022-12-23 | 东莞市朋志生物科技有限公司 | 抗甲型流感病毒的抗体和试剂盒 |
| TW202237850A (zh) | 2020-12-01 | 2022-10-01 | 賓州大學委員會 | 具有組織特異性靶向基序的新穎構成物及含有其之組成物 |
| WO2022232289A1 (en) | 2021-04-27 | 2022-11-03 | Generation Bio Co. | Non-viral dna vectors expressing therapeutic antibodies and uses thereof |
| WO2023177655A1 (en) | 2022-03-14 | 2023-09-21 | Generation Bio Co. | Heterologous prime boost vaccine compositions and methods of use |
| KR20240088574A (ko) | 2022-11-21 | 2024-06-20 | (주)샤페론 | 인플루엔자 바이러스에 대한 단일 도메인 항체 및 이의 용도 |
| CN119930806B (zh) * | 2025-01-21 | 2025-12-02 | 中国医学科学院病原生物学研究所 | 一种甲型流感病毒中和抗体及其应用 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US630064A (en) * | 1899-02-10 | 1899-08-01 | William Martindale | Safety-hook. |
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3766162A (en) | 1971-08-24 | 1973-10-16 | Hoffmann La Roche | Barbituric acid antigens and antibodies specific therefor |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4233402A (en) | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
| JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
| DE3380726D1 (en) | 1982-06-24 | 1989-11-23 | Japan Chem Res | Long-acting composition |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US4831175A (en) | 1986-09-05 | 1989-05-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
| RU2031941C1 (ru) * | 1991-03-14 | 1995-03-27 | Научно-исследовательский институт гриппа РАМН | Штамм вируса гриппа а(нini) для получения живой гриппозной интраназальной вакцины для взрослых и детей |
| US5595721A (en) | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
| DK1143006T3 (da) * | 1995-08-18 | 2008-07-14 | Morphosys Ip Gmbh | Vektorer/DNA-sekvenser fra humane kombinatoriske antistofbiblioteker |
| WO1998057993A1 (en) | 1997-06-19 | 1998-12-23 | The Regents Of The University Of California | Secretory immunoglobulin produced by single cells and methods for making and using same |
| MY133346A (en) | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
| US20020102208A1 (en) | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
| US8101553B1 (en) * | 2000-02-22 | 2012-01-24 | Medical & Biological Laboratories Co., Ltd. | Antibody library |
| AU2003251809A1 (en) | 2002-07-11 | 2004-02-02 | The General Hospital Corporation | Polynucleotide and polypeptide fat metabolism regulators and uses thereof |
| CN1756562A (zh) * | 2003-03-07 | 2006-04-05 | 麦克公司 | 流感病毒疫苗 |
| RU2390351C2 (ru) * | 2003-08-11 | 2010-05-27 | Дзе Ресерч Фаундейшн Фо Макробайал Дизизес Оф Осака Юниверсити | Вакцина против вируса гриппа для введения через слизистую и способ предотвращения гриппа |
| WO2006124269A2 (en) * | 2005-05-16 | 2006-11-23 | Amgen Fremont Inc. | Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders |
| EP2532677A1 (en) | 2005-10-21 | 2012-12-12 | Novartis AG | Human antibodies against il13 and therapeutic uses |
| TWI477602B (zh) | 2006-02-09 | 2015-03-21 | Educational Foundation Jichi Medical Univ | Novel viral vector |
| AU2007249160B2 (en) * | 2006-05-15 | 2013-09-12 | I2 Pharmaceuticals, Inc. | Neutralizing antibodies to influenza viruses |
| HRP20130163T1 (hr) * | 2006-09-07 | 2013-03-31 | Crucell Holland B.V. | Ljudske molekule za vezanje koje mogu neutralizirati virus influence h5n1 i njihova uporaba |
| EP2769992B1 (en) * | 2006-10-02 | 2020-12-30 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| WO2008066691A2 (en) * | 2006-11-08 | 2008-06-05 | Macrogenics West, Inc. | Tes7 and antibodies that bind thereto |
| EP1925318A1 (en) * | 2006-11-20 | 2008-05-28 | Paul-Ehrlich-Institut | Recombinant modified vaccinia virus Ankara (MVA)-based vaccine for the avian flu |
| RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
| GB0700133D0 (en) * | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
| JP5346820B2 (ja) | 2007-03-13 | 2013-11-20 | エイチユーエムエイビーエス・リミテッド・ライアビリティ・カンパニー | Ｈ５ｎ１亜型ａ型インフルエンザウィルスに対する抗体 |
| ITTO20080204A1 (it) | 2008-03-17 | 2009-09-18 | Pomona Biotechnologies Llc | Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a |
| US8871207B2 (en) * | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
| AU2009275227A1 (en) | 2008-07-25 | 2010-01-28 | Institute For Research In Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
-
2009
- 2009-07-27 AU AU2009275227A patent/AU2009275227A1/en not_active Abandoned
- 2009-07-27 WO PCT/IB2009/006616 patent/WO2010010466A2/en not_active Ceased
- 2009-07-27 CA CA2733218A patent/CA2733218A1/en not_active Abandoned
- 2009-07-27 CA CA2731686A patent/CA2731686C/en active Active
- 2009-07-27 JP JP2011519253A patent/JP2011528902A/ja active Pending
- 2009-07-27 EP EP09759983A patent/EP2313433A2/en not_active Withdrawn
- 2009-07-27 NZ NZ590891A patent/NZ590891A/xx not_active IP Right Cessation
- 2009-07-27 RU RU2011105062/10A patent/RU2553325C2/ru active
- 2009-07-27 US US12/509,731 patent/US9340603B2/en active Active
- 2009-07-27 ES ES09745097.7T patent/ES2662519T3/es active Active
- 2009-07-27 EP EP09745097.7A patent/EP2313112B1/en active Active
- 2009-07-27 KR KR1020117003495A patent/KR20110049802A/ko not_active Withdrawn
- 2009-07-27 MX MX2011000768A patent/MX2011000768A/es not_active Application Discontinuation
- 2009-07-27 CN CN2009801329884A patent/CN102216327A/zh active Pending
- 2009-07-27 JP JP2011519252A patent/JP5607620B2/ja active Active
- 2009-07-27 CN CN200980132989.9A patent/CN102164613B/zh active Active
- 2009-07-27 US US12/509,835 patent/US8685402B2/en active Active
- 2009-07-27 WO PCT/IB2009/006623 patent/WO2010010467A2/en not_active Ceased
- 2009-07-27 BR BRPI0911699A patent/BRPI0911699B8/pt active IP Right Grant
- 2009-07-27 NZ NZ590890A patent/NZ590890A/xx not_active IP Right Cessation
- 2009-07-27 KR KR1020117003526A patent/KR101732056B1/ko active Active
- 2009-07-27 MX MX2011000767A patent/MX2011000767A/es active IP Right Grant
- 2009-07-27 AU AU2009275226A patent/AU2009275226B2/en active Active
-
2011
- 2011-01-20 IL IL210772A patent/IL210772A0/en unknown
- 2011-01-20 IL IL210771A patent/IL210771A0/en unknown
- 2011-01-21 GT GT201100023A patent/GT201100023A/es unknown
- 2011-02-09 CO CO11015221A patent/CO6341572A2/es active IP Right Grant
- 2011-02-11 ZA ZA2011/01113A patent/ZA201101113B/en unknown
- 2011-02-11 CR CR20110079A patent/CR20110079A/es unknown
- 2011-02-11 EC EC2011010823A patent/ECSP11010823A/es unknown
- 2011-02-14 ZA ZA2011/01150A patent/ZA201101150B/en unknown
- 2011-02-14 CR CR20110084A patent/CR20110084A/es unknown
- 2011-02-22 MA MA33633A patent/MA32577B1/fr unknown
-
2014
- 2014-08-28 JP JP2014174221A patent/JP6022515B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011528902A5 (enExample) | ||
| JP2012504955A5 (enExample) | ||
| JP2010516229A5 (enExample) | ||
| RU2011105062A (ru) | Нейтрализующие антитела против вируса гриппа а и их использование | |
| RU2009129403A (ru) | Антитела, нейтрализующие цитомегаловирус человека, и их применение | |
| JP2020500538A5 (enExample) | ||
| HRP20201975T1 (hr) | Neutralizirajuća protutijela anti-influenca a virusa i njihova uporaba | |
| JP2020079252A5 (enExample) | ||
| JP2018521638A5 (enExample) | ||
| JP2018535650A5 (enExample) | ||
| FI3484915T3 (fi) | Uusia zikavirusepitooppeihin spesifisesti sitoutuvia vasta-aineita ja niiden käyttöjä | |
| JP2011528901A5 (enExample) | ||
| US10676520B2 (en) | Antibodies useful in passive influenza immunization | |
| RU2588467C3 (ru) | Стабильные и растворимые антитела, ингибирующие vegf | |
| JP2015534982A5 (enExample) | ||
| JP2018536393A5 (enExample) | ||
| CN105050622A (zh) | 针对呼吸道融合病毒f蛋白质的人类抗体及其使用方法 | |
| EP2793945B1 (en) | Antibodies useful in passive influenza immunization | |
| JP2015522252A5 (enExample) | ||
| JP2019522961A5 (enExample) | ||
| RU2016129274A (ru) | Канинизированные мышиные антитела к человеческому pd-1 | |
| RU2014146503A (ru) | Белки, связывающие антиген - лиганд cd30 человека | |
| JP2016503413A5 (enExample) | ||
| JP6949012B2 (ja) | Ｂ型肝炎表面抗原に対する抗体及びその使用 | |
| JP2015514068A5 (enExample) |