JP2011528902A5 - - Google Patents
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- JP2011528902A5 JP2011528902A5 JP2011519253A JP2011519253A JP2011528902A5 JP 2011528902 A5 JP2011528902 A5 JP 2011528902A5 JP 2011519253 A JP2011519253 A JP 2011519253A JP 2011519253 A JP2011519253 A JP 2011519253A JP 2011528902 A5 JP2011528902 A5 JP 2011528902A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antigen
- antibody
- binding fragment
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000000427 antigen Substances 0.000 claims 22
- 102000036639 antigens Human genes 0.000 claims 22
- 108091007433 antigens Proteins 0.000 claims 22
- 239000012634 fragment Substances 0.000 claims 21
- 125000003275 alpha amino acid group Chemical group 0.000 claims 17
- 241000712431 Influenza A virus Species 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 206010022000 influenza Diseases 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 230000002163 immunogen Effects 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000037797 influenza A Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8383808P | 2008-07-25 | 2008-07-25 | |
| US61/083,838 | 2008-07-25 | ||
| US18158209P | 2009-05-27 | 2009-05-27 | |
| US61/181,582 | 2009-05-27 | ||
| PCT/IB2009/006623 WO2010010467A2 (en) | 2008-07-25 | 2009-07-27 | Neutralizing anti-influenza a virus antibodies and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011528902A JP2011528902A (ja) | 2011-12-01 |
| JP2011528902A5 true JP2011528902A5 (enExample) | 2012-09-13 |
Family
ID=41570664
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011519253A Pending JP2011528902A (ja) | 2008-07-25 | 2009-07-27 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
| JP2011519252A Active JP5607620B2 (ja) | 2008-07-25 | 2009-07-27 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
| JP2014174221A Active JP6022515B2 (ja) | 2008-07-25 | 2014-08-28 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011519252A Active JP5607620B2 (ja) | 2008-07-25 | 2009-07-27 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
| JP2014174221A Active JP6022515B2 (ja) | 2008-07-25 | 2014-08-28 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8685402B2 (enExample) |
| EP (2) | EP2313112B1 (enExample) |
| JP (3) | JP2011528902A (enExample) |
| KR (2) | KR101732056B1 (enExample) |
| CN (2) | CN102216327A (enExample) |
| AU (2) | AU2009275227A1 (enExample) |
| BR (1) | BRPI0911699B8 (enExample) |
| CA (2) | CA2733218A1 (enExample) |
| CO (1) | CO6341572A2 (enExample) |
| CR (2) | CR20110079A (enExample) |
| EC (1) | ECSP11010823A (enExample) |
| ES (1) | ES2662519T3 (enExample) |
| GT (1) | GT201100023A (enExample) |
| IL (2) | IL210772A0 (enExample) |
| MA (1) | MA32577B1 (enExample) |
| MX (2) | MX2011000768A (enExample) |
| NZ (2) | NZ590891A (enExample) |
| RU (1) | RU2553325C2 (enExample) |
| WO (2) | WO2010010467A2 (enExample) |
| ZA (2) | ZA201101113B (enExample) |
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| BRPI0819971A2 (pt) | 2007-12-06 | 2017-06-27 | Burnham Institute For Medical Res | anticorpos contra vírus influenza e métodos de seu uso |
| US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
| CA2733218A1 (en) | 2008-07-25 | 2010-01-28 | Institute For Research In Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
| CA2849668A1 (en) * | 2010-03-08 | 2011-09-15 | Celltrion, Inc. | Human monoclonal antibodies derived from human b cells and having neutralizing activity against influenza a viruses |
| KR101849738B1 (ko) * | 2010-06-17 | 2018-04-17 | 트렐리스 바이오싸이언스 인코포레이티드 | 수동 인플루엔자 면역에 유용한 항체 |
| US9534042B2 (en) | 2010-09-03 | 2017-01-03 | Fujita Health University | Influenza virus-neutralizing antibody and screening method therefor |
| WO2012045001A2 (en) * | 2010-09-30 | 2012-04-05 | Vanderbilt University | Influenza virus antibodies and immunogens and uses therefor |
| EP2699688A1 (en) * | 2011-04-20 | 2014-02-26 | The Trustees Of The University Of Pennsylvania | Regimens and compositions for aav-mediated passive immunization of airborne pathogens |
| IN2014CN00953A (enExample) * | 2011-07-14 | 2015-04-10 | Crucell Holland Bv | |
| CN107417789A (zh) * | 2011-07-18 | 2017-12-01 | 生物医学学会 | 中和抗甲型流感病毒抗体及其用途 |
| EP3418300B1 (en) * | 2011-07-18 | 2020-10-28 | Institute for Research in Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
| CN104114186B (zh) * | 2011-08-03 | 2017-05-03 | 儿童医疗中心有限公司 | 识别流行性感冒血凝素的受体‑结合袋状结构的广泛中和人类抗体 |
| WO2013030165A1 (en) * | 2011-08-27 | 2013-03-07 | Universität Zürich | Multi-strain-reactive antibodies for therapy and diagnosis of influenza |
| JP5998222B2 (ja) | 2011-09-30 | 2016-09-28 | セルトリオン・インコーポレイテッド | ヒトｂ細胞で生産されたインフルエンザａウイルス中和活性を持つ結合分子 |
| CA2852474A1 (en) * | 2011-10-18 | 2013-04-25 | Emory University | Antibodies directed against influenza |
| KR20130059721A (ko) * | 2011-11-29 | 2013-06-07 | (주)셀트리온 | 인간 ｂ 세포에서 생산된 인플루엔자 ａ 바이러스 중화 활성을 가지는 결합 분자 |
| JP6325451B2 (ja) | 2011-12-02 | 2018-05-16 | アイム・セラピューティクス・べー・フェー | Ａ型インフルエンザに特異的な抗体 |
| EP2793945B1 (en) * | 2011-12-05 | 2018-08-15 | Trellis Bioscience, LLC | Antibodies useful in passive influenza immunization |
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| RU2502745C2 (ru) * | 2011-12-30 | 2013-12-27 | Общество с ограниченной ответственностью "Технофарма" | Наноантитело "anti-flu", рекомбинантные вирусные векторы и фармацевтические композиции для профилактики и терапии гриппа типа а |
| EP2822968B1 (en) * | 2012-03-08 | 2018-01-10 | Janssen Vaccines & Prevention B.V. | Human binding molecules capable of binding to and neutralizing influenza b viruses and uses thereof |
| CA2871160C (en) | 2012-05-10 | 2023-03-14 | Massachusetts Institute Of Technology | Agents for influenza neutralization |
| US9969794B2 (en) * | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| CN103665154B (zh) * | 2012-09-14 | 2016-08-03 | 中国科学院上海生命科学研究院 | 一种抗流感病毒广谱中和性的中和分子3c4 |
| CN103665156B (zh) * | 2012-09-14 | 2016-08-03 | 中国科学院上海生命科学研究院 | 一种抗流感病毒广谱中和性的结合分子3e1 |
| CN103665155B (zh) * | 2012-09-14 | 2016-07-06 | 中国科学院上海生命科学研究院 | 一种抗流感病毒广谱中和性的中和分子1f2 |
| CN103665157B (zh) * | 2012-09-14 | 2016-06-29 | 中国科学院上海生命科学研究院 | 一种抗流感病毒广谱中和性的中和分子1c4 |
| JP6386465B2 (ja) | 2012-11-13 | 2018-09-05 | ジェネンテック， インコーポレイテッド | 抗ヘマグルチニン抗体及び使用方法 |
| JP6595448B2 (ja) | 2013-03-14 | 2019-10-23 | コントラフェクト コーポレイション | 治療効率の増強のために鼻腔内送達する中和抗体に基づく組成物および方法 |
| KR20140118682A (ko) * | 2013-03-29 | 2014-10-08 | (주)셀트리온 | 2 이상의 인플루엔자 ａ 바이러스 중화 결합 분자를 포함하는 조성물 |
| WO2014161483A1 (zh) | 2013-04-02 | 2014-10-09 | 厦门大学 | 识别流感病毒血凝素蛋白ha1结构域的广谱单克隆抗体 |
| PT3052192T (pt) * | 2013-10-02 | 2020-09-24 | Medimmune Llc | Anticorpos neutralizantes anti-influenza a e suas utilizações |
| US20160264648A1 (en) * | 2013-11-06 | 2016-09-15 | Osaka University | Antibody having broad neutralization activity against group 1 influenza a viruses |
| US10639370B2 (en) | 2014-02-04 | 2020-05-05 | Contrafect Corporation | Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof |
| KR102344390B1 (ko) | 2014-02-04 | 2021-12-28 | 콘트라펙트 코포레이션 | 수동 인플루엔자 면역화에 유용한 항체, 및 이의 사용을 위한 조성물, 조합 및 방법 |
| CN110642944B (zh) * | 2014-03-07 | 2021-06-11 | 神州细胞工程有限公司 | 一种中和人感染h7n9甲型流感病毒的抗体及其用途 |
| MY186389A (en) | 2014-05-13 | 2021-07-22 | Univ Pennsylvania | Compositions comprising aav expressing dual antibody constructs and uses thereof |
| AU2015289831B2 (en) * | 2014-07-14 | 2021-01-28 | The Penn State Research Foundation | Compositions and methods for targeting of the surfactant protein a receptor |
| CA2954780A1 (en) | 2014-07-15 | 2016-01-21 | Medimmune, Llc | Neutralizing anti-influenza b antibodies and uses thereof |
| WO2016010160A1 (ja) * | 2014-07-18 | 2016-01-21 | 国立感染症研究所長が代表する日本国 | 抗インフルエンザウイルス抗体及びその利用 |
| WO2016089181A1 (ko) * | 2014-12-05 | 2016-06-09 | (주)셀트리온 | 1 이상의 인플루엔자 바이러스 중화 결합 분자를 포함하는 애주번트 조성물 및 이를 포함하는 백신 조성물 |
| US20180008702A1 (en) | 2014-12-05 | 2018-01-11 | Celltrion Inc. | Adjuvant composition containing at least one influenza virus neutralizing and binding molecule and vaccine composition containing same |
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| RU2671477C2 (ru) * | 2016-12-30 | 2018-10-31 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pBiPr-ABIgA2m1F16-ht ДЛЯ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ИММУНОГЛОБУЛИНА А ИЗОТИПА IGA2m1 |
| RU2656142C1 (ru) * | 2016-12-30 | 2018-05-31 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pBiPr-ABIgA1FI6-ht ДЛЯ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ИММУНОГЛОБУЛИНА А ИЗОТИПА IGA1 |
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| BR112019017697A2 (pt) | 2017-02-28 | 2020-04-07 | The Trustees Of The University Of Pennsylvania | vacinas contra influenza baseadas em vetores de vírus adenoassociado (aav) |
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| CN119930806B (zh) * | 2025-01-21 | 2025-12-02 | 中国医学科学院病原生物学研究所 | 一种甲型流感病毒中和抗体及其应用 |
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2009
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- 2009-07-27 MX MX2011000768A patent/MX2011000768A/es not_active Application Discontinuation
- 2009-07-27 KR KR1020117003526A patent/KR101732056B1/ko active Active
- 2009-07-27 CN CN2009801329884A patent/CN102216327A/zh active Pending
- 2009-07-27 MX MX2011000767A patent/MX2011000767A/es active IP Right Grant
- 2009-07-27 EP EP09759983A patent/EP2313433A2/en not_active Withdrawn
- 2009-07-27 AU AU2009275227A patent/AU2009275227A1/en not_active Abandoned
- 2009-07-27 JP JP2011519253A patent/JP2011528902A/ja active Pending
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