SG11202108398YA - Anti-claudin 18 antibodies and methods of use thereof - Google Patents
Anti-claudin 18 antibodies and methods of use thereofInfo
- Publication number
- SG11202108398YA SG11202108398YA SG11202108398YA SG11202108398YA SG11202108398YA SG 11202108398Y A SG11202108398Y A SG 11202108398YA SG 11202108398Y A SG11202108398Y A SG 11202108398YA SG 11202108398Y A SG11202108398Y A SG 11202108398YA SG 11202108398Y A SG11202108398Y A SG 11202108398YA
- Authority
- SG
- Singapore
- Prior art keywords
- claudin
- antibodies
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/828—Stomach
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/852—Pancreas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962800359P | 2019-02-01 | 2019-02-01 | |
US201962891925P | 2019-08-26 | 2019-08-26 | |
PCT/US2020/016459 WO2020160560A2 (en) | 2019-02-01 | 2020-02-03 | Anti-claudin 18 antibodies and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202108398YA true SG11202108398YA (en) | 2021-08-30 |
Family
ID=71842386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202108398YA SG11202108398YA (en) | 2019-02-01 | 2020-02-03 | Anti-claudin 18 antibodies and methods of use thereof |
Country Status (9)
Country | Link |
---|---|
US (3) | US11407828B2 (en) |
EP (1) | EP3917564A4 (en) |
JP (1) | JP2022519118A (en) |
KR (1) | KR20210134321A (en) |
CN (1) | CN113645996B (en) |
AU (1) | AU2020217012A1 (en) |
CA (1) | CA3128502A1 (en) |
SG (1) | SG11202108398YA (en) |
WO (1) | WO2020160560A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11643455B2 (en) | 2018-04-13 | 2023-05-09 | Albert Einstein College Of Medicine | High-affinity Mycobacterium tuberculosis capsule-specific human monoclonal antibody |
SG11202106534RA (en) * | 2018-12-28 | 2021-07-29 | Nanjing Genscript Biotech Co Ltd | Claudin18.2 binding moieties and uses thereof |
WO2022111616A1 (en) * | 2020-11-30 | 2022-06-02 | 石药集团巨石生物制药有限公司 | Anti-cldn18.2 antibody, drug conjugate, and preparation method therefor and use thereof |
WO2022122709A1 (en) | 2020-12-07 | 2022-06-16 | Sotio Biotech A.S. | Antibody-drug conjugates based on humanized cldn18.2 antibodies |
EP4263598A1 (en) * | 2020-12-15 | 2023-10-25 | Albert Einstein College of Medicine | High-affinity mycobacterium tuberculosis capsule-specific human monoclonal antibodies |
IL302894A (en) | 2020-12-23 | 2023-07-01 | Sotio Biotech A S | Tumor-specific claudin 18.2 antibody-drug conjugates |
EP4347664A1 (en) * | 2021-05-31 | 2024-04-10 | Shijiazhuang Yiling Pharmaceutical Co., Ltd. | Monoclonal antibodies against cldn18.2 and fc-engineered versions thereof |
WO2023081818A1 (en) | 2021-11-05 | 2023-05-11 | American Diagnostics & Therapy, Llc (Adxrx) | Monoclonal antibodies against carcinoembryonic antigens, and their uses |
WO2023231942A1 (en) * | 2022-05-31 | 2023-12-07 | 石药集团巨石生物制药有限公司 | Pharmaceutical composition of recombinant anti-human cldn18.2 monoclonal antibody-mmae conjugate |
CN117777288A (en) * | 2022-09-29 | 2024-03-29 | 南京博望医药科技有限公司 | Antibodies against claudin 18.2 |
Family Cites Families (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2261229A3 (en) | 1998-04-20 | 2011-03-23 | GlycArt Biotechnology AG | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
DE10254601A1 (en) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Gene products differentially expressed in tumors and their use |
AU2004204494B2 (en) | 2003-01-09 | 2011-09-29 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
GB0306137D0 (en) | 2003-03-18 | 2003-04-23 | Qinetiq Ltd | Fibre laser |
DE102004024617A1 (en) | 2004-05-18 | 2005-12-29 | Ganymed Pharmaceuticals Ag | Differentially expressed in tumors gene products and their use |
DK2573114T3 (en) | 2005-08-10 | 2016-07-04 | Macrogenics Inc | The identification and production of antibodies with variant Fc regions, and methods of using same |
EP1790664A1 (en) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
KR101372690B1 (en) * | 2005-12-13 | 2014-03-17 | 아스트라제네카 아베 | Binding proteins specific for insulin-like growth factors and uses thereof |
US20070214515A1 (en) * | 2006-03-09 | 2007-09-13 | E.I.Du Pont De Nemours And Company | Polynucleotide encoding a maize herbicide resistance gene and methods for use |
WO2008140603A2 (en) | 2006-12-08 | 2008-11-20 | Macrogenics, Inc. | METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING |
EP1997832A1 (en) * | 2007-05-29 | 2008-12-03 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against Claudin-18 for treatment of cancer |
CA2706419A1 (en) * | 2007-11-30 | 2009-06-04 | Glaxo Group Limited | Antigen-binding constructs binding il-13 |
MX2010008688A (en) | 2008-02-07 | 2010-08-30 | Schering Corp | Engineered anti-tslpr antibodies. |
US8871207B2 (en) * | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
ES2662519T3 (en) * | 2008-07-25 | 2018-04-06 | Institute For Research In Biomedicine | Neutralizing antibodies against influenza A virus and uses of these |
UA109633C2 (en) * | 2008-12-09 | 2015-09-25 | HUMAN ANTIBODY AGAINST TISSUE FACTOR | |
WO2011086001A1 (en) * | 2010-01-15 | 2011-07-21 | Cormus Srl | Antibodies for the treatment of hcv |
WO2011107989A1 (en) | 2010-03-01 | 2011-09-09 | Lostam Biopharmaceuticals Ltd | Improved therapeutic antibodies against flagellated pseudomonas aeruginosa |
GB201003701D0 (en) * | 2010-03-05 | 2010-04-21 | Cilian Ag | System for the expression of a protein |
EP2632951B1 (en) | 2010-10-27 | 2017-08-02 | Amgen Inc. | Dkk1 antibodies and methods of use |
US8771696B2 (en) | 2010-11-23 | 2014-07-08 | Regeneron Pharmaceuticals, Inc. | Method of reducing the severity of stress hyperglycemia with human antibodies to the glucagon receptor |
US9371383B2 (en) * | 2012-01-31 | 2016-06-21 | Regeneron Pharmaceuticals, Inc. | Anti-ASIC1 antibodies and uses thereof |
WO2013167153A1 (en) | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Antibodies useful in cancer diagnosis |
JO3462B1 (en) | 2012-08-22 | 2020-07-05 | Regeneron Pharma | Human Antibodies to GFR?3 and methods of use thereof |
WO2014127785A1 (en) | 2013-02-20 | 2014-08-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
EP4079760A3 (en) | 2013-03-15 | 2023-01-25 | Sanofi Pasteur Inc. | Antibodies against clostridium difficile toxins and methods of using the same |
WO2014204941A1 (en) * | 2013-06-17 | 2014-12-24 | The Johns Hopkins University | Antibodies to human resistin |
WO2016055432A2 (en) * | 2014-10-08 | 2016-04-14 | F. Hoffmann-La Roche Ag | Combination therapy of bispecific antibodies specific for fap and dr5 and chemotherapeutic agents |
KR102644115B1 (en) * | 2014-12-23 | 2024-03-05 | 브리스톨-마이어스 스큅 컴퍼니 | Antibodies to tigit |
KR102590740B1 (en) * | 2015-02-02 | 2023-10-18 | 칠드런스 헬스 케어 디/비/에이 칠드런스 미네소타 | Anti-surrogate light chain antibody |
WO2016165762A1 (en) | 2015-04-15 | 2016-10-20 | Ganymed Pharmaceuticals Ag | Drug conjugates comprising antibodies against claudin 18.2 |
CA2999747A1 (en) * | 2015-09-04 | 2017-03-09 | Remd Biotherapeutics, Inc. | Methods for treating heart failure using glucagon receptor antagonistic antibodies |
AR109625A1 (en) * | 2015-10-01 | 2019-01-09 | Potenza Therapeutics Inc | PROTEINS OF UNION TO ANTIGENS (ABP) THAT SELECTLY JOIN TIGIT AND METHODS FOR THE USE OF THE SAME |
WO2017055395A1 (en) * | 2015-10-02 | 2017-04-06 | F. Hoffmann-La Roche Ag | Anti-cd3xrob04 bispecific t cell activating antigen binding molecules |
EA201891121A1 (en) * | 2015-11-19 | 2018-12-28 | Бристол-Майерс Сквибб Компани | ANTIBODIES TO THE GLUKORTIKOID-INDUCED RECEPTOR OF THE TUMOR NECROSIS FACTOR (GITR) AND THEIR APPLICATIONS |
CN108495864A (en) * | 2016-01-22 | 2018-09-04 | 詹森生物科技公司 | Anti- ROR1 antibody, ROR1 × CD3 bispecific antibodies and its application method |
CA3024508A1 (en) * | 2016-05-27 | 2017-11-30 | Agenus Inc. | Anti-tim-3 antibodies and methods of use thereof |
KR20190038564A (en) | 2016-07-08 | 2019-04-08 | 카르스젠 테라퓨틱스 컴퍼니, 리미티드 | Antibodies to Anti-Claudine 18A2 and its Application |
WO2018151841A1 (en) * | 2017-02-17 | 2018-08-23 | Sanofi | Multispecific binding molecules having specificity to dystroglycan and laminin-2 |
US11312769B2 (en) * | 2017-03-22 | 2022-04-26 | Bluefin Biomedicine, Inc. | Anti-TMEFF1 antibodies and antibody drug conjugates |
CA3060573A1 (en) * | 2017-04-21 | 2018-10-25 | Baylor College Of Medicine | Oncolytic virotherapy and immunotherapy |
US10894833B2 (en) * | 2017-07-20 | 2021-01-19 | H. Lundbeck A/S | Agents, uses and methods for treatment |
EP3762031A4 (en) | 2018-03-08 | 2021-12-22 | Phanes Therapeutics, Inc. | Anti-claudin 18.2 antibodies and uses thereof |
CN112166123B (en) | 2018-03-14 | 2022-09-30 | 北京轩义医药科技有限公司 | Anti-claudin 18.2 antibodies |
EP3794037A4 (en) | 2018-05-18 | 2022-03-02 | Lanova Medicines Limited Company | Anti-claudin 18.2 antibodies and uses thereof |
WO2019242505A1 (en) | 2018-06-17 | 2019-12-26 | 上海健信生物医药科技有限公司 | Antibody targeting cldn18.2, bispecific antibody, adc, and car, and applications thereof |
WO2020018852A2 (en) | 2018-07-18 | 2020-01-23 | Askgene Pharma Inc. | Novel antibodies and methods for making and using the same |
WO2020025792A1 (en) | 2018-08-03 | 2020-02-06 | Amgen Research (Munich) Gmbh | Antibody constructs for cldn18.2 and cd3 |
CN110857322A (en) | 2018-08-22 | 2020-03-03 | 瑞阳(苏州)生物科技有限公司 | Anti-human claudin18.2 monoclonal antibody and application thereof |
CN110862454B (en) | 2018-08-27 | 2022-12-30 | 南京圣和药业股份有限公司 | anti-Claudin 18_2 antibody and application thereof |
BR112021007690A2 (en) | 2018-10-22 | 2021-08-10 | Shanghai GenBase Biotechnology Co., Ltd. | anti-cldn18.2 antibody and its use |
SG11202105885WA (en) | 2018-12-07 | 2021-07-29 | Zlip Holding Ltd | Anti-claudin antibodies and uses thereof |
CN113166246A (en) | 2018-12-28 | 2021-07-23 | 四川科伦博泰生物医药股份有限公司 | Antibody and application thereof |
WO2020139956A1 (en) | 2018-12-28 | 2020-07-02 | Sparx Therapeutics Inc. | Binding molecules specific for claudin 18.2, compositons and methods thereof, for treatment of cancer and other diseases |
CN109762067B (en) | 2019-01-17 | 2020-02-28 | 北京天广实生物技术股份有限公司 | Antibodies that bind human Claudin18.2 and uses thereof |
MX2021011887A (en) | 2019-03-29 | 2021-10-26 | Phanes Therapeutics Inc | Humanized anti-claudin 18.2 chimeric antigen receptors and uses thereof. |
US20220185881A1 (en) | 2019-04-01 | 2022-06-16 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-claudin 18.2 antibody and application thereof |
US20220372112A1 (en) | 2019-04-19 | 2022-11-24 | Keymed Biosciences Co., Ltd. | Tumor therapeutic agent and use thereof |
CN111944048B (en) | 2019-05-16 | 2023-10-03 | 启愈生物技术(上海)有限公司 | anti-CLDN antibody, pharmaceutical composition and detection method thereof |
BR112021023897A2 (en) | 2019-05-30 | 2022-01-25 | Shandong Boan Biotechnology Co Ltd | Chimeric antibody or antigen receptor targeting claudin18.2 |
KR20220032077A (en) | 2019-07-12 | 2022-03-15 | 퓨쳐진 바이오파머쓰티컬 (베이징) 코., 엘티디. | CLDN18.2 antibodies and uses thereof |
CA3146665A1 (en) | 2019-07-17 | 2021-01-21 | The Regents Of The University Of California | Claudin18 antibodies and methods of treating cancer |
TW202120558A (en) * | 2019-08-20 | 2021-06-01 | 中國大陸商邁博斯生物醫藥(蘇州)有限公司 | Novel anti- cldn18.2 antibodies |
-
2020
- 2020-02-03 EP EP20748335.5A patent/EP3917564A4/en active Pending
- 2020-02-03 WO PCT/US2020/016459 patent/WO2020160560A2/en unknown
- 2020-02-03 KR KR1020217027503A patent/KR20210134321A/en unknown
- 2020-02-03 SG SG11202108398YA patent/SG11202108398YA/en unknown
- 2020-02-03 AU AU2020217012A patent/AU2020217012A1/en active Pending
- 2020-02-03 CA CA3128502A patent/CA3128502A1/en active Pending
- 2020-02-03 CN CN202080025850.0A patent/CN113645996B/en active Active
- 2020-02-03 JP JP2021544859A patent/JP2022519118A/en active Pending
- 2020-02-03 US US17/427,909 patent/US11407828B2/en active Active
-
2022
- 2022-06-22 US US17/846,709 patent/US20230067757A1/en active Pending
- 2022-07-13 US US17/864,335 patent/US20230272063A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2020160560A2 (en) | 2020-08-06 |
WO2020160560A3 (en) | 2020-09-17 |
EP3917564A4 (en) | 2022-12-21 |
CN113645996A (en) | 2021-11-12 |
JP2022519118A (en) | 2022-03-18 |
US20220041712A1 (en) | 2022-02-10 |
US20230067757A1 (en) | 2023-03-02 |
AU2020217012A1 (en) | 2021-08-19 |
KR20210134321A (en) | 2021-11-09 |
US20230272063A1 (en) | 2023-08-31 |
US11407828B2 (en) | 2022-08-09 |
CA3128502A1 (en) | 2020-08-06 |
CN113645996B (en) | 2024-04-02 |
EP3917564A2 (en) | 2021-12-08 |
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