JP2015514068A5 - - Google Patents
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- Publication number
- JP2015514068A5 JP2015514068A5 JP2015501002A JP2015501002A JP2015514068A5 JP 2015514068 A5 JP2015514068 A5 JP 2015514068A5 JP 2015501002 A JP2015501002 A JP 2015501002A JP 2015501002 A JP2015501002 A JP 2015501002A JP 2015514068 A5 JP2015514068 A5 JP 2015514068A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- binding fragment
- rsv
- mpv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims description 25
- 102000036639 antigens Human genes 0.000 claims description 25
- 108091007433 antigens Proteins 0.000 claims description 25
- 239000012634 fragment Substances 0.000 claims description 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 16
- 208000015181 infectious disease Diseases 0.000 claims description 12
- 241001244708 Moroccan pepper virus Species 0.000 claims 18
- 241000724205 Rice stripe tenuivirus Species 0.000 claims 18
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 4
- 241000710181 Potato virus M Species 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261613197P | 2012-03-20 | 2012-03-20 | |
| US61/613,197 | 2012-03-20 | ||
| US201261655310P | 2012-06-04 | 2012-06-04 | |
| US61/655,310 | 2012-06-04 | ||
| PCT/IB2013/000627 WO2013140247A1 (en) | 2012-03-20 | 2013-03-14 | Antibodies that neutralize rsv, mpv and pvm and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018224174A Division JP6722264B2 (ja) | 2012-03-20 | 2018-11-29 | Ｒｓｖ、ｍｐｖおよびｐｖｍを中和する抗体およびその利用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514068A JP2015514068A (ja) | 2015-05-18 |
| JP2015514068A5 true JP2015514068A5 (enExample) | 2018-11-01 |
| JP6445423B2 JP6445423B2 (ja) | 2018-12-26 |
Family
ID=48471031
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015501002A Active JP6445423B2 (ja) | 2012-03-20 | 2013-03-14 | Ｒｓｖ、ｍｐｖおよびｐｖｍを中和する抗体およびその利用 |
| JP2018224174A Expired - Fee Related JP6722264B2 (ja) | 2012-03-20 | 2018-11-29 | Ｒｓｖ、ｍｐｖおよびｐｖｍを中和する抗体およびその利用 |
| JP2020106004A Active JP7069251B2 (ja) | 2012-03-20 | 2020-06-19 | Ｒｓｖ、ｍｐｖおよびｐｖｍを中和する抗体およびその利用 |
| JP2022076023A Pending JP2022132244A (ja) | 2012-03-20 | 2022-05-02 | Ｒｓｖ、ｍｐｖおよびｐｖｍを中和する抗体およびその利用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018224174A Expired - Fee Related JP6722264B2 (ja) | 2012-03-20 | 2018-11-29 | Ｒｓｖ、ｍｐｖおよびｐｖｍを中和する抗体およびその利用 |
| JP2020106004A Active JP7069251B2 (ja) | 2012-03-20 | 2020-06-19 | Ｒｓｖ、ｍｐｖおよびｐｖｍを中和する抗体およびその利用 |
| JP2022076023A Pending JP2022132244A (ja) | 2012-03-20 | 2022-05-02 | Ｒｓｖ、ｍｐｖおよびｐｖｍを中和する抗体およびその利用 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US9498531B2 (enExample) |
| EP (1) | EP2828293B1 (enExample) |
| JP (4) | JP6445423B2 (enExample) |
| KR (1) | KR102149069B1 (enExample) |
| CN (2) | CN107880121B (enExample) |
| AU (1) | AU2013237087B2 (enExample) |
| BR (1) | BR112014023063A2 (enExample) |
| CA (1) | CA2865856C (enExample) |
| DK (1) | DK2828293T3 (enExample) |
| EA (1) | EA030319B1 (enExample) |
| ES (1) | ES2657470T3 (enExample) |
| IL (1) | IL234710A (enExample) |
| IN (1) | IN2014DN07299A (enExample) |
| NZ (1) | NZ630920A (enExample) |
| PL (1) | PL2828293T3 (enExample) |
| WO (1) | WO2013140247A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ630920A (en) | 2012-03-20 | 2017-01-27 | Humabs Biomed Sa | Antibodies that neutralize rsv, mpv and pvm and uses thereof |
| WO2014115893A1 (ja) | 2013-01-28 | 2014-07-31 | 株式会社イーベック | ヒト・メタニューモウイルスに特異的なヒト抗体もしくはその抗原結合性断片 |
| TWI659968B (zh) | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒ｆ蛋白質的人類抗體及其使用方法 |
| WO2020160171A1 (en) * | 2019-01-29 | 2020-08-06 | Sanford Burnham Prebys Medical Discovery Institute | Topically formulated antibody compositions for reducing pathogen transmission and methods of using same |
| US20230085439A1 (en) * | 2019-05-21 | 2023-03-16 | University Of Georgia Research Foundation, Inc. | Antibodies that bind human metapneumovirus fusion protein and their use |
| US20240101648A1 (en) * | 2021-02-09 | 2024-03-28 | Humabs Biomed Sa | Antibodies against respiratory syncytial virus, human metapneumovirus and pneumonia virus of mice and methods of using the same |
| WO2022183018A1 (en) * | 2021-02-26 | 2022-09-01 | Fred Hutchinson Cancer Research Center | Protective antibodies against respiratory viral infections |
| CN115466326B (zh) * | 2021-06-11 | 2024-06-04 | 中国科学院微生物研究所 | 一种呼吸道合胞病毒的人源单克隆抗体及其应用 |
| WO2025015321A1 (en) * | 2023-07-13 | 2025-01-16 | Vir Biotechnology, Inc. | Broadly neutralizing antibodies against rsv and mpv paramyxoviruses |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3766162A (en) | 1971-08-24 | 1973-10-16 | Hoffmann La Roche | Barbituric acid antigens and antibodies specific therefor |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4233402A (en) | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
| JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
| US4609546A (en) | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US4831175A (en) | 1986-09-05 | 1989-05-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
| US5595721A (en) | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
| MY133346A (en) | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
| US20020102208A1 (en) | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
| UA93981C2 (ru) | 2001-01-19 | 2011-03-25 | Вироновативе Б.B. | Вирус, который вызывает заболевание дыхательных путей у чувствительных k этому млекопитающих |
| US8420353B2 (en) | 2002-03-22 | 2013-04-16 | Aprogen, Inc. | Humanized antibody and process for preparing same |
| CA2494485A1 (en) * | 2002-07-25 | 2004-02-05 | Medimmune, Inc. | Methods of treating and preventing rsv, hmpv, and piv using anti-rsv, anti-hmpv, and anti-piv antibodies |
| AU2004215125B2 (en) | 2003-02-26 | 2011-01-06 | Institute For Research In Biomedicine | Monoclonal antibody production by EBV transformation of B cells |
| WO2004092207A2 (en) * | 2003-04-16 | 2004-10-28 | Algonomics N.V. | Respiratory syncytial virus (rsv) peptides |
| EP1473037A1 (en) | 2003-05-02 | 2004-11-03 | Vironovative B.V. | Treatment of hPMV infections with Ribavirin |
| WO2006110214A2 (en) * | 2005-04-08 | 2006-10-19 | Medimmune, Inc. | Antibodies against mammalian metapneumovirus |
| EP1997830A1 (en) * | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
| ES2525346T3 (es) | 2008-10-22 | 2014-12-22 | Institute For Research In Biomedicine | Métodos para producir anticuerpos a partir de células plasmáticas |
| WO2010149743A2 (en) | 2009-06-24 | 2010-12-29 | Id Biomedical Corporation Of Quebec | Vaccine |
| US8568719B2 (en) * | 2009-08-13 | 2013-10-29 | Crucell Holland B.V. | Antibodies against human respiratory syncytial virus (RSV) and methods of use |
| CA3062786C (en) * | 2010-07-09 | 2022-04-19 | Janssen Vaccines & Prevention B.V. | Anti-human respiratory syncytial virus (rsv) antibodies and methods of use |
| NZ630920A (en) | 2012-03-20 | 2017-01-27 | Humabs Biomed Sa | Antibodies that neutralize rsv, mpv and pvm and uses thereof |
-
2013
- 2013-03-14 NZ NZ630920A patent/NZ630920A/en not_active IP Right Cessation
- 2013-03-14 KR KR1020147029324A patent/KR102149069B1/ko not_active Expired - Fee Related
- 2013-03-14 DK DK13724357.2T patent/DK2828293T3/en active
- 2013-03-14 CN CN201711120146.XA patent/CN107880121B/zh active Active
- 2013-03-14 JP JP2015501002A patent/JP6445423B2/ja active Active
- 2013-03-14 EA EA201491724A patent/EA030319B1/ru unknown
- 2013-03-14 BR BR112014023063A patent/BR112014023063A2/pt active Search and Examination
- 2013-03-14 US US13/827,845 patent/US9498531B2/en active Active
- 2013-03-14 EP EP13724357.2A patent/EP2828293B1/en active Active
- 2013-03-14 ES ES13724357.2T patent/ES2657470T3/es active Active
- 2013-03-14 CA CA2865856A patent/CA2865856C/en active Active
- 2013-03-14 AU AU2013237087A patent/AU2013237087B2/en not_active Ceased
- 2013-03-14 WO PCT/IB2013/000627 patent/WO2013140247A1/en not_active Ceased
- 2013-03-14 CN CN201380026218.8A patent/CN104350069B/zh active Active
- 2013-03-14 PL PL13724357T patent/PL2828293T3/pl unknown
-
2014
- 2014-08-29 IN IN7299DEN2014 patent/IN2014DN07299A/en unknown
- 2014-09-17 IL IL234710A patent/IL234710A/en active IP Right Grant
-
2016
- 2016-08-10 US US15/233,026 patent/US10072071B2/en active Active
-
2018
- 2018-08-09 US US16/059,408 patent/US20190153073A1/en not_active Abandoned
- 2018-11-29 JP JP2018224174A patent/JP6722264B2/ja not_active Expired - Fee Related
-
2020
- 2020-05-27 US US16/885,009 patent/US11421020B2/en active Active
- 2020-06-19 JP JP2020106004A patent/JP7069251B2/ja active Active
-
2022
- 2022-05-02 JP JP2022076023A patent/JP2022132244A/ja active Pending