JP2018518540A5 - - Google Patents

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Publication number
JP2018518540A5
JP2018518540A5 JP2018519261A JP2018519261A JP2018518540A5 JP 2018518540 A5 JP2018518540 A5 JP 2018518540A5 JP 2018519261 A JP2018519261 A JP 2018519261A JP 2018519261 A JP2018519261 A JP 2018519261A JP 2018518540 A5 JP2018518540 A5 JP 2018518540A5
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JP
Japan
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seq
amino acid
binding protein
antigen
vector
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JP2018519261A
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English (en)
Japanese (ja)
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JP2018518540A (ja
JP6974311B2 (ja
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Priority claimed from PCT/US2016/039015 external-priority patent/WO2016210129A1/en
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Publication of JP2018518540A5 publication Critical patent/JP2018518540A5/ja
Priority to JP2021117516A priority Critical patent/JP2021177768A/ja
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Publication of JP6974311B2 publication Critical patent/JP6974311B2/ja
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JP2018519261A 2015-06-23 2016-06-23 新規pd−1免疫調節剤 Active JP6974311B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021117516A JP2021177768A (ja) 2015-06-23 2021-07-16 新規pd−1免疫調節剤

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562183297P 2015-06-23 2015-06-23
US62/183,297 2015-06-23
US201562266398P 2015-12-11 2015-12-11
US62/266,398 2015-12-11
PCT/US2016/039015 WO2016210129A1 (en) 2015-06-23 2016-06-23 Novel pd-1 immune modulating agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021117516A Division JP2021177768A (ja) 2015-06-23 2021-07-16 新規pd−1免疫調節剤

Publications (3)

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JP2018518540A JP2018518540A (ja) 2018-07-12
JP2018518540A5 true JP2018518540A5 (enExample) 2019-08-08
JP6974311B2 JP6974311B2 (ja) 2021-12-01

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JP2018519261A Active JP6974311B2 (ja) 2015-06-23 2016-06-23 新規pd−1免疫調節剤
JP2021117516A Ceased JP2021177768A (ja) 2015-06-23 2021-07-16 新規pd−1免疫調節剤

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JP2021117516A Ceased JP2021177768A (ja) 2015-06-23 2021-07-16 新規pd−1免疫調節剤

Country Status (11)

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US (1) US11136392B2 (enExample)
EP (1) EP3313883B1 (enExample)
JP (2) JP6974311B2 (enExample)
KR (1) KR20180019725A (enExample)
CN (2) CN114133448A (enExample)
AU (1) AU2016281641B2 (enExample)
CA (1) CA3006224A1 (enExample)
HK (1) HK1254803A1 (enExample)
IL (1) IL256463A (enExample)
TW (1) TWI773647B (enExample)
WO (1) WO2016210129A1 (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3298033T (pt) 2015-05-18 2020-09-22 Tcr2 Therapeutics Inc Composições e utilizações médicas para reprogramação de tcr utilizando proteínas de fusão
TWI773647B (zh) * 2015-06-23 2022-08-11 史隆凱特林紀念癌症中心 新穎pd-1免疫調控劑
CN108368170B (zh) 2015-07-13 2022-04-15 西托姆克斯治疗公司 抗pd-1抗体、可活化抗pd-1抗体及其使用方法
KR102434314B1 (ko) 2015-09-01 2022-08-19 아게누스 인코포레이티드 항-pd-1 항체 및 이를 이용하는 방법
EA201890790A1 (ru) 2015-09-29 2018-10-31 Селджин Корпорейшн Связывающие pd-1 белки и способы их применения
PL3356411T3 (pl) 2015-10-02 2021-12-06 F. Hoffmann-La Roche Ag Przeciwciała dwuswoiste swoiste dla PD1 i TIM3
HUE057837T2 (hu) 2015-11-03 2022-06-28 Janssen Biotech Inc PD-1-et specifikusan kötõ ellenanyagok és alkalmazásaik
WO2017133175A1 (en) * 2016-02-04 2017-08-10 Nanjing Legend Biotech Co., Ltd. Engineered mammalian cells for cancer therapy
EP3432924A1 (en) 2016-03-23 2019-01-30 Novartis AG Cell secreted minibodies and uses thereof
WO2017180587A2 (en) 2016-04-11 2017-10-19 Obsidian Therapeutics, Inc. Regulated biocircuit systems
WO2018053401A1 (en) 2016-09-19 2018-03-22 Celgene Corporation Methods of treating vitiligo using pd-1 binding proteins
JP2019531284A (ja) 2016-09-19 2019-10-31 セルジーン コーポレイション Pd−1結合タンパク質を使用して免疫障害を治療する方法
EP3544996A2 (en) 2016-11-22 2019-10-02 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
WO2018106864A1 (en) 2016-12-07 2018-06-14 Agenus Inc. Antibodies and methods of use thereof
JP6430682B2 (ja) * 2016-12-19 2018-11-28 昭和電工株式会社 レドックスフロー電池の運転方法
AU2018234810B2 (en) 2017-03-15 2023-05-11 Pandion Operations, Inc. Targeted immunotolerance
EP3606946B1 (en) 2017-04-03 2022-08-24 F. Hoffmann-La Roche AG Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15
DK3606954T3 (en) * 2017-04-05 2022-09-26 Hoffmann La Roche Anti-LAG3-antistoffer
IL268527B2 (en) 2017-04-05 2024-03-01 Hoffmann La Roche Bispecific antibodies specifically binding to pd1 and lag3
WO2018195348A1 (en) * 2017-04-19 2018-10-25 University Of Southern California Compositions and methods for treating cancer
US11965021B2 (en) 2017-04-26 2024-04-23 Eureka Therapeutics, Inc. Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof
US11427636B2 (en) 2017-05-01 2022-08-30 The Children's Medical Center Corporation Methods and compositions relating to anti-PD1 antibody reagents
US10676516B2 (en) 2017-05-24 2020-06-09 Pandion Therapeutics, Inc. Targeted immunotolerance
CN111094350B (zh) * 2017-07-06 2024-09-03 美勒斯公司 调节由细胞表达的生物活性的抗体
WO2019018727A1 (en) * 2017-07-21 2019-01-24 Washington University METHODS AND COMPOSITIONS FOR T-CELL ACTIVATION
PE20200850A1 (es) 2017-11-01 2020-08-20 Juno Therapeutics Inc Receptores de antigenos quimericos especificos para el antigeno de maduracion de celulas b y polinucleotidos que codifican los mismos
US10174092B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
US12398209B2 (en) 2018-01-22 2025-08-26 Janssen Biotech, Inc. Methods of treating cancers with antagonistic anti-PD-1 antibodies
US20210069246A1 (en) * 2018-01-31 2021-03-11 Celgene Corporation Combination therapy using adoptive cell therapy and checkpoint inhibitor
EP3752601A4 (en) 2018-02-15 2022-03-23 Memorial Sloan-Kettering Cancer Center FOXP3-TARGETING AGENT COMPOSITIONS AND METHODS OF USE FOR ADOPTIVE CELL THERAPY
AR114127A1 (es) 2018-03-02 2020-07-22 Lilly Co Eli Anticuerpos agonistas contra pd-1 y usos de estos
JP7466459B2 (ja) 2018-04-17 2024-04-12 セルデックス セラピューティクス インコーポレイテッド 抗cd27および抗pd-l1抗体ならびに二重特異性構築物
SG11202101067XA (en) * 2018-07-04 2021-03-30 Cytoimmune Therapeutics Inc Compositions and methods for immunotherapy targeting flt3, pd-1, and/or pd-l1
US12263190B2 (en) 2018-11-08 2025-04-01 Juno Therapeutics, Inc. Methods and combinations for treatment and T cell modulation
CN111320690B (zh) * 2018-12-17 2022-04-05 程联胜 一种抗人Tim3单克隆抗体及其应用
CN111748580B (zh) * 2019-03-28 2022-09-13 百奥泰生物制药股份有限公司 一种检测免疫检查点抗体活性的方法
CN111892655B (zh) * 2019-05-06 2022-10-28 四川大学 抗pd-1纳米抗体的筛选及应用
US11739146B2 (en) 2019-05-20 2023-08-29 Pandion Operations, Inc. MAdCAM targeted immunotolerance
US20220275088A1 (en) * 2019-06-14 2022-09-01 Dana-Farber Cancer Institute, Inc. Antibodies against pd-1 and methods of use thereof
KR20220030956A (ko) 2019-07-05 2022-03-11 오노 야꾸힝 고교 가부시키가이샤 Pd-1/cd3 이중 특이성 단백질에 의한 혈액암 치료
WO2021011480A1 (en) * 2019-07-12 2021-01-21 The Research Foundation For The State University Of New York Compositions and methods to block and bind cxcr4 to modulate cellular function
JP7771749B2 (ja) 2019-08-08 2025-11-18 小野薬品工業株式会社 二重特異性タンパク質
US20220289862A1 (en) * 2019-08-16 2022-09-15 H. Lee Moffitt Cancer Center And Research Institute, Inc. Anti-cd83 chimeric antigen receptor expressing t regulatory cells
CN112852740A (zh) * 2019-11-27 2021-05-28 深圳市菲鹏生物治疗股份有限公司 Car-t细胞和检测方法
US11981715B2 (en) 2020-02-21 2024-05-14 Pandion Operations, Inc. Tissue targeted immunotolerance with a CD39 effector
HUE069403T2 (hu) 2020-05-26 2025-03-28 Boehringer Ingelheim Int Anti-PD-1 antitestek
CN114437229B (zh) * 2020-11-01 2024-03-12 复旦大学 携带pd-1単链抗体且靶向egfr抗原的car t免疫细胞的制备及其用途
CN112812174A (zh) * 2021-01-15 2021-05-18 新乡学院 猪pd-l14qn-af表位多肽及其应用
CN115521378B (zh) * 2021-07-23 2023-12-22 南京吉盛澳玛生物医药有限公司 Pd-l1抗体及其用途
WO2024182754A2 (en) * 2023-03-02 2024-09-06 Fred Hutchinson Cancer Center Anti-pd-1 chimeric antigen receptor t cells and therapeutic uses thereof
WO2025059162A1 (en) 2023-09-11 2025-03-20 Dana-Farber Cancer Institute, Inc. Car-engager containing il-2 variants to enhance the functionality of car t cells
WO2025085538A1 (en) * 2023-10-17 2025-04-24 Lanier Biotherapeutics, Inc. Alarmin binding molecules and treatment of cancer

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4834976A (en) * 1986-07-03 1989-05-30 Genetic Systems Corporation Monoclonal antibodies to pseudomonas aeruginosa flagella
BR0316880A (pt) * 2002-12-23 2005-10-25 Wyeth Corp Anticorpos contra pd-1 e usos dos mesmos
CA2970873C (en) * 2005-05-09 2022-05-17 E. R. Squibb & Sons, L.L.C. Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
US20100150918A1 (en) * 2007-04-03 2010-06-17 Micromet Ag Cross-species-specific binding domain
SI2170959T1 (sl) * 2007-06-18 2014-04-30 Merck Sharp & Dohme B.V. Protitelesa proti receptorjem pd-1 za humano programirano smrt
ES2723181T3 (es) * 2011-07-29 2019-08-22 Univ Pennsylvania Receptores de conmutación coestimulante
US20140242077A1 (en) 2013-01-23 2014-08-28 Abbvie, Inc. Methods and compositions for modulating an immune response
CN103965363B (zh) * 2013-02-06 2021-01-15 上海白泽生物科技有限公司 与pd-1和vegf高效结合的融合蛋白、其编码序列及用途
LT2961831T (lt) * 2013-02-26 2020-11-10 Memorial Sloan Kettering Cancer Center Kompozicijos ir būdai, skirti imunoterapijai
CN103242448B (zh) * 2013-05-27 2015-01-14 郑州大学 一种全人源化抗pd-1单克隆抗体及其制备方法和应用
CN104558177B (zh) * 2013-10-25 2020-02-18 苏州思坦维生物技术股份有限公司 拮抗抑制程序性死亡受体pd-1与其配体结合的单克隆抗体及其编码序列与用途
JP7174522B2 (ja) * 2014-12-05 2022-11-17 メモリアル スローン ケタリング キャンサー センター Fc受容体様5を標的とするキメラ抗原受容体およびその使用
CN104479020B (zh) * 2014-12-26 2019-08-02 上海复宏汉霖生物技术股份有限公司 一种抗pd-1人源抗体
CA2986713A1 (en) * 2015-05-22 2016-12-01 Memorial Sloan-Kettering Cancer Center T cell receptor-like antibodies specific for a prame peptide
TWI773647B (zh) * 2015-06-23 2022-08-11 史隆凱特林紀念癌症中心 新穎pd-1免疫調控劑
AU2016362402A1 (en) * 2015-12-04 2018-06-28 Eureka Therapeutics, Inc. Antibodies targeting Fc receptor-like 5 and methods of use
CN109069627A (zh) * 2016-01-14 2018-12-21 纪念斯隆-凯特琳癌症中心 对foxp3衍生肽特异性的t细胞受体样抗体
JP7086066B2 (ja) * 2016-11-02 2022-06-17 ジョンス セラピューティクス, インコーポレイテッド Pd-1に対する抗体及びその使用
KR20200070236A (ko) * 2017-09-26 2020-06-17 롱우드 유니버시티 면역치료제로서의 pd1-특이적 키메라 항원 수용체

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