JP6974311B2 - 新規pd−1免疫調節剤 - Google Patents

新規pd−1免疫調節剤 Download PDF

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JP6974311B2
JP6974311B2 JP2018519261A JP2018519261A JP6974311B2 JP 6974311 B2 JP6974311 B2 JP 6974311B2 JP 2018519261 A JP2018519261 A JP 2018519261A JP 2018519261 A JP2018519261 A JP 2018519261A JP 6974311 B2 JP6974311 B2 JP 6974311B2
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antigen
cells
seq
binding protein
cell
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JP2018518540A5 (enExample
JP2018518540A (ja
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ジェイ. ブレンチェンス,レニエ
ジェイン ジャクソン,ホリー
リュー,チェン
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Eureka Therapeutics Inc
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Eureka Therapeutics Inc
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JP2018519261A 2015-06-23 2016-06-23 新規pd−1免疫調節剤 Expired - Fee Related JP6974311B2 (ja)

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JP2021117516A JP2021177768A (ja) 2015-06-23 2021-07-16 新規pd−1免疫調節剤

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US201562183297P 2015-06-23 2015-06-23
US62/183,297 2015-06-23
US201562266398P 2015-12-11 2015-12-11
US62/266,398 2015-12-11
PCT/US2016/039015 WO2016210129A1 (en) 2015-06-23 2016-06-23 Novel pd-1 immune modulating agents

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US (1) US11136392B2 (enExample)
EP (1) EP3313883B1 (enExample)
JP (2) JP6974311B2 (enExample)
KR (1) KR20180019725A (enExample)
CN (2) CN108337890B (enExample)
AU (1) AU2016281641B2 (enExample)
CA (1) CA3006224A1 (enExample)
HK (1) HK1254803A1 (enExample)
IL (1) IL256463A (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021177768A (ja) * 2015-06-23 2021-11-18 メモリアル スローン ケタリング キャンサー センター 新規pd−1免疫調節剤

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3770168A1 (en) 2015-05-18 2021-01-27 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
PT3310805T (pt) 2015-06-19 2021-05-19 Kobold Sebastian Proteínas de fusão pd-1-cd28 e a sua utilização em medicina
MX383464B (es) 2015-07-13 2025-03-14 Cytomx Therapeutics Inc Anticuerpos anti-pd-1, anticuerpos anti-pd-1 activables, y métodos de uso de los mismos.
JP6869987B2 (ja) 2015-09-01 2021-05-12 アジェナス インコーポレイテッド 抗pd−1抗体及びその使用方法
BR112018006237A2 (pt) 2015-09-29 2018-10-09 Celgene Corp proteínas de ligação a pd-1 e métodos de uso das mesmas
MA43028B1 (fr) 2015-10-02 2021-09-30 Hoffmann La Roche Anticorps bispécifiques pour pd1 et tim3
PT3370768T (pt) 2015-11-03 2022-04-21 Janssen Biotech Inc Anticorpos que se ligam especificamente ao pd-1 e seus usos
WO2017133175A1 (en) * 2016-02-04 2017-08-10 Nanjing Legend Biotech Co., Ltd. Engineered mammalian cells for cancer therapy
EP3432924A1 (en) 2016-03-23 2019-01-30 Novartis AG Cell secreted minibodies and uses thereof
WO2017180587A2 (en) 2016-04-11 2017-10-19 Obsidian Therapeutics, Inc. Regulated biocircuit systems
EP3515944A4 (en) 2016-09-19 2020-05-06 Celgene Corporation METHOD FOR TREATING IMMUNE DISEASES USING PD-1 BINDING PROTEINS
EP3515943A4 (en) 2016-09-19 2020-05-06 Celgene Corporation METHODS OF TREATING VITILIGO WITH PD-1 BINDING PROTEINS
CN110177803A (zh) 2016-11-22 2019-08-27 T细胞受体治疗公司 用于使用融合蛋白进行tcr重新编程的组合物和方法
CN110300599B (zh) 2016-12-07 2024-07-02 艾吉纳斯公司 抗体和其使用方法
US20190334192A1 (en) * 2016-12-19 2019-10-31 Showa Denko K.K. Method for operating redox flow cell
BR112019018915A2 (pt) 2017-03-15 2020-04-14 Pandion Therapeutics Inc imunotolerância direcionada
KR102461885B1 (ko) 2017-04-03 2022-11-03 에프. 호프만-라 로슈 아게 항-pd-1 항체와 돌연변이 il-2 또는 il-15의 면역접합체
CA3052532A1 (en) 2017-04-05 2018-10-11 F. Hoffmann-La Roche Ag Bispecific antibodies specifically binding to pd1 and lag3
UA128387C2 (uk) * 2017-04-05 2024-07-03 Ф. Хоффманн-Ля Рош Аг Антитіло до lag3
JP2020517263A (ja) * 2017-04-19 2020-06-18 ユニバーシティ オブ サザン カリフォルニア がんを治療するための組成物及び方法
WO2018200582A1 (en) 2017-04-26 2018-11-01 Eureka Therapeutics, Inc. Chimeric antibody/t-cell receptor constructs and uses thereof
CN110809582B (zh) * 2017-05-01 2023-12-22 儿童医疗中心有限公司 涉及抗pd1抗体试剂的方法以及组合物
AU2018273914A1 (en) 2017-05-24 2019-11-14 Pandion Operations, Inc. Targeted immunotolerance
KR20200037250A (ko) * 2017-07-06 2020-04-08 메뤼스 엔.페. 세포에 의해 발현되는 생물학적 활성을 조절하는 항체
US11884934B2 (en) * 2017-07-21 2024-01-30 Washington University Methods and compositions for T cell activation
US11851679B2 (en) 2017-11-01 2023-12-26 Juno Therapeutics, Inc. Method of assessing activity of recombinant antigen receptors
US11066475B2 (en) 2017-11-01 2021-07-20 Juno Therapeutics, Inc. Chimeric antigen receptors specific for B-cell maturation antigen and encoding polynucleotides
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
US12398209B2 (en) 2018-01-22 2025-08-26 Janssen Biotech, Inc. Methods of treating cancers with antagonistic anti-PD-1 antibodies
CN111971059A (zh) * 2018-01-31 2020-11-20 细胞基因公司 使用过继细胞疗法和检查点抑制剂的组合疗法
CN112041432A (zh) 2018-02-15 2020-12-04 纪念斯隆-凯特林癌症中心 Foxp3靶向剂组合物以及用于过继细胞疗法的使用方法
TWI708787B (zh) 2018-03-02 2020-11-01 美商美國禮來大藥廠 Pd-1促效劑抗體及其用途
KR20210011919A (ko) 2018-04-17 2021-02-02 셀덱스 쎄라퓨틱스, 인크. 항-cd27 항체 및 항-pd-l1 항체 및 이중특이적 작제물
AU2019299555A1 (en) * 2018-07-04 2021-02-25 Cytoimmune Therapeutics, Inc. Compositions and methods for immunotherapy targeting FLT3, PD-1, and/or PD-L1
CN113573719A (zh) 2018-11-08 2021-10-29 朱诺治疗学股份有限公司 治疗和t细胞调节的方法和组合
CN111320690B (zh) * 2018-12-17 2022-04-05 程联胜 一种抗人Tim3单克隆抗体及其应用
CN111748580B (zh) * 2019-03-28 2022-09-13 百奥泰生物制药股份有限公司 一种检测免疫检查点抗体活性的方法
CN111892655B (zh) * 2019-05-06 2022-10-28 四川大学 抗pd-1纳米抗体的筛选及应用
AU2020279240A1 (en) 2019-05-20 2021-12-23 Pandion Operations, Inc. MAdCAM targeted immunotolerance
JP7680967B2 (ja) * 2019-06-14 2025-05-21 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド Pd-1に対する抗体およびその使用方法
JP6881658B2 (ja) 2019-07-05 2021-06-02 小野薬品工業株式会社 Pd−1/cd3二重特異性タンパク質による血液がん治療
WO2021011480A1 (en) * 2019-07-12 2021-01-21 The Research Foundation For The State University Of New York Compositions and methods to block and bind cxcr4 to modulate cellular function
WO2021025140A1 (ja) 2019-08-08 2021-02-11 小野薬品工業株式会社 二重特異性タンパク質
EP4013447A4 (en) * 2019-08-16 2024-05-29 H. Lee Moffitt Cancer Center & Research Institute, Inc. T CELLS EXPRESSING A CHIMERIC ANTI-CD83 ANTIGEN RECEPTOR
CN112852740A (zh) * 2019-11-27 2021-05-28 深圳市菲鹏生物治疗股份有限公司 Car-t细胞和检测方法
WO2021133036A1 (ko) 2019-12-23 2021-07-01 주식회사 엘지화학 항-lilrb1 항체 및 그의 용도
US11981715B2 (en) 2020-02-21 2024-05-14 Pandion Operations, Inc. Tissue targeted immunotolerance with a CD39 effector
CA3181776A1 (en) 2020-05-26 2021-12-02 Boehringer Ingelheim International Gmbh Anti-pd-1 antibodies
CN114437229B (zh) * 2020-11-01 2024-03-12 复旦大学 携带pd-1単链抗体且靶向egfr抗原的car t免疫细胞的制备及其用途
CN112812174A (zh) * 2021-01-15 2021-05-18 新乡学院 猪pd-l14qn-af表位多肽及其应用
CN115521378B (zh) * 2021-07-23 2023-12-22 南京吉盛澳玛生物医药有限公司 Pd-l1抗体及其用途
WO2024182754A2 (en) * 2023-03-02 2024-09-06 Fred Hutchinson Cancer Center Anti-pd-1 chimeric antigen receptor t cells and therapeutic uses thereof
CN121969385A (zh) 2023-09-11 2026-05-01 丹娜-法伯癌症研究院 含有il-2变体以增强car t细胞的功能性的car-衔接子
WO2025085538A1 (en) * 2023-10-17 2025-04-24 Lanier Biotherapeutics, Inc. Alarmin binding molecules and treatment of cancer

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4834976A (en) * 1986-07-03 1989-05-30 Genetic Systems Corporation Monoclonal antibodies to pseudomonas aeruginosa flagella
ES2367430T3 (es) * 2002-12-23 2011-11-03 Wyeth Llc Anticuerpos contra pd-1 y sus usos.
EP3530736A3 (en) * 2005-05-09 2019-11-06 ONO Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
WO2008119565A2 (en) * 2007-04-03 2008-10-09 Micromet Ag Cross-species-specific binding domain
PT2170959E (pt) * 2007-06-18 2014-01-07 Merck Sharp & Dohme Anticorpos para o receptor humano de morte programada pd-1
MX2014001222A (es) * 2011-07-29 2014-09-15 Univ Pennsylvania Receptores coestimuladores de cambio.
EP2948475A2 (en) 2013-01-23 2015-12-02 AbbVie Inc. Methods and compositions for modulating an immune response
CN103965363B (zh) * 2013-02-06 2021-01-15 上海白泽生物科技有限公司 与pd-1和vegf高效结合的融合蛋白、其编码序列及用途
IL298125A (en) * 2013-02-26 2023-01-01 Memorial Sloan Kettering Cancer Center Preparations and methods for immunotherapy
CN103242448B (zh) * 2013-05-27 2015-01-14 郑州大学 一种全人源化抗pd-1单克隆抗体及其制备方法和应用
CN104558177B (zh) * 2013-10-25 2020-02-18 苏州思坦维生物技术股份有限公司 拮抗抑制程序性死亡受体pd-1与其配体结合的单克隆抗体及其编码序列与用途
WO2016090337A1 (en) * 2014-12-05 2016-06-09 Memorial Sloan-Kettering Cancer Center Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof
CN104479020B (zh) * 2014-12-26 2019-08-02 上海复宏汉霖生物技术股份有限公司 一种抗pd-1人源抗体
TW201702272A (zh) * 2015-05-22 2017-01-16 美國紀念斯隆 凱特琳癌症中心 Prame肽專一性類t細胞受體抗體
JP6974311B2 (ja) * 2015-06-23 2021-12-01 メモリアル スローン ケタリング キャンサー センター 新規pd−1免疫調節剤
PH12018501177B1 (en) * 2015-12-04 2024-01-24 Eureka Therapeutics Inc Antibodies targeting fc receptor-like 5 and methods of use
US11505599B2 (en) * 2016-01-14 2022-11-22 Memorial Sloan-Kettering Cancer Center T cell receptor-like antibodies specific for Foxp3-derived peptides
LT3535298T (lt) * 2016-11-02 2021-12-27 Jounce Therapeutics, Inc. Antikūnai prieš pd-1 ir jų panaudojimas
JP2020536531A (ja) * 2017-09-26 2020-12-17 ロングウッド ユニバーシティーLongwood University 免疫療法としてのpd1特異的キメラ抗原受容体

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021177768A (ja) * 2015-06-23 2021-11-18 メモリアル スローン ケタリング キャンサー センター 新規pd−1免疫調節剤

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