|
GB335768A
(en)
|
1929-10-24 |
1930-10-02 |
Jacoviac Maurice |
Improvements in protecting devices for gramophone disc records
|
|
FI903489A7
(fi)
|
1988-11-11 |
1990-07-10 |
Medical Res Council |
Yhden osan sisältävät ligandit, näitä ligandeja sisältävät reseptorit, menetelmiä niiden valmistamiseksi sekä ligandien ja reseptorien käytt ö
|
|
SE509359C2
(sv)
|
1989-08-01 |
1999-01-18 |
Cemu Bioteknik Ab |
Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
|
|
WO1994002610A1
(en)
|
1992-07-17 |
1994-02-03 |
Dana-Farber Cancer Institute |
Method of intracellular binding of target molecules
|
|
DE69334275D1
(de)
|
1992-08-21 |
2009-05-20 |
Univ Bruxelles |
Immunoglobuline ohne Leichtkette
|
|
WO1994025591A1
(en)
|
1993-04-29 |
1994-11-10 |
Unilever N.V. |
PRODUCTION OF ANTIBODIES OR (FUNCTIONALIZED) FRAGMENTS THEREOF DERIVED FROM HEAVY CHAIN IMMUNOGLOBULINS OF $i(CAMELIDAE)
|
|
CA2162878A1
(en)
|
1993-06-09 |
1994-12-22 |
Leon Gerardus Joseph Frenken |
Process for producing fusion proteins comprising scfv fragments by a transformed mould
|
|
FR2708622B1
(fr)
|
1993-08-02 |
1997-04-18 |
Raymond Hamers |
Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides.
|
|
US6091639A
(en)
|
1993-08-27 |
2000-07-18 |
Kabushiki Kaisha Toshiba |
Non-volatile semiconductor memory device and data programming method
|
|
CA2169298A1
(en)
|
1993-09-10 |
1995-03-16 |
Martin Chalfie |
Uses of green fluorescent protein
|
|
WO1995021191A1
(en)
|
1994-02-04 |
1995-08-10 |
William Ward |
Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein
|
|
JPH10501681A
(ja)
|
1994-02-22 |
1998-02-17 |
ダナ−ファーバー キャンサー インスティチュート |
核酸送達システムならびにその合成および使用方法
|
|
US5625048A
(en)
|
1994-11-10 |
1997-04-29 |
The Regents Of The University Of California |
Modified green fluorescent proteins
|
|
EP0739981A1
(en)
|
1995-04-25 |
1996-10-30 |
Vrije Universiteit Brussel |
Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
|
|
US5693492A
(en)
|
1995-05-05 |
1997-12-02 |
Merck & Co., Inc. |
DNA encoding glutamate gated chloride channels
|
|
DE69604298T2
(de)
|
1995-09-22 |
2000-05-18 |
Bioimage A/S, Soeborg |
Varianten des grünen fluoreszenzproteins, gfp
|
|
US6027881A
(en)
|
1996-05-08 |
2000-02-22 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Mutant Aequorea victoria fluorescent proteins having increased cellular fluorescence
|
|
ATE374248T1
(de)
|
1996-06-27 |
2007-10-15 |
Vlaams Interuniv Inst Biotech |
Antikörpermoleküle, die spezifisch mit dem aktiven zentrum oder dem aktiven spalt eines zielmoleküls interagieren
|
|
US6124128A
(en)
|
1996-08-16 |
2000-09-26 |
The Regents Of The University Of California |
Long wavelength engineered fluorescent proteins
|
|
WO1998021355A1
(en)
|
1996-11-15 |
1998-05-22 |
Life Technologies, Inc. |
Mutants of green fluorescent protein
|
|
EP1027073A2
(en)
|
1996-11-19 |
2000-08-16 |
Sangstat Medical Corporation |
Enhanced effects for hapten conjugated therapeutics
|
|
US6329516B1
(en)
|
1997-04-28 |
2001-12-11 |
Fmc Corporation |
Lepidopteran GABA-gated chloride channels
|
|
DK1027439T3
(da)
|
1997-10-27 |
2010-05-10 |
Bac Ip Bv |
Multivalente antigenbindende proteiner
|
|
AU3596599A
(en)
|
1998-01-26 |
1999-08-09 |
Unilever Plc |
Method for producing antibody fragments
|
|
ID26964A
(id)
|
1998-02-19 |
2001-02-22 |
Xcyte Therapies Inc |
Komposisi dan metode untuk pengaturan pengaktifan limfosit
|
|
CA2326389C
(en)
|
1998-04-21 |
2007-01-23 |
Micromet Gesellschaft Fur Biomedizinische Forschung Mbh |
Novel cd19xcd3 specific polypeptides and uses thereof
|
|
EP0967284A1
(en)
|
1998-05-28 |
1999-12-29 |
Pfizer Limited |
Phosphodiesterases
|
|
GB9824632D0
(en)
|
1998-11-10 |
1999-01-06 |
Celltech Therapeutics Ltd |
Biological compounds
|
|
BR9916765A
(pt)
|
1999-01-05 |
2001-09-25 |
Unilever Nv |
Processo para produzir um material imunoadsorvente, uso de uma proteìna que é ligada por meio de uma ligação covalente a um fragmento de anticorpo, material imunadsorvente, uso de um material, e, kit de teste diagnóstico
|
|
ATE276359T1
(de)
|
1999-01-19 |
2004-10-15 |
Unilever Nv |
Verfahren zur herstellung von antikörperfragmenten
|
|
NZ513356A
(en)
|
1999-02-05 |
2004-01-30 |
Univ Leiden |
Method of modulating metabolite biosynthesis in recombinant cells using an AP2-domain transcription factor that is involved in the response of a plant cell to a jasmonate
|
|
WO2000055318A2
(en)
|
1999-03-15 |
2000-09-21 |
University Of British Columbia |
Abc1 polypeptide and methods and reagents for modulating cholesterol levels
|
|
CN1252264C
(zh)
|
1999-04-22 |
2006-04-19 |
荷兰联合利华有限公司 |
利用单价抗原－结合蛋白抑制病毒感染
|
|
EP1190065A2
(en)
|
1999-06-18 |
2002-03-27 |
Cv Therapeutics, Inc. |
Atp binding cassette transporter protein abc1 polypeptides
|
|
WO2001009300A2
(en)
|
1999-08-02 |
2001-02-08 |
Keygene N.V. |
Method for generating cgmmv resistant plants, genetic constructs, and obtained cgmmv-resistant plants
|
|
GB9922124D0
(en)
|
1999-09-17 |
1999-11-17 |
Pfizer Ltd |
Phosphodiesterase enzymes
|
|
US6479280B1
(en)
|
1999-09-24 |
2002-11-12 |
Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw |
Recombinant phages capable of entering host cells via specific interaction with an artificial receptor
|
|
DE19955408A1
(de)
|
1999-11-18 |
2001-05-23 |
Bayer Ag |
GABA-B-Rezeptoren
|
|
ATE440111T1
(de)
|
1999-11-29 |
2009-09-15 |
Bac Ip B V |
Immobilisierte antigenbindende moleküle aus einer domäne
|
|
ATE342922T1
(de)
|
1999-11-29 |
2006-11-15 |
Unilever Nv |
Immobilisierung von proteinen mit hilfe eines polypeptidsegments
|
|
US7608681B2
(en)
|
1999-12-24 |
2009-10-27 |
Genentech, Inc. |
Methods and compositions for prolonging elimination half-times of bioactive compounds
|
|
ATE428733T1
(de)
|
2000-03-14 |
2009-05-15 |
Unilever Nv |
Variabele domänen der schweren kette eines antikörpers gegen menschliche ernährungslipasen und deren verwendungen
|
|
US20030190598A1
(en)
|
2000-05-26 |
2003-10-09 |
Jasmid Tanha |
Single-domain antigen-binding antibody fragments derived from llama antibodies
|
|
US6741957B1
(en)
|
2000-07-21 |
2004-05-25 |
Daimlerchrysler Corporation |
Analytical tire model for vehicle durability and ride comfort analysis
|
|
AU2002229639A1
(en)
|
2000-12-13 |
2002-06-24 |
De Haard, Johannes Joseph Wilhelmus |
Camelidae antibody arrays
|
|
US7829084B2
(en)
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
EP1361892A4
(en)
|
2001-01-17 |
2004-10-13 |
Trubion Pharmaceuticals Inc |
BINDING DOMAIN FUSION PROTEIN Immunoglobulin
|
|
US7211395B2
(en)
|
2001-03-09 |
2007-05-01 |
Dyax Corp. |
Serum albumin binding moieties
|
|
JP4303105B2
(ja)
|
2001-06-28 |
2009-07-29 |
ドマンティス リミテッド |
二重特異性リガンドとその利用
|
|
US20060073141A1
(en)
|
2001-06-28 |
2006-04-06 |
Domantis Limited |
Compositions and methods for treating inflammatory disorders
|
|
CA2456121A1
(en)
|
2001-08-03 |
2003-02-20 |
Medical Research Council |
Intracellular antibodies
|
|
JP4213586B2
(ja)
|
2001-09-13 |
2009-01-21 |
株式会社抗体研究所 |
ラクダ抗体ライブラリーの作製方法
|
|
JP2005289809A
(ja)
|
2001-10-24 |
2005-10-20 |
Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) |
突然変異重鎖抗体
|
|
KR100599789B1
(ko)
|
2001-12-03 |
2006-07-12 |
삼성에스디아이 주식회사 |
방열효율이 향상된 플라즈마 디스플레이 장치 및 그 제조방법
|
|
EP1456410A2
(en)
|
2001-12-11 |
2004-09-15 |
AlgoNomics N.V. |
Method for displaying loops from immunoglobulin domains in different contexts
|
|
JP4323317B2
(ja)
|
2001-12-21 |
2009-09-02 |
フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー（ヴェーイーベー・ヴェーゼットウェー） |
可変領域配列のクローニング方法
|
|
WO2003055527A2
(en)
|
2002-01-03 |
2003-07-10 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw |
Immunoconjugates useful for treatment of tumours
|
|
CN1678634A
(zh)
|
2002-06-28 |
2005-10-05 |
多曼蒂斯有限公司 |
免疫球蛋白单个变体抗原结合区及其特异性构建体
|
|
GB2408369A
(en)
|
2002-09-10 |
2005-05-25 |
Acres Gaming Inc |
Method and device for collecting and reporting data
|
|
US7004940B2
(en)
|
2002-10-10 |
2006-02-28 |
Ethicon, Inc. |
Devices for performing thermal ablation having movable ultrasound transducers
|
|
EP1565482B1
(en)
|
2002-10-23 |
2014-04-30 |
Ludwig Institute for Cancer Research Ltd. |
A34 and a33-like 3 dna, proteins, antibodies thereto and methods of treatment using same
|
|
EP1558645B1
(en)
|
2002-11-08 |
2011-07-27 |
Ablynx N.V. |
Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation
|
|
NZ540194A
(en)
|
2002-11-08 |
2008-07-31 |
Ablynx Nv |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
|
GB0230203D0
(en)
|
2002-12-27 |
2003-02-05 |
Domantis Ltd |
Fc fusion
|
|
ATE444984T1
(de)
|
2002-12-31 |
2009-10-15 |
Nektar Therapeutics Al Corp |
Hydrolysestabile maleimidendgruppen-enthaltende polymere
|
|
US7461263B2
(en)
|
2003-01-23 |
2008-12-02 |
Unspam, Llc. |
Method and apparatus for a non-revealing do-not-contact list system
|
|
JP5087274B2
(ja)
|
2003-06-30 |
2012-12-05 |
ドマンティス リミテッド |
ポリペプチド
|
|
JP2007521234A
(ja)
|
2003-08-12 |
2007-08-02 |
ウィリアム エム ヤーブロー |
尋常性ざ瘡の治療薬及び使用方法
|
|
PT1687338E
(pt)
|
2003-11-07 |
2011-01-20 |
Ablynx Nv |
Anticorpos de domínio único vhh de camelídeos direccionados para o receptor do factor de crescimento epidérmico e suas utilizações
|
|
US7207410B2
(en)
|
2004-04-29 |
2007-04-24 |
Daimlerchrysler Corporation |
Apparatus and method for enhanced impact sensing
|
|
US7563443B2
(en)
|
2004-09-17 |
2009-07-21 |
Domantis Limited |
Monovalent anti-CD40L antibody polypeptides and compositions thereof
|
|
WO2006040153A2
(en)
|
2004-10-13 |
2006-04-20 |
Ablynx N.V. |
Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease
|
|
JP2008528010A
(ja)
|
2005-01-31 |
2008-07-31 |
アブリンクス ナームローゼ フェンノートシャップ |
重鎖抗体の可変ドメイン配列を作出する方法
|
|
AU2006249144B2
(en)
|
2005-05-18 |
2011-11-17 |
Ablynx Nv |
Improved NanobodiesTM against Tumor Necrosis Factor-alpha
|
|
LT2444424T
(lt)
|
2005-05-20 |
2018-10-25 |
Ablynx N.V. |
Pagerintos tm nanodalelės, skirtos agregacijos sąlygotų sutrikimų gydymui
|
|
JP2010500876A
(ja)
|
2006-08-18 |
2010-01-14 |
アブリンクス エン．ヴェー． |
Ｉｌ−６媒介性シグナル伝達に関連する疾患及び障害の治療のための、ｉｌ−６ｒに指向性を有するアミノ酸配列及びこれを含むポリペプチド
|
|
US20100113339A1
(en)
|
2006-09-08 |
2010-05-06 |
Ablynx N. V. |
Serum albumin binding proteins with long half-lives
|
|
US20100129368A9
(en)
|
2006-10-11 |
2010-05-27 |
Ablynx N.V. |
Amino acid sequences that bind to serum proteins in a manner that is essentially independent of the pH, compounds comprising the same, and uses thereof
|
|
US20100034194A1
(en)
|
2006-10-11 |
2010-02-11 |
Siemens Communications Inc. |
Eliminating unreachable subscribers in voice-over-ip networks
|
|
JP2010511397A
(ja)
|
2006-12-05 |
2010-04-15 |
アブリンクス エン．ヴェー． |
血清タンパク質と結合可能なペプチド
|
|
CN101663319A
(zh)
|
2007-02-21 |
2010-03-03 |
埃博灵克斯股份有限公司 |
针对血管内皮生长因子的氨基酸序列和包括其的多肽用于治疗特征在于过量和/或病理性血管发生或新血管形成的病症和疾病
|
|
MX2009012650A
(es)
|
2007-05-24 |
2010-02-18 |
Ablynx Nv |
Secuencias de aminoacido dirigidas contra rank-l y polipeptidos que comprenden lo mismo para el tratamiento de enfermedades y trastornos de huesos.
|
|
CA2706425A1
(en)
|
2007-11-27 |
2009-06-04 |
Ablynx N.V. |
Method for obtaining polypeptide constructs comprising two or more single domain antibodies
|
|
MX2010008578A
(es)
|
2008-02-08 |
2010-11-10 |
Medimmune Llc |
Anticuerpos anti-receptor 1 de interferon alfa con afinidad reducida al ligando fc.
|
|
CA2721202A1
(en)
|
2008-04-17 |
2009-10-22 |
Hilde Adi Pierrette Revets |
Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same
|
|
LT2285408T
(lt)
*
|
2008-06-05 |
2019-01-25 |
Ablynx N.V. |
Aminorūgščių sekos, nukreiptos prieš viruso apvalkalo baltymus, ir tokias sekas turintys polipeptidai, skirti virusinių ligų gydymui
|
|
MX2011010681A
(es)
|
2009-04-10 |
2012-01-20 |
Ablynx Nv |
Secuencias mejoradas de aminoacidos dirigidas contra il-6r y polipeptidos que comprenden el mismo para el tratamiento de enfermedades y trastornos relacionados con il-6r.
|
|
CA2759370C
(en)
|
2009-04-30 |
2020-02-11 |
Peter Schotte |
Method for the production of domain antibodies
|
|
ES2804450T3
(es)
|
2009-07-10 |
2021-02-08 |
Ablynx Nv |
Método para la producción de dominios variables
|
|
EP2531523A1
(en)
|
2010-02-05 |
2012-12-12 |
Ablynx N.V. |
Peptides capable of binding to serum albumin and compounds, constructs and polypeptides comprising the same
|
|
EP2632946B1
(en)
|
2010-10-29 |
2017-12-06 |
Ablynx N.V. |
Method for the production of immunoglobulin single variable domains
|
|
EP3974453A3
(en)
*
|
2010-11-16 |
2022-08-03 |
Amgen Inc. |
Agents and methods for treating diseases that correlate with bcma expression
|
|
LT3466972T
(lt)
|
2011-06-23 |
2026-06-25 |
Ablynx Nv |
Serumo albuminą surišantys baltymai
|
|
CA3141978A1
(en)
|
2011-06-23 |
2012-12-27 |
Ablynx Nv |
Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
|
|
EP2850106B1
(en)
*
|
2012-05-18 |
2022-03-23 |
Aptevo Research and Development LLC |
Bispecific scfv immunofusion (bif) binding to cd123 and cd3
|
|
US9657105B2
(en)
*
|
2013-03-15 |
2017-05-23 |
City Of Hope |
CD123-specific chimeric antigen receptor redirected T cells and methods of their use
|
|
EP2839842A1
(en)
|
2013-08-23 |
2015-02-25 |
MacroGenics, Inc. |
Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof
|
|
US20160251440A1
(en)
*
|
2013-09-26 |
2016-09-01 |
Ablynx N.V. |
Bispecific nanobodies
|
|
LT3248986T
(lt)
|
2014-05-16 |
2022-03-25 |
Ablynx Nv |
Imunoglobulino kintami domenai
|
|
EP3712171A1
(en)
*
|
2014-08-19 |
2020-09-23 |
Novartis AG |
Treatment of cancer using a cd123 chimeric antigen receptor
|
|
AR103488A1
(es)
*
|
2015-01-23 |
2017-05-10 |
Sanofi Sa |
Anticuerpos anti-cd3, anticuerpos anti-cd123 y anticuerpos biespecíficos que se unen específicamente a cd3 y/o cd123
|
|
HRP20191800T1
(hr)
|
2015-05-13 |
2019-12-27 |
Ablynx N.V. |
Polipeptidi koji regrutiraju t stanice koji se temelje na tcr alfa/beta reaktivnosti
|
|
AU2016357460B2
(en)
|
2015-11-18 |
2023-07-27 |
Ablynx Nv |
Improved serum albumin binders
|
|
US11840569B2
(en)
|
2016-11-16 |
2023-12-12 |
Ablynx N.V. |
T cell recruiting polypeptides capable of binding CD123 and TCR alpha/beta
|