JP2018537421A5 - - Google Patents
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- JP2018537421A5 JP2018537421A5 JP2018520394A JP2018520394A JP2018537421A5 JP 2018537421 A5 JP2018537421 A5 JP 2018537421A5 JP 2018520394 A JP2018520394 A JP 2018520394A JP 2018520394 A JP2018520394 A JP 2018520394A JP 2018537421 A5 JP2018537421 A5 JP 2018537421A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- cdr3
- cdr1
- cdr2
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562245188P | 2015-10-22 | 2015-10-22 | |
| US62/245,188 | 2015-10-22 | ||
| US201662276352P | 2016-01-08 | 2016-01-08 | |
| US62/276,352 | 2016-01-08 | ||
| PCT/EP2016/075558 WO2017068186A1 (en) | 2015-10-22 | 2016-10-24 | Gitr agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537421A JP2018537421A (ja) | 2018-12-20 |
| JP2018537421A5 true JP2018537421A5 (enExample) | 2019-11-07 |
| JP7084870B2 JP7084870B2 (ja) | 2022-06-15 |
Family
ID=57211500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018520394A Active JP7084870B2 (ja) | 2015-10-22 | 2016-10-24 | Ｇｉｔｒアゴニスト |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11059899B1 (enExample) |
| EP (1) | EP3365371B1 (enExample) |
| JP (1) | JP7084870B2 (enExample) |
| CN (1) | CN108473579B (enExample) |
| AU (1) | AU2016341403B2 (enExample) |
| CA (1) | CA3002711A1 (enExample) |
| ES (1) | ES3057922T3 (enExample) |
| HK (1) | HK1258509A1 (enExample) |
| WO (1) | WO2017068186A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017015623A2 (en) * | 2015-07-23 | 2017-01-26 | Inhibrx Lp | Multivalent and multispecific gitr-binding fusion proteins |
| US11059899B1 (en) | 2015-10-22 | 2021-07-13 | Ablynx N.V. | Polypeptides that bind glucocorticoid-induced TNFR family-related receptor (GITR) |
| TWI781934B (zh) | 2016-05-27 | 2022-11-01 | 美商艾吉納斯公司 | 抗-tim-3抗體及其使用方法 |
| CN109641967A (zh) | 2016-07-01 | 2019-04-16 | 戊瑞治疗有限公司 | 用GITR激动剂和CpG的组合的抗肿瘤疗法 |
| TW202436356A (zh) | 2016-10-11 | 2024-09-16 | 美商艾吉納斯公司 | 抗ｌａｇ－３抗體及其使用方法 |
| KR20200006115A (ko) | 2017-05-16 | 2020-01-17 | 브리스톨-마이어스 스큅 컴퍼니 | 항-gitr 효능제 항체에 의한 암의 치료 |
| CN110461874B (zh) | 2017-06-30 | 2022-04-12 | 江苏恒瑞医药股份有限公司 | 抗gitr抗体、其抗原结合片段及其医药用途 |
| CN110357958A (zh) * | 2018-03-26 | 2019-10-22 | 信达生物制药(苏州)有限公司 | 抗糖皮质激素诱导的肿瘤坏死因子受体(gitr)的小型化抗体、其聚合物及应用 |
| CN108640993B (zh) * | 2018-06-06 | 2020-09-04 | 暨南大学 | 一种抗重组人碱性成纤维细胞生长因子纳米抗体及其应用 |
| TW202035451A (zh) | 2018-07-24 | 2020-10-01 | 美商英伊布里克斯公司 | 含有受限cd3結合域及受體結合區之多重特異性多肽構築體及其使用方法 |
| RU2734432C1 (ru) | 2019-04-23 | 2020-10-16 | Закрытое Акционерное Общество "Биокад" | Моноклональное антитело, которое специфически связывается с GITR |
| MX2022006880A (es) * | 2019-12-06 | 2022-07-11 | Ablynx Nv | Polipeptidos que comprenden dominios variables unicos de inmunoglobulina dirigidos a tnf alfa e il-23. |
| MX2023003522A (es) * | 2020-09-25 | 2023-04-19 | Ablynx Nv | Polipeptidos que comprenden dominios variables unicos de inmunoglobulina que se dirigen a il-13 y ox40l. |
| WO2022129572A1 (en) * | 2020-12-18 | 2022-06-23 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting il-6 and tnf-alpha |
| CN112851811B (zh) * | 2021-01-28 | 2022-08-09 | 姜国胜 | 一种cd44v6纳米抗体及其作为白血病研究试剂的应用 |
| CN117813327A (zh) * | 2021-05-10 | 2024-04-02 | 美帝马布生物公司 | 抗gitr抗体及其用途 |
| WO2023213763A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab |
| WO2023213764A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf |
| US20260015405A1 (en) | 2022-07-01 | 2026-01-15 | Transgene | Fusion protein comprising a surfactant-protein-d and a member of the tnfsf |
| AR131494A1 (es) | 2022-12-23 | 2025-03-26 | Ablynx Nv | Vehículos de conjugación a base de proteína |
| EP4665755A1 (en) | 2023-02-17 | 2025-12-24 | Ablynx N.V. | Polypeptides binding to the neonatal fc receptor |
| US20250270274A1 (en) * | 2024-02-26 | 2025-08-28 | Serpentide Inc. | Super long-lasting glp1 or glp1/gip analogue drug for type-2 diabetes and obesity |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1809589A (zh) * | 2003-05-23 | 2006-07-26 | Wyeth公司 | Gitr配体和gitr配体相关分子和抗体及其应用 |
| WO2006105021A2 (en) | 2005-03-25 | 2006-10-05 | Tolerrx, Inc. | Gitr binding molecules and uses therefor |
| CN101218257A (zh) * | 2005-03-25 | 2008-07-09 | 托勒克斯股份有限公司 | Gitr结合分子及其用途 |
| RU2595409C2 (ru) * | 2009-09-03 | 2016-08-27 | Мерк Шарп И Доум Корп., | Анти-gitr-антитела |
| TW201605896A (zh) | 2013-08-30 | 2016-02-16 | 安美基股份有限公司 | Gitr抗原結合蛋白 |
| AU2015266958A1 (en) * | 2014-05-28 | 2016-12-08 | Agenus Inc. | Anti-GITR antibodies and methods of use thereof |
| JP6449338B2 (ja) | 2014-06-06 | 2019-01-09 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | グルココルチコイド誘導腫瘍壊死因子受容体（ｇｉｔｒ）に対する抗体およびその使用 |
| JP6812364B2 (ja) | 2015-06-03 | 2021-01-13 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 癌診断用抗ｇｉｔｒ抗体 |
| WO2017015623A2 (en) | 2015-07-23 | 2017-01-26 | Inhibrx Lp | Multivalent and multispecific gitr-binding fusion proteins |
| US11059899B1 (en) | 2015-10-22 | 2021-07-13 | Ablynx N.V. | Polypeptides that bind glucocorticoid-induced TNFR family-related receptor (GITR) |
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2016
- 2016-10-24 US US15/769,205 patent/US11059899B1/en active Active
- 2016-10-24 EP EP16788484.0A patent/EP3365371B1/en active Active
- 2016-10-24 HK HK19100858.0A patent/HK1258509A1/zh unknown
- 2016-10-24 ES ES16788484T patent/ES3057922T3/es active Active
- 2016-10-24 CA CA3002711A patent/CA3002711A1/en active Pending
- 2016-10-24 CN CN201680075294.1A patent/CN108473579B/zh active Active
- 2016-10-24 JP JP2018520394A patent/JP7084870B2/ja active Active
- 2016-10-24 AU AU2016341403A patent/AU2016341403B2/en active Active
- 2016-10-24 WO PCT/EP2016/075558 patent/WO2017068186A1/en not_active Ceased
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2021
- 2021-05-14 US US17/320,395 patent/US11919966B2/en active Active