JP2018537421A5 - - Google Patents
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- JP2018537421A5 JP2018537421A5 JP2018520394A JP2018520394A JP2018537421A5 JP 2018537421 A5 JP2018537421 A5 JP 2018537421A5 JP 2018520394 A JP2018520394 A JP 2018520394A JP 2018520394 A JP2018520394 A JP 2018520394A JP 2018537421 A5 JP2018537421 A5 JP 2018537421A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- cdr3
- cdr1
- cdr2
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562245188P | 2015-10-22 | 2015-10-22 | |
| US62/245,188 | 2015-10-22 | ||
| US201662276352P | 2016-01-08 | 2016-01-08 | |
| US62/276,352 | 2016-01-08 | ||
| PCT/EP2016/075558 WO2017068186A1 (en) | 2015-10-22 | 2016-10-24 | Gitr agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537421A JP2018537421A (ja) | 2018-12-20 |
| JP2018537421A5 true JP2018537421A5 (enExample) | 2019-11-07 |
| JP7084870B2 JP7084870B2 (ja) | 2022-06-15 |
Family
ID=57211500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018520394A Active JP7084870B2 (ja) | 2015-10-22 | 2016-10-24 | Ｇｉｔｒアゴニスト |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11059899B1 (enExample) |
| EP (1) | EP3365371B1 (enExample) |
| JP (1) | JP7084870B2 (enExample) |
| CN (1) | CN108473579B (enExample) |
| AU (1) | AU2016341403B2 (enExample) |
| CA (1) | CA3002711A1 (enExample) |
| ES (1) | ES3057922T3 (enExample) |
| WO (1) | WO2017068186A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3325512B1 (en) | 2015-07-23 | 2023-09-06 | Inhibrx, Inc. | Multivalent and multispecific gitr-binding fusion proteins |
| EP3365371B1 (en) | 2015-10-22 | 2025-10-08 | Ablynx NV | Gitr agonists |
| KR102543118B1 (ko) | 2016-05-27 | 2023-06-14 | 아게누스 인코포레이티드 | 항-tim-3 항체 및 이의 사용 방법 |
| US20190263919A1 (en) | 2016-07-01 | 2019-08-29 | Five Prime Therapeutics, Inc. | Combined anti tumor therapy with a gitr agonist and cpg |
| KR20230133934A (ko) | 2016-10-11 | 2023-09-19 | 아게누스 인코포레이티드 | 항-lag-3 항체 및 이의 사용 방법 |
| WO2018213297A1 (en) | 2017-05-16 | 2018-11-22 | Bristol-Myers Squibb Company | Treatment of cancer with anti-gitr agonist antibodies |
| TWI685504B (zh) | 2017-06-30 | 2020-02-21 | 大陸商江蘇恒瑞醫藥股份有限公司 | 抗gitr抗體、其抗原結合片段及其醫藥用途 |
| CN110357958A (zh) | 2018-03-26 | 2019-10-22 | 信达生物制药(苏州)有限公司 | 抗糖皮质激素诱导的肿瘤坏死因子受体(gitr)的小型化抗体、其聚合物及应用 |
| CN113105546B (zh) * | 2018-06-06 | 2022-02-08 | 暨南大学 | 一种抗重组人碱性成纤维细胞生长因子纳米抗体及其应用 |
| WO2020023553A1 (en) | 2018-07-24 | 2020-01-30 | Inhibrx, Inc. | Multispecific polypeptide constructs containing a constrained cd3 binding domain and a receptor binding region and methods of using the same |
| RU2734432C1 (ru) | 2019-04-23 | 2020-10-16 | Закрытое Акционерное Общество "Биокад" | Моноклональное антитело, которое специфически связывается с GITR |
| EP4069733A1 (en) | 2019-12-06 | 2022-10-12 | Ablynx N.V. | POLYPEPTIDES COMPRISING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS TARGETING TNFalpha AND IL-23 |
| WO2022063984A1 (en) * | 2020-09-25 | 2022-03-31 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting il-13 and ox40l |
| WO2022129572A1 (en) * | 2020-12-18 | 2022-06-23 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting il-6 and tnf-alpha |
| CN112851811B (zh) * | 2021-01-28 | 2022-08-09 | 姜国胜 | 一种cd44v6纳米抗体及其作为白血病研究试剂的应用 |
| JP7671092B2 (ja) * | 2021-05-10 | 2025-05-01 | メディマブバイオ インコーポレイテッド | 抗ｇｉｔｒ抗体およびその用途 |
| WO2023213763A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab |
| WO2023213764A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf |
| CN119654339A (zh) | 2022-07-01 | 2025-03-18 | 特兰斯吉恩股份有限公司 | 包含表面活性蛋白-d和tnfsf成员的融合蛋白 |
| US20240415974A1 (en) | 2022-12-23 | 2024-12-19 | Ablynx N.V. | Protein-based conjugation carriers |
| IL322519A (en) | 2023-02-17 | 2025-10-01 | Ablynx Nv | Polypeptides that bind to the neonatal fc receptor |
| US20250270274A1 (en) * | 2024-02-26 | 2025-08-28 | Serpentide Inc. | Super long-lasting glp1 or glp1/gip analogue drug for type-2 diabetes and obesity |
| WO2026133294A1 (en) * | 2024-12-20 | 2026-06-25 | Sanofi | Pd-1/gitr multispecific binding polypeptides and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1809589A (zh) * | 2003-05-23 | 2006-07-26 | Wyeth公司 | Gitr配体和gitr配体相关分子和抗体及其应用 |
| JP5238936B2 (ja) * | 2005-03-25 | 2013-07-17 | ジーアイティーアール，インク． | Ｇｉｔｒ結合分子およびその使用 |
| CN101218257A (zh) * | 2005-03-25 | 2008-07-09 | 托勒克斯股份有限公司 | Gitr结合分子及其用途 |
| IN2015DN02826A (enExample) * | 2009-09-03 | 2015-09-11 | Merck Sharp & Dohme | |
| TW201605896A (zh) | 2013-08-30 | 2016-02-16 | 安美基股份有限公司 | Gitr抗原結合蛋白 |
| LT3148579T (lt) * | 2014-05-28 | 2021-05-25 | Agenus Inc. | Anti-gitr antikūnai ir jų panaudojimo būdai |
| PL3151921T3 (pl) * | 2014-06-06 | 2020-02-28 | Bristol-Myers Squibb Company | Przeciwciała przeciwko receptorowi indukowanego glukokortykoidami czynnika martwicy nowotworu (gitr) i ich zastosowania |
| EP3304079B1 (en) * | 2015-06-03 | 2020-06-03 | Bristol-Myers Squibb Company | Anti-gitr antibodies for cancer diagnostics |
| EP3325512B1 (en) | 2015-07-23 | 2023-09-06 | Inhibrx, Inc. | Multivalent and multispecific gitr-binding fusion proteins |
| EP3365371B1 (en) | 2015-10-22 | 2025-10-08 | Ablynx NV | Gitr agonists |
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2016
- 2016-10-24 EP EP16788484.0A patent/EP3365371B1/en active Active
- 2016-10-24 AU AU2016341403A patent/AU2016341403B2/en active Active
- 2016-10-24 CA CA3002711A patent/CA3002711A1/en active Pending
- 2016-10-24 JP JP2018520394A patent/JP7084870B2/ja active Active
- 2016-10-24 US US15/769,205 patent/US11059899B1/en active Active
- 2016-10-24 WO PCT/EP2016/075558 patent/WO2017068186A1/en not_active Ceased
- 2016-10-24 CN CN201680075294.1A patent/CN108473579B/zh active Active
- 2016-10-24 ES ES16788484T patent/ES3057922T3/es active Active
-
2021
- 2021-05-14 US US17/320,395 patent/US11919966B2/en active Active