JP2018532766A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018532766A5 JP2018532766A5 JP2018526303A JP2018526303A JP2018532766A5 JP 2018532766 A5 JP2018532766 A5 JP 2018532766A5 JP 2018526303 A JP2018526303 A JP 2018526303A JP 2018526303 A JP2018526303 A JP 2018526303A JP 2018532766 A5 JP2018532766 A5 JP 2018532766A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- region
- antibody
- bcma
- cdr2l
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100035359 Cerebellar degeneration-related protein 2-like Human genes 0.000 claims description 28
- 101000737792 Homo sapiens Cerebellar degeneration-related protein 2-like Proteins 0.000 claims description 28
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 18
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims description 18
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 17
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 17
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 239000000427 antigen Substances 0.000 claims description 6
- 102000036639 antigens Human genes 0.000 claims description 6
- 108091007433 antigens Proteins 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 4
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims description 3
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 150000007523 nucleic acids Chemical class 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 208000023761 AL amyloidosis Diseases 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 208000005531 Immunoglobulin Light-chain Amyloidosis Diseases 0.000 claims description 2
- 208000034578 Multiple myelomas Diseases 0.000 claims description 2
- 208000021161 Plasma cell disease Diseases 0.000 claims description 2
- 230000006044 T cell activation Effects 0.000 claims description 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 208000031223 plasma cell leukemia Diseases 0.000 claims description 2
- 238000003786 synthesis reaction Methods 0.000 claims description 2
- 230000001131 transforming effect Effects 0.000 claims description 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 description 9
- 229940024606 amino acid Drugs 0.000 description 9
- 150000001413 amino acids Chemical group 0.000 description 9
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 5
- 230000003211 malignant effect Effects 0.000 description 4
- 210000004180 plasmocyte Anatomy 0.000 description 4
- 239000004475 Arginine Substances 0.000 description 3
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 3
- 239000004472 Lysine Substances 0.000 description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 3
- 235000013922 glutamic acid Nutrition 0.000 description 3
- 239000004220 glutamic acid Substances 0.000 description 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
- 241000282567 Macaca fascicularis Species 0.000 description 2
- 235000003704 aspartic acid Nutrition 0.000 description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 description 2
- 206010025135 lupus erythematosus Diseases 0.000 description 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 201000000050 myeloid neoplasm Diseases 0.000 description 2
- 238000002823 phage display Methods 0.000 description 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- 101000801255 Homo sapiens Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 102000046935 human TNFRSF17 Human genes 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000004091 panning Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020054175A JP6903188B2 (ja) | 2015-08-03 | 2020-03-25 | Ｂｃｍａに対するモノクローナル抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15179549 | 2015-08-03 | ||
| EP15179549.9 | 2015-08-03 | ||
| PCT/EP2016/068549 WO2017021450A1 (en) | 2015-08-03 | 2016-08-03 | Monoclonal antibodies against bcma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020054175A Division JP6903188B2 (ja) | 2015-08-03 | 2020-03-25 | Ｂｃｍａに対するモノクローナル抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018532766A JP2018532766A (ja) | 2018-11-08 |
| JP2018532766A5 true JP2018532766A5 (enExample) | 2019-09-12 |
| JP6682632B2 JP6682632B2 (ja) | 2020-04-15 |
Family
ID=53776451
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526303A Active JP6682632B2 (ja) | 2015-08-03 | 2016-08-03 | Ｂｃｍａに対するモノクローナル抗体 |
| JP2020054175A Active JP6903188B2 (ja) | 2015-08-03 | 2020-03-25 | Ｂｃｍａに対するモノクローナル抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020054175A Active JP6903188B2 (ja) | 2015-08-03 | 2020-03-25 | Ｂｃｍａに対するモノクローナル抗体 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US10683369B2 (enExample) |
| EP (2) | EP3670535A1 (enExample) |
| JP (2) | JP6682632B2 (enExample) |
| KR (1) | KR102717307B1 (enExample) |
| CN (1) | CN108350073B (enExample) |
| AU (1) | AU2016302881B2 (enExample) |
| BR (1) | BR112018001955B1 (enExample) |
| CA (1) | CA2992797A1 (enExample) |
| CL (3) | CL2018000281A1 (enExample) |
| CO (1) | CO2018001149A2 (enExample) |
| CY (1) | CY1122804T1 (enExample) |
| DK (1) | DK3331910T3 (enExample) |
| EA (2) | EA202092435A3 (enExample) |
| EC (1) | ECSP18007905A (enExample) |
| ES (1) | ES2777602T3 (enExample) |
| HR (1) | HRP20200390T1 (enExample) |
| HU (1) | HUE048939T2 (enExample) |
| IL (1) | IL257233B (enExample) |
| LT (1) | LT3331910T (enExample) |
| MX (2) | MX377710B (enExample) |
| PL (1) | PL3331910T3 (enExample) |
| PT (1) | PT3331910T (enExample) |
| RS (1) | RS60030B1 (enExample) |
| SA (1) | SA518390854B1 (enExample) |
| SG (1) | SG10202007177XA (enExample) |
| SI (1) | SI3331910T1 (enExample) |
| SM (1) | SMT202000139T1 (enExample) |
| WO (1) | WO2017021450A1 (enExample) |
| ZA (1) | ZA201800435B (enExample) |
Families Citing this family (108)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101681818B1 (ko) | 2011-08-23 | 2016-12-01 | 로슈 글리카트 아게 | T 세포 활성화 항원 및 종양 항원에 대해 특이적인 이중특이적 항체 및 이의 사용 방법 |
| EP2904016B1 (en) | 2012-10-08 | 2018-11-14 | Roche Glycart AG | Fc-free antibodies comprising two fab-fragments and methods of use |
| KR20180023035A (ko) | 2013-02-26 | 2018-03-06 | 로슈 글리카트 아게 | 이중특이적 t 세포 활성화 항원 결합 분자 |
| DK3177643T3 (da) | 2014-08-04 | 2019-07-15 | Hoffmann La Roche | Bispecifikke T-celle-aktiverende antigenbindende molekyler |
| JP6708635B2 (ja) | 2014-10-09 | 2020-06-10 | エンクマフ エスアーエールエル | ＣＤ３εおよびＲＯＲ１に対する二特異性抗体 |
| DK4141032T3 (da) | 2014-11-20 | 2024-08-05 | Hoffmann La Roche | Kombinationsbehandling med T-celleaktiverende bispecifikke antigenbindende molekyler og PD-1-aksebindende antagonister |
| DK3221356T3 (da) | 2014-11-20 | 2020-11-02 | Hoffmann La Roche | T-celleaktiverende, bispecifikke, antigenbindende molekyler mod folr1 og cd3 |
| DK3221357T3 (da) | 2014-11-20 | 2020-08-10 | Hoffmann La Roche | Fælles letkæder og fremgangsmåder til anvendelse |
| CN107849148B (zh) | 2015-05-21 | 2023-09-19 | 哈普恩治疗公司 | 三特异性结合蛋白质及使用方法 |
| KR20180073561A (ko) | 2015-10-02 | 2018-07-02 | 에프. 호프만-라 로슈 아게 | 이중특이적 항-ceaxcd3 t 세포 활성화 항원 결합 분자 |
| KR102850929B1 (ko) | 2015-12-09 | 2025-08-27 | 에프. 호프만-라 로슈 아게 | 항-약물 항체의 형성을 감소시키기 위한 ii형 항-cd20 항체 |
| ES2837428T3 (es) | 2016-01-08 | 2021-06-30 | Hoffmann La Roche | Procedimientos de tratamiento de cánceres positivos para CEA usando antagonistas de unión al eje PD-1 y anticuerpos biespecíficos anti-CEA/anti-CD3 |
| HK1259075A1 (zh) | 2016-02-17 | 2019-11-22 | Seattle Genetics, Inc. | Bcma抗体和其用以治疗癌症和免疫病症的用途 |
| JP7015244B2 (ja) | 2016-03-22 | 2022-02-02 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | プロテアーゼ活性化ｔ細胞二重特異性分子 |
| ES2897217T3 (es) | 2016-09-30 | 2022-02-28 | Hoffmann La Roche | Anticuerpos biespecíficos frente a p95HER2 |
| CN110167964B (zh) * | 2016-11-02 | 2023-12-01 | 百时美施贵宝公司 | 组合用于治疗多发性骨髓瘤的针对bcma和cd3的双特异性抗体和免疫药物 |
| WO2018144535A1 (en) | 2017-01-31 | 2018-08-09 | Novartis Ag | Treatment of cancer using chimeric t cell receptor proteins having multiple specificities |
| EP3615068A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| US20200055948A1 (en) | 2017-04-28 | 2020-02-20 | Novartis Ag | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| CA3075716A1 (en) | 2017-09-14 | 2019-03-21 | Glaxosmithkline Intellectual Property Development Limited | Combination treatment for cancer |
| US11401334B2 (en) * | 2017-09-14 | 2022-08-02 | Glaxosmithkline Intellectual Property Development Limited | Combination treatment for cancer with anti-BCMA binding protein and proteosome inhibitor |
| CN111094353A (zh) | 2017-09-14 | 2020-05-01 | 葛兰素史密斯克莱知识产权发展有限公司 | 用于癌症的组合治疗 |
| IL315737A (en) * | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| KR102425983B1 (ko) | 2017-10-13 | 2022-07-29 | 하푼 테라퓨틱스, 인크. | 삼중특이적 단백질 및 사용 방법 |
| KR20200086278A (ko) | 2017-10-18 | 2020-07-16 | 노파르티스 아게 | 선택적 단백질 분해를 위한 조성물 및 방법 |
| TW201922774A (zh) | 2017-11-15 | 2019-06-16 | 瑞士商諾華公司 | 標靶bcma嵌合抗原受體、標靶cd19嵌合抗原受體及組合療法 |
| AU2018375738A1 (en) | 2017-11-30 | 2020-06-11 | Novartis Ag | BCMA-targeting chimeric antigen receptor, and uses thereof |
| WO2019136432A1 (en) | 2018-01-08 | 2019-07-11 | Novartis Ag | Immune-enhancing rnas for combination with chimeric antigen receptor therapy |
| WO2019139987A1 (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases |
| EP3746116A1 (en) | 2018-01-31 | 2020-12-09 | Novartis AG | Combination therapy using a chimeric antigen receptor |
| CA3081125C (en) | 2018-02-01 | 2025-09-16 | Innovent Biologics (Suzhou) Co., Ltd. | All-Human Single-Chain Variable Fragment Anti-Antigen for B Lymphocyte Maturation (BCMA), and Associated Application |
| CN118772288A (zh) | 2018-02-08 | 2024-10-15 | 豪夫迈·罗氏有限公司 | 双特异性抗原结合分子和使用方法 |
| WO2019160956A1 (en) | 2018-02-13 | 2019-08-22 | Novartis Ag | Chimeric antigen receptor therapy in combination with il-15r and il15 |
| BR112020017053A2 (pt) | 2018-02-21 | 2020-12-15 | Celgene Corporation | Anticorpos que se ligam ao bcma e usos dos mesmos |
| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| WO2019190969A1 (en) * | 2018-03-26 | 2019-10-03 | Sutro Biopharma, Inc. | Anti-bcma receptor antibodies, compositions comprising anti bcma receptor antibodies and methods of making and using anti-bcma antibodies |
| BR112020019795A2 (pt) | 2018-03-30 | 2021-01-05 | Merus N.V. | Anticorpo multivalente |
| HRP20230449T1 (hr) * | 2018-05-23 | 2023-07-21 | Celgene Corporation | Antiproliferativni spojevi i bispecifična protutijela protiv bcma i cd3 za kombiniranu upotrebu |
| CN118459594A (zh) | 2018-06-01 | 2024-08-09 | 诺华股份有限公司 | 针对bcma的结合分子及其用途 |
| CN112955465A (zh) | 2018-07-03 | 2021-06-11 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| EA202190468A1 (ru) * | 2018-08-08 | 2021-07-06 | Драгонфлай Терапьютикс, Инк. | Мультиспецифические связывающие белки, которые связывают bcma, nkg2d и cd16, и способы их применения |
| CN109134665B (zh) * | 2018-08-24 | 2021-06-11 | 上海先博生物科技有限公司 | 一种基于单域抗体的bcma嵌合抗原受体及应用 |
| SG11202101825QA (en) | 2018-08-31 | 2021-03-30 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| WO2020047449A2 (en) | 2018-08-31 | 2020-03-05 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| IL281683B2 (en) | 2018-09-25 | 2023-04-01 | Harpoon Therapeutics Inc | dll3 binding proteins and methods of use |
| CN109503716B (zh) * | 2018-10-08 | 2021-04-27 | 浙江生研生物科技有限公司 | 一种双特异性嵌合抗原受体分子及其在肿瘤治疗上的应用 |
| WO2020089437A1 (en) | 2018-10-31 | 2020-05-07 | Engmab Sàrl | Combination therapy |
| CN112955748A (zh) | 2018-10-31 | 2021-06-11 | 葛兰素史密斯克莱知识产权发展有限公司 | 治疗癌症的方法 |
| PE20211058A1 (es) | 2018-11-01 | 2021-06-07 | Juno Therapeutics Inc | Receptores de antigenos quimericos especificos para el miembro d del grupo 5 de la clase c del receptor acoplado a proteina g (gprc5d) |
| CN109678961A (zh) * | 2019-01-15 | 2019-04-26 | 深圳市南科生物工程有限公司 | 一种基于bmca纳米抗体序列的嵌合抗原受体的构建方法及其应用 |
| CN119661722A (zh) | 2019-02-21 | 2025-03-21 | 马伦戈治疗公司 | 结合t细胞相关癌细胞的多功能分子及其用途 |
| CN119039441A (zh) | 2019-02-21 | 2024-11-29 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
| SG11202107825WA (en) | 2019-02-25 | 2021-09-29 | Novartis Ag | Mesoporous silica particles compositions for viral delivery |
| WO2020191316A1 (en) | 2019-03-21 | 2020-09-24 | Novartis Ag | Car-t cell therapies with enhanced efficacy |
| US20220168389A1 (en) | 2019-04-12 | 2022-06-02 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| WO2020219742A1 (en) | 2019-04-24 | 2020-10-29 | Novartis Ag | Compositions and methods for selective protein degradation |
| WO2020219978A1 (en) | 2019-04-25 | 2020-10-29 | Celgene Corporation | Bcma/cd3 bispecific trivalent t-cell engaging (tce) antibodies and their use to treat hematological malignancies |
| JP7489407B2 (ja) | 2019-05-21 | 2024-05-23 | ノバルティス アーゲー | Ｃｄ１９結合分子及びその使用 |
| CN110229232B (zh) * | 2019-06-19 | 2020-05-19 | 北京智仁美博生物科技有限公司 | 双特异性抗体及其用途 |
| WO2021022304A2 (en) * | 2019-07-30 | 2021-02-04 | Qlsf Biotherapeutics, Inc. | MULTISPECIFIC BINDING COMPOUNDS THAT BIND TO LRRC15 AND CD3ε |
| CA3146394A1 (en) * | 2019-07-30 | 2021-02-04 | Shanghai Hansoh Biomedical Co., Ltd. | Anti-bcma antibody, antigen-binding fragment thereof and medical use thereof |
| CN120204384A (zh) | 2019-08-06 | 2025-06-27 | 葛兰素史密斯克莱知识产权发展有限公司 | 生物药物组合物和相关方法 |
| CN112574308A (zh) * | 2019-09-30 | 2021-03-30 | 和铂医药(苏州)有限公司 | 靶向bcma的抗体、双特异性抗体及其用途 |
| CN112646032B (zh) * | 2019-10-10 | 2025-08-05 | 再凌生物医药(香港)有限公司 | 靶向bcma的具有人猴交叉的人源化单克隆抗体 |
| IL292704A (en) * | 2019-11-05 | 2022-07-01 | Bristol Myers Squibb Co | Methods of treatment with antibodies against bcma and cd3 |
| ES2987783T3 (es) | 2019-11-11 | 2024-11-18 | Amgen Res Munich Gmbh | Régimen de dosificación para agentes anti-BCMA |
| AR120566A1 (es) | 2019-11-26 | 2022-02-23 | Novartis Ag | Receptores de antígeno quiméricos y sus usos |
| KR102837521B1 (ko) * | 2020-01-03 | 2025-07-22 | 바이오션, 인코포레이티드 | Bcma에 결합하는 항체 및 이의 용도 |
| WO2021136323A1 (en) * | 2020-01-03 | 2021-07-08 | Salubris (Chengdu) Biotech Co., Ltd. | Antibodies binding bcma and uses thereof |
| GB2609554B (en) | 2020-01-03 | 2025-08-20 | Marengo Therapeutics Inc | Anti-TCR antibody molecules and uses thereof |
| CN111234020B (zh) * | 2020-01-23 | 2020-10-23 | 和铂医药(苏州)有限公司 | 一种bcma结合蛋白及其制备方法和应用 |
| CN111171147B (zh) * | 2020-02-11 | 2021-07-20 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c3分子的全人源单克隆抗体及应用 |
| KR20220141306A (ko) * | 2020-02-12 | 2022-10-19 | 브리스톨-마이어스 스큅 컴퍼니 | 자가면역 질환의 항-bcma 요법(anti-bcma therapy in autoimmune disorders) |
| KR20220147109A (ko) | 2020-02-27 | 2022-11-02 | 노파르티스 아게 | 키메라 항원 수용체 발현 세포의 제조 방법 |
| AR121461A1 (es) | 2020-02-27 | 2022-06-08 | Novartis Ag | Métodos para la fabricación de células que expresan el receptor de antígeno quimérico |
| CN116097096A (zh) * | 2020-03-27 | 2023-05-09 | 印地安纳大学理事会 | 多发性骨髓瘤中的免疫治疗靶点及其鉴定方法 |
| US20230172923A1 (en) | 2020-04-30 | 2023-06-08 | Bristol-Myers Squibb Company | Methods of treating cytokine-related adverse events |
| AU2021288224A1 (en) | 2020-06-11 | 2023-01-05 | Novartis Ag | ZBTB32 inhibitors and uses thereof |
| EP4192875A1 (en) * | 2020-08-10 | 2023-06-14 | Precision BioSciences, Inc. | Antibodies and fragments specific for b-cell maturation antigen and uses thereof |
| TW202227124A (zh) | 2020-08-21 | 2022-07-16 | 瑞士商諾華公司 | 用於體內產生ｃａｒ表現細胞的組成物和方法 |
| WO2022094245A1 (en) | 2020-10-30 | 2022-05-05 | Vor Biopharma, Inc. | Compositions and methods for bcma modification |
| CN112321713B (zh) * | 2020-12-31 | 2021-05-25 | 北京艺妙神州医药科技有限公司 | 一种抗bcma的抗体及其应用 |
| KR20240004462A (ko) | 2021-04-08 | 2024-01-11 | 마렝고 테라퓨틱스, 인크. | Tcr에 결합하는 다기능성 분자 및 이의 용도 |
| US20240384293A1 (en) | 2021-04-27 | 2024-11-21 | Novartis Ag | Viral vector production system |
| CN117396231A (zh) | 2021-04-30 | 2024-01-12 | 新基公司 | 使用抗BCMA抗体药物缀合物（ADC）与γ分泌酶抑制剂（GSI）的组合的组合疗法 |
| EP4330282A1 (en) | 2021-04-30 | 2024-03-06 | F. Hoffmann-La Roche AG | Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate |
| JP2024521187A (ja) | 2021-05-28 | 2024-05-28 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | ガンの治療のための組み合わせ療法 |
| CA3227515A1 (en) | 2021-08-03 | 2023-02-09 | Glaxosmithkline Intellectual Property Development Limited | Biopharmaceutical compositions and stable isotope labeling peptide mapping method |
| WO2023020474A1 (en) * | 2021-08-16 | 2023-02-23 | Utc Therapeutics (Shanghai) Co., Ltd. | Bcma targetting antibodies and uses thereof in cancer therapies |
| WO2023019398A1 (en) * | 2021-08-16 | 2023-02-23 | Utc Therapeutics (Shanghai) Co., Ltd. | Bcma targetting antibodies, chimeric antigen receptors, and uses thereof |
| AU2022330406A1 (en) | 2021-08-20 | 2024-03-07 | Novartis Ag | Methods of making chimeric antigen receptor–expressing cells |
| EP4412713A1 (en) | 2021-10-05 | 2024-08-14 | GlaxoSmithKline Intellectual Property Development Ltd | Combination therapies for treating cancer |
| JP2025503949A (ja) | 2022-01-25 | 2025-02-06 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | ガンに対する併用療法 |
| WO2024031091A2 (en) | 2022-08-05 | 2024-02-08 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for gprc5d and bcma |
| AU2023369684A1 (en) | 2022-10-26 | 2025-04-17 | Novartis Ag | Lentiviral formulations |
| WO2024121711A1 (en) | 2022-12-05 | 2024-06-13 | Glaxosmithkline Intellectual Property Development Limited | Methods of treatment using b-cell maturation antigen antagonists |
| WO2024249954A1 (en) | 2023-05-31 | 2024-12-05 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025042742A1 (en) | 2023-08-18 | 2025-02-27 | Bristol-Myers Squibb Company | Compositions comprising antibodies that bind bcma and cd3 and methods of treatment |
| WO2025059162A1 (en) | 2023-09-11 | 2025-03-20 | Dana-Farber Cancer Institute, Inc. | Car-engager containing il-2 variants to enhance the functionality of car t cells |
| WO2025059362A1 (en) | 2023-09-13 | 2025-03-20 | Juno Therapeutics, Inc. | Combination therapies with a cell therapy expressing a gprc5d-targeting car and related methods and uses |
| US20250127728A1 (en) | 2023-10-05 | 2025-04-24 | Capstan Therapeutics, Inc. | Constrained Ionizable Cationic Lipids and Lipid Nanoparticles |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| TW202532433A (zh) * | 2023-10-10 | 2025-08-16 | 瑞典商阿斯特捷利康公司 | Ｔ細胞結合組成物和方法 |
| US20250230251A1 (en) | 2023-12-20 | 2025-07-17 | Bristol-Myers Squibb Company | Antibodies targeting il-18 receptor beta (il-18rb) and related methods |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
Family Cites Families (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US6410516B1 (en) | 1986-01-09 | 2002-06-25 | President & Fellows Of Harvard College | Nuclear factors associated with transcriptional regulation |
| EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
| WO1988009344A1 (en) | 1987-05-21 | 1988-12-01 | Creative Biomolecules, Inc. | Targeted multifunctional proteins |
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5273743A (en) | 1990-03-09 | 1993-12-28 | Hybritech Incorporated | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
| US5837821A (en) | 1992-11-04 | 1998-11-17 | City Of Hope | Antibody construct |
| EP0672142B1 (en) | 1992-12-04 | 2001-02-28 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
| ES2162863T3 (es) | 1993-04-29 | 2002-01-16 | Unilever Nv | Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae. |
| US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| DE69535557T2 (de) | 1994-12-30 | 2008-04-30 | Planet Biotechnology, Inc., San Diego | Verfahren zur herstellung von schutzproteine enthaltende immunoglobuline und ihre verwendung |
| GB9501079D0 (en) | 1995-01-19 | 1995-03-08 | Bioinvent Int Ab | Activation of T-cells |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| DK0826696T3 (da) | 1996-09-03 | 2002-09-23 | Gsf Forschungszentrum Umwelt | Anvendelse af bi- og trispecifikke antistoffer til inducering af en tumorimmunitet |
| CA2288994C (en) | 1997-04-30 | 2011-07-05 | Enzon, Inc. | Polyalkylene oxide-modified single chain polypeptides |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| PT1071700E (pt) | 1998-04-20 | 2010-04-23 | Glycart Biotechnology Ag | Modificação por glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| ES2694002T3 (es) | 1999-01-15 | 2018-12-17 | Genentech, Inc. | Polipéptido que comprende una región Fc de IgG1 humana variante |
| US20020142000A1 (en) | 1999-01-15 | 2002-10-03 | Digan Mary Ellen | Anti-CD3 immunotoxins and therapeutic uses therefor |
| WO2000061739A1 (fr) | 1999-04-09 | 2000-10-19 | Kyowa Hakko Kogyo Co., Ltd. | Methode de regulation de l'activite d'une molecule immunologiquement fonctionnelle |
| AU6232899A (en) | 1999-10-06 | 2001-05-10 | Campina Melkunie B.V. | Use of transforming growth factor beta and growth factors in the treatment and prevention of diseases of the intestinal mucosa |
| UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
| US7504256B1 (en) | 1999-10-19 | 2009-03-17 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing polypeptide |
| JP5291279B2 (ja) | 2000-09-08 | 2013-09-18 | ウニヴェルジテート・チューリッヒ | 反復モジュールを含む反復タンパク質の集合体 |
| EP1333032A4 (en) | 2000-10-06 | 2005-03-16 | Kyowa Hakko Kogyo Kk | PROCESS FOR PURIFYING ANTIBODY |
| MXPA03002974A (es) | 2000-10-06 | 2004-05-05 | Kyowa Hakko Kogyo Kk | Celulas que producen composiciones de anticuerpo. |
| GB0029407D0 (en) | 2000-12-01 | 2001-01-17 | Affitech As | Product |
| EP2301971A1 (en) | 2001-02-20 | 2011-03-30 | ZymoGenetics, L.L.C. | Antibodies that bind both BCMA and TACI |
| EP2281837B1 (en) | 2001-08-10 | 2016-10-05 | Aberdeen University | Antigen binding domains from fish |
| ES2276735T3 (es) | 2001-09-14 | 2007-07-01 | Affimed Therapeutics Ag | Anticuerpos fv multimericos de cadena sencilla en tandem. |
| ES2283368T3 (es) | 2001-11-14 | 2007-11-01 | Affimed Therapeutics Ag | Anticuerpos biespecificos anti-cd19 y anti-cd16 y usos de los mismos. |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| GB0230201D0 (en) | 2002-12-27 | 2003-02-05 | Domantis Ltd | Retargeting |
| PL222220B1 (pl) | 2003-01-22 | 2016-07-29 | Glycart Biotechnology Ag | Komórka gospodarza i sposób wytwarzania polipeptydu w komórce gospodarza |
| WO2004076489A1 (en) | 2003-02-25 | 2004-09-10 | Medinnova As | Modified antibody |
| AU2003259718A1 (en) | 2003-08-07 | 2005-03-07 | Epitomics, Inc. | Methods for humanizing rabbit monoclonal antibodies |
| AU2004290070A1 (en) | 2003-11-12 | 2005-05-26 | Biogen Idec Ma Inc. | Neonatal Fc receptor (FcRn)-binding polypeptide variants, dimeric Fc binding proteins and methods related thereto |
| US7235641B2 (en) | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
| DK2330121T3 (en) | 2004-06-02 | 2014-12-15 | Adalta Pty Ltd | Binding moieties based on shark IgNar domains |
| ATE414718T1 (de) | 2005-01-05 | 2008-12-15 | F Star Biotech Forsch & Entw | Synthetische immunoglobulindomänen mit in regionen des moleküls, die sich von den die komplementarität bestimmenden bereichen unterscheiden, modifizierten bindeeigenschaften |
| CN101198698B (zh) | 2005-03-31 | 2014-03-19 | 中外制药株式会社 | 通过调节多肽缔合制备多肽的方法 |
| JP5838021B2 (ja) | 2005-04-15 | 2015-12-24 | マクロジェニクス，インコーポレーテッド | 共有結合型ダイアボディとその使用 |
| CA2605781A1 (en) | 2005-05-09 | 2007-04-12 | Glycart Biotechnology Ag | Antigen binding molecules having modified fc regions and altered binding to fc receptors |
| RU2008110060A (ru) | 2005-08-15 | 2009-09-27 | Арана Терапьютикс Лимитед (Au) | Сконструированные антитела с каркасными участками приматов нового света |
| NO345919B1 (no) | 2005-08-26 | 2021-10-18 | Roche Glycart Ag | Modifiserte antigen-bindende molekyler med endret celle-signaliseringsaktivitet |
| EP1931709B1 (en) | 2005-10-03 | 2016-12-07 | Xencor, Inc. | Fc variants with optimized fc receptor binding properties |
| EP3770174A1 (en) | 2005-10-11 | 2021-01-27 | Amgen Research (Munich) GmbH | Compositions comprising cross-species-specific antibodies and uses thereof |
| WO2007117600A2 (en) | 2006-04-07 | 2007-10-18 | Macrogenics, Inc. | Combination therapy for treating autoimmune diseases |
| BRPI0710011A2 (pt) | 2006-04-14 | 2011-08-02 | Trubion Pharmaceuticals Inc | proteìnas de ligação compreendendo articulação de imunoglobulina e regiões fc dotadas de funções efetoras fc alteradas |
| AU2008234248C1 (en) | 2007-03-29 | 2015-01-22 | Genmab A/S | Bispecific antibodies and methods for production thereof |
| WO2008119566A2 (en) | 2007-04-03 | 2008-10-09 | Micromet Ag | Cross-species-specific bispecific binders |
| RU2561457C2 (ru) | 2007-04-03 | 2015-08-27 | Эмджен Рисерч (Мьюник) Гмбх | Cd3-эпсилон-связывающий домен с межвидовой специфичностью |
| PT2520590T (pt) | 2007-04-03 | 2018-11-14 | Amgen Res Munich Gmbh | Domínio de ligação específico de espécies cruzadas |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| AU2009204974A1 (en) | 2008-01-15 | 2009-07-23 | F. Hoffmann-La Roche Ag | Afucosylated antibodies against CCR5 and their use |
| EP2842575B1 (en) | 2008-03-18 | 2017-09-27 | Seattle Genetics, Inc. | Auristatin drug linker conjugates |
| WO2009132058A2 (en) | 2008-04-25 | 2009-10-29 | Zymogenetics, Inc. | Levels of bcma protein expression on b cells and use in diagnostic methods |
| CA2738566C (en) | 2008-10-01 | 2024-04-30 | Micromet Ag | Bispecific single chain antibodies with specificity for high molecular weight target antigens |
| EP2352765B1 (en) | 2008-10-01 | 2018-01-03 | Amgen Research (Munich) GmbH | Cross-species-specific single domain bispecific single chain antibody |
| DK2356153T3 (en) | 2008-10-01 | 2016-07-04 | Amgen Res Munich Gmbh | Bispecific single CHAIN PSMAXCD3 ANTIBODY THAT ARE SPECIFICALLY TO ALL SPECIES |
| AU2009324092A1 (en) | 2008-12-03 | 2011-06-23 | Genmab A/S | Antibody variants having modifications in the constant region |
| NZ594985A (en) | 2009-03-10 | 2013-07-26 | Biogen Idec Inc | Anti-bcma (b-cell maturation antigen, cd269, tnfrsf17) antibodies |
| TWI409079B (zh) | 2009-08-14 | 2013-09-21 | Roche Glycart Ag | 非典型岩藻醣化ｃｄ２０抗體與苯達莫斯汀（ｂｅｎｄａｍｕｓｔｉｎｅ）之組合療法 |
| JP2014500879A (ja) * | 2010-11-16 | 2014-01-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｂｃｍａ発現に相関性を有する疾患を治療する因子及び方法 |
| SI2691417T2 (sl) | 2011-03-29 | 2025-05-30 | Roche Glycart Ag | FC variante protitelesa |
| US20130101599A1 (en) | 2011-04-21 | 2013-04-25 | Boehringer Ingelheim International Gmbh | Bcma-based stratification and therapy for multiple myeloma patients |
| PE20141045A1 (es) * | 2011-05-27 | 2014-09-10 | Glaxo Group Ltd | Proteinas de union a bcma (cd269/tnfrsf17) |
| TWI679212B (zh) | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對ｂｃｍａ之e3以及ｃｄ３的結合分子 |
| KR102086874B1 (ko) | 2012-04-11 | 2020-03-10 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | B-세포 성숙 항원을 표적화하는 키메라 항원 수용체 |
| US10077315B2 (en) * | 2013-02-05 | 2018-09-18 | Engmab Sàrl | Bispecific antibodies against CD3 and BCMA |
| AR095374A1 (es) | 2013-03-15 | 2015-10-14 | Amgen Res Munich Gmbh | Moléculas de unión para bcma y cd3 |
| GB201317929D0 (en) | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Chimeric antigen receptor |
| CA2934436A1 (en) | 2013-12-20 | 2015-06-25 | Cellectis | Method of engineering multi-input signal sensitive t cell for immunotherapy |
| JP6793902B2 (ja) | 2013-12-20 | 2020-12-02 | ノバルティス アーゲー | 調節可能キメラ抗原受容体 |
| WO2016094304A2 (en) | 2014-12-12 | 2016-06-16 | Bluebird Bio, Inc. | Bcma chimeric antigen receptors |
-
2016
- 2016-08-03 CA CA2992797A patent/CA2992797A1/en active Pending
- 2016-08-03 JP JP2018526303A patent/JP6682632B2/ja active Active
- 2016-08-03 SI SI201630675T patent/SI3331910T1/sl unknown
- 2016-08-03 EA EA202092435A patent/EA202092435A3/ru unknown
- 2016-08-03 LT LTEP16750150.1T patent/LT3331910T/lt unknown
- 2016-08-03 HU HUE16750150A patent/HUE048939T2/hu unknown
- 2016-08-03 US US15/747,385 patent/US10683369B2/en active Active
- 2016-08-03 BR BR112018001955-0A patent/BR112018001955B1/pt active IP Right Grant
- 2016-08-03 DK DK16750150.1T patent/DK3331910T3/da active
- 2016-08-03 AU AU2016302881A patent/AU2016302881B2/en active Active
- 2016-08-03 PL PL16750150T patent/PL3331910T3/pl unknown
- 2016-08-03 KR KR1020187005941A patent/KR102717307B1/ko active Active
- 2016-08-03 WO PCT/EP2016/068549 patent/WO2017021450A1/en not_active Ceased
- 2016-08-03 HR HRP20200390TT patent/HRP20200390T1/hr unknown
- 2016-08-03 RS RS20200276A patent/RS60030B1/sr unknown
- 2016-08-03 PT PT167501501T patent/PT3331910T/pt unknown
- 2016-08-03 ES ES16750150T patent/ES2777602T3/es active Active
- 2016-08-03 EA EA201890441A patent/EA036975B1/ru not_active IP Right Cessation
- 2016-08-03 EP EP19208343.4A patent/EP3670535A1/en active Pending
- 2016-08-03 CN CN201680054839.0A patent/CN108350073B/zh active Active
- 2016-08-03 EP EP16750150.1A patent/EP3331910B1/en active Active
- 2016-08-03 MX MX2018001398A patent/MX377710B/es active IP Right Grant
- 2016-08-03 SG SG10202007177XA patent/SG10202007177XA/en unknown
- 2016-08-03 SM SM20200139T patent/SMT202000139T1/it unknown
-
2018
- 2018-01-22 ZA ZA2018/00435A patent/ZA201800435B/en unknown
- 2018-01-30 IL IL257233A patent/IL257233B/en active IP Right Grant
- 2018-01-31 CL CL2018000281A patent/CL2018000281A1/es unknown
- 2018-02-01 SA SA518390854A patent/SA518390854B1/ar unknown
- 2018-02-01 MX MX2020009649A patent/MX2020009649A/es unknown
- 2018-02-02 CO CONC2018/0001149A patent/CO2018001149A2/es unknown
- 2018-02-02 EC ECIEPI20187905A patent/ECSP18007905A/es unknown
-
2020
- 2020-03-10 CY CY20201100212T patent/CY1122804T1/el unknown
- 2020-03-17 US US16/821,895 patent/US20200283545A1/en not_active Abandoned
- 2020-03-25 JP JP2020054175A patent/JP6903188B2/ja active Active
- 2020-04-17 CL CL2020001048A patent/CL2020001048A1/es unknown
- 2020-10-28 CL CL2020002801A patent/CL2020002801A1/es unknown
-
2022
- 2022-11-21 US US18/057,566 patent/US20230322957A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018532766A5 (enExample) | ||
| HRP20200390T1 (hr) | Monoklonska antitijela protiv humanog antigena starenja b stanica (bcma) | |
| JP2020122013A5 (enExample) | ||
| JP2016507523A5 (enExample) | ||
| JP2018502050A5 (enExample) | ||
| EP3645741A2 (en) | Anti-4-1bb antibodies and methods of making and using thereof | |
| JP2020501531A5 (enExample) | ||
| JP6421371B2 (ja) | トランスポーターに対する抗体およびその用途 | |
| JP2018527919A5 (enExample) | ||
| JP2018532383A5 (enExample) | ||
| JP2015519375A5 (enExample) | ||
| CN112119099A (zh) | 三特异性抗原结合蛋白 | |
| JP2014534242A5 (enExample) | ||
| JP2018526981A5 (enExample) | ||
| JP2020515277A5 (enExample) | ||
| JP2020502233A5 (enExample) | ||
| JP2018522888A5 (enExample) | ||
| RU2022108410A (ru) | Терапевтические антитела против лиганда cd40 | |
| WO2019196309A1 (zh) | 抗pd-l1抗体及其用途 | |
| JP2019512207A5 (enExample) | ||
| TW202200618A (zh) | 微型導引和導航控制(miniGNC)類抗體蛋白及其製造和使用方法 | |
| RU2019134462A (ru) | Антитела, связывающиеся с steap-1 | |
| JP2016518333A5 (enExample) | ||
| JPWO2020252366A5 (enExample) | ||
| JPWO2022111425A5 (enExample) |