JP2018526981A5 - - Google Patents
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- JP2018526981A5 JP2018526981A5 JP2018501159A JP2018501159A JP2018526981A5 JP 2018526981 A5 JP2018526981 A5 JP 2018526981A5 JP 2018501159 A JP2018501159 A JP 2018501159A JP 2018501159 A JP2018501159 A JP 2018501159A JP 2018526981 A5 JP2018526981 A5 JP 2018526981A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- cdr2
- cdr1
- region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021168124A JP7604351B2 (ja) | 2015-07-15 | 2021-10-13 | ヒト化またはキメラｃｄ３抗体 |
| JP2024216521A JP2025038049A (ja) | 2015-07-15 | 2024-12-11 | ヒト化またはキメラｃｄ３抗体 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201500413 | 2015-07-15 | ||
| DKPA201500414 | 2015-07-15 | ||
| DKPA201500413 | 2015-07-15 | ||
| DKPA201500414 | 2015-07-15 | ||
| DKPA201500416 | 2015-07-16 | ||
| DKPA201500416 | 2015-07-16 | ||
| EPPCT/EP2016/050296 | 2016-01-08 | ||
| PCT/EP2016/050296 WO2016110576A1 (en) | 2015-01-08 | 2016-01-08 | Bispecific antibodies against cd3 and cd20 |
| PCT/EP2016/066845 WO2017009442A1 (en) | 2015-07-15 | 2016-07-14 | Humanized or chimeric cd3 antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021168124A Division JP7604351B2 (ja) | 2015-07-15 | 2021-10-13 | ヒト化またはキメラｃｄ３抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018526981A JP2018526981A (ja) | 2018-09-20 |
| JP2018526981A5 true JP2018526981A5 (enExample) | 2019-08-29 |
Family
ID=57757079
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018501159A Pending JP2018526981A (ja) | 2015-07-15 | 2016-07-14 | ヒト化またはキメラｃｄ３抗体 |
| JP2021168124A Active JP7604351B2 (ja) | 2015-07-15 | 2021-10-13 | ヒト化またはキメラｃｄ３抗体 |
| JP2024216521A Pending JP2025038049A (ja) | 2015-07-15 | 2024-12-11 | ヒト化またはキメラｃｄ３抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021168124A Active JP7604351B2 (ja) | 2015-07-15 | 2021-10-13 | ヒト化またはキメラｃｄ３抗体 |
| JP2024216521A Pending JP2025038049A (ja) | 2015-07-15 | 2024-12-11 | ヒト化またはキメラｃｄ３抗体 |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US11359015B2 (enExample) |
| EP (2) | EP4759831A2 (enExample) |
| JP (3) | JP2018526981A (enExample) |
| KR (2) | KR20250048113A (enExample) |
| CN (3) | CN108368172B (enExample) |
| AU (3) | AU2016293073B2 (enExample) |
| BR (1) | BR112018000696A2 (enExample) |
| CA (1) | CA2992380A1 (enExample) |
| DK (1) | DK3322727T3 (enExample) |
| EA (1) | EA201890305A1 (enExample) |
| ES (1) | ES3063317T3 (enExample) |
| FI (1) | FI3322727T3 (enExample) |
| IL (2) | IL310467A (enExample) |
| MX (2) | MX395317B (enExample) |
| NZ (1) | NZ739028A (enExample) |
| PL (1) | PL3322727T3 (enExample) |
| PT (1) | PT3322727T (enExample) |
| RS (1) | RS67909B1 (enExample) |
| SI (1) | SI3322727T1 (enExample) |
| UA (1) | UA128057C2 (enExample) |
| WO (1) | WO2017009442A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014006217A1 (en) | 2012-07-06 | 2014-01-09 | Genmab B.V. | Dimeric protein with triple mutations |
| KR102813816B1 (ko) | 2013-07-05 | 2025-05-29 | 젠맵 에이/에스 | 인간화 또는 키메라 cd3 항체 |
| FI3322727T3 (fi) | 2015-07-15 | 2026-03-17 | Genmab As | Humanisoituja tai kimeerisiä CD3-vasta-aineita |
| KR102379464B1 (ko) | 2016-06-20 | 2022-03-29 | 키맵 리미티드 | 항-pd-l1 항체 |
| LT3592769T (lt) * | 2017-03-09 | 2024-08-26 | Genmab A/S | Antikūnai, atpažįstantys pd-l1 |
| US11668021B2 (en) | 2017-05-09 | 2023-06-06 | Yale University | Basehit, a high-throughput assay to identify proteins involved in host-microbe interaction |
| EP3409322A1 (en) | 2017-06-01 | 2018-12-05 | F. Hoffmann-La Roche AG | Treatment method |
| JP7009517B2 (ja) | 2017-06-21 | 2022-01-25 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖ ｇｐ１２０およびｃｄ３を標的とする多重特異性抗体 |
| KR20250020679A (ko) | 2017-08-04 | 2025-02-11 | 젠맵 에이/에스 | Pd-l1 및 cd137에 결합하는 결합제 및 그의 용도 |
| MA52152A (fr) | 2018-03-12 | 2021-01-20 | Genmab As | Anticorps |
| CN120399075A (zh) * | 2018-03-14 | 2025-08-01 | 诺维莫尼公司 | 抗-CD3ε抗体及其应用方法 |
| EP3844188A1 (en) * | 2018-08-28 | 2021-07-07 | Ambrx, Inc. | Anti-cd3 antibody folate bioconjugates and their uses |
| KR20220035369A (ko) * | 2019-06-07 | 2022-03-22 | 아디맵 엘엘씨 | 고 친화도 항-cd3 항체, 및 이의 생성 및 사용 방법 |
| CA3146123A1 (en) * | 2019-07-29 | 2021-02-04 | Russell B. Wilson | Antibodies to candida and uses thereof |
| US12674001B2 (en) | 2019-09-12 | 2026-07-07 | Genmab A/S | Method of treating cancer by administering an antibody which binds to 5T4 |
| KR20220154757A (ko) * | 2020-03-18 | 2022-11-22 | 젠맵 에이/에스 | B7h4에 결합하는 항체 |
| KR20230008775A (ko) | 2020-05-08 | 2023-01-16 | 젠맵 에이/에스 | Cd3 및 cd20에 대한 이중특이적 항체 |
| CN116437956A (zh) | 2020-09-10 | 2023-07-14 | 健玛保 | 用于治疗慢性淋巴细胞白血病的针对cd3和cd20的双特异性抗体 |
| WO2022053654A1 (en) | 2020-09-10 | 2022-03-17 | Genmab A/S | Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma |
| US20230365714A1 (en) | 2020-10-02 | 2023-11-16 | Genmab A/S | Antibodies capable of binding to ror2 and bispecific antibodies binding to ror2 and cd3 |
| MX2023004299A (es) | 2020-10-13 | 2023-07-07 | Univ Pennsylvania | Direccionamiento de células t cd4+ in vivo para terapeuticos de arnm. |
| KR20240004949A (ko) | 2021-05-07 | 2024-01-11 | 젠맵 에이/에스 | B7h4 및 cd3에 결합하는 이중특이적 항체를 포함하는 제약 조성물 |
| CN113527493B (zh) * | 2021-07-20 | 2023-10-27 | 广州爱思迈生物医药科技有限公司 | 一种b7-h3抗体及其应用 |
| KR20240040097A (ko) * | 2021-08-04 | 2024-03-27 | 에이비프로 코퍼레이션 | Cd3 표적화 항체 및 이의 용도 |
| AR127298A1 (es) * | 2021-10-08 | 2024-01-10 | Genmab As | Anticuerpos que se unen a cd30 y cd3 |
| CN115368446B (zh) * | 2022-07-19 | 2025-08-08 | 合肥天港免疫药物有限公司 | 双特异性抗体及其应用 |
| WO2024088987A1 (en) | 2022-10-26 | 2024-05-02 | F. Hoffmann-La Roche Ag | Combination therapy for the treatment of cancer |
| TW202506178A (zh) | 2023-04-05 | 2025-02-16 | 丹麥商珍美寶股份有限公司 | 包含與ｃｄ３０和ｃｄ３結合之抗體之醫藥組成物 |
| US20260209367A1 (en) | 2024-11-22 | 2026-07-23 | Gilead Sciences, Inc. | SINGLE IMMUNOGLOBULIN DOMAIN BISPECIFIC ANTIBODIES AGAINST IL 10R alpha AND beta SUBUNITS AND METHODS OF USE |
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| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
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| KR101866623B1 (ko) | 2005-11-28 | 2018-07-04 | 젠맵 에이/에스 | 재조합 １가 항체 및 그의 제조 방법 |
| EA015992B1 (ru) | 2006-03-17 | 2012-01-30 | Байоджен Айдек Эмэй Инк. | Стабилизированное антитело и многовалентная антигенсвязывающая молекула на его основе, способы получения и использования вышеназванного стабилизированного антитела |
| DK1999154T3 (da) | 2006-03-24 | 2012-12-03 | Merck Patent Gmbh | Fremstillede heterodimere proteindomæner |
| AT503902B1 (de) | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | Verfahren zur manipulation von immunglobulinen |
| EP2626372B1 (en) | 2007-03-29 | 2018-03-21 | Genmab A/S | Bispecific antibodies and methods for production thereof |
| WO2008119567A2 (en) | 2007-04-03 | 2008-10-09 | Micromet Ag | Cross-species-specific cd3-epsilon binding domain |
| EP2158221B1 (en) | 2007-06-21 | 2018-08-29 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
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| EP3904391B1 (en) | 2010-03-10 | 2024-07-10 | Genmab A/S | Monoclonal antibodies against c-met |
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| WO2012143524A2 (en) * | 2011-04-20 | 2012-10-26 | Genmab A/S | Bispecific antibodies against her2 and cd3 |
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| IN2014CN03887A (enExample) | 2011-10-27 | 2015-10-16 | Genmab As | |
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| EP2892924B1 (en) * | 2012-06-14 | 2020-11-25 | Therapix Biosciences Ltd. | Humanized antibodies to cluster of differentiation 3 (cd3) |
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| DK2869845T3 (da) | 2012-07-06 | 2019-12-09 | Genmab Bv | Dimert protein med tredobbelte mutationer |
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| DK2924052T3 (da) | 2012-11-21 | 2019-09-30 | Pharmabcine Inc | Dual-target-antistof målrettet mod vegfr-2 og dll4, og farmaceutisk sammensætning omfattende samme |
| KR102813816B1 (ko) | 2013-07-05 | 2025-05-29 | 젠맵 에이/에스 | 인간화 또는 키메라 cd3 항체 |
| CN107660214B (zh) | 2015-01-08 | 2022-02-08 | 根马布股份公司 | 针对cd3和cd20的双特异性抗体 |
| FI3322727T3 (fi) | 2015-07-15 | 2026-03-17 | Genmab As | Humanisoituja tai kimeerisiä CD3-vasta-aineita |
| IL304871A (en) | 2016-01-11 | 2023-10-01 | Inhibrx Inc | Multispecific and multivalent binding fusion proteins - 41BB, preparations containing them and their uses |
| MA52152A (fr) | 2018-03-12 | 2021-01-20 | Genmab As | Anticorps |
| KR20220154757A (ko) | 2020-03-18 | 2022-11-22 | 젠맵 에이/에스 | B7h4에 결합하는 항체 |
| JP2023539525A (ja) | 2020-09-02 | 2023-09-14 | ジェンマブ エー／エス | 抗体療法 |
| WO2022053654A1 (en) | 2020-09-10 | 2022-03-17 | Genmab A/S | Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma |
| US20230365714A1 (en) | 2020-10-02 | 2023-11-16 | Genmab A/S | Antibodies capable of binding to ror2 and bispecific antibodies binding to ror2 and cd3 |
| EP4695293A1 (en) | 2023-04-13 | 2026-02-18 | Genmab A/S | Methods of treating lymphoma with bispecific antibodies against cd3 and cd20 |
-
2016
- 2016-07-14 FI FIEP16739459.2T patent/FI3322727T3/fi active
- 2016-07-14 IL IL310467A patent/IL310467A/en unknown
- 2016-07-14 EP EP25223890.2A patent/EP4759831A2/en active Pending
- 2016-07-14 MX MX2018000347A patent/MX395317B/es unknown
- 2016-07-14 JP JP2018501159A patent/JP2018526981A/ja active Pending
- 2016-07-14 CN CN201680054638.0A patent/CN108368172B/zh active Active
- 2016-07-14 ES ES16739459T patent/ES3063317T3/es active Active
- 2016-07-14 US US15/744,317 patent/US11359015B2/en active Active
- 2016-07-14 PT PT167394592T patent/PT3322727T/pt unknown
- 2016-07-14 BR BR112018000696-3A patent/BR112018000696A2/en active IP Right Grant
- 2016-07-14 SI SI201631947T patent/SI3322727T1/sl unknown
- 2016-07-14 EP EP16739459.2A patent/EP3322727B1/en active Active
- 2016-07-14 DK DK16739459.2T patent/DK3322727T3/da active
- 2016-07-14 WO PCT/EP2016/066845 patent/WO2017009442A1/en not_active Ceased
- 2016-07-14 AU AU2016293073A patent/AU2016293073B2/en active Active
- 2016-07-14 UA UAA201801453A patent/UA128057C2/uk unknown
- 2016-07-14 NZ NZ739028A patent/NZ739028A/en unknown
- 2016-07-14 PL PL16739459.2T patent/PL3322727T3/pl unknown
- 2016-07-14 KR KR1020257009196A patent/KR20250048113A/ko active Pending
- 2016-07-14 CN CN202511003204.5A patent/CN120842408A/zh active Pending
- 2016-07-14 KR KR1020187004157A patent/KR102786353B1/ko active Active
- 2016-07-14 RS RS20260358A patent/RS67909B1/sr unknown
- 2016-07-14 EA EA201890305A patent/EA201890305A1/ru unknown
- 2016-07-14 CN CN202210585379.1A patent/CN114989302B/zh active Active
- 2016-07-14 IL IL256562A patent/IL256562B2/en unknown
- 2016-07-14 CA CA2992380A patent/CA2992380A1/en active Pending
-
2018
- 2018-01-09 MX MX2022011002A patent/MX2022011002A/es unknown
-
2021
- 2021-10-13 JP JP2021168124A patent/JP7604351B2/ja active Active
-
2022
- 2022-05-09 US US17/739,923 patent/US12673994B2/en active Active
- 2022-05-09 US US17/739,934 patent/US12617854B2/en active Active
- 2022-05-09 US US17/739,940 patent/US20220389101A1/en not_active Abandoned
-
2023
- 2023-03-20 AU AU2023201733A patent/AU2023201733A1/en not_active Abandoned
-
2024
- 2024-12-11 JP JP2024216521A patent/JP2025038049A/ja active Pending
-
2026
- 2026-05-11 AU AU2026203568A patent/AU2026203568A1/en active Pending
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