JP2018526981A - ヒト化またはキメラｃｄ３抗体 - Google Patents

ヒト化またはキメラｃｄ３抗体 Download PDF

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Publication number
JP2018526981A
JP2018526981A JP2018501159A JP2018501159A JP2018526981A JP 2018526981 A JP2018526981 A JP 2018526981A JP 2018501159 A JP2018501159 A JP 2018501159A JP 2018501159 A JP2018501159 A JP 2018501159A JP 2018526981 A JP2018526981 A JP 2018526981A
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seq
antibody
cdr2
cdr1
cdr3 sequences
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JP2018526981A5 (enExample
Inventor
リック ラーデメイカー
リック ラーデメイカー
イシル アルティンタス
イシル アルティンタス
パトリック エンジェルバーツ
パトリック エンジェルバーツ
ジャニーヌ シュールマン
ジャニーヌ シュールマン
ポール パレン
ポール パレン
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Genmab AS
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Genmab AS
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Priority claimed from PCT/EP2016/050296 external-priority patent/WO2016110576A1/en
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Publication of JP2018526981A publication Critical patent/JP2018526981A/ja
Publication of JP2018526981A5 publication Critical patent/JP2018526981A5/ja
Priority to JP2021168124A priority Critical patent/JP7604351B2/ja
Priority to JP2024216521A priority patent/JP2025038049A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4216—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-viral Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2018501159A 2015-07-15 2016-07-14 ヒト化またはキメラｃｄ３抗体 Pending JP2018526981A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021168124A JP7604351B2 (ja) 2015-07-15 2021-10-13 ヒト化またはキメラｃｄ３抗体
JP2024216521A JP2025038049A (ja) 2015-07-15 2024-12-11 ヒト化またはキメラｃｄ３抗体

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
DKPA201500413 2015-07-15
DKPA201500413 2015-07-15
DKPA201500414 2015-07-15
DKPA201500414 2015-07-15
DKPA201500416 2015-07-16
DKPA201500416 2015-07-16
EPPCT/EP2016/050296 2016-01-08
PCT/EP2016/050296 WO2016110576A1 (en) 2015-01-08 2016-01-08 Bispecific antibodies against cd3 and cd20
PCT/EP2016/066845 WO2017009442A1 (en) 2015-07-15 2016-07-14 Humanized or chimeric cd3 antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021168124A Division JP7604351B2 (ja) 2015-07-15 2021-10-13 ヒト化またはキメラｃｄ３抗体

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JP2018526981A true JP2018526981A (ja) 2018-09-20
JP2018526981A5 JP2018526981A5 (enExample) 2019-08-29

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JP2018501159A Pending JP2018526981A (ja) 2015-07-15 2016-07-14 ヒト化またはキメラｃｄ３抗体
JP2021168124A Active JP7604351B2 (ja) 2015-07-15 2021-10-13 ヒト化またはキメラｃｄ３抗体
JP2024216521A Pending JP2025038049A (ja) 2015-07-15 2024-12-11 ヒト化またはキメラｃｄ３抗体

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JP2021168124A Active JP7604351B2 (ja) 2015-07-15 2021-10-13 ヒト化またはキメラｃｄ３抗体
JP2024216521A Pending JP2025038049A (ja) 2015-07-15 2024-12-11 ヒト化またはキメラｃｄ３抗体

Country Status (14)

Country Link
US (4) US11359015B2 (enExample)
EP (1) EP3322727A1 (enExample)
JP (3) JP2018526981A (enExample)
KR (2) KR20250048113A (enExample)
CN (3) CN108368172B (enExample)
AU (2) AU2016293073B2 (enExample)
BR (1) BR112018000696A2 (enExample)
CA (1) CA2992380A1 (enExample)
EA (1) EA201890305A1 (enExample)
IL (2) IL310467A (enExample)
MX (2) MX395317B (enExample)
NZ (1) NZ739028A (enExample)
UA (1) UA128057C2 (enExample)
WO (1) WO2017009442A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022536247A (ja) * 2019-06-07 2022-08-15 アディマブ・リミテッド・ライアビリティ・カンパニー 高アフィニティ抗ｃｄ３抗体、ならびにその作製方法及び使用方法
JP2023517753A (ja) * 2020-03-18 2023-04-26 ジェンマブ エー／エス Ｂ７ｈ４に結合する抗体
JP2023547329A (ja) * 2020-10-02 2023-11-10 ジェンマブ エー／エス Ｒｏｒ２へと結合することができる抗体ならびにｒｏｒ２およびｃｄ３に結合する二重特異性抗体

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JP6514103B2 (ja) 2012-07-06 2019-05-15 ゲンマブ ビー．ブイ． 三重変異を有する二量体タンパク質
ES2776706T3 (es) 2013-07-05 2020-07-31 Genmab As Anticuerpos contra CD3 humanizados o quiméricos
JP7461741B2 (ja) 2016-06-20 2024-04-04 カイマブ・リミテッド 抗ｐｄ－ｌ１およびｉｌ－２サイトカイン
FI3592769T3 (fi) 2017-03-09 2024-07-30 Genmab As Vasta-aineita PD-L1:tä vastaan
WO2018208877A1 (en) * 2017-05-09 2018-11-15 Yale University Basehit, a high-throughput assay to identify proteins involved in host-microbe interaction
EP3409322A1 (en) 2017-06-01 2018-12-05 F. Hoffmann-La Roche AG Treatment method
WO2018237148A1 (en) 2017-06-21 2018-12-27 Gilead Sciences, Inc. Multispecific antibodies that target hiv gp120 and cd3
AU2019233523A1 (en) 2018-03-12 2020-10-01 Genmab A/S Antibodies
EP3765520A1 (en) * 2018-03-14 2021-01-20 NovImmune SA Anti-cd3 epsilon antibodies and methods of use thereof
JP7759805B2 (ja) * 2018-08-28 2025-10-24 アンブルックス，インコーポレイテッド 抗ｃｄ３抗体葉酸生物複合体およびその使用
CN114901688A (zh) * 2019-07-29 2022-08-12 杜兰教育基金委员会 针对念珠菌的抗体及其用途
EP4028424A1 (en) 2019-09-12 2022-07-20 Genmab A/S Bispecific antibodies binding to 5t4 and cd3 for use in treatment of cancer
EP4146175A1 (en) 2020-05-08 2023-03-15 Genmab A/S Bispecific antibodies against cd3 and cd20
WO2022053653A1 (en) 2020-09-10 2022-03-17 Genmab A/S Bispecific antibodies against cd3 and cd20 for treating chronic lymphocytic leukemia
CA3192251A1 (en) 2020-09-10 2022-03-17 Genmab A/S Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma
JP2024519212A (ja) 2021-05-07 2024-05-09 ジェンマブ エー／エス Ｂ７ｈ４およびｃｄ３に結合する二重特異性抗体を含む薬学的組成物
CN113527493B (zh) * 2021-07-20 2023-10-27 广州爱思迈生物医药科技有限公司 一种b7-h3抗体及其应用
KR20240082397A (ko) * 2021-10-08 2024-06-10 젠맵 에이/에스 Cd30 및 cd3에 결합하는 항체
CN115368446B (zh) * 2022-07-19 2025-08-08 合肥天港免疫药物有限公司 双特异性抗体及其应用
WO2024088987A1 (en) 2022-10-26 2024-05-02 F. Hoffmann-La Roche Ag Combination therapy for the treatment of cancer
AR132290A1 (es) 2023-04-05 2025-06-11 Genmab As Composiciones farmacéuticas que comprenden anticuerpos que se unen a cd30 y cd3

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022536247A (ja) * 2019-06-07 2022-08-15 アディマブ・リミテッド・ライアビリティ・カンパニー 高アフィニティ抗ｃｄ３抗体、ならびにその作製方法及び使用方法
JP7774447B2 (ja) 2019-06-07 2025-11-21 アディマブ・リミテッド・ライアビリティ・カンパニー 高アフィニティ抗ｃｄ３抗体、ならびにその作製方法及び使用方法
JP2023517753A (ja) * 2020-03-18 2023-04-26 ジェンマブ エー／エス Ｂ７ｈ４に結合する抗体
JP7749575B2 (ja) 2020-03-18 2025-10-06 ジェンマブ エー／エス Ｂ７ｈ４に結合する抗体
JP2023547329A (ja) * 2020-10-02 2023-11-10 ジェンマブ エー／エス Ｒｏｒ２へと結合することができる抗体ならびにｒｏｒ２およびｃｄ３に結合する二重特異性抗体

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US20190284278A1 (en) 2019-09-19
AU2016293073A1 (en) 2018-02-01
KR20250048113A (ko) 2025-04-07
US20220389101A1 (en) 2022-12-08
NZ739028A (en) 2023-05-26
IL256562B2 (en) 2024-07-01
IL310467A (en) 2024-03-01
US20220380464A1 (en) 2022-12-01
JP2025038049A (ja) 2025-03-18
CN108368172B (zh) 2022-06-14
JP2022023862A (ja) 2022-02-08
KR102786353B1 (ko) 2025-03-26
NZ778208A (en) 2025-05-02
AU2016293073B2 (en) 2022-12-22
EA201890305A1 (ru) 2018-07-31
CA2992380A1 (en) 2017-01-19
AU2023201733A1 (en) 2023-07-13
UA128057C2 (uk) 2024-03-27
KR20180030635A (ko) 2018-03-23
BR112018000696A2 (pt) 2018-09-18
MX2018000347A (es) 2018-03-14
CN114989302B (zh) 2025-08-05
IL256562B1 (en) 2024-03-01
EP3322727A1 (en) 2018-05-23
WO2017009442A1 (en) 2017-01-19
NZ778205A (en) 2025-05-02
US11359015B2 (en) 2022-06-14
US20230027394A1 (en) 2023-01-26
CN114989302A (zh) 2022-09-02
CN108368172A (zh) 2018-08-03
CN120842408A (zh) 2025-10-28
IL256562A (en) 2018-02-28
MX395317B (es) 2025-03-25
MX2022011002A (es) 2022-10-07
JP7604351B2 (ja) 2024-12-23

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