KR20250048113A - 인간화 또는 키메라 cd3 항체 - Google Patents

인간화 또는 키메라 cd3 항체 Download PDF

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Publication number
KR20250048113A
KR20250048113A KR1020257009196A KR20257009196A KR20250048113A KR 20250048113 A KR20250048113 A KR 20250048113A KR 1020257009196 A KR1020257009196 A KR 1020257009196A KR 20257009196 A KR20257009196 A KR 20257009196A KR 20250048113 A KR20250048113 A KR 20250048113A
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KR
South Korea
Prior art keywords
seq
set forth
cdr2
cdr1
antibody
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Pending
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KR1020257009196A
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English (en)
Korean (ko)
Inventor
릭 라데마케르
이실 알틴타스
파트릭 엥겔베르츠
야니너 스휘르만
파울 파런
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젠맵 에이/에스
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Priority claimed from PCT/EP2016/050296 external-priority patent/WO2016110576A1/en
Application filed by 젠맵 에이/에스 filed Critical 젠맵 에이/에스
Publication of KR20250048113A publication Critical patent/KR20250048113A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4216—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-viral Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020257009196A 2015-07-15 2016-07-14 인간화 또는 키메라 cd3 항체 Pending KR20250048113A (ko)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
DKPA201500413 2015-07-15
DKPA201500413 2015-07-15
DKPA201500414 2015-07-15
DKPA201500414 2015-07-15
DKPA201500416 2015-07-16
DKPA201500416 2015-07-16
EPPCT/EP2016/050296 2016-01-08
PCT/EP2016/050296 WO2016110576A1 (en) 2015-01-08 2016-01-08 Bispecific antibodies against cd3 and cd20
PCT/EP2016/066845 WO2017009442A1 (en) 2015-07-15 2016-07-14 Humanized or chimeric cd3 antibodies
KR1020187004157A KR102786353B1 (ko) 2015-07-15 2016-07-14 인간화 또는 키메라 cd3 항체

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020187004157A Division KR102786353B1 (ko) 2015-07-15 2016-07-14 인간화 또는 키메라 cd3 항체

Publications (1)

Publication Number Publication Date
KR20250048113A true KR20250048113A (ko) 2025-04-07

Family

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Family Applications (2)

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KR1020257009196A Pending KR20250048113A (ko) 2015-07-15 2016-07-14 인간화 또는 키메라 cd3 항체
KR1020187004157A Active KR102786353B1 (ko) 2015-07-15 2016-07-14 인간화 또는 키메라 cd3 항체

Family Applications After (1)

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KR1020187004157A Active KR102786353B1 (ko) 2015-07-15 2016-07-14 인간화 또는 키메라 cd3 항체

Country Status (14)

Country Link
US (4) US11359015B2 (enExample)
EP (1) EP3322727A1 (enExample)
JP (3) JP2018526981A (enExample)
KR (2) KR20250048113A (enExample)
CN (3) CN108368172B (enExample)
AU (2) AU2016293073B2 (enExample)
BR (1) BR112018000696A2 (enExample)
CA (1) CA2992380A1 (enExample)
EA (1) EA201890305A1 (enExample)
IL (2) IL310467A (enExample)
MX (2) MX395317B (enExample)
NZ (1) NZ739028A (enExample)
UA (1) UA128057C2 (enExample)
WO (1) WO2017009442A1 (enExample)

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Publication number Publication date
US20190284278A1 (en) 2019-09-19
AU2016293073A1 (en) 2018-02-01
US20220389101A1 (en) 2022-12-08
NZ739028A (en) 2023-05-26
IL256562B2 (en) 2024-07-01
IL310467A (en) 2024-03-01
US20220380464A1 (en) 2022-12-01
JP2025038049A (ja) 2025-03-18
CN108368172B (zh) 2022-06-14
JP2022023862A (ja) 2022-02-08
KR102786353B1 (ko) 2025-03-26
NZ778208A (en) 2025-05-02
AU2016293073B2 (en) 2022-12-22
EA201890305A1 (ru) 2018-07-31
CA2992380A1 (en) 2017-01-19
AU2023201733A1 (en) 2023-07-13
UA128057C2 (uk) 2024-03-27
KR20180030635A (ko) 2018-03-23
BR112018000696A2 (pt) 2018-09-18
MX2018000347A (es) 2018-03-14
CN114989302B (zh) 2025-08-05
IL256562B1 (en) 2024-03-01
EP3322727A1 (en) 2018-05-23
WO2017009442A1 (en) 2017-01-19
NZ778205A (en) 2025-05-02
US11359015B2 (en) 2022-06-14
JP2018526981A (ja) 2018-09-20
US20230027394A1 (en) 2023-01-26
CN114989302A (zh) 2022-09-02
CN108368172A (zh) 2018-08-03
CN120842408A (zh) 2025-10-28
IL256562A (en) 2018-02-28
MX395317B (es) 2025-03-25
MX2022011002A (es) 2022-10-07
JP7604351B2 (ja) 2024-12-23

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