UA128057C2 - Гуманізоване або химерне антитіло, яке зв'язує cd3 людини - Google Patents

Гуманізоване або химерне антитіло, яке зв'язує cd3 людини Download PDF

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Publication number
UA128057C2
UA128057C2 UAA201801453A UAA201801453A UA128057C2 UA 128057 C2 UA128057 C2 UA 128057C2 UA A201801453 A UAA201801453 A UA A201801453A UA A201801453 A UAA201801453 A UA A201801453A UA 128057 C2 UA128057 C2 UA 128057C2
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Ukraine
Prior art keywords
antibody
presented
sequence
zeo
region
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UAA201801453A
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English (en)
Ukrainian (uk)
Inventor
Рік Радемакер
Рик Радемакер
Ізіл Алтінтас
Изил Алтинтас
Патрік Енґелбертс
Патрик Энгелбертс
Яніне Схюірман
Янине Схюирман
Паул Паррен
Original Assignee
Ґенмаб А/С
Генмаб А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from PCT/EP2016/050296 external-priority patent/WO2016110576A1/en
Application filed by Ґенмаб А/С, Генмаб А/С filed Critical Ґенмаб А/С
Publication of UA128057C2 publication Critical patent/UA128057C2/uk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4216—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-viral Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
UAA201801453A 2015-07-15 2016-07-14 Гуманізоване або химерне антитіло, яке зв'язує cd3 людини UA128057C2 (uk)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA201500413 2015-07-15
DKPA201500414 2015-07-15
DKPA201500416 2015-07-16
PCT/EP2016/050296 WO2016110576A1 (en) 2015-01-08 2016-01-08 Bispecific antibodies against cd3 and cd20
PCT/EP2016/066845 WO2017009442A1 (en) 2015-07-15 2016-07-14 Humanized or chimeric cd3 antibodies

Publications (1)

Publication Number Publication Date
UA128057C2 true UA128057C2 (uk) 2024-03-27

Family

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Family Applications (1)

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UAA201801453A UA128057C2 (uk) 2015-07-15 2016-07-14 Гуманізоване або химерне антитіло, яке зв'язує cd3 людини

Country Status (21)

Country Link
US (4) US11359015B2 (enExample)
EP (2) EP4759831A2 (enExample)
JP (3) JP2018526981A (enExample)
KR (2) KR20250048113A (enExample)
CN (3) CN108368172B (enExample)
AU (3) AU2016293073B2 (enExample)
BR (1) BR112018000696A2 (enExample)
CA (1) CA2992380A1 (enExample)
DK (1) DK3322727T3 (enExample)
EA (1) EA201890305A1 (enExample)
ES (1) ES3063317T3 (enExample)
FI (1) FI3322727T3 (enExample)
IL (2) IL310467A (enExample)
MX (2) MX395317B (enExample)
NZ (1) NZ739028A (enExample)
PL (1) PL3322727T3 (enExample)
PT (1) PT3322727T (enExample)
RS (1) RS67909B1 (enExample)
SI (1) SI3322727T1 (enExample)
UA (1) UA128057C2 (enExample)
WO (1) WO2017009442A1 (enExample)

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Publication number Publication date
US11359015B2 (en) 2022-06-14
WO2017009442A1 (en) 2017-01-19
JP2018526981A (ja) 2018-09-20
US12673994B2 (en) 2026-07-07
CA2992380A1 (en) 2017-01-19
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AU2026203568A1 (en) 2026-05-28
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JP2022023862A (ja) 2022-02-08
IL310467A (en) 2024-03-01
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US20190284278A1 (en) 2019-09-19
RS67909B1 (sr) 2026-04-30
CN120842408A (zh) 2025-10-28
EP3322727B1 (en) 2025-12-31
KR20180030635A (ko) 2018-03-23
CN108368172A (zh) 2018-08-03
US20220389101A1 (en) 2022-12-08
MX2018000347A (es) 2018-03-14
AU2016293073A1 (en) 2018-02-01
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EA201890305A1 (ru) 2018-07-31
FI3322727T3 (fi) 2026-03-17
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US20220380464A1 (en) 2022-12-01
DK3322727T3 (da) 2026-03-30
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PT3322727T (pt) 2026-03-16
MX395317B (es) 2025-03-25
BR112018000696A2 (en) 2018-09-18
CN108368172B (zh) 2022-06-14
IL256562A (en) 2018-02-28
CN114989302A (zh) 2022-09-02
KR102786353B1 (ko) 2025-03-26
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