JP2021512159A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2021512159A5 JP2021512159A5 JP2020561952A JP2020561952A JP2021512159A5 JP 2021512159 A5 JP2021512159 A5 JP 2021512159A5 JP 2020561952 A JP2020561952 A JP 2020561952A JP 2020561952 A JP2020561952 A JP 2020561952A JP 2021512159 A5 JP2021512159 A5 JP 2021512159A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- fragment
- sequence
- fusion protein
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 26
- 108020001507 fusion proteins Proteins 0.000 claims 16
- 102000037865 fusion proteins Human genes 0.000 claims 16
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 12
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims 11
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 10
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 10
- 229920001184 polypeptide Polymers 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 7
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 4
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 4
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 4
- 210000004899 c-terminal region Anatomy 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 3
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 230000008499 blood brain barrier function Effects 0.000 claims 3
- 210000001218 blood-brain barrier Anatomy 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 230000008827 biological function Effects 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000012423 maintenance Methods 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023094278A JP2023123535A (ja) | 2017-01-30 | 2023-06-07 | 血液脳関門移動化合物及びその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762452015P | 2017-01-30 | 2017-01-30 | |
| US201762530980P | 2017-07-11 | 2017-07-11 | |
| IBPCT/IB2018/050576 | 2018-01-30 | ||
| PCT/IB2018/050576 WO2018138709A1 (en) | 2017-01-30 | 2018-01-30 | Blood-brain barrier transmigrating compounds and uses thereof |
| PCT/IB2018/055747 WO2019150183A1 (en) | 2017-01-30 | 2018-07-31 | Blood-brain barrier transmigrating compounds and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023094278A Division JP2023123535A (ja) | 2017-01-30 | 2023-06-07 | 血液脳関門移動化合物及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021512159A JP2021512159A (ja) | 2021-05-13 |
| JP2021512159A5 true JP2021512159A5 (enExample) | 2021-09-09 |
| JP7458327B2 JP7458327B2 (ja) | 2024-03-29 |
Family
ID=62977950
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019541280A Active JP7449092B2 (ja) | 2017-01-30 | 2018-01-30 | 血液脳関門移動化合物及びその使用 |
| JP2020561952A Active JP7458327B2 (ja) | 2017-01-30 | 2018-07-31 | 血液脳関門移動化合物及びその使用 |
| JP2023094278A Pending JP2023123535A (ja) | 2017-01-30 | 2023-06-07 | 血液脳関門移動化合物及びその使用 |
| JP2024031648A Pending JP2024081644A (ja) | 2017-01-30 | 2024-03-01 | 血液脳関門移動化合物及びその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019541280A Active JP7449092B2 (ja) | 2017-01-30 | 2018-01-30 | 血液脳関門移動化合物及びその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023094278A Pending JP2023123535A (ja) | 2017-01-30 | 2023-06-07 | 血液脳関門移動化合物及びその使用 |
| JP2024031648A Pending JP2024081644A (ja) | 2017-01-30 | 2024-03-01 | 血液脳関門移動化合物及びその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US11702466B2 (enExample) |
| EP (2) | EP3574002A4 (enExample) |
| JP (4) | JP7449092B2 (enExample) |
| KR (3) | KR20240095466A (enExample) |
| CN (2) | CN110382522B (enExample) |
| AU (4) | AU2018212860A1 (enExample) |
| CA (2) | CA3052058A1 (enExample) |
| WO (2) | WO2018138709A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7449092B2 (ja) * | 2017-01-30 | 2024-03-13 | ナショナル リサーチ カウンシル オブ カナダ | 血液脳関門移動化合物及びその使用 |
| WO2019023247A1 (en) | 2017-07-25 | 2019-01-31 | Immutics, Inc. | TREATMENT OF CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND ITS LIGAND |
| BR112021008105A2 (pt) * | 2018-10-29 | 2021-08-03 | Biogen Ma Inc. | variantes de fc5 humanizadas e estabilizadas para intensificação de transporte através de barreira hematoencefálica |
| EP3918323A4 (en) | 2019-01-30 | 2022-12-28 | TrueBinding, Inc. | ANTI-GAL3 ANTIBODIES AND USES THEREOF |
| EP4058479A4 (en) | 2019-11-15 | 2024-02-28 | University of Tennessee Research Foundation | MODIFIED IMMUNOLOBULINES FOR TARGETING AMYLOID DEPOSITS |
| WO2021242776A2 (en) | 2020-05-26 | 2021-12-02 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking galectin-3 |
| MX2023012871A (es) * | 2021-05-05 | 2024-01-17 | Univ Tennessee Res Found | Fusiones de peptido-fc para el tratamiento de trastornos amiloides. |
| WO2022246433A1 (en) * | 2021-05-18 | 2022-11-24 | University Of Tennessee Research Foundation | Antibody-peptide fusion proteins for treating amyloid disorders |
| KR102475326B1 (ko) * | 2022-01-27 | 2022-12-07 | 한국기초과학지원연구원 | 신규한 펩타이드 유사체 및 이를 포함하는 알츠하이머 병 예방 조성물 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5385915A (en) | 1990-05-16 | 1995-01-31 | The Rockefeller University | Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation |
| EP0711303B2 (en) | 1993-07-30 | 2009-06-10 | Affymax, Inc. | Biotinylation of proteins |
| AU2001263006A1 (en) | 2000-05-18 | 2001-11-26 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| CA2380443C (en) * | 2000-05-26 | 2013-03-12 | Ginette Dubuc | Single-domain antigen-binding antibody fragments derived from llama antibodies |
| WO2002057445A1 (en) * | 2000-05-26 | 2002-07-25 | National Research Council Of Canada | Single-domain brain-targeting antibody fragments derived from llama antibodies |
| WO2002086122A2 (en) | 2001-03-14 | 2002-10-31 | Hybrigenics | Protein-protein interactions in adipocytes |
| US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| JP2003135075A (ja) * | 2001-11-05 | 2003-05-13 | Research Association For Biotechnology | 新規な全長ｃＤＮＡ |
| JP4471656B2 (ja) | 2001-11-30 | 2010-06-02 | ナショナル リサーチ カウンシル オブ カナダ | 新規自己集合分子 |
| EP1452601A1 (en) | 2003-02-28 | 2004-09-01 | Roche Diagnostics GmbH | Enhanced expression of fusion polypeptides with a biotinylation tag |
| EP2259063B1 (en) * | 2004-04-27 | 2012-05-23 | Galapagos N.V. | Compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts |
| WO2006133566A1 (en) | 2005-06-17 | 2006-12-21 | National Research Council Of Canada | NOVEL Aß-BINDING PROTEIN AND ITS PEPTIDE DERIVATIVES AND USES THEREOF |
| US20090233357A1 (en) | 2005-09-27 | 2009-09-17 | Abedelnasser Abulrob | Targeted Delivery of Compounds Using Multimerization Technology |
| TW200907056A (en) * | 2007-03-28 | 2009-02-16 | Astrazeneca Ab | New method |
| CA2796215C (en) | 2010-04-14 | 2021-05-18 | National Research Council Of Canada | Compositions and methods for brain delivery of analgesic peptides |
| US20110269735A1 (en) * | 2010-04-19 | 2011-11-03 | Celera Corporation | Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof |
| CA2813133C (en) | 2010-10-01 | 2023-10-31 | National Research Council Of Canada | Anti-ceacam6 antibodies and uses thereof |
| PL2802606T3 (pl) * | 2012-01-10 | 2018-09-28 | Biogen Ma Inc. | Udoskonalenie transportu cząsteczek terapeutycznych przez barierę krew-mózg |
| KR20150039798A (ko) | 2012-08-29 | 2015-04-13 | 에프. 호프만-라 로슈 아게 | 혈액 뇌 장벽 셔틀 |
| DK3114141T3 (da) * | 2014-03-06 | 2020-08-10 | Nat Res Council Canada | Insulinlignende vækstfaktor 1-receptor-specifikke antistoffer og anvendelse deraf |
| US10100117B2 (en) * | 2014-03-06 | 2018-10-16 | National Research Council Of Canada | Insulin-like growth factor 1 receptor-specific antibodies and uses thereof |
| UA120048C2 (uk) | 2014-03-06 | 2019-09-25 | Нешнл Рісеч Каунсіл Оф Канада | Антигензв'язуючий фрагмент антитіла, який специфічно зв'язується з рецептором інсуліноподібного фактора росту 1 (igf1r) |
| JP2018505662A (ja) * | 2014-12-19 | 2018-03-01 | メッドイミューン・リミテッド | 血液脳関門輸送分子およびそれらの使用 |
| WO2017037634A1 (en) | 2015-08-31 | 2017-03-09 | National Research Council Of Canada | Tgf-β-receptor ectodomain fusion molecules and uses thereof |
| KR102406610B1 (ko) | 2016-07-06 | 2022-06-08 | 내셔날 리서치 카운실 오브 캐나다 | 혈액-뇌 장벽을 통과이동하는 인간화 항체 및 그의 용도 |
| WO2018109663A1 (en) | 2016-12-12 | 2018-06-21 | National Research Council Of Canada | Antibody variants transmigrating the blood-brain barrier and uses thereof |
| JP7449092B2 (ja) | 2017-01-30 | 2024-03-13 | ナショナル リサーチ カウンシル オブ カナダ | 血液脳関門移動化合物及びその使用 |
-
2018
- 2018-01-30 JP JP2019541280A patent/JP7449092B2/ja active Active
- 2018-01-30 KR KR1020247019801A patent/KR20240095466A/ko active Pending
- 2018-01-30 KR KR1020197025302A patent/KR102676279B1/ko active Active
- 2018-01-30 AU AU2018212860A patent/AU2018212860A1/en not_active Abandoned
- 2018-01-30 WO PCT/IB2018/050576 patent/WO2018138709A1/en not_active Ceased
- 2018-01-30 CA CA3052058A patent/CA3052058A1/en active Pending
- 2018-01-30 US US16/481,898 patent/US11702466B2/en active Active
- 2018-01-30 CN CN201880015949.5A patent/CN110382522B/zh active Active
- 2018-01-30 EP EP18745446.7A patent/EP3574002A4/en active Pending
- 2018-07-31 CN CN201880091218.9A patent/CN111886240A/zh active Pending
- 2018-07-31 US US16/965,885 patent/US20230257424A1/en not_active Abandoned
- 2018-07-31 AU AU2018405992A patent/AU2018405992A1/en not_active Abandoned
- 2018-07-31 JP JP2020561952A patent/JP7458327B2/ja active Active
- 2018-07-31 WO PCT/IB2018/055747 patent/WO2019150183A1/en not_active Ceased
- 2018-07-31 EP EP18904229.4A patent/EP3746460A4/en active Pending
- 2018-07-31 KR KR1020207025008A patent/KR20200116143A/ko not_active Ceased
- 2018-07-31 CA CA3089816A patent/CA3089816A1/en active Pending
-
2022
- 2022-03-23 AU AU2022202015A patent/AU2022202015B2/en active Active
-
2023
- 2023-03-14 US US18/183,812 patent/US20230279088A1/en active Pending
- 2023-06-07 JP JP2023094278A patent/JP2023123535A/ja active Pending
-
2024
- 2024-03-01 JP JP2024031648A patent/JP2024081644A/ja active Pending
- 2024-03-20 AU AU2024201813A patent/AU2024201813A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021512159A5 (enExample) | ||
| US20240076370A1 (en) | Antibodies targeting g-protein coupled receptor and methods of use | |
| US12343401B2 (en) | Modular self assembly disassembly (SADA) technologies | |
| CN110627906B (zh) | 抗pd-l1/4-1bb双特异性抗体及其用途 | |
| US10899835B2 (en) | IgM Fc and J-chain mutations that affect IgM serum half-life | |
| JP7019198B2 (ja) | 補体関連疾患の予防及び治療のためのｃ５抗体及び方法 | |
| JP7191134B2 (ja) | Ｉｇｆ－１ｒ抗体および癌処置のためのアドレッシングビヒクルとしてのその使用 | |
| KR102501921B1 (ko) | 유도성 결합 단백질 및 사용 방법 | |
| RU2558301C2 (ru) | Полипептиды для связывания с "рецептором конечных продуктов гликирования", а также их композиции и способы, в которых они принимают участие | |
| JP5911821B2 (ja) | 受容体チロシンキナーゼａｌｋの細胞外ドメインに結合する抗体 | |
| KR20190134997A (ko) | 항-tau 항체 및 이의 사용 방법 | |
| JP2017529067A (ja) | Ｃｄ３結合ドメイン | |
| JP2020124203A (ja) | 血液脳関門輸送分子およびそれらの使用 | |
| JP2017537082A5 (enExample) | ||
| KR20230104229A (ko) | Cd3에 결합하는 폴리펩티드 구축물 | |
| KR20230098335A (ko) | 클리핑 비율이 감소된 항원 결합 도메인 | |
| CA3160855A1 (en) | Antibodies targeting cell surface deposited complement protein c3d and use thereof | |
| EP2319871A1 (en) | Polypeptides for binding to the "receptor for advanced glycation endproducts" as well as compositions and methods involving the same | |
| EP2308896A1 (en) | Polypeptides for binding to the "receptor for advanced glycation endproducts" as well as compositions and methods involving the same |