MA54070A - Variants fc5 humanisés et stabilisés pour l'amélioration du transport à travers la barrière hémato-encéphalique - Google Patents
Variants fc5 humanisés et stabilisés pour l'amélioration du transport à travers la barrière hémato-encéphaliqueInfo
- Publication number
- MA54070A MA54070A MA054070A MA54070A MA54070A MA 54070 A MA54070 A MA 54070A MA 054070 A MA054070 A MA 054070A MA 54070 A MA54070 A MA 54070A MA 54070 A MA54070 A MA 54070A
- Authority
- MA
- Morocco
- Prior art keywords
- humanized
- variants
- stabilized
- blood
- brain barrier
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862751962P | 2018-10-29 | 2018-10-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA54070A true MA54070A (fr) | 2021-09-08 |
Family
ID=68582454
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA054070A MA54070A (fr) | 2018-10-29 | 2019-10-28 | Variants fc5 humanisés et stabilisés pour l'amélioration du transport à travers la barrière hémato-encéphalique |
Country Status (13)
Country | Link |
---|---|
US (1) | US20220089704A1 (fr) |
EP (1) | EP3873934A2 (fr) |
JP (1) | JP2022509372A (fr) |
KR (1) | KR20210111242A (fr) |
CN (1) | CN113508135A (fr) |
AU (1) | AU2019371814A1 (fr) |
BR (1) | BR112021008105A2 (fr) |
CA (1) | CA3117409A1 (fr) |
EA (1) | EA202191179A1 (fr) |
IL (1) | IL282677A (fr) |
MA (1) | MA54070A (fr) |
MX (1) | MX2021004772A (fr) |
WO (1) | WO2020092202A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230272052A1 (en) * | 2020-07-31 | 2023-08-31 | CureVac SE | Nucleic acid encoded antibody mixtures |
CN116650660B (zh) * | 2023-07-27 | 2023-11-03 | 上海偌妥生物科技有限公司 | 制备抗体偶联小分子药物的方法及其应用 |
Family Cites Families (54)
Publication number | Priority date | Publication date | Assignee | Title |
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US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
GB8620926D0 (en) | 1986-08-29 | 1986-10-08 | Delta Biotechnology Ltd | Yeast promoter |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
CA2545539A1 (fr) | 2003-10-15 | 2005-04-28 | Pdl Biopharma, Inc. | Modification de demi-vies seriques de proteines de fusion fc par mutagenese de positions 250, 314 et/ou 428 de la region constante de la chaine lourde des immunoglobulines |
US8546543B2 (en) | 2004-11-12 | 2013-10-01 | Xencor, Inc. | Fc variants that extend antibody half-life |
HUE030701T2 (hu) | 2005-05-27 | 2017-05-29 | Biogen Ma Inc | Tweak-kötõ antitestek |
SI3308788T1 (sl) | 2005-06-23 | 2019-01-31 | Biogen Ma Inc. | Sestave in metode za modulacijo združevanja SMN2 |
WO2007025385A1 (fr) | 2005-08-31 | 2007-03-08 | Universite Laval | Anticorps et leur utilisation dans le traitement, la prevention et le diagnostic d'une maladie associee a des anomalies de sod1 |
US7846445B2 (en) | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
EA017611B1 (ru) | 2007-01-05 | 2013-01-30 | Юнивэсэти Оф Цюрих | Способ получения связывающей молекулы, специфичной к белку, ассоциированному с расстройством, или антитела или его связывающего фрагмента или по меньшей мере одной цепи иммуноглобулина, связывающих вышеуказанный белок (варианты), связывающая молекула, антитело, цепь иммуноглобулина или их связывающий фрагмент (варианты), антиген, полинуклеотид, вектор и клетка-хозяин, их включающие композиция и набор и способ диагностики или лечения неврологических расстройств посредством |
US8128926B2 (en) | 2007-01-09 | 2012-03-06 | Biogen Idec Ma Inc. | Sp35 antibodies and uses thereof |
AU2008287340A1 (en) | 2007-08-15 | 2009-02-19 | Amunix, Inc. | Compositions and methods for modifying properties of biologically active polypeptides |
CA2729961C (fr) | 2008-07-09 | 2018-05-01 | Biogen Idec Ma Inc. | Anticorps anti-lingo, li113, li62 variant co2 |
EP3521309A1 (fr) | 2008-12-19 | 2019-08-07 | Biogen International Neuroscience GmbH | Anticorps humains anti-alpha-synucléine |
AU2010206681A1 (en) | 2009-01-23 | 2011-09-01 | Biogen Idec Ma Inc. | Stabilized Fc polypeptides with reduced effector function and methods of use |
PT2393828T (pt) | 2009-02-03 | 2017-01-18 | Amunix Operating Inc | Polipéptidos recombinantes estendidos e composições que compreendem os mesmos |
US8703717B2 (en) | 2009-02-03 | 2014-04-22 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
US8680050B2 (en) | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
AU2010258898B8 (en) | 2009-06-08 | 2015-02-05 | Amunix Operating Inc. | Glucose-regulating polypeptides and methods of making and using same |
NZ596787A (en) | 2009-06-08 | 2014-03-28 | Amunix Operating Inc | Growth hormone polypeptides and methods of making and using same |
SI3305302T1 (sl) | 2009-06-17 | 2018-12-31 | Biogen Ma Inc. | Sestave in metode za modulacijo združevanja smn2 pri subjektu |
JP5813641B2 (ja) | 2009-08-24 | 2015-11-17 | アムニクス オペレーティング インコーポレイテッド | 凝固第ix因子組成物ならびにそれを製造および使用する方法 |
WO2011028344A2 (fr) | 2009-08-25 | 2011-03-10 | Amunix Operating Inc. | Compositions d'antagonistes des récepteurs d'interleukine-1 et leurs procédés de préparation et d'utilisation |
GB2488077A (en) | 2009-10-30 | 2012-08-15 | Novozymes Biopharma Dk As | Albumin variants |
CN102781960B (zh) | 2010-02-16 | 2014-12-10 | 米迪缪尼有限公司 | Hsa相关组合物及使用方法 |
BR112012022102A2 (pt) * | 2010-03-03 | 2017-01-10 | Boehringer Ingelheim Int | polipeptídeos de ligação a a-beta. |
KR20130070576A (ko) | 2010-04-09 | 2013-06-27 | 노보자임스 바이오파마 디케이 에이/에스 | 알부민 유도체 및 변이체 |
US20130017997A1 (en) | 2010-08-19 | 2013-01-17 | Amunix Operating Inc. | Factor VIII Compositions and Methods of Making and Using Same |
ES2686550T3 (es) | 2010-10-11 | 2018-10-18 | Biogen International Neuroscience Gmbh | Anticuerpos anti-tau humanos |
US20130225496A1 (en) | 2010-11-01 | 2013-08-29 | Novozymes Biopharma Dk A/S | Albumin Variants |
EP2651979B1 (fr) | 2010-12-17 | 2019-08-28 | Neurimmune Holding AG | Anticorps anti-sod1 humains |
CN103379915A (zh) | 2011-02-15 | 2013-10-30 | 米迪缪尼有限公司 | Hsa相关组合物及使用方法 |
US9045564B2 (en) | 2011-02-15 | 2015-06-02 | Medimmune, Llc | HSA-related compositions and methods of use |
GB2491006A (en) | 2011-05-05 | 2012-11-21 | Novozymes Biopharma Uk Ltd | Albumin variants |
TR201815563T4 (tr) | 2011-06-23 | 2018-11-21 | Biogen Int Neuroscience Gmbh | Anti-alfa sinüklein bağlayıcı moleküller. |
PL2766397T3 (pl) | 2011-10-11 | 2018-10-31 | F.Hoffmann-La Roche Ag | Ulepszone składanie przeciwciał bispecyficznych |
ES2883212T3 (es) | 2011-10-28 | 2021-12-07 | Biogen Int Neuroscience Gmbh | Moléculas de unión específica a TDP-43 |
LT2802606T (lt) * | 2012-01-10 | 2018-10-10 | Biogen Ma Inc. | Terapinių molekulių transporto per kraujo-smegenų barjerą padidinimas |
US10172953B2 (en) | 2012-02-27 | 2019-01-08 | Amunix Operating Inc. | XTEN conjugate compositions and methods of making same |
SI2885010T1 (sl) | 2012-08-16 | 2020-07-31 | Ipierian, Inc. | Metode zdravljenja tauopatije |
MX2015008024A (es) | 2012-12-21 | 2016-08-08 | Biogen Int Neuroscience Gmbh | Anticuerpos anti-tau humanos. |
US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
EP2956002B1 (fr) | 2013-02-16 | 2017-09-06 | Albumedix A/S | Modèle pharmacocinétique animal |
US20160052993A1 (en) | 2013-05-03 | 2016-02-25 | Eleven Biotherapeutics, Inc. | Albumin variants binding to fcrn |
IL278941B (en) | 2014-09-30 | 2022-07-01 | Neurimmune Holding Ag | dprs antibodies which originate in the human body |
US10184008B2 (en) * | 2014-12-19 | 2019-01-22 | Medimmune Limited | Blood brain barrier transport molecules and uses thereof |
US10654917B2 (en) * | 2015-01-29 | 2020-05-19 | Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa | Antibody molecules and peptide delivery systems for use in alzheimer's disease and related disorders |
CN108601830B (zh) | 2015-12-18 | 2023-02-03 | 比奥根Ma公司 | 双特异性抗体平台 |
US10738115B2 (en) * | 2016-07-06 | 2020-08-11 | National Research Council Of Canada | Humanized antibodies transmigrating the blood-brain barrier and uses thereof |
WO2018109663A1 (fr) * | 2016-12-12 | 2018-06-21 | National Research Council Of Canada | Variants d'anticorps franchissant la barrière hémato-encéphalique et leurs utilisations |
CA3052058A1 (fr) * | 2017-01-30 | 2018-08-02 | National Research Council Of Canada | Agents de migration a travers la barriere hemato-encephalique et utilisations associees |
-
2019
- 2019-10-28 BR BR112021008105-4A patent/BR112021008105A2/pt unknown
- 2019-10-28 AU AU2019371814A patent/AU2019371814A1/en not_active Abandoned
- 2019-10-28 EP EP19805038.7A patent/EP3873934A2/fr active Pending
- 2019-10-28 WO PCT/US2019/058286 patent/WO2020092202A2/fr unknown
- 2019-10-28 EA EA202191179A patent/EA202191179A1/ru unknown
- 2019-10-28 KR KR1020217016206A patent/KR20210111242A/ko unknown
- 2019-10-28 US US17/288,445 patent/US20220089704A1/en active Pending
- 2019-10-28 MX MX2021004772A patent/MX2021004772A/es unknown
- 2019-10-28 JP JP2021547670A patent/JP2022509372A/ja active Pending
- 2019-10-28 MA MA054070A patent/MA54070A/fr unknown
- 2019-10-28 CA CA3117409A patent/CA3117409A1/fr active Pending
- 2019-10-28 CN CN201980081497.5A patent/CN113508135A/zh active Pending
-
2021
- 2021-04-27 IL IL282677A patent/IL282677A/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2021004772A (es) | 2021-08-16 |
US20220089704A1 (en) | 2022-03-24 |
AU2019371814A1 (en) | 2021-06-17 |
WO2020092202A2 (fr) | 2020-05-07 |
IL282677A (en) | 2021-06-30 |
EA202191179A1 (ru) | 2021-09-09 |
KR20210111242A (ko) | 2021-09-10 |
JP2022509372A (ja) | 2022-01-20 |
EP3873934A2 (fr) | 2021-09-08 |
CA3117409A1 (fr) | 2020-05-07 |
BR112021008105A2 (pt) | 2021-08-03 |
WO2020092202A3 (fr) | 2020-07-23 |
WO2020092202A9 (fr) | 2021-05-14 |
CN113508135A (zh) | 2021-10-15 |
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