PL2766397T3 - Ulepszone składanie przeciwciał bispecyficznych - Google Patents
Ulepszone składanie przeciwciał bispecyficznychInfo
- Publication number
- PL2766397T3 PL2766397T3 PL12778018T PL12778018T PL2766397T3 PL 2766397 T3 PL2766397 T3 PL 2766397T3 PL 12778018 T PL12778018 T PL 12778018T PL 12778018 T PL12778018 T PL 12778018T PL 2766397 T3 PL2766397 T3 PL 2766397T3
- Authority
- PL
- Poland
- Prior art keywords
- bispecific antibodies
- improved assembly
- assembly
- improved
- bispecific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161545863P | 2011-10-11 | 2011-10-11 | |
| US201161546503P | 2011-10-12 | 2011-10-12 | |
| US201161560704P | 2011-11-16 | 2011-11-16 | |
| US201261676837P | 2012-07-27 | 2012-07-27 | |
| PCT/US2012/059810 WO2013055958A1 (en) | 2011-10-11 | 2012-10-11 | Improved assembly of bispecific antibodies |
| EP12778018.7A EP2766397B1 (en) | 2011-10-11 | 2012-10-11 | Improved assembly of bispecific antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2766397T3 true PL2766397T3 (pl) | 2018-10-31 |
Family
ID=47073551
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12778018T PL2766397T3 (pl) | 2011-10-11 | 2012-10-11 | Ulepszone składanie przeciwciał bispecyficznych |
| PL18167907.7T PL3418306T3 (pl) | 2011-10-11 | 2012-10-11 | Ulepszone składanie przeciwciał dwuswoistych |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18167907.7T PL3418306T3 (pl) | 2011-10-11 | 2012-10-11 | Ulepszone składanie przeciwciał dwuswoistych |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US9862778B2 (pl) |
| EP (2) | EP2766397B1 (pl) |
| JP (1) | JP6216321B2 (pl) |
| KR (3) | KR102492792B1 (pl) |
| CN (2) | CN104093744A (pl) |
| BR (1) | BR112014008684B1 (pl) |
| CA (1) | CA2850818A1 (pl) |
| ES (2) | ES2682081T3 (pl) |
| HK (1) | HK1202878A1 (pl) |
| HR (2) | HRP20240230T1 (pl) |
| HU (1) | HUE065876T2 (pl) |
| MX (1) | MX359384B (pl) |
| PL (2) | PL2766397T3 (pl) |
| RU (1) | RU2654567C2 (pl) |
| SI (1) | SI2766397T1 (pl) |
| TR (1) | TR201809151T4 (pl) |
| WO (1) | WO2013055958A1 (pl) |
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| JPH0711282B2 (ja) | 1990-02-23 | 1995-02-08 | シーケーデイ株式会社 | ロツドレスシリンダ |
| JPH07111203B2 (ja) | 1991-09-06 | 1995-11-29 | エスエムシー株式会社 | ロッドレスシリンダ |
| DE4137789C2 (de) | 1991-11-16 | 1994-01-20 | Festo Kg | Linearantrieb |
| WO2013055958A1 (en) | 2011-10-11 | 2013-04-18 | Genentech, Inc. | Improved assembly of bispecific antibodies |
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| RS57393B1 (sr) | 2013-03-15 | 2018-09-28 | Hoffmann La Roche | Il-22 polipeptiidi i il-22 fuzioni proteini i metode za njihovu upotrebu |
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| US10370776B2 (en) * | 2013-09-25 | 2019-08-06 | Idea Orchard, Llc | Antibody like protein |
| ES3030987T3 (en) * | 2013-11-27 | 2025-07-03 | Zymeworks Bc Inc | Bispecific antigen-binding constructs targeting her2 |
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| RU2739500C2 (ru) | 2014-11-05 | 2020-12-25 | Дженентек, Инк. | Способы получения двуцепочечных белков в бактериях |
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