AU2018212860A1 - Blood-brain barrier transmigrating compounds and uses thereof - Google Patents

Blood-brain barrier transmigrating compounds and uses thereof Download PDF

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Publication number
AU2018212860A1
AU2018212860A1 AU2018212860A AU2018212860A AU2018212860A1 AU 2018212860 A1 AU2018212860 A1 AU 2018212860A1 AU 2018212860 A AU2018212860 A AU 2018212860A AU 2018212860 A AU2018212860 A AU 2018212860A AU 2018212860 A1 AU2018212860 A1 AU 2018212860A1
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AU
Australia
Prior art keywords
seq
abp
fragment
antibody
sequence
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Abandoned
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AU2018212860A
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English (en)
Inventor
Balu Chakravarthy
Yves Durocher
Danica Stanimirovic
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National Research Council of Canada
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National Research Council of Canada
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Filing date
Publication date
Application filed by National Research Council of Canada filed Critical National Research Council of Canada
Publication of AU2018212860A1 publication Critical patent/AU2018212860A1/en
Priority to AU2022202015A priority Critical patent/AU2022202015B2/en
Priority to AU2024201813A priority patent/AU2024201813A1/en
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711Alzheimer's disease; Amyloid plaque core protein
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1282Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/33Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2018212860A 2017-01-30 2018-01-30 Blood-brain barrier transmigrating compounds and uses thereof Abandoned AU2018212860A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2022202015A AU2022202015B2 (en) 2017-01-30 2022-03-23 Blood-brain barrier transmigrating compounds and uses thereof
AU2024201813A AU2024201813A1 (en) 2017-01-30 2024-03-20 Blood-brain barrier transmigrating compounds and uses thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762452015P 2017-01-30 2017-01-30
US62/452,015 2017-01-30
US201762530980P 2017-07-11 2017-07-11
US62/530,980 2017-07-11
PCT/IB2018/050576 WO2018138709A1 (en) 2017-01-30 2018-01-30 Blood-brain barrier transmigrating compounds and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022202015A Division AU2022202015B2 (en) 2017-01-30 2022-03-23 Blood-brain barrier transmigrating compounds and uses thereof

Publications (1)

Publication Number Publication Date
AU2018212860A1 true AU2018212860A1 (en) 2019-08-15

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
AU2018212860A Abandoned AU2018212860A1 (en) 2017-01-30 2018-01-30 Blood-brain barrier transmigrating compounds and uses thereof
AU2018405992A Abandoned AU2018405992A1 (en) 2017-01-30 2018-07-31 Blood-brain barrier transmigrating compounds and uses thereof
AU2022202015A Active AU2022202015B2 (en) 2017-01-30 2022-03-23 Blood-brain barrier transmigrating compounds and uses thereof
AU2024201813A Pending AU2024201813A1 (en) 2017-01-30 2024-03-20 Blood-brain barrier transmigrating compounds and uses thereof

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2018405992A Abandoned AU2018405992A1 (en) 2017-01-30 2018-07-31 Blood-brain barrier transmigrating compounds and uses thereof
AU2022202015A Active AU2022202015B2 (en) 2017-01-30 2022-03-23 Blood-brain barrier transmigrating compounds and uses thereof
AU2024201813A Pending AU2024201813A1 (en) 2017-01-30 2024-03-20 Blood-brain barrier transmigrating compounds and uses thereof

Country Status (8)

Country Link
US (3) US11702466B2 (enExample)
EP (2) EP3574002A4 (enExample)
JP (4) JP7449092B2 (enExample)
KR (3) KR102676279B1 (enExample)
CN (2) CN110382522B (enExample)
AU (4) AU2018212860A1 (enExample)
CA (2) CA3052058A1 (enExample)
WO (2) WO2018138709A1 (enExample)

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KR102676279B1 (ko) * 2017-01-30 2024-06-20 내션얼 리서치 카운슬 오브 캐나다 혈액-뇌 장벽을 관통이동하는 화합물 및 이의 용도
JP7368856B2 (ja) 2017-07-25 2023-10-25 トゥルーバインディング,インコーポレイテッド Tim-3とそのリガンドとの相互作用の遮断によるがん治療
CA3117409A1 (en) * 2018-10-29 2020-05-07 Biogen Ma Inc. Humanized and stabilized fc5 variants for enhancement of blood brain barrier transport
CN116063505B (zh) 2019-01-30 2024-05-03 真和制药有限公司 抗gal3抗体及其用途
EP4058479A4 (en) 2019-11-15 2024-02-28 University of Tennessee Research Foundation MODIFIED IMMUNOLOBULINES FOR TARGETING AMYLOID DEPOSITS
US12281166B2 (en) 2020-05-26 2025-04-22 Truebinding, Inc. Methods of treating inflammatory diseases by blocking Galectin-3
EP4333871A4 (en) * 2021-05-05 2025-05-07 University of Tennessee Research Foundation PEPTIDE-FC FUSIONS FOR THE TREATMENT OF AMYLOID DISEASES
CN117915949A (zh) * 2021-05-18 2024-04-19 田纳西大学研究基金会 用于治疗淀粉样蛋白病症的抗体-肽融合蛋白
KR102475326B1 (ko) * 2022-01-27 2022-12-07 한국기초과학지원연구원 신규한 펩타이드 유사체 및 이를 포함하는 알츠하이머 병 예방 조성물

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EP3551666A4 (en) 2016-12-12 2020-07-29 National Research Council of Canada VARIANTS OF ANTIBODIES CROSSING THE HEMATOENCEPHALIC BARRIER AND THEIR USES
KR102676279B1 (ko) 2017-01-30 2024-06-20 내션얼 리서치 카운슬 오브 캐나다 혈액-뇌 장벽을 관통이동하는 화합물 및 이의 용도

Also Published As

Publication number Publication date
KR20240095466A (ko) 2024-06-25
JP2023123535A (ja) 2023-09-05
AU2018405992A1 (en) 2020-08-20
JP7449092B2 (ja) 2024-03-13
JP2024081644A (ja) 2024-06-18
CA3089816A1 (en) 2019-08-08
KR20200116143A (ko) 2020-10-08
EP3574002A1 (en) 2019-12-04
KR20190112768A (ko) 2019-10-07
JP2021512159A (ja) 2021-05-13
KR102676279B1 (ko) 2024-06-20
AU2022202015A1 (en) 2022-04-14
CN110382522A (zh) 2019-10-25
AU2024201813A1 (en) 2024-04-11
EP3746460A1 (en) 2020-12-09
CA3052058A1 (en) 2018-08-02
JP7458327B2 (ja) 2024-03-29
US20190352383A1 (en) 2019-11-21
US20230257424A1 (en) 2023-08-17
WO2018138709A1 (en) 2018-08-02
US20230279088A1 (en) 2023-09-07
EP3574002A4 (en) 2021-04-21
US11702466B2 (en) 2023-07-18
WO2019150183A1 (en) 2019-08-08
EP3746460A4 (en) 2022-04-20
CN111886240A (zh) 2020-11-03
CN110382522B (zh) 2024-08-30
AU2022202015B2 (en) 2023-12-21
JP2020505926A (ja) 2020-02-27

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