JP2016524463A5 - - Google Patents

Info

Publication number

JP2016524463A5

JP2016524463A5 JP2016509450A JP2016509450A JP2016524463A5 JP 2016524463 A5 JP2016524463 A5 JP 2016524463A5 JP 2016509450 A JP2016509450 A JP 2016509450A JP 2016509450 A JP2016509450 A JP 2016509450A JP 2016524463 A5 JP2016524463 A5 JP 2016524463A5

Authority

JP

Japan

Prior art keywords

antigen

binding molecule

specific antigen

seq

specific

Prior art date

2014-04-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000000427 antigen Substances 0.000 claims description 146
• 102000036639 antigens Human genes 0.000 claims description 146
• 108091007433 antigens Proteins 0.000 claims description 146
• 230000027455 binding Effects 0.000 claims description 70
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 40
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 26
• 108020001507 fusion proteins Proteins 0.000 claims description 20
• 102000037865 fusion proteins Human genes 0.000 claims description 20
• 238000000034 method Methods 0.000 claims description 17
• 201000010099 disease Diseases 0.000 claims description 10
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
• 238000004519 manufacturing process Methods 0.000 claims description 10
• 230000009870 specific binding Effects 0.000 claims description 10
• 150000007523 nucleic acids Chemical class 0.000 claims description 9
• 239000013598 vector Substances 0.000 claims description 9
• 238000010367 cloning Methods 0.000 claims description 8
• 239000013604 expression vector Substances 0.000 claims description 8
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 7
• 108020004707 nucleic acids Proteins 0.000 claims description 7
• 102000039446 nucleic acids Human genes 0.000 claims description 7
• 241000251729 Elasmobranchii Species 0.000 claims description 6
• 241000894007 species Species 0.000 claims description 6
• 230000001131 transforming effect Effects 0.000 claims description 6
• 239000008194 pharmaceutical composition Substances 0.000 claims description 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
• 108020004414 DNA Proteins 0.000 claims description 4
• 125000000539 amino acid group Chemical group 0.000 claims description 4
• 239000012491 analyte Substances 0.000 claims description 4
• 230000000295 complement effect Effects 0.000 claims description 4
• 239000003814 drug Substances 0.000 claims description 4
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
• 108060003951 Immunoglobulin Proteins 0.000 claims description 2
• 238000003384 imaging method Methods 0.000 claims description 2
• 102000018358 immunoglobulin Human genes 0.000 claims description 2
• 102000004169 proteins and genes Human genes 0.000 claims description 2
• 108090000623 proteins and genes Proteins 0.000 claims description 2
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
• 102100033553 Delta-like protein 4 Human genes 0.000 claims 1
• 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
• 230000000975 bioactive effect Effects 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 101100112922 Candida albicans CDR3 gene Proteins 0.000 description 7
• 101001019455 Homo sapiens ICOS ligand Proteins 0.000 description 1
• 102100034980 ICOS ligand Human genes 0.000 description 1
• 239000011324 bead Substances 0.000 description 1
• 238000004091 panning Methods 0.000 description 1