JP2015143226A5 - - Google Patents

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JP2015143226A5
JP2015143226A5 JP2015018098A JP2015018098A JP2015143226A5 JP 2015143226 A5 JP2015143226 A5 JP 2015143226A5 JP 2015018098 A JP2015018098 A JP 2015018098A JP 2015018098 A JP2015018098 A JP 2015018098A JP 2015143226 A5 JP2015143226 A5 JP 2015143226A5
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variable region
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amino acid
light chain
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JP6063494B2 (ja
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JP2015018098A 2006-07-10 2015-02-02 抗体及びその用途 Active JP6063494B2 (ja)

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JP2015018098A JP6063494B2 (ja) 2006-07-10 2015-02-02 抗体及びその用途

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JP2006189872 2006-07-10
JP2006189872 2006-07-10
JP2007058458 2007-03-08
JP2007058458 2007-03-08
JP2015018098A JP6063494B2 (ja) 2006-07-10 2015-02-02 抗体及びその用途

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JP2013197808A Division JP2014027941A (ja) 2006-07-10 2013-09-25 抗体及びその用途

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JP2016156097A Division JP2017012181A (ja) 2006-07-10 2016-08-09 抗体及びその用途

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JP2015143226A JP2015143226A (ja) 2015-08-06
JP2015143226A5 true JP2015143226A5 (enExample) 2015-10-15
JP6063494B2 JP6063494B2 (ja) 2017-01-18

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JP2008524791A Expired - Fee Related JP5382692B2 (ja) 2006-07-10 2007-07-09 抗体の分類法、抗原の同定法、抗体又は抗体セットの取得法、抗体パネルの作成法、並びに抗体又は抗体セット及びその用途
JP2013197808A Pending JP2014027941A (ja) 2006-07-10 2013-09-25 抗体及びその用途
JP2015018098A Active JP6063494B2 (ja) 2006-07-10 2015-02-02 抗体及びその用途
JP2016156097A Pending JP2017012181A (ja) 2006-07-10 2016-08-09 抗体及びその用途

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JP2008524791A Expired - Fee Related JP5382692B2 (ja) 2006-07-10 2007-07-09 抗体の分類法、抗原の同定法、抗体又は抗体セットの取得法、抗体パネルの作成法、並びに抗体又は抗体セット及びその用途
JP2013197808A Pending JP2014027941A (ja) 2006-07-10 2013-09-25 抗体及びその用途

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US (2) US20090203538A1 (enExample)
EP (2) EP2078732B1 (enExample)
JP (4) JP5382692B2 (enExample)
WO (1) WO2008007648A1 (enExample)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040081653A1 (en) * 2002-08-16 2004-04-29 Raitano Arthur B. Nucleic acids and corresponding proteins entitled 251P5G2 useful in treatment and detection of cancer
US7480593B2 (en) * 2005-08-03 2009-01-20 Suresh Gopalan Methods and systems for high confidence utilization of datasets
DK2069793T3 (en) * 2006-08-29 2017-04-24 Oxford Biotherapeutics Ltd IDENTIFICATION OF PROTEIN IN CONNECTION WITH HEPATOCELLULAR CARCINOMA, GLIOBLASTOMA AND LUNG CANCER
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
JP2012513194A (ja) * 2008-12-23 2012-06-14 アストラゼネカ アクチボラグ α5β1に向けられた標的結合剤およびその使用
EP2379588A2 (en) 2008-12-30 2011-10-26 Cellartis AB The use of basigin-1 in stem cell and cancer applications
ME02842B (me) 2009-03-05 2018-01-20 Squibb & Sons Llc Potpuno ljudska antitijela specifična za cadm1
US9441032B2 (en) 2010-04-07 2016-09-13 Agency For Science, Technology And Research Binding molecules against Chikungunya virus and uses thereof
EP2374816B1 (en) * 2010-04-07 2016-09-28 Agency For Science, Technology And Research Binding molecules against Chikungunya virus and uses thereof
US9714294B2 (en) 2010-05-27 2017-07-25 Genmab A/S Monoclonal antibodies against HER2 epitope
CA3051311A1 (en) 2010-05-27 2011-12-01 Genmab A/S Monoclonal antibodies against her2
KR102810907B1 (ko) 2010-07-16 2025-05-21 아디맵 엘엘씨 항체 라이브러리
US9778264B2 (en) 2010-09-03 2017-10-03 Abbvie Stemcentrx Llc Identification and enrichment of cell subpopulations
CN106434561A (zh) * 2010-09-03 2017-02-22 艾伯维施特姆森特克斯有限责任公司 细胞亚群的鉴定和富集
BR112013005116A2 (pt) 2010-09-03 2019-09-24 Stem Centrx Inc moduladores e métodos de uso
MX347954B (es) * 2010-09-29 2017-05-19 Agensys Inc Conjugados de anticuerpo farmaco (adc) que enlazan a proteinas 191p4d12.
AU2015234335B2 (en) * 2010-09-29 2017-09-28 Agensys, Inc. Antibody drug conjugates (ADC) that bind to 191P4D12 proteins
JOP20210044A1 (ar) 2010-12-30 2017-06-16 Takeda Pharmaceuticals Co الأجسام المضادة لـ cd38
CA2835603A1 (en) * 2011-05-09 2012-11-15 Perseus Proteomics Inc. Antibody capable of specifically recognizing transferrin receptor
CN104302321A (zh) * 2011-12-05 2015-01-21 特瑞利斯生物科学有限责任公司 可用于被动流感免疫的抗体
DK2809681T3 (en) * 2012-01-31 2019-03-11 Regeneron Pharma ANTI-ASIC1 antibodies and uses thereof
JP5939855B2 (ja) * 2012-03-23 2016-06-22 国立大学法人 宮崎大学 トランスフェリン受容体抗体
EP2863946A4 (en) * 2012-06-21 2016-04-13 Sorrento Therapeutics Inc ANTIGEN-BINDING PROTEINS THAT BIND TO C-MET
UY34887A (es) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
US9593165B2 (en) * 2012-11-08 2017-03-14 University Of Miyazaki Antibody capable of specifically recognizing transferrin receptor
JP6467225B2 (ja) * 2012-11-21 2019-02-06 Kmバイオロジクス株式会社 新規なヒト抗il−18抗体
CN105209071A (zh) 2013-03-14 2015-12-30 抗非特公司 用于提高疗效的基于鼻内递送中和抗体的组合物和方法
US9475874B2 (en) 2013-08-26 2016-10-25 MabVax Therapeutics, Inc. Nucleic acids encoding human antibodies to sialyl-lewisa
JP6552412B2 (ja) 2013-09-05 2019-07-31 国立大学法人 宮崎大学 ヒトインテグリンa6b4と特異的に反応する抗体
SI3508502T1 (sl) 2013-09-20 2023-07-31 Bristol-Myers Squibb Company Kombinacija anti-lag-3 protiteles in anti-pd-1 protiteles za zdravljenje tumorjev
ES2716685T3 (es) 2014-01-24 2019-06-14 Dana Farber Cancer Inst Inc Moléculas de anticuerpo para PD-1 y usos de las mismas
US10639370B2 (en) 2014-02-04 2020-05-05 Contrafect Corporation Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof
KR102344390B1 (ko) 2014-02-04 2021-12-28 콘트라펙트 코포레이션 수동 인플루엔자 면역화에 유용한 항체, 및 이의 사용을 위한 조성물, 조합 및 방법
TWI777174B (zh) 2014-03-14 2022-09-11 瑞士商諾華公司 針對lag-3之抗體分子及其用途
US20170173005A1 (en) 2014-03-27 2017-06-22 Research Foundation Of The City University Of New York Method for detecting or treating triple negative breast cancer
US9975960B2 (en) * 2014-05-09 2018-05-22 Samsung Electronics Co., Ltd. Anti-HER2 antibody and anti-c-Met/anti-HER2 bispecific antibodies comprising the same
KR102401595B1 (ko) * 2014-05-09 2022-05-24 삼성전자주식회사 항 HER2 scFv 단편 및 이를 포함하는 항 c-Met/항 HER2 이중 특이 항체
KR102536786B1 (ko) 2014-10-10 2023-05-26 이나뜨 파르마 에스.에이. Cd73 차단
MX385320B (es) 2014-11-10 2025-03-18 Medimmune Ltd Moléculas de unión específicas para grupo de diferenciación 73 (cd73) y usos de las mismas.
HUE050596T2 (hu) * 2014-11-21 2020-12-28 Bristol Myers Squibb Co Antitestek CD73 ellen és azok felhasználásai
LT3221346T (lt) 2014-11-21 2020-11-10 Bristol-Myers Squibb Company Antikūnai, apimantys modifikuotas sunkiosios grandinės pastoviąsias sritis
EP3234598B1 (en) 2014-12-18 2019-11-06 F.Hoffmann-La Roche Ag Assay and method for determining cdc eliciting antibodies
EP3259288A1 (en) * 2015-02-20 2017-12-27 Innate Pharma Cd73 blockade
AU2016258988A1 (en) * 2015-05-04 2017-12-07 Cytomx Therapeutics, Inc Anti-ITGa3 antibodies, activatable anti-ITGa3 antibodies, and methods of use thereof
SG10202110908WA (en) 2015-05-04 2021-11-29 Cytomx Therapeutics Inc Anti-cd166 antibodies, activatable anti-cd166 antibodies, and methods of use thereof
JP7420334B2 (ja) * 2015-06-25 2024-01-23 株式会社カネカ 液体注入方法
EP3322969B1 (en) * 2015-07-15 2020-03-04 Becton, Dickinson and Company System and method for adjusting cytometer measurements
WO2017064043A1 (en) 2015-10-12 2017-04-20 Innate Pharma Cd73 blocking agents
WO2018013611A1 (en) * 2016-07-11 2018-01-18 Corvus Pharmaceuticals, Inc. Anti-cd73 antibodies
EP3484923A1 (en) 2016-07-15 2019-05-22 Takeda Pharmaceutical Company Limited Methods and materials for assessing response to plasmablast- and plasma cell-depleting therapies
AU2017307610B2 (en) 2016-08-04 2023-10-05 Memorial Sloan-Kettering Cancer Center Cancer antigen targets and uses thereof
US10617720B2 (en) * 2016-10-20 2020-04-14 Miltenyi Biotech, GmbH Chimeric antigen receptor specific for tumor cells
FI3548515T3 (fi) 2016-12-01 2026-03-04 Regeneron Pharma Radioleimattuja anti-PD-L1-vasta-aineita immuno-PET-kuvantamiseen
CA3046432A1 (en) * 2016-12-13 2018-06-21 Astellas Pharma Inc. Anti-human cd73 antibody
PL3383916T3 (pl) 2017-01-24 2023-06-12 I-Mab Biopharma Us Limited Przeciwciała anty-cd73 i ich zastosowania
KR102713203B1 (ko) 2017-05-30 2024-10-10 브리스톨-마이어스 스큅 컴퍼니 Lag-3 양성 종양의 치료
KR20240155979A (ko) 2017-05-30 2024-10-29 브리스톨-마이어스 스큅 컴퍼니 항-lag-3 항체 또는 항-lag-3 항체 및 항-pd-1 또는 항-pd-l1 항체를 포함하는 조성물
WO2018237173A1 (en) 2017-06-22 2018-12-27 Novartis Ag Antibody molecules to cd73 and uses thereof
EA202090247A1 (ru) 2017-07-14 2020-05-12 Цитомкс Терапьютикс, Инк. Антитела против cd166 и их применения
CN112739715A (zh) 2018-01-12 2021-04-30 武田药品工业株式会社 抗cd38抗体的皮下给药
US20190292188A1 (en) 2018-02-27 2019-09-26 Incyte Corporation Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors
BR112020017382A2 (pt) 2018-03-09 2021-01-26 Agenus Inc. anticorpos anti-cd73 e métodos de uso dos mesmos
SG11202007199XA (en) 2018-03-09 2020-09-29 Phanes Therapeutics Inc Anti-cd73 antibodies and uses thereof
MA52940A (fr) 2018-05-18 2021-04-28 Incyte Corp Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b
EP3569618A1 (en) 2018-05-19 2019-11-20 Boehringer Ingelheim International GmbH Antagonizing cd73 antibody
CN113166153B (zh) 2018-07-05 2024-11-01 因赛特公司 作为a2a/a2b抑制剂的稠合吡嗪衍生物
WO2020020307A1 (en) 2018-07-25 2020-01-30 I-Mab Biopharma Co., Ltd. Anti-cd73 anti-pd-l1 bispecific antibodies
TWI894130B (zh) 2018-12-03 2025-08-21 美商艾澤西公司 包含抗191p4d12抗體藥物結合物之醫藥組合物及其使用方法
KR102063341B1 (ko) * 2018-12-31 2020-01-07 다이노나(주) Icam-1에 특이적으로 결합하는 항체 및 그의 용도
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
US12221484B2 (en) 2019-03-29 2025-02-11 Lankenau Institute For Medical Research Anti-NMDA receptor antibodies and methods of use
CA3154387A1 (en) * 2019-09-13 2021-03-18 Tri-Institutional Therapeutics Discovery Institute, Inc. Anti-cd371 antibodies and uses thereof
WO2021053559A1 (en) 2019-09-18 2021-03-25 Novartis Ag Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies
KR20220100963A (ko) * 2019-12-18 2022-07-18 에프. 호프만-라 로슈 아게 Hla-a2/mage-a4에 결합하는 항체
PH12022551621A1 (en) 2020-01-03 2023-10-23 Incyte Corp Cd73 inhibitor and a2a/a2b adenosine receptor inhibitor combination therapy
TWI873265B (zh) 2020-01-03 2025-02-21 美商英塞特公司 抗cd73抗體及其用途
EP4088113A4 (en) * 2020-01-12 2024-05-15 Vanderbilt University HUMAN ANTIBODIES AGAINST RIFT VALLEY FEVER VIRUS
CN111738980B (zh) * 2020-05-14 2023-08-04 北京深睿博联科技有限责任公司 一种医学影像的显示方法、计算机设备及存储介质
EP4159763A4 (en) * 2020-05-29 2024-06-12 BrightPath Biotherapeutics Co., Ltd. ANTI-CD73 ANTIBODIES AND USE THEREOF
AU2021364837A1 (en) 2020-10-23 2023-05-25 Bristol-Myers Squibb Company Lag-3 antagonist therapy for lung cancer
KR20230157940A (ko) 2020-12-29 2023-11-17 인사이트 코포레이션 A2a/a2b 저해제, pd-1/pd-l1 저해제 및 항-cd73 항체를포함하는 병용 요법
KR102887692B1 (ko) * 2021-05-21 2025-11-18 주식회사 지놈앤컴퍼니 항-bcam 항체 또는 그의 항원 결합 단편
MX2023014695A (es) * 2021-06-08 2024-01-15 Merck Patent Gmbh Proteinas que unen cd80 y/o cd86 y ox40l.
EP4396236A4 (en) 2021-08-30 2025-10-01 Lassen Therapeutics 1 Inc ANTI-IL-11R ALPHA ANTIBODIES
CN114137231B (zh) * 2022-01-29 2022-04-29 北京大有天弘科技有限公司 一种血型不规则抗体的检测试剂盒及其应用
US12187806B2 (en) 2022-03-04 2025-01-07 Development Center For Biotechnology Anti-CD73 antibodies and use thereof
WO2024040194A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
WO2024215624A2 (en) * 2023-04-13 2024-10-17 A & G Pharmaceutical, Inc. Antibodies and conjugates against prostaglandin f2 receptor inhibitor and uses thereof
CN121666232A (zh) 2023-05-31 2026-03-13 开普斯坦治疗公司 脂质纳米颗粒制剂和组合物
WO2025076113A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Ionizable cationic lipids with conserved spacing and lipid nanoparticles
WO2025076127A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles
WO2025179294A2 (en) 2024-02-22 2025-08-28 Capstan Therapeutics, Inc. Immune engineering amplification
WO2025217454A2 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Ionizable cationic lipids and lipid nanoparticles
WO2025217452A1 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904582A (en) 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
MX9504802A (es) * 1994-03-17 1997-05-31 Merck Patent Gmbh Anticuerpos anti-egfr y fvs de cadena simple anti-egfr.
JP2000000097A (ja) * 1998-06-15 2000-01-07 Nippon Zoki Pharmaceut Co Ltd Nef結合蛋白質、該蛋白質をコードするDNA並びに該蛋白質に対するモノクローナル抗体
US8101553B1 (en) 2000-02-22 2012-01-24 Medical & Biological Laboratories Co., Ltd. Antibody library
KR20020091170A (ko) * 2000-03-31 2002-12-05 아이덱 파마슈티칼즈 코포레이션 B 세포 림프종의 치료를 위한 항-사이토카인 항체 또는길항제 및 항-cd20의 조합된 사용
EP1314740A4 (en) 2000-06-14 2005-01-19 Med & Biological Lab Co Ltd PREPARATION METHODS OF FLUORESCENCE PROTEIN FUSIONED SCFV ANTIBODIES
DE60143798D1 (de) * 2000-06-16 2011-02-17 Cambridge Antibody Tech Immunspezifisch bindende antikörper gegen blys
US7595378B2 (en) 2001-06-13 2009-09-29 Genmab A/S Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
EP1429143A4 (en) * 2001-08-22 2006-04-12 Inst Antibodies Co Ltd SELECTION PROCEDURE FOR BINDING MOLECULES
WO2004005890A2 (en) * 2002-07-03 2004-01-15 The Trustees Of The University Of Pennsylvania Compositions, methods and kits relating to anti-platelet autoantibodies and inhibitors thereof
JP4870348B2 (ja) 2003-12-04 2012-02-08 株式会社ペルセウスプロテオミクス 細胞表面抗原に対する抗体取得とその抗原同定
WO2006017173A1 (en) * 2004-07-10 2006-02-16 Alexion Pharmaceuticals, Inc. Methods for discovering antibodies specific to cancer cells and antibodies discovered thereby
JP2006025749A (ja) 2004-07-21 2006-02-02 Kawabe:Kk ペット用引き綱
WO2006090750A1 (ja) 2005-02-28 2006-08-31 Institute For Antibodies Co., Ltd. 抗IgSF4抗体及びその利用
JP2006303195A (ja) 2005-04-20 2006-11-02 Sony Corp レーザモジュール
US7498142B2 (en) * 2006-01-31 2009-03-03 Yeda Research And Development Co., Ltd. Methods of identifying combinations of antibodies with an improved anti-tumor activity and compositions and methods using the antibodies
JP5242382B2 (ja) * 2006-04-14 2013-07-24 株式会社医学生物学研究所 エフェクター機能を有するポリペプチド変異体
JP6203812B2 (ja) 2012-03-19 2017-09-27 ミリケン・アンド・カンパニーMilliken & Company カルボキシレート染料

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