JP2014515602A5 - - Google Patents
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- JP2014515602A5 JP2014515602A5 JP2014501665A JP2014501665A JP2014515602A5 JP 2014515602 A5 JP2014515602 A5 JP 2014515602A5 JP 2014501665 A JP2014501665 A JP 2014501665A JP 2014501665 A JP2014501665 A JP 2014501665A JP 2014515602 A5 JP2014515602 A5 JP 2014515602A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- binding
- domain
- ang2
- vegf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102100034608 Angiopoietin-2 Human genes 0.000 claims 7
- 101000924533 Homo sapiens Angiopoietin-2 Proteins 0.000 claims 7
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 6
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 6
- 102000007562 Serum Albumin Human genes 0.000 claims 5
- 108010071390 Serum Albumin Proteins 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 102100024952 Protein CBFA2T1 Human genes 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 102100034594 Angiopoietin-1 Human genes 0.000 claims 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 1
- 101000924552 Homo sapiens Angiopoietin-1 Proteins 0.000 claims 1
- 101100216078 Mus musculus Ang4 gene Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11160921.0 | 2011-04-01 | ||
| EP11160921 | 2011-04-01 | ||
| PCT/EP2012/055901 WO2012131078A1 (en) | 2011-04-01 | 2012-03-30 | Bispecific binding molecules binding to vegf and ang2 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016198857A Division JP6297657B2 (ja) | 2011-04-01 | 2016-10-07 | ＶＥＧＦ及びＡｎｇ２と結合する二重特異性結合分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014515602A JP2014515602A (ja) | 2014-07-03 |
| JP2014515602A5 true JP2014515602A5 (enExample) | 2015-05-07 |
| JP6023786B2 JP6023786B2 (ja) | 2016-11-09 |
Family
ID=45895502
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014501665A Active JP6023786B2 (ja) | 2011-04-01 | 2012-03-30 | ＶＥＧＦ及びＡｎｇ２と結合する二重特異性結合分子 |
| JP2016198857A Active JP6297657B2 (ja) | 2011-04-01 | 2016-10-07 | ＶＥＧＦ及びＡｎｇ２と結合する二重特異性結合分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016198857A Active JP6297657B2 (ja) | 2011-04-01 | 2016-10-07 | ＶＥＧＦ及びＡｎｇ２と結合する二重特異性結合分子 |
Country Status (36)
Families Citing this family (59)
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| JP2015532272A (ja) * | 2012-09-28 | 2015-11-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 二重アンジオポエチン−２／Ｄｌｌ４結合剤および抗ＶＥＧＦ−Ｒ剤を含む薬学的組み合わせ |
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| EP4019548A1 (en) * | 2020-12-23 | 2022-06-29 | Vrije Universiteit Brussel | Anti lag3 vhhs and their use |
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| JP2024515220A (ja) | 2021-04-26 | 2024-04-05 | セラニーズ・イーブイエイ・パフォーマンス・ポリマーズ・エルエルシー | 高分子薬剤化合物の持続放出用の埋め込み型デバイス |
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| KR20240048555A (ko) * | 2021-09-10 | 2024-04-15 | 소테르 바이오파마 피티이. 리미티드 | 항 ang2 항체 및 그 제조방법과 응용 |
| CU24770B1 (es) * | 2021-12-15 | 2025-09-01 | Ct Ingenieria Genetica Biotecnologia | Polipéptidos que se unen al factor de crecimiento del endotelio vascular y al factor básico de crecimiento de fibroblastos |
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| WO2024178730A1 (zh) * | 2023-03-02 | 2024-09-06 | 清华大学 | 用于抑制脉络膜新生血管的玻璃体内抗vegf可结晶蛋白药物 |
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