SG10201602373TA - Bispecific Binding Molecules Binding To VEGF And ANG2 - Google Patents
Bispecific Binding Molecules Binding To VEGF And ANG2Info
- Publication number
- SG10201602373TA SG10201602373TA SG10201602373TA SG10201602373TA SG10201602373TA SG 10201602373T A SG10201602373T A SG 10201602373TA SG 10201602373T A SG10201602373T A SG 10201602373TA SG 10201602373T A SG10201602373T A SG 10201602373TA SG 10201602373T A SG10201602373T A SG 10201602373TA
- Authority
- SG
- Singapore
- Prior art keywords
- binding
- ang2
- vegf
- bispecific
- binding molecules
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11160921 | 2011-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201602373TA true SG10201602373TA (en) | 2016-05-30 |
Family
ID=45895502
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2013070842A SG193561A1 (en) | 2011-04-01 | 2012-03-30 | Bispecific binding molecules binding to vegf and ang2 |
| SG10201602373TA SG10201602373TA (en) | 2011-04-01 | 2012-03-30 | Bispecific Binding Molecules Binding To VEGF And ANG2 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2013070842A SG193561A1 (en) | 2011-04-01 | 2012-03-30 | Bispecific binding molecules binding to vegf and ang2 |
Country Status (35)
| Country | Link |
|---|---|
| US (4) | US9527925B2 (en) |
| EP (2) | EP3144322A3 (en) |
| JP (2) | JP6023786B2 (en) |
| KR (1) | KR101907572B1 (en) |
| CN (2) | CN105820243A (en) |
| AP (1) | AP2013007085A0 (en) |
| AR (1) | AR085984A1 (en) |
| AU (2) | AU2012237234B2 (en) |
| BR (1) | BR112013025304B1 (en) |
| CA (1) | CA2827817C (en) |
| CL (1) | CL2013002623A1 (en) |
| CO (1) | CO6801639A2 (en) |
| CY (1) | CY1118339T1 (en) |
| DK (1) | DK2694546T3 (en) |
| EA (2) | EA036746B1 (en) |
| EC (1) | ECSP13013001A (en) |
| ES (1) | ES2606302T3 (en) |
| HK (2) | HK1225400A1 (en) |
| HR (1) | HRP20161689T1 (en) |
| HU (1) | HUE030148T2 (en) |
| IL (1) | IL227936B (en) |
| LT (1) | LT2694546T (en) |
| MA (1) | MA34979B1 (en) |
| MX (2) | MX343440B (en) |
| MY (1) | MY171007A (en) |
| PE (1) | PE20140448A1 (en) |
| PL (1) | PL2694546T3 (en) |
| PT (1) | PT2694546T (en) |
| RS (1) | RS55361B1 (en) |
| SG (2) | SG193561A1 (en) |
| SI (1) | SI2694546T1 (en) |
| TN (1) | TN2013000390A1 (en) |
| UA (1) | UA114707C2 (en) |
| UY (1) | UY33998A (en) |
| WO (1) | WO2012131078A1 (en) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9101674B2 (en) | 2010-03-29 | 2015-08-11 | Vib Vzw | Targeting and in vivo imaging of tumor-associated macrophages |
| US9556273B2 (en) | 2010-03-29 | 2017-01-31 | Vib Vzw | Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages |
| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| DK2831111T3 (en) * | 2012-03-30 | 2019-04-29 | Boehringer Ingelheim Int | Ang2-binding molecules |
| HUE056217T2 (en) | 2012-07-13 | 2022-02-28 | Roche Glycart Ag | Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases |
| US20140093499A1 (en) * | 2012-09-28 | 2014-04-03 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf agents |
| JP2015532272A (en) * | 2012-09-28 | 2015-11-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Pharmaceutical combination comprising a dual angiopoietin-2 / Dll4 binding agent and an anti-VEGF-R agent |
| AR100270A1 (en) * | 2014-05-19 | 2016-09-21 | Lilly Co Eli | ANTIBODIES ANG2 |
| US10668165B2 (en) * | 2015-01-16 | 2020-06-02 | Immunwork Inc. | Molecular constructs for treating tumors |
| AR103477A1 (en) * | 2015-01-28 | 2017-05-10 | Lilly Co Eli | VEGFA / ANG2 COMPOUNDS |
| CA2981103A1 (en) * | 2015-03-31 | 2016-10-06 | Vhsquared Limited | Polypeptides |
| EA035638B1 (en) | 2015-03-31 | 2020-07-20 | ВиЭйчСКВЕАРД ЛИМИТЕД | Polypeptides |
| AU2016298398A1 (en) | 2015-07-29 | 2018-02-08 | Allergan, Inc. | Heavy chain only antibodies to ANG-2 |
| EP3334762A1 (en) * | 2015-08-14 | 2018-06-20 | Allergan, Inc. | Heavy chain only antibodies to pdgf |
| SG10201911226QA (en) * | 2015-09-23 | 2020-01-30 | Genentech Inc | Optimized variants of anti-vegf antibodies |
| CA3005061A1 (en) * | 2015-11-13 | 2017-05-18 | Ablynx Nv | Improved serum albumin-binding immunoglobulin variable domains |
| WO2017093478A1 (en) | 2015-12-04 | 2017-06-08 | Boehringer Ingelheim International Gmbh | Biparatopic polypeptides antagonizing wnt signaling in tumor cells |
| EP3504236B1 (en) | 2016-08-23 | 2020-09-23 | Medimmune Limited | Anti-vegf-a antibodies and uses thereof |
| WO2018037000A1 (en) * | 2016-08-23 | 2018-03-01 | Medimmune Limited | Anti-vegf-a and anti-ang2 antibodies and uses thereof |
| EP4190318A1 (en) * | 2016-12-14 | 2023-06-07 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a jak inhibitor and devices |
| RU2648164C1 (en) * | 2016-12-19 | 2018-03-22 | Федеральное государственное учреждение науки Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | Selective bifunctional drug on the basis of fragments of camelized single-chain antibodies, aimed to oncotic receptors cd47/erbb2, intended for the therapy of malignant neoplasms |
| WO2018114728A1 (en) | 2016-12-20 | 2018-06-28 | F. Hoffmann-La Roche Ag | Combination therapy with a bispecific anti-ang2/vegf antibody and a bispecific anti-her2 antibody |
| US10537637B2 (en) | 2017-01-05 | 2020-01-21 | Gensun Biopharma Inc. | Checkpoint regulator antagonists |
| MX2019014331A (en) | 2017-05-31 | 2020-01-27 | Boehringer Ingelheim Int | Polypeptides antagonizing wnt signaling in tumor cells. |
| US11198726B2 (en) | 2017-06-02 | 2021-12-14 | Boerhinger Ingelheim International Gmbh | Anti-cancer combination therapy |
| CN111699004A (en) | 2018-02-06 | 2020-09-22 | 豪夫迈·罗氏有限公司 | Treatment of ophthalmic disorders |
| WO2019246273A1 (en) * | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a jak or other kinase inhibitor |
| EP3813880A4 (en) | 2018-06-29 | 2022-07-13 | Gensun Biopharma Inc. | Antitumor immune checkpoint regulator antagonists |
| BR112021007946A2 (en) | 2018-10-29 | 2021-08-03 | F. Hoffmann-La Roche Ag | antibody formulation |
| US20220185875A1 (en) * | 2019-03-18 | 2022-06-16 | Jiangsu Hengrui Medicine Co., Ltd. | Bispecific antibody specifically bound to vegf and ang2 |
| CN114514243A (en) | 2019-06-21 | 2022-05-17 | 索瑞索制药公司 | Polypeptides |
| CN114466864A (en) | 2019-06-21 | 2022-05-10 | 索瑞索制药公司 | Polypeptides |
| US10851157B2 (en) | 2019-07-01 | 2020-12-01 | Gensun Biopharma, Inc. | Antagonists targeting the TGF-β pathway |
| CN110452297B (en) * | 2019-09-03 | 2020-04-14 | 上海洛启生物医药技术有限公司 | anti-VEGF single domain antibody and application thereof |
| WO2021119531A1 (en) * | 2019-12-11 | 2021-06-17 | Cullinan Management, Inc. | Anti-serum albumin antibodies |
| WO2021155151A1 (en) * | 2020-01-29 | 2021-08-05 | The Methodist Hospital System | Multivalent ligands targeting cell surface receptors and force measurement platform for making the same |
| WO2021209458A1 (en) | 2020-04-14 | 2021-10-21 | Ares Trading S.A. | Combination treatment of cancer |
| US20230242633A1 (en) | 2020-07-07 | 2023-08-03 | Kanaph Therapeutics Inc. | Fusion protein including complement pathway inhibitor and angiogenesis inhibitor and use thereof |
| JP2023550591A (en) | 2020-11-02 | 2023-12-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Substituted 1H-pyrazolo[4,3-c] and derivatives as EGFR inhibitors |
| EP4019548A1 (en) * | 2020-12-23 | 2022-06-29 | Vrije Universiteit Brussel | Anti lag3 vhhs and their use |
| US20220389120A1 (en) | 2021-06-03 | 2022-12-08 | Gensun Biopharma Inc. | Multispecific antagonists |
| KR20240023095A (en) * | 2021-06-04 | 2024-02-20 | 이노벤트 바이오로직스 (쑤저우) 컴퍼니, 리미티드 | Bispecific binding molecules that bind to VEGF and ANG2 and their uses |
| CA3229250A1 (en) * | 2021-08-13 | 2023-02-16 | Innovent Biologics (Suzhou) Co., Ltd. | Anti-vegf a and vegf c bispecific antibodies and use thereof |
| IL311318A (en) * | 2021-09-10 | 2024-05-01 | Soter Biopharma Pte Ltd | Anti-ang2 antibody, preparation method therefor, and application thereof |
| CU20210101A7 (en) * | 2021-12-15 | 2023-07-12 | Ct Ingenieria Genetica Biotecnologia | POLYPEPTIDES THAT BIND PROANGIOGENIC GROWTH FACTORS |
| WO2024055996A1 (en) * | 2022-09-14 | 2024-03-21 | 寻济生物科技（北京）有限公司 | Anti-vegfa antibody or antigen-binding fragment thereof and use thereof |
| WO2024114746A1 (en) * | 2022-12-01 | 2024-06-06 | 信达生物制药(苏州)有限公司 | Preparation containing bispecific binding molecule binding to vegf and ang2 and use thereof |
| WO2024114799A1 (en) * | 2022-12-01 | 2024-06-06 | 信达生物制药(苏州)有限公司 | Trispecific fusion protein and use thereof |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0656946T4 (en) | 1992-08-21 | 2010-07-26 | Univ Bruxelles | Immunoglobulins without light chains |
| US5408535A (en) | 1993-09-07 | 1995-04-18 | Miles Inc. | Video test strip reader and method for evaluating test strips |
| IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
| EP1325932B9 (en) | 1997-04-07 | 2006-07-19 | Genentech, Inc. | Anti-vegf antibodies |
| US6329516B1 (en) | 1997-04-28 | 2001-12-11 | Fmc Corporation | Lepidopteran GABA-gated chloride channels |
| US7070959B1 (en) | 1999-06-08 | 2006-07-04 | Regeneron Pharmaceuticals, Inc. | Modified chimeric polypeptides with improved pharmacokinetic properties |
| EP2267026A1 (en) | 2000-04-12 | 2010-12-29 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| CN1911965B (en) | 2001-01-17 | 2013-05-29 | 新兴产品开发西雅图有限公司 | Binding domain-immunoglobulin fusion proteins |
| EP1399484B1 (en) | 2001-06-28 | 2010-08-11 | Domantis Limited | Dual-specific ligand and its use |
| AU2002364587A1 (en) | 2001-12-21 | 2003-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| AU2003217852A1 (en) | 2002-03-01 | 2003-09-16 | Ball Horticultural Company | Lis promoter for expression of transgenes in floral tissues |
| AU2003217912A1 (en) * | 2002-03-01 | 2003-09-16 | Xencor | Antibody optimization |
| AU2003267563A1 (en) | 2002-09-10 | 2004-04-30 | Lorantis Limited | Pharmaceutical composition and medical treatments comprising notch ligand proteins |
| US20050043220A1 (en) | 2002-11-08 | 2005-02-24 | Guyer David R. | Methods and compositions for treating macular degeneration |
| WO2004041865A2 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Stabilized single domain antibodies |
| AU2003286003B2 (en) | 2002-11-08 | 2011-05-26 | Ablynx N.V. | Stabilized single domain antibodies |
| DE60329627D1 (en) | 2002-12-31 | 2009-11-19 | Nektar Therapeutics Al Corp | HYDROLYSIS STABILE MALEIDEND GROUP POLYMERS CONTAINING |
| JP2006517789A (en) | 2003-01-10 | 2006-08-03 | アブリンクス エン．ヴェー． | Therapeutic polypeptides, homologues thereof, fragments thereof, and use in modulating platelet-mediated aggregation |
| CA2529819A1 (en) | 2003-06-30 | 2004-09-23 | Domantis Limited | Pegylated single domain antibodies |
| EP3168304A1 (en) | 2003-08-27 | 2017-05-17 | Ophthotech Corporation | Combination therapy for the treatment of ocular neovascular disorders |
| WO2005040219A1 (en) | 2003-10-28 | 2005-05-06 | Novo Nordisk A/S | Laminin-5 gamma2-binding peptides, related compositions, and use thereof |
| ATE485307T1 (en) | 2003-11-07 | 2010-11-15 | Ablynx Nv | CAMELIDAE HEAVY CHAIN ANTIBODIES VHHS TO EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) AND THEIR USE |
| US20050284249A1 (en) | 2004-06-29 | 2005-12-29 | Arnone David F | Worm type gear mover assembly |
| KR20070084170A (en) | 2004-10-13 | 2007-08-24 | 아블린쓰 엔.브이. | Single domain camelide anti-amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenerative neural diseases such as alzheimer's disease |
| US20060134121A1 (en) | 2004-10-29 | 2006-06-22 | Gavin Thurston | DII4 antagonists, assays, and therapeutic methods thereof |
| US8048418B2 (en) | 2004-10-29 | 2011-11-01 | Regeneron Pharmaceuticals, Inc. | Therapeutic methods for inhibiting tumor growth with combination of Dll4 antagonists and VEGF antagonists |
| SV2006002342A (en) | 2004-12-17 | 2006-06-01 | Genentech Inc | ANTIOGENESIS THERAPY FOR AUTOIMMUNE DISEASES IN PATIENTS WHO HAD THE INTERRUPTED PREVIOUS THERAPY |
| WO2006068953A2 (en) | 2004-12-21 | 2006-06-29 | Astrazeneca Ab | Antibodies directed to angiopoietin-2 and uses thereof |
| CN103254309B (en) * | 2005-05-18 | 2017-09-26 | 埃博灵克斯股份有限公司 | For the improved nanometer body of tumor necrosis factor αTM |
| CA2960105A1 (en) | 2005-05-20 | 2006-11-23 | Ablynx Nv | Single domain vhh antibodies against von willebrand factor |
| EP1910824A4 (en) | 2005-05-31 | 2012-11-21 | Labnow Inc | Methods and compositions related to determination and use of white blood cell counts |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| US20070213266A1 (en) | 2005-09-01 | 2007-09-13 | Vasgene Therapeutics, Inc. | Methods for using and identifying modulators of Delta-like 4 |
| JPWO2007043109A1 (en) | 2005-09-30 | 2009-04-16 | 富士通株式会社 | Information storage device |
| CN101370519B (en) | 2005-12-15 | 2013-07-24 | 阿斯利康(瑞典)有限公司 | Combination of angiopoietin-2 antagonist and of VEGF-A, KDR and/or Flt1 antagonist for treating cancer |
| NZ568739A (en) | 2005-12-16 | 2010-09-30 | Regeneron Pharma | Therapeutic methods for inhibiting tumor growth with delta-like ligand 4 antagonists |
| CA2636854A1 (en) | 2006-01-24 | 2007-08-02 | Domantis Limited | Ligands that bind il-4 and/or il-13 |
| AR059066A1 (en) | 2006-01-27 | 2008-03-12 | Amgen Inc | COMBINATIONS OF THE ANGIOPOYETINE INHIBITOR -2 (ANG2) AND THE VASCULAR ENDOTELIAL GROWTH FACTOR INHIBITOR (VEGF) |
| US7570881B2 (en) | 2006-02-21 | 2009-08-04 | Nokia Corporation | Color balanced camera with a flash light unit |
| US20070269422A1 (en) * | 2006-05-17 | 2007-11-22 | Ablynx N.V. | Serum albumin binding proteins with long half-lives |
| EP2029159A2 (en) | 2006-06-06 | 2009-03-04 | Genentech, Inc. | Compositions and methods for modulating vascular development |
| SG175615A1 (en) | 2006-06-06 | 2011-11-28 | Genentech Inc | Anti-dll4 antibodies and methods using same |
| SI2054082T1 (en) | 2006-08-07 | 2013-04-30 | Regeneron Pharmaceuticals, Inc. | Use of Dll4 antagonists in ischemic injury or vascular insufficiency |
| US8629244B2 (en) | 2006-08-18 | 2014-01-14 | Ablynx N.V. | Interleukin-6 receptor binding polypeptides |
| AU2007293614A1 (en) | 2006-09-08 | 2008-03-13 | Ablynx N.V. | Serum albumin binding proteins with long half-lives |
| AU2007306340A1 (en) | 2006-10-11 | 2008-04-17 | Ablynx N.V. | Amino acid sequences that bind to serum proteins in a manner that is essentially independent of the pH, compounds comprising the same, and use thereof |
| JP2010507594A (en) | 2006-10-20 | 2010-03-11 | シェーリング コーポレイション | Fully human anti-VEGF antibodies and methods of use |
| RU2448979C2 (en) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Human antibodies to delta-like human ligand-4 |
| CA2678218A1 (en) | 2007-02-21 | 2008-08-28 | Ablynx N.V. | Amino acid sequences directed against vascular endothelial growth factor and polypeptides comprising the same for the treatment of conditions and diseases characterized by excessive and/or pathological angiogenesis or neovascularization |
| US10259860B2 (en) | 2007-02-27 | 2019-04-16 | Aprogen Inc. | Fusion proteins binding to VEGF and angiopoietin |
| AU2008234248C1 (en) * | 2007-03-29 | 2015-01-22 | Genmab A/S | Bispecific antibodies and methods for production thereof |
| GB0709333D0 (en) | 2007-05-15 | 2007-06-20 | Smart Targeting Ltd | Binding protein |
| JP2010528647A (en) | 2007-06-06 | 2010-08-26 | ドマンティス リミテッド | Polypeptides, antibody variable domains and antagonists |
| KR20100018040A (en) | 2007-06-06 | 2010-02-16 | 도만티스 리미티드 | Methods for selecting protease resistant polypeptides |
| EP2014680A1 (en) | 2007-07-10 | 2009-01-14 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Recombinant, single-chain, trivalent tri-specific or bi-specific antibody derivatives |
| US8216571B2 (en) | 2007-10-22 | 2012-07-10 | Schering Corporation | Fully human anti-VEGF antibodies and methods of using |
| AU2008329221B2 (en) | 2007-11-26 | 2013-11-07 | Bayer Intellectual Property Gmbh | Anti-mesothelin antibodies and uses therefor |
| WO2009095489A2 (en) | 2008-02-01 | 2009-08-06 | Ablynx N.V. | Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling |
| JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof |
| CA2717015A1 (en) | 2008-03-05 | 2009-09-11 | Ablynx Nv | Novel antigen binding dimer-complexes, methods of making and uses thereof |
| UA127472C2 (en) | 2008-03-18 | 2023-09-06 | Дженентек, Інк. | COMBINATION OF ANTI-HER2-ANTIBODY-DRUG AND CHEMOTHERAPEUTIC CONJUGATE AND METHOD OF ADMINISTRATION |
| EP2260058A2 (en) | 2008-04-07 | 2010-12-15 | Ablynx N.V. | Single variable domains against the notch pathways |
| KR20110014607A (en) | 2008-04-29 | 2011-02-11 | 아보트 러보러터리즈 | Dual variable domain immunoglobulins and uses thereof |
| US20100260668A1 (en) | 2008-04-29 | 2010-10-14 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
| PT2285408T (en) | 2008-06-05 | 2019-02-01 | Ablynx Nv | Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases |
| PL3216803T3 (en) | 2008-06-25 | 2020-10-19 | Novartis Ag | Stable and soluble antibodies inhibiting vegf |
| AU2009288167B2 (en) | 2008-09-03 | 2015-10-22 | Genentech, Inc. | Multispecific antibodies |
| CA2735900A1 (en) | 2008-09-19 | 2010-03-25 | Medimmune, Llc | Antibodies directed to dll4 and uses thereof |
| US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| WO2010066836A2 (en) | 2008-12-10 | 2010-06-17 | Ablynx Nv | Amino acid sequences directed against the angiopoietin/tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis |
| US8133979B2 (en) | 2008-12-16 | 2012-03-13 | Hoffmann-La Roche Inc. | Antibodies against human angiopoietin 2 |
| WO2010081219A1 (en) | 2009-01-13 | 2010-07-22 | Fio Corporation | A handheld diagnostic test device and method for use with an electronic device and a test cartridge in a rapid diagnostic test |
| WO2010124009A2 (en) | 2009-04-21 | 2010-10-28 | Schering Corporation | Fully human anti-vegf antibodies and methods of using |
| EP2424567B1 (en) | 2009-04-27 | 2018-11-21 | OncoMed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
| UA104626C2 (en) | 2009-06-17 | 2014-02-25 | Эббви Биотерапеутикс Инк. | Anti-vegf antibodies and their uses |
| JO3182B1 (en) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | High Affinity Human Antibodies to Human Angiopoietin-2 |
| UY32920A (en) * | 2009-10-02 | 2011-04-29 | Boehringer Ingelheim Int | BISPECIFIC UNION MOLECULES FOR ANTI-ANGIOGENESIS THERAPY |
| US20110195494A1 (en) | 2009-10-02 | 2011-08-11 | Boehringer Ingelheim International Gmbh | Dll4-binging molecules |
| AU2011221229B2 (en) | 2010-02-23 | 2015-06-18 | F. Hoffmann-La Roche Ag | Anti-angiogenesis therapy for the treatment of ovarian cancer |
| TWI426920B (en) | 2010-03-26 | 2014-02-21 | Hoffmann La Roche | Bispecific, bivalent anti-vegf/anti-ang-2 antibodies |
| WO2012012499A1 (en) | 2010-07-20 | 2012-01-26 | Nurx Pharmaceuticals, Inc. | Optical reader system |
| US20120225081A1 (en) * | 2010-09-03 | 2012-09-06 | Boehringer Ingelheim International Gmbh | Vegf-binding molecules |
| CN103492583A (en) | 2010-11-02 | 2014-01-01 | Abbvie公司 | Dual variable domain immunoglobulins and uses thereof |
| US20130078247A1 (en) * | 2011-04-01 | 2013-03-28 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to dii4 and ang2 |
| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| RU2013158328A (en) | 2011-05-27 | 2015-07-10 | Новартис Аг | METHOD FOR TREATING VISION DISORDERS |
| ES2707580T3 (en) | 2011-09-23 | 2019-04-04 | Oncomed Pharm Inc | VEGF / DLL4 binding agents and uses thereof |
| DK2831111T3 (en) * | 2012-03-30 | 2019-04-29 | Boehringer Ingelheim Int | Ang2-binding molecules |
| US9292583B2 (en) * | 2012-11-27 | 2016-03-22 | Google Inc. | Method of displaying search results |
-
2012
- 2012-03-29 US US13/433,359 patent/US9527925B2/en active Active
- 2012-03-30 CN CN201610173463.7A patent/CN105820243A/en active Pending
- 2012-03-30 JP JP2014501665A patent/JP6023786B2/en active Active
- 2012-03-30 PL PL12711201T patent/PL2694546T3/en unknown
- 2012-03-30 ES ES12711201.9T patent/ES2606302T3/en active Active
- 2012-03-30 MX MX2016000726A patent/MX343440B/en unknown
- 2012-03-30 EP EP16189545.3A patent/EP3144322A3/en not_active Withdrawn
- 2012-03-30 UA UAA201312685A patent/UA114707C2/en unknown
- 2012-03-30 KR KR1020137028120A patent/KR101907572B1/en active IP Right Grant
- 2012-03-30 MX MX2013010949A patent/MX337543B/en active IP Right Grant
- 2012-03-30 AP AP2013007085A patent/AP2013007085A0/en unknown
- 2012-03-30 AU AU2012237234A patent/AU2012237234B2/en active Active
- 2012-03-30 RS RS20161083A patent/RS55361B1/en unknown
- 2012-03-30 EP EP12711201.9A patent/EP2694546B1/en active Active
- 2012-03-30 DK DK12711201.9T patent/DK2694546T3/en active
- 2012-03-30 AR ARP120101130A patent/AR085984A1/en active IP Right Grant
- 2012-03-30 MY MYPI2013003467A patent/MY171007A/en unknown
- 2012-03-30 PE PE2013002134A patent/PE20140448A1/en active IP Right Grant
- 2012-03-30 SI SI201230813A patent/SI2694546T1/en unknown
- 2012-03-30 PT PT127112019T patent/PT2694546T/en unknown
- 2012-03-30 UY UY0001033998A patent/UY33998A/en unknown
- 2012-03-30 SG SG2013070842A patent/SG193561A1/en unknown
- 2012-03-30 HU HUE12711201A patent/HUE030148T2/en unknown
- 2012-03-30 WO PCT/EP2012/055901 patent/WO2012131078A1/en active Application Filing
- 2012-03-30 CN CN201280026064.8A patent/CN103562222B/en active Active
- 2012-03-30 MA MA36274A patent/MA34979B1/en unknown
- 2012-03-30 SG SG10201602373TA patent/SG10201602373TA/en unknown
- 2012-03-30 EA EA201600338A patent/EA036746B1/en not_active IP Right Cessation
- 2012-03-30 LT LTEP12711201.9T patent/LT2694546T/en unknown
- 2012-03-30 EA EA201301108A patent/EA025148B1/en not_active IP Right Cessation
- 2012-03-30 BR BR112013025304-5A patent/BR112013025304B1/en active IP Right Grant
- 2012-03-30 CA CA2827817A patent/CA2827817C/en active Active
-
2013
- 2013-08-13 IL IL227936A patent/IL227936B/en active IP Right Grant
- 2013-09-12 CL CL2013002623A patent/CL2013002623A1/en unknown
- 2013-09-26 TN TNP2013000390A patent/TN2013000390A1/en unknown
- 2013-09-27 CO CO13230713A patent/CO6801639A2/en active IP Right Grant
- 2013-10-28 EC ECSP13013001 patent/ECSP13013001A/en unknown
-
2014
- 2014-04-10 HK HK16113827A patent/HK1225400A1/en unknown
- 2014-04-10 HK HK14103437.9A patent/HK1190412A1/en unknown
-
2016
- 2016-10-07 JP JP2016198857A patent/JP6297657B2/en active Active
- 2016-11-14 US US15/350,364 patent/US10414828B2/en active Active
- 2016-12-09 HR HRP20161689TT patent/HRP20161689T1/en unknown
- 2016-12-13 CY CY20161101286T patent/CY1118339T1/en unknown
-
2017
- 2017-01-13 AU AU2017200237A patent/AU2017200237B2/en active Active
-
2019
- 2019-07-18 US US16/515,231 patent/US11161916B2/en active Active
-
2021
- 2021-09-27 US US17/485,561 patent/US20220017642A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1225400A1 (en) | Bispecific binding molecules binding to vegf and ang2 | |
| IL270223B (en) | Tdp-43 specific binding molecules | |
| HRP20181355T1 (en) | Bispecific antigen binding molecules | |
| HK1247938A1 (en) | Generation of binding molecules | |
| IL268336B (en) | Il-18 binding molecules | |
| EP2762569A4 (en) | Ngf aptamer and application thereof | |
| AP2013007086A0 (en) | Bispecific binding molecules binding to DII4 and Ang2 | |
| ZA201409540B (en) | Binding molecules targeting pathogens |