JP2013107899A5 - - Google Patents
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- Publication number
- JP2013107899A5 JP2013107899A5 JP2013030740A JP2013030740A JP2013107899A5 JP 2013107899 A5 JP2013107899 A5 JP 2013107899A5 JP 2013030740 A JP2013030740 A JP 2013030740A JP 2013030740 A JP2013030740 A JP 2013030740A JP 2013107899 A5 JP2013107899 A5 JP 2013107899A5
- Authority
- JP
- Japan
- Prior art keywords
- activin
- binding protein
- amino acids
- isolated
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010023082 activin A Proteins 0.000 claims 22
- 102000025171 antigen binding proteins Human genes 0.000 claims 14
- 108091000831 antigen binding proteins Proteins 0.000 claims 14
- 235000001014 amino acid Nutrition 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 11
- 238000010171 animal model Methods 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 102000008186 Collagen Human genes 0.000 claims 3
- 108010035532 Collagen Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 229920001436 collagen Polymers 0.000 claims 3
- 235000018417 cysteine Nutrition 0.000 claims 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 238000011084 recovery Methods 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 208000016261 weight loss Diseases 0.000 claims 3
- 230000004580 weight loss Effects 0.000 claims 3
- 206010006895 Cachexia Diseases 0.000 claims 2
- 241000699670 Mus sp. Species 0.000 claims 2
- 239000004235 Orange GGN Substances 0.000 claims 2
- 239000000488 activin Substances 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000003259 recombinant expression Methods 0.000 claims 2
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84343006P | 2006-09-08 | 2006-09-08 | |
| US60/843,430 | 2006-09-08 | ||
| US95665307P | 2007-08-17 | 2007-08-17 | |
| US60/956,653 | 2007-08-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009527594A Division JP5497438B2 (ja) | 2006-09-08 | 2007-09-07 | 抗アクチビンａ抗体およびその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016092915A Division JP6457431B2 (ja) | 2006-09-08 | 2016-05-06 | 抗アクチビンａ抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013107899A JP2013107899A (ja) | 2013-06-06 |
| JP2013107899A5 true JP2013107899A5 (enExample) | 2014-05-22 |
| JP5986518B2 JP5986518B2 (ja) | 2016-09-06 |
Family
ID=39103486
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009527594A Active JP5497438B2 (ja) | 2006-09-08 | 2007-09-07 | 抗アクチビンａ抗体およびその使用 |
| JP2013030740A Active JP5986518B2 (ja) | 2006-09-08 | 2013-02-20 | 抗アクチビンａ抗体およびその使用 |
| JP2016092915A Active JP6457431B2 (ja) | 2006-09-08 | 2016-05-06 | 抗アクチビンａ抗体およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009527594A Active JP5497438B2 (ja) | 2006-09-08 | 2007-09-07 | 抗アクチビンａ抗体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016092915A Active JP6457431B2 (ja) | 2006-09-08 | 2016-05-06 | 抗アクチビンａ抗体およびその使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US8309082B2 (enExample) |
| EP (5) | EP2064239B1 (enExample) |
| JP (3) | JP5497438B2 (enExample) |
| AR (1) | AR062703A1 (enExample) |
| AU (1) | AU2007294580C1 (enExample) |
| CA (1) | CA2661878C (enExample) |
| CL (1) | CL2007002567A1 (enExample) |
| CY (2) | CY1116037T1 (enExample) |
| DK (2) | DK2559705T3 (enExample) |
| ES (2) | ES2528798T3 (enExample) |
| HR (2) | HRP20150171T1 (enExample) |
| HU (1) | HUE030463T2 (enExample) |
| LT (1) | LT2559705T (enExample) |
| ME (1) | ME02539B (enExample) |
| MX (1) | MX2009002571A (enExample) |
| PE (1) | PE20080914A1 (enExample) |
| PL (2) | PL2064239T3 (enExample) |
| PT (2) | PT2559705T (enExample) |
| RS (2) | RS53819B1 (enExample) |
| SI (2) | SI2064239T1 (enExample) |
| TW (1) | TW200819466A (enExample) |
| WO (1) | WO2008031061A2 (enExample) |
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| TWI782836B (zh) | 2007-02-02 | 2022-11-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
| TWI606062B (zh) | 2007-02-09 | 2017-11-21 | 艾瑟勒朗法瑪公司 | 包含ＡｃｔＲＩＩａ-Ｆｃ融合蛋白的醫藥組合物；ＡｃｔＲＩＩａ-Ｆｃ融合蛋白於治療或預防與癌症相關的骨質流失之用途；ＡｃｔＲＩＩａ-Ｆｃ融合蛋白於治療或預防多發性骨髓瘤之用途 |
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