JP2012511545A5 - - Google Patents
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- Publication number
- JP2012511545A5 JP2012511545A5 JP2011540102A JP2011540102A JP2012511545A5 JP 2012511545 A5 JP2012511545 A5 JP 2012511545A5 JP 2011540102 A JP2011540102 A JP 2011540102A JP 2011540102 A JP2011540102 A JP 2011540102A JP 2012511545 A5 JP2012511545 A5 JP 2012511545A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- polypeptide according
- variable domain
- single variable
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12122808P | 2008-12-10 | 2008-12-10 | |
| US61/121,228 | 2008-12-10 | ||
| PCT/EP2009/066822 WO2010066836A2 (en) | 2008-12-10 | 2009-12-10 | Amino acid sequences directed against the angiopoietin/tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012511545A JP2012511545A (ja) | 2012-05-24 |
| JP2012511545A5 true JP2012511545A5 (enExample) | 2013-01-24 |
| JP5823871B2 JP5823871B2 (ja) | 2015-11-25 |
Family
ID=42026361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540102A Expired - Fee Related JP5823871B2 (ja) | 2008-12-10 | 2009-12-10 | 血管新生に関連した疾患及び障害の治療のための、アンジオポイエチン／Ｔｉｅシステムに指向性を有するアミノ酸配列及びこれを含むポリペプチド |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8858940B2 (enExample) |
| EP (1) | EP2364328A2 (enExample) |
| JP (1) | JP5823871B2 (enExample) |
| CN (1) | CN102307902B (enExample) |
| AU (2) | AU2009324354B2 (enExample) |
| CA (1) | CA2746395C (enExample) |
| WO (1) | WO2010066836A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101970490A (zh) * | 2007-11-27 | 2011-02-09 | 埃博灵克斯股份有限公司 | 针对异二聚体细胞因子和/或其受体的氨基酸序列以及包括所述氨基酸序列的多肽 |
| US8557243B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
| SG189769A1 (en) | 2008-01-03 | 2013-05-31 | Scripps Research Inst | Antibody targeting through a modular recognition domain |
| US8574577B2 (en) | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
| US8557242B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
| US8454960B2 (en) | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
| WO2010066836A2 (en) | 2008-12-10 | 2010-06-17 | Ablynx Nv | Amino acid sequences directed against the angiopoietin/tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis |
| US20120100166A1 (en) | 2010-07-15 | 2012-04-26 | Zyngenia, Inc. | Ang-2 Binding Complexes and Uses Thereof |
| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| EP2714738B1 (en) | 2011-05-24 | 2018-10-10 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| HUE044263T2 (hu) * | 2012-03-30 | 2019-10-28 | Boehringer Ingelheim Int | ANG2-kötõ molekulák |
| EP3424530A1 (en) | 2013-03-15 | 2019-01-09 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| KR102131371B1 (ko) | 2013-07-02 | 2020-07-08 | 삼성전자주식회사 | Ang-2 특이적 항체 및 그의 용도 |
| KR20250099289A (ko) | 2014-05-16 | 2025-07-01 | 아블린쓰 엔.브이. | 개선된 면역글로불린 가변 도메인 |
| WO2016020882A2 (en) | 2014-08-07 | 2016-02-11 | Novartis Ag | Angiopoetin-like 4 (angptl4) antibodies and methods of use |
| PT3177642T (pt) | 2014-08-07 | 2022-02-14 | Novartis Ag | Anticorpos semelhantes a angiopoietina 4 e métodos de uso |
| MA41899A (fr) | 2015-04-07 | 2018-02-13 | Shire Human Genetic Therapies | Anticorps anti-flt-1 pour traiter la dystrophie musculaire de duchenne |
| RU2749674C2 (ru) * | 2015-07-29 | 2021-06-16 | Аллерган, Инк. | Антитела против ang-2, содержащие только тяжелую цепь |
| CN117860868A (zh) * | 2016-11-14 | 2024-04-12 | 诺华股份有限公司 | 用于治疗软骨损伤和关节炎的方法和组合物 |
| BR112019014492A2 (pt) * | 2017-01-13 | 2020-02-18 | Vasomune Therapeutics Inc. | Agente de promoção da angiogênese, métodos e seus usos |
| KR101955886B1 (ko) * | 2017-05-05 | 2019-03-12 | 주식회사 유비프로틴 | 안지오포이에틴-1 반감기를 증가시키는 방법 |
| JP7638989B2 (ja) * | 2019-11-21 | 2025-03-04 | ユニティ バイオテクノロジー インコーポレイテッド | Ｔｉｅ－２に対する抗体および使用方法 |
| JP2024534964A (ja) * | 2021-09-10 | 2024-09-26 | ソーター・バイオファーマ・プライベイト・リミテッド | 抗ａｎｇ２抗体、その調製方法及び使用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI903489A0 (fi) | 1988-11-11 | 1990-07-10 | Medical Res Council | Ligander med en enda sektion, receptorer innehaollande naemnda ligander, foerfaranden foer deras framstaellning samt anvaendning av liganderna och receptorerna. |
| US6376653B1 (en) | 1998-09-28 | 2002-04-23 | Smithkline Beecham Plc | Tie2 antagonist antibodies |
| US6365154B1 (en) | 1998-09-28 | 2002-04-02 | Smithkline Beecham Corporation | Tie2 agonist antibodies |
| US20060073141A1 (en) | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| US7461263B2 (en) | 2003-01-23 | 2008-12-02 | Unspam, Llc. | Method and apparatus for a non-revealing do-not-contact list system |
| JP2007521234A (ja) | 2003-08-12 | 2007-08-02 | ウィリアム エム ヤーブロー | 尋常性ざ瘡の治療薬及び使用方法 |
| JP2007528720A (ja) * | 2003-08-12 | 2007-10-18 | ダイアックス コーポレイション | Ｔｉｅ１結合リガンド |
| CA2550551C (en) * | 2004-01-16 | 2013-10-29 | Regeneron Pharmaceuticals, Inc. | Fusion polypeptides capable of activating receptors |
| WO2006005361A1 (en) | 2004-07-13 | 2006-01-19 | Centre National De La Recherche Scientifique | Peptides liable to bind to the tie2 receptor, nucleic acids encoding them, and their uses |
| US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| JP2009523460A (ja) | 2006-01-24 | 2009-06-25 | ドマンティス リミテッド | Ｉｌ−４および／またはｉｌ−１３に結合するリガンド |
| AU2007227251A1 (en) | 2006-03-20 | 2007-09-27 | Amgen Fremont, Inc. | Antibodies directed to angiopoietin-like protein 4 and uses thereof |
| AU2007285695B2 (en) * | 2006-08-18 | 2012-05-24 | Ablynx N.V. | Amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of diseases and disorders associated with IL-6-mediated signalling |
| WO2008089070A2 (en) * | 2007-01-12 | 2008-07-24 | Dyax Corp. | Combination therapy for the treatment of cancer |
| WO2009052830A1 (en) * | 2007-10-22 | 2009-04-30 | Genmab A/S | Novel antibody therapies |
| CN101970490A (zh) * | 2007-11-27 | 2011-02-09 | 埃博灵克斯股份有限公司 | 针对异二聚体细胞因子和/或其受体的氨基酸序列以及包括所述氨基酸序列的多肽 |
| ES2713864T3 (es) | 2008-06-05 | 2019-05-24 | Ablynx Nv | Secuencias de aminoácidos dirigidas contra proteínas de la envuelta de un virus y polipéptidos que comprenden las mismas para el tratamiento de enfermedades virales |
| WO2010066836A2 (en) | 2008-12-10 | 2010-06-17 | Ablynx Nv | Amino acid sequences directed against the angiopoietin/tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis |
-
2009
- 2009-12-10 WO PCT/EP2009/066822 patent/WO2010066836A2/en not_active Ceased
- 2009-12-10 AU AU2009324354A patent/AU2009324354B2/en not_active Ceased
- 2009-12-10 CN CN200980158260.9A patent/CN102307902B/zh not_active Expired - Fee Related
- 2009-12-10 CA CA2746395A patent/CA2746395C/en not_active Expired - Fee Related
- 2009-12-10 JP JP2011540102A patent/JP5823871B2/ja not_active Expired - Fee Related
- 2009-12-10 US US13/133,685 patent/US8858940B2/en active Active
- 2009-12-10 EP EP09768527A patent/EP2364328A2/en not_active Withdrawn
-
2014
- 2014-09-04 US US14/476,802 patent/US9382333B2/en active Active
-
2016
- 2016-05-18 US US15/157,972 patent/US9822175B2/en active Active
- 2016-05-25 AU AU2016204023A patent/AU2016204023B2/en not_active Ceased
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