JP2012511545A5 - - Google Patents
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- Publication number
- JP2012511545A5 JP2012511545A5 JP2011540102A JP2011540102A JP2012511545A5 JP 2012511545 A5 JP2012511545 A5 JP 2012511545A5 JP 2011540102 A JP2011540102 A JP 2011540102A JP 2011540102 A JP2011540102 A JP 2011540102A JP 2012511545 A5 JP2012511545 A5 JP 2012511545A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- polypeptide according
- variable domain
- single variable
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 101100481408 Danio rerio tie2 gene Proteins 0.000 claims 7
- 101100481410 Mus musculus Tek gene Proteins 0.000 claims 7
- 230000033115 angiogenesis Effects 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 101100481404 Danio rerio tie1 gene Proteins 0.000 claims 3
- 101100216078 Mus musculus Ang4 gene Proteins 0.000 claims 3
- 101100481406 Mus musculus Tie1 gene Proteins 0.000 claims 3
- 102100034594 Angiopoietin-1 Human genes 0.000 claims 2
- 101000924552 Homo sapiens Angiopoietin-1 Proteins 0.000 claims 2
- 101000693093 Homo sapiens Angiopoietin-related protein 1 Proteins 0.000 claims 2
- 101000693076 Homo sapiens Angiopoietin-related protein 4 Proteins 0.000 claims 2
- 101000924549 Homo sapiens Angiopoietin-related protein 6 Proteins 0.000 claims 2
- 101000955962 Homo sapiens Vacuolar protein sorting-associated protein 51 homolog Proteins 0.000 claims 2
- 230000003042 antagnostic effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 102000052496 human ANGPTL1 Human genes 0.000 claims 2
- 102000055659 human ANGPTL4 Human genes 0.000 claims 2
- 102000055024 human ANGPTL6 Human genes 0.000 claims 2
- 102000052216 human VPS51 Human genes 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 101150054149 ANGPTL4 gene Proteins 0.000 claims 1
- 102100034608 Angiopoietin-2 Human genes 0.000 claims 1
- -1 Angptl1 Proteins 0.000 claims 1
- 101000924533 Homo sapiens Angiopoietin-2 Proteins 0.000 claims 1
- 101000693081 Homo sapiens Angiopoietin-related protein 2 Proteins 0.000 claims 1
- 101000693085 Homo sapiens Angiopoietin-related protein 3 Proteins 0.000 claims 1
- 101000924346 Homo sapiens Angiopoietin-related protein 5 Proteins 0.000 claims 1
- 101100323232 Mus musculus Ang3 gene Proteins 0.000 claims 1
- 101100001703 Mus musculus Angptl2 gene Proteins 0.000 claims 1
- 101100001705 Mus musculus Angptl3 gene Proteins 0.000 claims 1
- 101100434901 Mus musculus Angptl6 gene Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 102000057758 human ANGPTL2 Human genes 0.000 claims 1
- 102000053580 human ANGPTL3 Human genes 0.000 claims 1
- 102000051085 human ANGPTL5 Human genes 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12122808P | 2008-12-10 | 2008-12-10 | |
| US61/121,228 | 2008-12-10 | ||
| PCT/EP2009/066822 WO2010066836A2 (en) | 2008-12-10 | 2009-12-10 | Amino acid sequences directed against the angiopoietin/tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012511545A JP2012511545A (ja) | 2012-05-24 |
| JP2012511545A5 true JP2012511545A5 (enExample) | 2013-01-24 |
| JP5823871B2 JP5823871B2 (ja) | 2015-11-25 |
Family
ID=42026361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540102A Expired - Fee Related JP5823871B2 (ja) | 2008-12-10 | 2009-12-10 | 血管新生に関連した疾患及び障害の治療のための、アンジオポイエチン／Ｔｉｅシステムに指向性を有するアミノ酸配列及びこれを含むポリペプチド |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8858940B2 (enExample) |
| EP (1) | EP2364328A2 (enExample) |
| JP (1) | JP5823871B2 (enExample) |
| CN (1) | CN102307902B (enExample) |
| AU (2) | AU2009324354B2 (enExample) |
| CA (1) | CA2746395C (enExample) |
| WO (1) | WO2010066836A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101970490A (zh) | 2007-11-27 | 2011-02-09 | 埃博灵克斯股份有限公司 | 针对异二聚体细胞因子和/或其受体的氨基酸序列以及包括所述氨基酸序列的多肽 |
| GEP20156390B (en) | 2008-01-03 | 2015-11-10 | Scripps Research Inst | Antibody targeting through a modular recognition domain |
| US8557242B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
| US8557243B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
| US8574577B2 (en) | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
| US8454960B2 (en) | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
| CN102307902B (zh) | 2008-12-10 | 2016-02-24 | 埃博灵克斯股份有限公司 | 用于治疗与血管发生相关的疾病和病症的针对血管生成素/Tie系统的氨基酸序列和包括其的多肽 |
| WO2012009705A1 (en) | 2010-07-15 | 2012-01-19 | Zyngenia, Inc. | Ang-2 binding complexes and uses thereof |
| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| CN106432506A (zh) | 2011-05-24 | 2017-02-22 | 泽恩格尼亚股份有限公司 | 多价和单价多特异性复合物及其用途 |
| CA2865464C (en) * | 2012-03-30 | 2022-07-12 | Boehringer Ingelheim International Gmbh | Ang2-binding molecules |
| EP3424530A1 (en) | 2013-03-15 | 2019-01-09 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| KR102131371B1 (ko) | 2013-07-02 | 2020-07-08 | 삼성전자주식회사 | Ang-2 특이적 항체 및 그의 용도 |
| KR20250099289A (ko) | 2014-05-16 | 2025-07-01 | 아블린쓰 엔.브이. | 개선된 면역글로불린 가변 도메인 |
| WO2016020882A2 (en) | 2014-08-07 | 2016-02-11 | Novartis Ag | Angiopoetin-like 4 (angptl4) antibodies and methods of use |
| SG10201805646WA (en) | 2014-08-07 | 2018-08-30 | Novartis Ag | Angiopoietin-like 4 antibodies and methods of use |
| MA41899A (fr) | 2015-04-07 | 2018-02-13 | Shire Human Genetic Therapies | Anticorps anti-flt-1 pour traiter la dystrophie musculaire de duchenne |
| CN107849126B (zh) * | 2015-07-29 | 2022-04-08 | 阿勒根公司 | 仅有重链的抗ang-2抗体 |
| IL266361B2 (en) * | 2016-11-14 | 2024-02-01 | Novartis Ag | Methods and preparations for the treatment of cartilage damage and arthritis |
| US11384130B2 (en) * | 2017-01-13 | 2022-07-12 | Vasomune Therapeutics Inc. | Agent for promoting angiogenesis and methods and uses thereof |
| KR101955886B1 (ko) * | 2017-05-05 | 2019-03-12 | 주식회사 유비프로틴 | 안지오포이에틴-1 반감기를 증가시키는 방법 |
| CN114901700B (zh) | 2019-11-21 | 2025-04-22 | 尤尼蒂生物技术公司 | 针对tie-2的抗体及其使用方法 |
| KR20240048555A (ko) * | 2021-09-10 | 2024-04-15 | 소테르 바이오파마 피티이. 리미티드 | 항 ang2 항체 및 그 제조방법과 응용 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990005144A1 (en) | 1988-11-11 | 1990-05-17 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
| US6376653B1 (en) | 1998-09-28 | 2002-04-23 | Smithkline Beecham Plc | Tie2 antagonist antibodies |
| US6365154B1 (en) | 1998-09-28 | 2002-04-02 | Smithkline Beecham Corporation | Tie2 agonist antibodies |
| US20060073141A1 (en) | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| US7461263B2 (en) | 2003-01-23 | 2008-12-02 | Unspam, Llc. | Method and apparatus for a non-revealing do-not-contact list system |
| CA2535550A1 (en) | 2003-08-12 | 2005-03-03 | William M. Yarbrough | Treatment for acne vulgaris and method of use |
| US7348001B2 (en) | 2003-08-12 | 2008-03-25 | Dyax Corp. | Tie1-binding ligands |
| DK1709081T3 (da) * | 2004-01-16 | 2011-06-06 | Regeneron Pharma | Fusionspolypeptider, der kan aktivere receptorer |
| WO2006005361A1 (en) | 2004-07-13 | 2006-01-19 | Centre National De La Recherche Scientifique | Peptides liable to bind to the tie2 receptor, nucleic acids encoding them, and their uses |
| US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| AU2007209202A1 (en) * | 2006-01-24 | 2007-08-02 | Domantis Limited | Ligands that bind IL-4 and/or IL-13 |
| EP2007899B1 (en) | 2006-03-20 | 2017-06-07 | Celldex Therapeutics, Inc. | Antibodies directed to angiopoietin-like protein 4 and uses thereof |
| EP2057191A1 (en) * | 2006-08-18 | 2009-05-13 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
| US20080213253A1 (en) | 2007-01-12 | 2008-09-04 | Dyax Corp. | Combination therapy for the treatment of cancer |
| US20110091473A1 (en) * | 2007-10-22 | 2011-04-21 | Genmab A/S | Novel antibody therapies |
| CN101970490A (zh) * | 2007-11-27 | 2011-02-09 | 埃博灵克斯股份有限公司 | 针对异二聚体细胞因子和/或其受体的氨基酸序列以及包括所述氨基酸序列的多肽 |
| DK2285408T3 (en) | 2008-06-05 | 2019-02-04 | Ablynx Nv | AMINO ACID SEQUENCES AGAINST COATING PROTEINS IN A VIRUS AND POLYPEPTIDES INCLUDING THESE FOR TREATMENT OF VIRUSAL DISEASES |
| CN102307902B (zh) | 2008-12-10 | 2016-02-24 | 埃博灵克斯股份有限公司 | 用于治疗与血管发生相关的疾病和病症的针对血管生成素/Tie系统的氨基酸序列和包括其的多肽 |
-
2009
- 2009-12-10 CN CN200980158260.9A patent/CN102307902B/zh not_active Expired - Fee Related
- 2009-12-10 AU AU2009324354A patent/AU2009324354B2/en not_active Ceased
- 2009-12-10 US US13/133,685 patent/US8858940B2/en active Active
- 2009-12-10 CA CA2746395A patent/CA2746395C/en not_active Expired - Fee Related
- 2009-12-10 WO PCT/EP2009/066822 patent/WO2010066836A2/en not_active Ceased
- 2009-12-10 JP JP2011540102A patent/JP5823871B2/ja not_active Expired - Fee Related
- 2009-12-10 EP EP09768527A patent/EP2364328A2/en not_active Withdrawn
-
2014
- 2014-09-04 US US14/476,802 patent/US9382333B2/en active Active
-
2016
- 2016-05-18 US US15/157,972 patent/US9822175B2/en active Active
- 2016-05-25 AU AU2016204023A patent/AU2016204023B2/en not_active Ceased
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