JP2012511545A5 - - Google Patents
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- Publication number
- JP2012511545A5 JP2012511545A5 JP2011540102A JP2011540102A JP2012511545A5 JP 2012511545 A5 JP2012511545 A5 JP 2012511545A5 JP 2011540102 A JP2011540102 A JP 2011540102A JP 2011540102 A JP2011540102 A JP 2011540102A JP 2012511545 A5 JP2012511545 A5 JP 2012511545A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- polypeptide according
- variable domain
- single variable
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12122808P | 2008-12-10 | 2008-12-10 | |
| US61/121,228 | 2008-12-10 | ||
| PCT/EP2009/066822 WO2010066836A2 (en) | 2008-12-10 | 2009-12-10 | Amino acid sequences directed against the angiopoietin/tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012511545A JP2012511545A (ja) | 2012-05-24 |
| JP2012511545A5 true JP2012511545A5 (enExample) | 2013-01-24 |
| JP5823871B2 JP5823871B2 (ja) | 2015-11-25 |
Family
ID=42026361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540102A Expired - Fee Related JP5823871B2 (ja) | 2008-12-10 | 2009-12-10 | 血管新生に関連した疾患及び障害の治療のための、アンジオポイエチン／Ｔｉｅシステムに指向性を有するアミノ酸配列及びこれを含むポリペプチド |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8858940B2 (enExample) |
| EP (1) | EP2364328A2 (enExample) |
| JP (1) | JP5823871B2 (enExample) |
| CN (1) | CN102307902B (enExample) |
| AU (2) | AU2009324354B2 (enExample) |
| CA (1) | CA2746395C (enExample) |
| WO (1) | WO2010066836A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2706425A1 (en) * | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Method for obtaining polypeptide constructs comprising two or more single domain antibodies |
| US8454960B2 (en) | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
| EA021967B1 (ru) | 2008-01-03 | 2015-10-30 | Дзе Скриппс Рисерч Инститьют | Доставка антител посредством модульного домена распознавания |
| US8557243B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
| US8557242B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
| US8574577B2 (en) | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
| CA2746395C (en) | 2008-12-10 | 2019-07-09 | Ablynx N.V. | Polypeptides comprising amino acid sequences directed against tie 2 for the treatment of diseases and disorders related to angiogenesis |
| WO2012009705A1 (en) | 2010-07-15 | 2012-01-19 | Zyngenia, Inc. | Ang-2 binding complexes and uses thereof |
| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| DK2714738T3 (en) | 2011-05-24 | 2019-01-28 | Zyngenia Inc | MULTIVALENT AND MONOVALENT MULTISPECIFIC COMPLEXES AND THEIR APPLICATIONS |
| PL2831111T3 (pl) * | 2012-03-30 | 2019-09-30 | Boehringer Ingelheim International Gmbh | Cząsteczki wiążące Ang2 |
| MX2015013163A (es) | 2013-03-15 | 2016-04-04 | Zyngenia Inc | Complejos multiespecificos multivalente y monovalentes y sus usos. |
| KR102131371B1 (ko) | 2013-07-02 | 2020-07-08 | 삼성전자주식회사 | Ang-2 특이적 항체 및 그의 용도 |
| IL318433A (en) | 2014-05-16 | 2025-03-01 | Ablynx Nv | Improved immunoglobulin variable complexes |
| LT3248986T (lt) * | 2014-05-16 | 2022-03-25 | Ablynx Nv | Imunoglobulino kintami domenai |
| EA201790336A1 (ru) | 2014-08-07 | 2017-06-30 | Новартис Аг | Антитела к ангиопоэтинподобному белку 4 и способы применения |
| TW201613977A (en) | 2014-08-07 | 2016-04-16 | Novartis Ag | Angiopoetin-like 4 (ANGPTL4) antibodies and methods of use |
| MA41899A (fr) | 2015-04-07 | 2018-02-13 | Shire Human Genetic Therapies | Anticorps anti-flt-1 pour traiter la dystrophie musculaire de duchenne |
| RU2749674C2 (ru) * | 2015-07-29 | 2021-06-16 | Аллерган, Инк. | Антитела против ang-2, содержащие только тяжелую цепь |
| CN109963579A (zh) * | 2016-11-14 | 2019-07-02 | 诺华股份有限公司 | 用于治疗软骨损伤和关节炎的方法和组合物 |
| EP3568409B1 (en) * | 2017-01-13 | 2022-12-21 | Vasomune Therapeutics Inc. | Agent for promoting angiogenesis and uses thereof |
| KR101955886B1 (ko) * | 2017-05-05 | 2019-03-12 | 주식회사 유비프로틴 | 안지오포이에틴-1 반감기를 증가시키는 방법 |
| AU2020385991A1 (en) | 2019-11-21 | 2022-06-23 | Unity Biotechnology | Antibodies directed to Tie-2 and methods of use |
| EP4400512A4 (en) * | 2021-09-10 | 2025-07-23 | Soter Biopharma Pte Ltd | ANTI-ANG2 ANTIBODY, ITS PREPARATION METHOD AND ITS USE |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI903489A7 (fi) | 1988-11-11 | 1990-07-10 | Medical Res Council | Yhden osan sisältävät ligandit, näitä ligandeja sisältävät reseptorit, menetelmiä niiden valmistamiseksi sekä ligandien ja reseptorien käytt ö |
| US6376653B1 (en) * | 1998-09-28 | 2002-04-23 | Smithkline Beecham Plc | Tie2 antagonist antibodies |
| US6365154B1 (en) | 1998-09-28 | 2002-04-02 | Smithkline Beecham Corporation | Tie2 agonist antibodies |
| US20060073141A1 (en) | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| US7461263B2 (en) | 2003-01-23 | 2008-12-02 | Unspam, Llc. | Method and apparatus for a non-revealing do-not-contact list system |
| CA2535171A1 (en) | 2003-08-12 | 2005-03-03 | Dyax Corp. | Tie1-binding ligands |
| JP2007521234A (ja) | 2003-08-12 | 2007-08-02 | ウィリアム エム ヤーブロー | 尋常性ざ瘡の治療薬及び使用方法 |
| JP4906094B2 (ja) * | 2004-01-16 | 2012-03-28 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | レセプターを活性化し得る融合ポリペプチド |
| WO2006005361A1 (en) | 2004-07-13 | 2006-01-19 | Centre National De La Recherche Scientifique | Peptides liable to bind to the tie2 receptor, nucleic acids encoding them, and their uses |
| US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| BRPI0710572A2 (pt) | 2006-01-24 | 2013-01-08 | Domantis Limited | ligante, uso do ligante, mÉtodos para o tratamento de uma doenÇa alÉrgica, de asma e de cÂncer, para a inibiÇço de uma resposta imune do tipo th2, e administraÇço de tratamento anti-il-4 e tratamento anti-il-13, composiÇço farmacÊutica, dispositivo de dispensaÇço de droga, Ácido nucleico isolado ou recombinante, vetor, cÉlula hospedeira, mÉtodos para a produÇço de um ligante e de inibiÇço da proliferaÇço de cÉlulas |
| EP2007899B1 (en) | 2006-03-20 | 2017-06-07 | Celldex Therapeutics, Inc. | Antibodies directed to angiopoietin-like protein 4 and uses thereof |
| JP2010500876A (ja) * | 2006-08-18 | 2010-01-14 | アブリンクス エン．ヴェー． | Ｉｌ−６媒介性シグナル伝達に関連する疾患及び障害の治療のための、ｉｌ−６ｒに指向性を有するアミノ酸配列及びこれを含むポリペプチド |
| US20080213253A1 (en) | 2007-01-12 | 2008-09-04 | Dyax Corp. | Combination therapy for the treatment of cancer |
| WO2009052830A1 (en) * | 2007-10-22 | 2009-04-30 | Genmab A/S | Novel antibody therapies |
| CA2706425A1 (en) * | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Method for obtaining polypeptide constructs comprising two or more single domain antibodies |
| LT2285408T (lt) | 2008-06-05 | 2019-01-25 | Ablynx N.V. | Aminorūgščių sekos, nukreiptos prieš viruso apvalkalo baltymus, ir tokias sekas turintys polipeptidai, skirti virusinių ligų gydymui |
| CA2746395C (en) | 2008-12-10 | 2019-07-09 | Ablynx N.V. | Polypeptides comprising amino acid sequences directed against tie 2 for the treatment of diseases and disorders related to angiogenesis |
-
2009
- 2009-12-10 CA CA2746395A patent/CA2746395C/en not_active Expired - Fee Related
- 2009-12-10 AU AU2009324354A patent/AU2009324354B2/en not_active Ceased
- 2009-12-10 EP EP09768527A patent/EP2364328A2/en not_active Withdrawn
- 2009-12-10 JP JP2011540102A patent/JP5823871B2/ja not_active Expired - Fee Related
- 2009-12-10 US US13/133,685 patent/US8858940B2/en active Active
- 2009-12-10 WO PCT/EP2009/066822 patent/WO2010066836A2/en not_active Ceased
- 2009-12-10 CN CN200980158260.9A patent/CN102307902B/zh not_active Expired - Fee Related
-
2014
- 2014-09-04 US US14/476,802 patent/US9382333B2/en active Active
-
2016
- 2016-05-18 US US15/157,972 patent/US9822175B2/en active Active
- 2016-05-25 AU AU2016204023A patent/AU2016204023B2/en not_active Ceased
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