CN102307902B - 用于治疗与血管发生相关的疾病和病症的针对血管生成素/Tie系统的氨基酸序列和包括其的多肽 - Google Patents

用于治疗与血管发生相关的疾病和病症的针对血管生成素/Tie系统的氨基酸序列和包括其的多肽 Download PDF

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CN102307902B
CN102307902B CN200980158260.9A CN200980158260A CN102307902B CN 102307902 B CN102307902 B CN 102307902B CN 200980158260 A CN200980158260 A CN 200980158260A CN 102307902 B CN102307902 B CN 102307902B
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amino acid
sequences
acid sequence
tie2
sequence
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CN102307902A (zh
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玛丽亚·冈萨雷斯
迈克尔·约翰·斯科特·桑德斯
约翰内斯·约瑟夫·威廉姆斯·德哈德
彼得·万兰德舒特
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Ablynx NV
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
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CN200980158260.9A 2008-12-10 2009-12-10 用于治疗与血管发生相关的疾病和病症的针对血管生成素/Tie系统的氨基酸序列和包括其的多肽 Expired - Fee Related CN102307902B (zh)

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Application Number Priority Date Filing Date Title
US12122808P 2008-12-10 2008-12-10
US61/121,228 2008-12-10
PCT/EP2009/066822 WO2010066836A2 (en) 2008-12-10 2009-12-10 Amino acid sequences directed against the angiopoietin/tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis

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CN102307902A CN102307902A (zh) 2012-01-04
CN102307902B true CN102307902B (zh) 2016-02-24

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US (3) US8858940B2 (enExample)
EP (1) EP2364328A2 (enExample)
JP (1) JP5823871B2 (enExample)
CN (1) CN102307902B (enExample)
AU (2) AU2009324354B2 (enExample)
CA (1) CA2746395C (enExample)
WO (1) WO2010066836A2 (enExample)

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SG189769A1 (en) 2008-01-03 2013-05-31 Scripps Research Inst Antibody targeting through a modular recognition domain
US8574577B2 (en) 2008-01-03 2013-11-05 The Scripps Research Institute VEGF antibodies comprising modular recognition domains
US8557242B2 (en) 2008-01-03 2013-10-15 The Scripps Research Institute ERBB2 antibodies comprising modular recognition domains
US8454960B2 (en) 2008-01-03 2013-06-04 The Scripps Research Institute Multispecific antibody targeting and multivalency through modular recognition domains
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US20120100166A1 (en) 2010-07-15 2012-04-26 Zyngenia, Inc. Ang-2 Binding Complexes and Uses Thereof
US9527925B2 (en) 2011-04-01 2016-12-27 Boehringer Ingelheim International Gmbh Bispecific binding molecules binding to VEGF and ANG2
EP2714738B1 (en) 2011-05-24 2018-10-10 Zyngenia, Inc. Multivalent and monovalent multispecific complexes and their uses
HUE044263T2 (hu) * 2012-03-30 2019-10-28 Boehringer Ingelheim Int ANG2-kötõ molekulák
EP3424530A1 (en) 2013-03-15 2019-01-09 Zyngenia, Inc. Multivalent and monovalent multispecific complexes and their uses
KR102131371B1 (ko) 2013-07-02 2020-07-08 삼성전자주식회사 Ang-2 특이적 항체 및 그의 용도
KR20250099289A (ko) 2014-05-16 2025-07-01 아블린쓰 엔.브이. 개선된 면역글로불린 가변 도메인
WO2016020882A2 (en) 2014-08-07 2016-02-11 Novartis Ag Angiopoetin-like 4 (angptl4) antibodies and methods of use
PT3177642T (pt) 2014-08-07 2022-02-14 Novartis Ag Anticorpos semelhantes a angiopoietina 4 e métodos de uso
MA41899A (fr) 2015-04-07 2018-02-13 Shire Human Genetic Therapies Anticorps anti-flt-1 pour traiter la dystrophie musculaire de duchenne
RU2749674C2 (ru) * 2015-07-29 2021-06-16 Аллерган, Инк. Антитела против ang-2, содержащие только тяжелую цепь
CN117860868A (zh) * 2016-11-14 2024-04-12 诺华股份有限公司 用于治疗软骨损伤和关节炎的方法和组合物
BR112019014492A2 (pt) * 2017-01-13 2020-02-18 Vasomune Therapeutics Inc. Agente de promoção da angiogênese, métodos e seus usos
KR101955886B1 (ko) * 2017-05-05 2019-03-12 주식회사 유비프로틴 안지오포이에틴-1 반감기를 증가시키는 방법
JP7638989B2 (ja) * 2019-11-21 2025-03-04 ユニティ バイオテクノロジー インコーポレイテッド Ｔｉｅ－２に対する抗体および使用方法
JP2024534964A (ja) * 2021-09-10 2024-09-26 ソーター・バイオファーマ・プライベイト・リミテッド 抗ａｎｇ２抗体、その調製方法及び使用

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JP2012511545A (ja) 2012-05-24
US20150093377A1 (en) 2015-04-02
US20160368978A1 (en) 2016-12-22
US20120076796A1 (en) 2012-03-29
US9382333B2 (en) 2016-07-05
AU2009324354A1 (en) 2011-06-30
WO2010066836A2 (en) 2010-06-17
WO2010066836A3 (en) 2010-08-05
CA2746395C (en) 2019-07-09
AU2016204023A1 (en) 2016-08-18
EP2364328A2 (en) 2011-09-14
CA2746395A1 (en) 2010-06-17
AU2009324354B2 (en) 2016-04-14
US8858940B2 (en) 2014-10-14
AU2016204023B2 (en) 2018-02-01
US9822175B2 (en) 2017-11-21
JP5823871B2 (ja) 2015-11-25
CN102307902A (zh) 2012-01-04

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