JP2016539946A5 - - Google Patents
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- Publication number
- JP2016539946A5 JP2016539946A5 JP2016534936A JP2016534936A JP2016539946A5 JP 2016539946 A5 JP2016539946 A5 JP 2016539946A5 JP 2016534936 A JP2016534936 A JP 2016534936A JP 2016534936 A JP2016534936 A JP 2016534936A JP 2016539946 A5 JP2016539946 A5 JP 2016539946A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogenic composition
- acid sequence
- seq
- amino acid
- set forth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002163 immunogen Effects 0.000 claims 39
- 125000003275 alpha amino acid group Chemical group 0.000 claims 25
- 150000007523 nucleic acids Chemical class 0.000 claims 24
- 108020004707 nucleic acids Proteins 0.000 claims 16
- 102000039446 nucleic acids Human genes 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 9
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 241000127282 Middle East respiratory syndrome-related coronavirus Species 0.000 claims 5
- 238000004520 electroporation Methods 0.000 claims 3
- 238000001802 infusion Methods 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361910153P | 2013-11-29 | 2013-11-29 | |
| US61/910,153 | 2013-11-29 | ||
| PCT/US2014/067537 WO2015081155A1 (en) | 2013-11-29 | 2014-11-26 | Mers-cov vaccine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016539946A JP2016539946A (ja) | 2016-12-22 |
| JP2016539946A5 true JP2016539946A5 (enExample) | 2017-12-28 |
| JP6412131B2 JP6412131B2 (ja) | 2018-10-24 |
Family
ID=53199622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016534936A Active JP6412131B2 (ja) | 2013-11-29 | 2014-11-26 | ＭＥＲＳ‐ＣｏＶワクチン |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US10016497B2 (enExample) |
| EP (1) | EP3074051A4 (enExample) |
| JP (1) | JP6412131B2 (enExample) |
| KR (2) | KR20230122181A (enExample) |
| CN (2) | CN112057613A (enExample) |
| AU (1) | AU2014354797C1 (enExample) |
| CA (1) | CA2932055A1 (enExample) |
| IL (3) | IL276210B2 (enExample) |
| SA (1) | SA516371223B1 (enExample) |
| WO (1) | WO2015081155A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9889194B2 (en) | 2013-03-01 | 2018-02-13 | New York Blood Center, Inc. | Immunogenic composition for MERS coronavirus infection |
| CN112057613A (zh) * | 2013-11-29 | 2020-12-11 | 宾夕法尼亚大学理事会 | MERS-CoV疫苗 |
| US11103575B2 (en) | 2014-02-28 | 2021-08-31 | The New York Blood Center, Inc. | Immunogenic composition for MERS coronavirus infection |
| EP3045181B1 (en) * | 2015-01-19 | 2018-11-14 | Ludwig-Maximilians-Universität München | A novel vaccine against the middle east respiratory syndrome coronavirus (MERS-CoV) |
| US11058779B2 (en) | 2015-09-08 | 2021-07-13 | Sirnaomics, Inc. | Sirna/nanoparticle formulations for treatment of middle-east respiratory syndrome coronaviral infection |
| MD3718565T2 (ro) * | 2015-10-22 | 2022-09-30 | Modernatx Inc | Vaccinuri împotriva virusului respirator |
| CN106397549B (zh) * | 2016-10-11 | 2019-08-06 | 中国疾病预防控制中心病毒病预防控制所 | MERS-CoV特异性多肽及其应用 |
| US11617753B2 (en) | 2016-11-10 | 2023-04-04 | Oyagen, Inc. | Methods of treating and inhibiting Ebola virus infection |
| WO2018097603A2 (ko) * | 2016-11-23 | 2018-05-31 | 에스케이케미칼 주식회사 | 중동호흡기증후군 코로나바이러스 s 단백질 면역원 조성물 및 이의 제작 방법 |
| WO2018170347A1 (en) | 2017-03-17 | 2018-09-20 | Modernatx, Inc. | Zoonotic disease rna vaccines |
| KR102017217B1 (ko) * | 2017-10-19 | 2019-09-02 | 주식회사 엔케이맥스 | 중동호흡기증후군 코로나바이러스에 대한 항체 및 이를 이용한 항체역가 측정방법 |
| US11738025B2 (en) | 2020-02-04 | 2023-08-29 | Oyagen, Inc. | Method for treating coronavirus infections |
| IL295697B1 (en) * | 2020-02-25 | 2026-02-01 | Inovio Pharmaceuticals Inc | Coronavirus vaccines and methods of use |
| CN111378785A (zh) * | 2020-03-12 | 2020-07-07 | 仁宽(上海)生物科技有限公司 | 用于核酸诊断新型冠状病毒2019-nCov的假病毒标准品及其应用 |
| US11559577B2 (en) | 2020-03-31 | 2023-01-24 | Engimata, Inc. | Immunogenic composition forming a vaccine, and a method for its manufacture |
| US20230181681A1 (en) * | 2020-05-08 | 2023-06-15 | Industry Academic Cooperation Foundation, Hallym University | Peptide for suppressing coronavirus and use thereof |
| WO2021231560A1 (en) * | 2020-05-12 | 2021-11-18 | Greffex, Inc. | Engineering coronavirus spike proteins as vaccine antigens, their design and uses |
| US20230210981A1 (en) * | 2020-06-09 | 2023-07-06 | The Wistar Institute Of Anatomy And Biology | Coronavirus disease 2019 (covid-19) combination vaccine |
| EP4178545A4 (en) * | 2020-07-10 | 2024-08-07 | Engimata, Inc | IMMUNOGENIC COMPOSITION FORMING A VACCINE AND METHOD OF MANUFACTURE THEREOF |
| JP2023535007A (ja) * | 2020-07-22 | 2023-08-15 | グレフェックス， インコーポレイテッド | 多価ベータコロナウイルスワクチン、それらの設計及び使用 |
| WO2022025029A1 (ja) * | 2020-07-27 | 2022-02-03 | 国立大学法人滋賀医科大学 | ｉｎ ｖｉｔｒｏにおいてコロナウイルス科に属するウイルスを増殖させる方法、コロナウイルス科に属するウイルスに対する中和抗体の産生方法、及びＳｅｖｅｒｅ ａｃｕｔｅ ｒｅｓｐｉｒａｔｏｒｙ ｓｙｎｄｒｏｍｅ ｃｏｒｏｎａｖｉｒｕｓ ２の感染モデルの製造方法 |
| US20220047697A1 (en) * | 2020-08-14 | 2022-02-17 | Julius-Maximilians-Universität Würzburg | Salmonella vaccine for the treatment of coronavirus |
| WO2022046737A1 (en) * | 2020-08-25 | 2022-03-03 | The Wistar Institute Of Anatomy And Biology | Intradermal mers-cov vaccine |
| US20230349889A1 (en) * | 2020-09-10 | 2023-11-02 | The Council Of The Queensland Institute Of Medical Research | Methods of Determining Immune Response |
| US20220090134A1 (en) * | 2020-09-11 | 2022-03-24 | Memgen, Inc. | Enhancing Immunity Using Chimeric CD40 Ligand and Coronavirus Vaccine |
| EP4333887A4 (en) * | 2021-05-05 | 2025-05-21 | Inovio Pharmaceuticals, Inc. | Vaccines against coronavirus and methods of use |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US21579A (en) | 1858-09-21 | Rotary valve fob steam-engines | ||
| US3805783A (en) | 1971-02-12 | 1974-04-23 | A Ismach | Hand powered hypodermic jet injector gun |
| US4342310A (en) | 1980-07-08 | 1982-08-03 | Istvan Lindmayer | Hydro-pneumatic jet injector |
| US4447223A (en) | 1982-04-16 | 1984-05-08 | Cct Associates | Medicament implant applicator |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5545130A (en) | 1992-04-08 | 1996-08-13 | Genetronics, Inc. | Flow through electroporation method |
| WO1993024640A2 (en) | 1992-06-04 | 1993-12-09 | The Regents Of The University Of California | Methods and compositions for in vivo gene therapy |
| US5702359A (en) | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
| US5993434A (en) | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
| US5679647A (en) | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
| US5505697A (en) | 1994-01-14 | 1996-04-09 | Mckinnon, Jr.; Charles N. | Electrically powered jet injector |
| US5869326A (en) | 1996-09-09 | 1999-02-09 | Genetronics, Inc. | Electroporation employing user-configured pulsing scheme |
| US6241701B1 (en) | 1997-08-01 | 2001-06-05 | Genetronics, Inc. | Apparatus for electroporation mediated delivery of drugs and genes |
| US6216034B1 (en) | 1997-08-01 | 2001-04-10 | Genetronics, Inc. | Method of programming an array of needle electrodes for electroporation therapy of tissue |
| US6055453A (en) | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
| US6208893B1 (en) | 1998-01-27 | 2001-03-27 | Genetronics, Inc. | Electroporation apparatus with connective electrode template |
| US6009347A (en) | 1998-01-27 | 1999-12-28 | Genetronics, Inc. | Electroporation apparatus with connective electrode template |
| US6120493A (en) | 1998-01-27 | 2000-09-19 | Genetronics, Inc. | Method for the introduction of therapeutic agents utilizing an electroporation apparatus |
| WO2000002620A1 (en) | 1998-07-13 | 2000-01-20 | Genetronics, Inc. | Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications |
| US6192270B1 (en) | 1998-08-14 | 2001-02-20 | Genetronics, Inc. | Apparatus and method for the delivery of drugs and genes into tissue |
| US6150148A (en) | 1998-10-21 | 2000-11-21 | Genetronics, Inc. | Electroporation apparatus for control of temperature during the process |
| US7171264B1 (en) | 1999-05-10 | 2007-01-30 | Genetronics, Inc. | Intradermal delivery of active agents by needle-free injection and electroporation |
| EP1183068A4 (en) | 1999-05-10 | 2008-12-17 | Gentronics Inc | ENHANCED ACTIVE AGENT DELIVERY METHOD BY ELECTROPORATION |
| US7245963B2 (en) | 2002-03-07 | 2007-07-17 | Advisys, Inc. | Electrode assembly for constant-current electroporation and use |
| US7328064B2 (en) | 2002-07-04 | 2008-02-05 | Inovio As | Electroporation device and injection apparatus |
| CA2536235C (en) * | 2003-08-18 | 2017-11-21 | Amsterdam Institute Of Viral Genomics B.V. | Coronavirus, nucleic acid, protein, and methods for the generation of vaccine, medicaments and diagnostics |
| CN101098710A (zh) * | 2004-06-02 | 2008-01-02 | 纽约血液中心 | 产生高度有效抗体的sars疫苗和方法 |
| WO2005118874A1 (en) * | 2004-06-04 | 2005-12-15 | Wyeth | Enhancing protein expression |
| US7553944B2 (en) * | 2004-07-21 | 2009-06-30 | The University Of Hong Kong | Human virus causing respiratory tract infection and uses thereof |
| KR101793161B1 (ko) | 2008-08-08 | 2017-11-03 | 다케다 백신즈 인코포레이티드 | 강화된 교차 반응성을 가진 복합체 캡시드 아미노산 서열들을 포함하는 바이러스-유사 입자들 |
| CN105821078A (zh) * | 2010-12-09 | 2016-08-03 | 巴斯德研究所 | 用于获得高产量重组蛋白表达的基于mgmt的方法 |
| JP6215223B2 (ja) | 2011-12-09 | 2017-10-18 | アンスティテュ・パストゥール | マルチプレックス免疫スクリーニングアッセイ |
| EP2876161B1 (en) * | 2012-07-23 | 2018-12-05 | The Institute of Biological Resources | Vaccine |
| HK1225631A1 (zh) | 2013-09-19 | 2017-09-15 | Novavax, Inc. | 免疫原性中东呼吸综合征冠状病毒(mers-cov)组合物和方法 |
| CN112057613A (zh) * | 2013-11-29 | 2020-12-11 | 宾夕法尼亚大学理事会 | MERS-CoV疫苗 |
-
2014
- 2014-11-26 CN CN202010825164.3A patent/CN112057613A/zh active Pending
- 2014-11-26 CA CA2932055A patent/CA2932055A1/en active Pending
- 2014-11-26 IL IL276210A patent/IL276210B2/en unknown
- 2014-11-26 CN CN201480074433.XA patent/CN105939730B/zh active Active
- 2014-11-26 JP JP2016534936A patent/JP6412131B2/ja active Active
- 2014-11-26 WO PCT/US2014/067537 patent/WO2015081155A1/en not_active Ceased
- 2014-11-26 IL IL305392A patent/IL305392A/en unknown
- 2014-11-26 AU AU2014354797A patent/AU2014354797C1/en active Active
- 2014-11-26 KR KR1020237027157A patent/KR20230122181A/ko not_active Ceased
- 2014-11-26 EP EP14866748.8A patent/EP3074051A4/en not_active Withdrawn
- 2014-11-26 US US15/039,672 patent/US10016497B2/en active Active
- 2014-11-26 KR KR1020167015308A patent/KR20160091350A/ko not_active Ceased
-
2016
- 2016-05-29 IL IL245903A patent/IL245903B/en active IP Right Grant
- 2016-05-29 SA SA516371223A patent/SA516371223B1/ar unknown
-
2018
- 2018-06-29 US US16/022,839 patent/US10548971B2/en active Active
-
2020
- 2020-02-04 US US16/781,433 patent/US11135284B2/en not_active Expired - Fee Related
-
2021
- 2021-09-10 US US17/472,003 patent/US11801298B2/en active Active
-
2023
- 2023-09-28 US US18/476,921 patent/US20240123056A1/en not_active Abandoned
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