JP2016539946A5 - - Google Patents
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- JP2016539946A5 JP2016539946A5 JP2016534936A JP2016534936A JP2016539946A5 JP 2016539946 A5 JP2016539946 A5 JP 2016539946A5 JP 2016534936 A JP2016534936 A JP 2016534936A JP 2016534936 A JP2016534936 A JP 2016534936A JP 2016539946 A5 JP2016539946 A5 JP 2016539946A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogenic composition
- acid sequence
- seq
- amino acid
- set forth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000002163 immunogen Effects 0.000 claims 39
- 125000003275 alpha amino acid group Chemical group 0.000 claims 25
- 150000007523 nucleic acids Chemical class 0.000 claims 24
- 108020004707 nucleic acids Proteins 0.000 claims 16
- 102000039446 nucleic acids Human genes 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 9
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 241000127282 Middle East respiratory syndrome-related coronavirus Species 0.000 claims 5
- 238000004520 electroporation Methods 0.000 claims 3
- 238000001802 infusion Methods 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361910153P | 2013-11-29 | 2013-11-29 | |
| US61/910,153 | 2013-11-29 | ||
| PCT/US2014/067537 WO2015081155A1 (en) | 2013-11-29 | 2014-11-26 | Mers-cov vaccine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016539946A JP2016539946A (ja) | 2016-12-22 |
| JP2016539946A5 true JP2016539946A5 (enExample) | 2017-12-28 |
| JP6412131B2 JP6412131B2 (ja) | 2018-10-24 |
Family
ID=53199622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016534936A Active JP6412131B2 (ja) | 2013-11-29 | 2014-11-26 | ＭＥＲＳ‐ＣｏＶワクチン |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US10016497B2 (enExample) |
| EP (1) | EP3074051A4 (enExample) |
| JP (1) | JP6412131B2 (enExample) |
| KR (2) | KR20230122181A (enExample) |
| CN (2) | CN112057613A (enExample) |
| AU (1) | AU2014354797C1 (enExample) |
| CA (1) | CA2932055A1 (enExample) |
| IL (3) | IL305392A (enExample) |
| SA (1) | SA516371223B1 (enExample) |
| WO (1) | WO2015081155A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2961768A4 (en) | 2013-03-01 | 2016-10-26 | New York Blood Ct Inc | IMMUNOGENIC COMPOSITION AGAINST MERS CORONA VIRUS INFECTIONS |
| KR20230122181A (ko) * | 2013-11-29 | 2023-08-22 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 중동 호흡기 증후군 코로나바이러스(MERS-CoV) 백신 |
| US11103575B2 (en) | 2014-02-28 | 2021-08-31 | The New York Blood Center, Inc. | Immunogenic composition for MERS coronavirus infection |
| EP3045181B1 (en) * | 2015-01-19 | 2018-11-14 | Ludwig-Maximilians-Universität München | A novel vaccine against the middle east respiratory syndrome coronavirus (MERS-CoV) |
| US11058779B2 (en) | 2015-09-08 | 2021-07-13 | Sirnaomics, Inc. | Sirna/nanoparticle formulations for treatment of middle-east respiratory syndrome coronaviral infection |
| MA52645B1 (fr) * | 2015-10-22 | 2022-06-30 | Modernatx Inc | Vaccins contre le virus respiratoire |
| CN106397549B (zh) * | 2016-10-11 | 2019-08-06 | 中国疾病预防控制中心病毒病预防控制所 | MERS-CoV特异性多肽及其应用 |
| EP3538108A4 (en) | 2016-11-10 | 2020-06-17 | Oyagen, Inc. | METHODS OF TREATING AND INHIBITING EBOLA VIRUS INFECTION |
| KR20180058206A (ko) * | 2016-11-23 | 2018-05-31 | 에스케이케미칼 주식회사 | 중동호흡기증후군 코로나바이러스 s 단백질 면역원 조성물 및 이의 제작 방법 |
| US20200030432A1 (en) | 2017-03-17 | 2020-01-30 | Modernatx, Inc. | Zoonotic disease rna vaccines |
| WO2019078600A1 (ko) * | 2017-10-19 | 2019-04-25 | (주)에이티젠 | 중동호흡기증후군 코로나바이러스에 대한 항체 및 이를 이용한 항체역가 측정방법 |
| WO2021158248A1 (en) | 2020-02-04 | 2021-08-12 | Oyagen, Inc. | Method for treating coronavirus infections |
| CA3168353A1 (en) * | 2020-02-25 | 2021-09-02 | Jian Yan | Vaccines against coronavirus and methods of use |
| CN111378785A (zh) * | 2020-03-12 | 2020-07-07 | 仁宽(上海)生物科技有限公司 | 用于核酸诊断新型冠状病毒2019-nCov的假病毒标准品及其应用 |
| US11559577B2 (en) | 2020-03-31 | 2023-01-24 | Engimata, Inc. | Immunogenic composition forming a vaccine, and a method for its manufacture |
| WO2021225344A1 (ko) * | 2020-05-08 | 2021-11-11 | 한림대학교 산학협력단 | 코로나 바이러스 억제용 펩타이드 및 그 용도 |
| KR20230008867A (ko) * | 2020-05-12 | 2023-01-16 | 그레펙스 인코포레이티드 | 백신 항원으로서의 코로나바이러스 스파이크 단백질의 조작, 이의 설계 및 용도 |
| WO2021252604A1 (en) * | 2020-06-09 | 2021-12-16 | The Wistar Institute Of Anatomy And Biology | Coronavirus disease 2019 (covid-19) combination vaccine |
| WO2022011332A2 (en) * | 2020-07-10 | 2022-01-13 | Engimata, Inc | Immunogenic composition forming a vaccine, and a method for its manufacture |
| US20230270844A1 (en) * | 2020-07-22 | 2023-08-31 | Greffex, Inc. | Multivalent beta-coronavirus vaccines, their designs and uses |
| US20230279361A1 (en) * | 2020-07-27 | 2023-09-07 | National University Corporation Shiga University Of Medical Science | Method for in vitro proliferating virus belonging to family coronaviridae, method for producing neutralizing antibody to virus belonging to family coronaviridae, and method for producing infection model of severe acute respiratory syndrome coronavirus 2 |
| EP4196158A1 (en) * | 2020-08-14 | 2023-06-21 | Julius-Maximilians-Universität Würzburg | Salmonella vaccine for the treatment of coronavirus |
| US20240016919A1 (en) * | 2020-08-25 | 2024-01-18 | The Wistar Institute Of Anatomy And Biology | INTRADERMAL MERS-CoV VACCINE |
| US20230349889A1 (en) * | 2020-09-10 | 2023-11-02 | The Council Of The Queensland Institute Of Medical Research | Methods of Determining Immune Response |
| US20220090134A1 (en) * | 2020-09-11 | 2022-03-24 | Memgen, Inc. | Enhancing Immunity Using Chimeric CD40 Ligand and Coronavirus Vaccine |
| EP4333887A4 (en) * | 2021-05-05 | 2025-05-21 | Inovio Pharmaceuticals, Inc. | Vaccines against coronavirus and methods of use |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US21579A (en) | 1858-09-21 | Rotary valve fob steam-engines | ||
| US3805783A (en) | 1971-02-12 | 1974-04-23 | A Ismach | Hand powered hypodermic jet injector gun |
| US4342310A (en) | 1980-07-08 | 1982-08-03 | Istvan Lindmayer | Hydro-pneumatic jet injector |
| US4447223A (en) | 1982-04-16 | 1984-05-08 | Cct Associates | Medicament implant applicator |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5545130A (en) | 1992-04-08 | 1996-08-13 | Genetronics, Inc. | Flow through electroporation method |
| AU4528493A (en) | 1992-06-04 | 1994-01-04 | Regents Of The University Of California, The | In vivo gene therapy with intron-free sequence of interest |
| US5993434A (en) | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
| US5702359A (en) | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
| US5679647A (en) | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
| US5505697A (en) | 1994-01-14 | 1996-04-09 | Mckinnon, Jr.; Charles N. | Electrically powered jet injector |
| US5869326A (en) | 1996-09-09 | 1999-02-09 | Genetronics, Inc. | Electroporation employing user-configured pulsing scheme |
| US6216034B1 (en) | 1997-08-01 | 2001-04-10 | Genetronics, Inc. | Method of programming an array of needle electrodes for electroporation therapy of tissue |
| US6055453A (en) | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
| US6241701B1 (en) | 1997-08-01 | 2001-06-05 | Genetronics, Inc. | Apparatus for electroporation mediated delivery of drugs and genes |
| US6120493A (en) | 1998-01-27 | 2000-09-19 | Genetronics, Inc. | Method for the introduction of therapeutic agents utilizing an electroporation apparatus |
| US6208893B1 (en) | 1998-01-27 | 2001-03-27 | Genetronics, Inc. | Electroporation apparatus with connective electrode template |
| US6009347A (en) | 1998-01-27 | 1999-12-28 | Genetronics, Inc. | Electroporation apparatus with connective electrode template |
| JP2002520101A (ja) | 1998-07-13 | 2002-07-09 | ジェネトロニクス、インコーポレーテッド | 電気的に補助される化粧用薬剤の局部送達法および装置 |
| US6192270B1 (en) | 1998-08-14 | 2001-02-20 | Genetronics, Inc. | Apparatus and method for the delivery of drugs and genes into tissue |
| US6150148A (en) | 1998-10-21 | 2000-11-21 | Genetronics, Inc. | Electroporation apparatus for control of temperature during the process |
| US7171264B1 (en) | 1999-05-10 | 2007-01-30 | Genetronics, Inc. | Intradermal delivery of active agents by needle-free injection and electroporation |
| AU4996300A (en) | 1999-05-10 | 2000-11-21 | Gentronics, Inc. | Method of electroporation-enhanced delivery of active agents |
| US7245963B2 (en) | 2002-03-07 | 2007-07-17 | Advisys, Inc. | Electrode assembly for constant-current electroporation and use |
| US7328064B2 (en) | 2002-07-04 | 2008-02-05 | Inovio As | Electroporation device and injection apparatus |
| US7803918B2 (en) * | 2003-08-18 | 2010-09-28 | Amsterdam Institute Of Viral Genomics B.V. | Coronavirus, nucleic acid, protein, and methods for the generation of vaccine, medicaments and diagnostics |
| CN101098710A (zh) * | 2004-06-02 | 2008-01-02 | 纽约血液中心 | 产生高度有效抗体的sars疫苗和方法 |
| US20090069256A1 (en) * | 2004-06-04 | 2009-03-12 | Smith Larry R | Enhancing protein expression |
| US7553944B2 (en) * | 2004-07-21 | 2009-06-30 | The University Of Hong Kong | Human virus causing respiratory tract infection and uses thereof |
| AU2009279456B2 (en) * | 2008-08-08 | 2015-02-05 | Takeda Vaccines, Inc. | Virus-like particles comprising composite capsid amino acid sequences for enhanced cross reactivity |
| BR112013014457A8 (pt) * | 2010-12-09 | 2017-12-19 | Pasteur Institut | usos da enzima 6-metilguanina-dna-metiltrasferase (mgmt, ec 2.1.1.63) para aumentar a produção de proteína heteróloga, bem como vetor de expressão, células recombinantes e polipeptídeo de fusão compreendendo sinal de secreção peptídica e proteína snap |
| DK2788478T3 (en) | 2011-12-09 | 2017-10-09 | Pasteur Institut | Multiplex IMMUNSCREENINGSASSAY |
| WO2014017493A1 (ja) * | 2012-07-23 | 2014-01-30 | 有限会社生物資源研究所 | ワクチン |
| EP3046579A1 (en) | 2013-09-19 | 2016-07-27 | Novavax, Inc. | Immunogenic middle east respiratory syndrome coronavirus (mers-cov) compositions and methods |
| KR20230122181A (ko) * | 2013-11-29 | 2023-08-22 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 중동 호흡기 증후군 코로나바이러스(MERS-CoV) 백신 |
-
2014
- 2014-11-26 KR KR1020237027157A patent/KR20230122181A/ko not_active Ceased
- 2014-11-26 IL IL305392A patent/IL305392A/en unknown
- 2014-11-26 KR KR1020167015308A patent/KR20160091350A/ko not_active Ceased
- 2014-11-26 US US15/039,672 patent/US10016497B2/en active Active
- 2014-11-26 CN CN202010825164.3A patent/CN112057613A/zh active Pending
- 2014-11-26 IL IL276210A patent/IL276210B2/en unknown
- 2014-11-26 CA CA2932055A patent/CA2932055A1/en active Pending
- 2014-11-26 JP JP2016534936A patent/JP6412131B2/ja active Active
- 2014-11-26 WO PCT/US2014/067537 patent/WO2015081155A1/en not_active Ceased
- 2014-11-26 AU AU2014354797A patent/AU2014354797C1/en active Active
- 2014-11-26 EP EP14866748.8A patent/EP3074051A4/en not_active Withdrawn
- 2014-11-26 CN CN201480074433.XA patent/CN105939730B/zh active Active
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2016
- 2016-05-29 IL IL245903A patent/IL245903B/en active IP Right Grant
- 2016-05-29 SA SA516371223A patent/SA516371223B1/ar unknown
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2018
- 2018-06-29 US US16/022,839 patent/US10548971B2/en active Active
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2020
- 2020-02-04 US US16/781,433 patent/US11135284B2/en not_active Expired - Fee Related
-
2021
- 2021-09-10 US US17/472,003 patent/US11801298B2/en active Active
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2023
- 2023-09-28 US US18/476,921 patent/US20240123056A1/en not_active Abandoned