JP2015529678A5 - - Google Patents
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- Publication number
- JP2015529678A5 JP2015529678A5 JP2015531903A JP2015531903A JP2015529678A5 JP 2015529678 A5 JP2015529678 A5 JP 2015529678A5 JP 2015531903 A JP2015531903 A JP 2015531903A JP 2015531903 A JP2015531903 A JP 2015531903A JP 2015529678 A5 JP2015529678 A5 JP 2015529678A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- hiv
- envelope protein
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 19
- 101710091045 Envelope protein Proteins 0.000 claims description 18
- 101710188315 Protein X Proteins 0.000 claims description 18
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims description 17
- 239000013598 vector Substances 0.000 claims description 12
- 241000124008 Mammalia Species 0.000 claims description 6
- 239000002773 nucleotide Substances 0.000 claims description 6
- 125000003729 nucleotide group Chemical group 0.000 claims description 6
- 230000028993 immune response Effects 0.000 claims description 4
- 230000001939 inductive effect Effects 0.000 claims description 4
- 238000011081 inoculation Methods 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 230000006698 induction Effects 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 230000004044 response Effects 0.000 claims description 2
- 241000701161 unidentified adenovirus Species 0.000 claims description 2
- 239000013603 viral vector Substances 0.000 claims description 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 9
- 102100021696 Syncytin-1 Human genes 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 1
- 108700038320 Human immunodeficiency virus 1 gp140 envelope Proteins 0.000 claims 1
- 102100027723 Endogenous retrovirus group K member 6 Rec protein Human genes 0.000 description 9
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 2
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261700252P | 2012-09-12 | 2012-09-12 | |
| US61/700,252 | 2012-09-12 | ||
| US201261708466P | 2012-10-01 | 2012-10-01 | |
| US61/708,466 | 2012-10-01 | ||
| US201361764421P | 2013-02-13 | 2013-02-13 | |
| US61/764,421 | 2013-02-13 | ||
| PCT/US2013/000210 WO2014042669A1 (en) | 2012-09-12 | 2013-09-12 | Antibody evolution immunogens |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015529678A JP2015529678A (ja) | 2015-10-08 |
| JP2015529678A5 true JP2015529678A5 (enExample) | 2017-06-08 |
| JP6491095B2 JP6491095B2 (ja) | 2019-04-03 |
Family
ID=50278581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531903A Active JP6491095B2 (ja) | 2012-09-12 | 2013-09-12 | 抗体進化免疫原 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10004800B2 (enExample) |
| EP (1) | EP2895500B1 (enExample) |
| JP (1) | JP6491095B2 (enExample) |
| CN (1) | CN104968671B (enExample) |
| AU (3) | AU2013316100B8 (enExample) |
| CA (1) | CA2884859C (enExample) |
| WO (1) | WO2014042669A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014042669A1 (en) | 2012-09-12 | 2014-03-20 | Duke University | Antibody evolution immunogens |
| EP3119890A4 (en) * | 2014-03-19 | 2017-12-27 | Duke University | Swarm immunization with envelopes from ch505 |
| US10322141B2 (en) | 2014-03-31 | 2019-06-18 | Duke University | Compositions comprising CH848 envelopes and uses thereof |
| WO2016049633A1 (en) * | 2014-09-28 | 2016-03-31 | Duke University | Compositions and methods for transient immune response modulation during vaccination |
| EP3197488A4 (en) * | 2014-09-28 | 2018-03-21 | Duke University | Compositions comprising ch505 envelopes, and trimers |
| WO2016105492A1 (en) * | 2014-12-24 | 2016-06-30 | Duke University | Compositions comprising ch505 envelopes, and trimers (eight valent hiv-1 composition and methods) |
| CA2983259A1 (en) * | 2015-04-20 | 2016-10-27 | Duke University | Swarm immunization with envelopes from ch505 |
| WO2017151801A1 (en) | 2016-03-01 | 2017-09-08 | Duke University | Compositions comprising hiv envelopes to induce ch235 lineage antibodies |
| CA3016352A1 (en) | 2016-03-03 | 2017-09-08 | Duke University | Compositions and methods for inducing hiv-1 antibodies |
| US11318197B2 (en) | 2016-03-03 | 2022-05-03 | Duke University | Compositions and methods for inducing HIV-1 antibodies |
| US11161895B2 (en) | 2016-10-03 | 2021-11-02 | Duke University | Methods to identify immunogens by targeting improbable mutations |
| WO2018218225A1 (en) | 2017-05-25 | 2018-11-29 | Duke University | Compositions comprising modified hiv envelopes |
| EP3860650A4 (en) | 2018-10-01 | 2022-06-29 | Duke University | Hiv-1 envelope stabilizing mutations |
| EP3999107A1 (en) | 2019-07-16 | 2022-05-25 | Gilead Sciences, Inc. | Hiv vaccines and methods of making and using |
| JP7693813B2 (ja) | 2021-01-14 | 2025-06-17 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖワクチン及び使用方法 |
| WO2022235988A1 (en) * | 2021-05-05 | 2022-11-10 | Leveragen, Inc. | Engineered non-human animals for producing antibodies |
| CN117651486A (zh) * | 2021-05-05 | 2024-03-05 | 利威瑞健股份有限公司 | 用于生产抗体的工程改造的非人动物 |
| CA3234597A1 (en) * | 2021-10-11 | 2023-04-20 | Duke University | Compositions comprising hiv envelopes to induce hiv-1 antibodies |
| EP4415752A2 (en) * | 2021-10-12 | 2024-08-21 | Duke University | Compositions comprising v2 opt hiv envelopes |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0218817D0 (en) * | 2002-08-13 | 2002-09-18 | San Raffaele Centro Fond | Pharmaceutical compounds |
| AU2005280004B2 (en) | 2004-08-27 | 2012-02-23 | Institute Of Tropical Medicine | Modified HIV-1 envelope proteins |
| EP1802332A4 (en) | 2004-09-09 | 2010-08-18 | Henry M Jackson Foundation | MODIFIED HIV-1 CREAM PROTEINS |
| JP2006149234A (ja) | 2004-11-25 | 2006-06-15 | Japan Science & Technology Agency | プライム−ブーストワクチン接種法 |
| WO2009058989A1 (en) | 2007-10-30 | 2009-05-07 | International Aids Vaccine Initiative | Antigen-antibody complexes as hiv-1 vaccines |
| US8628782B2 (en) * | 2009-02-26 | 2014-01-14 | The United States Of America, As Represented By The Department Of Health And Human Services | Deletion of the beta 20-21 loop in HIV gp120 exposes the CD4 binding site for improved antibody binding and antibody induction |
| JP2013505256A (ja) | 2009-09-17 | 2013-02-14 | サノフィ パストゥール インコーポレイテッド | Ｈｉｖ用の免疫学的組成物 |
| WO2011046623A2 (en) | 2009-10-16 | 2011-04-21 | Duke University | Hiv-1 antibodies |
| EP2763699A4 (en) | 2011-10-03 | 2015-05-20 | Univ Duke | VACCINE |
| WO2014042669A1 (en) | 2012-09-12 | 2014-03-20 | Duke University | Antibody evolution immunogens |
-
2013
- 2013-09-12 WO PCT/US2013/000210 patent/WO2014042669A1/en not_active Ceased
- 2013-09-12 EP EP13837551.4A patent/EP2895500B1/en active Active
- 2013-09-12 AU AU2013316100A patent/AU2013316100B8/en active Active
- 2013-09-12 CN CN201380058891.XA patent/CN104968671B/zh active Active
- 2013-09-12 JP JP2015531903A patent/JP6491095B2/ja active Active
- 2013-09-12 CA CA2884859A patent/CA2884859C/en active Active
- 2013-09-12 US US14/427,581 patent/US10004800B2/en active Active
-
2018
- 2018-01-08 US US15/864,822 patent/US10849970B2/en active Active
- 2018-05-30 AU AU2018203805A patent/AU2018203805A1/en not_active Abandoned
-
2020
- 2020-01-22 AU AU2020200453A patent/AU2020200453A1/en not_active Abandoned