CN104968671B - 抗体进化免疫原 - Google Patents

抗体进化免疫原 Download PDF

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Publication number
CN104968671B
CN104968671B CN201380058891.XA CN201380058891A CN104968671B CN 104968671 B CN104968671 B CN 104968671B CN 201380058891 A CN201380058891 A CN 201380058891A CN 104968671 B CN104968671 B CN 104968671B
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hiv
composition
seq
env
antibodies
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Chinese (zh)
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CN104968671A (zh
Inventor
巴顿·F·海恩斯
廖华欣
丽贝卡·M·林奇
周桐青
高峰
史葛·博伊德
乔治·M·肖
比阿特丽丝·H·哈恩
托马斯·B·开普勒
贝蒂·T·科伯
彼得·邝
约翰·马斯科拉
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Triea National Security Co Ltd
US Government Office Of Health And Utilities
Boston University
University of Pennsylvania Penn
Duke University
Leland Stanford Junior University
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Government Of United States, Asrepresented By Secretary Of Department Ofhe
Boston University
University of Pennsylvania Penn
Los Alamos National Security LLC
Duke University
Leland Stanford Junior University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
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  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201380058891.XA 2012-09-12 2013-09-12 抗体进化免疫原 Active CN104968671B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261700252P 2012-09-12 2012-09-12
US61/700,252 2012-09-12
US201261708466P 2012-10-01 2012-10-01
US61/708,466 2012-10-01
US201361764421P 2013-02-13 2013-02-13
US61/764,421 2013-02-13
PCT/US2013/000210 WO2014042669A1 (en) 2012-09-12 2013-09-12 Antibody evolution immunogens

Publications (2)

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CN104968671A CN104968671A (zh) 2015-10-07
CN104968671B true CN104968671B (zh) 2020-07-03

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US (2) US10004800B2 (enExample)
EP (1) EP2895500B1 (enExample)
JP (1) JP6491095B2 (enExample)
CN (1) CN104968671B (enExample)
AU (3) AU2013316100B8 (enExample)
CA (1) CA2884859C (enExample)
WO (1) WO2014042669A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014042669A1 (en) 2012-09-12 2014-03-20 Duke University Antibody evolution immunogens
EP3119890A4 (en) * 2014-03-19 2017-12-27 Duke University Swarm immunization with envelopes from ch505
US10322141B2 (en) 2014-03-31 2019-06-18 Duke University Compositions comprising CH848 envelopes and uses thereof
WO2016049633A1 (en) * 2014-09-28 2016-03-31 Duke University Compositions and methods for transient immune response modulation during vaccination
EP3197488A4 (en) * 2014-09-28 2018-03-21 Duke University Compositions comprising ch505 envelopes, and trimers
WO2016105492A1 (en) * 2014-12-24 2016-06-30 Duke University Compositions comprising ch505 envelopes, and trimers (eight valent hiv-1 composition and methods)
CA2983259A1 (en) * 2015-04-20 2016-10-27 Duke University Swarm immunization with envelopes from ch505
WO2017151801A1 (en) 2016-03-01 2017-09-08 Duke University Compositions comprising hiv envelopes to induce ch235 lineage antibodies
CA3016352A1 (en) 2016-03-03 2017-09-08 Duke University Compositions and methods for inducing hiv-1 antibodies
US11318197B2 (en) 2016-03-03 2022-05-03 Duke University Compositions and methods for inducing HIV-1 antibodies
US11161895B2 (en) 2016-10-03 2021-11-02 Duke University Methods to identify immunogens by targeting improbable mutations
WO2018218225A1 (en) 2017-05-25 2018-11-29 Duke University Compositions comprising modified hiv envelopes
EP3860650A4 (en) 2018-10-01 2022-06-29 Duke University Hiv-1 envelope stabilizing mutations
EP3999107A1 (en) 2019-07-16 2022-05-25 Gilead Sciences, Inc. Hiv vaccines and methods of making and using
JP7693813B2 (ja) 2021-01-14 2025-06-17 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖワクチン及び使用方法
WO2022235988A1 (en) * 2021-05-05 2022-11-10 Leveragen, Inc. Engineered non-human animals for producing antibodies
CN117651486A (zh) * 2021-05-05 2024-03-05 利威瑞健股份有限公司 用于生产抗体的工程改造的非人动物
CA3234597A1 (en) * 2021-10-11 2023-04-20 Duke University Compositions comprising hiv envelopes to induce hiv-1 antibodies
EP4415752A2 (en) * 2021-10-12 2024-08-21 Duke University Compositions comprising v2 opt hiv envelopes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004014420A1 (en) * 2002-08-13 2004-02-19 Fondazione Centro San Raffaele Del Monte Tabor Pharmaceutical compositions comprising an hiv envelope protein and cd4
WO2009058989A1 (en) * 2007-10-30 2009-05-07 International Aids Vaccine Initiative Antigen-antibody complexes as hiv-1 vaccines

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005280004B2 (en) 2004-08-27 2012-02-23 Institute Of Tropical Medicine Modified HIV-1 envelope proteins
EP1802332A4 (en) 2004-09-09 2010-08-18 Henry M Jackson Foundation MODIFIED HIV-1 CREAM PROTEINS
JP2006149234A (ja) 2004-11-25 2006-06-15 Japan Science & Technology Agency プライム−ブーストワクチン接種法
US8628782B2 (en) * 2009-02-26 2014-01-14 The United States Of America, As Represented By The Department Of Health And Human Services Deletion of the beta 20-21 loop in HIV gp120 exposes the CD4 binding site for improved antibody binding and antibody induction
JP2013505256A (ja) 2009-09-17 2013-02-14 サノフィ パストゥール インコーポレイテッド Ｈｉｖ用の免疫学的組成物
WO2011046623A2 (en) 2009-10-16 2011-04-21 Duke University Hiv-1 antibodies
EP2763699A4 (en) 2011-10-03 2015-05-20 Univ Duke VACCINE
WO2014042669A1 (en) 2012-09-12 2014-03-20 Duke University Antibody evolution immunogens

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004014420A1 (en) * 2002-08-13 2004-02-19 Fondazione Centro San Raffaele Del Monte Tabor Pharmaceutical compositions comprising an hiv envelope protein and cd4
WO2009058989A1 (en) * 2007-10-30 2009-05-07 International Aids Vaccine Initiative Antigen-antibody complexes as hiv-1 vaccines

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Publication number Publication date
US20180360948A1 (en) 2018-12-20
US20150366961A1 (en) 2015-12-24
CA2884859C (en) 2024-06-18
AU2013316100B2 (en) 2018-03-01
AU2018203805A1 (en) 2018-06-21
EP2895500B1 (en) 2019-11-27
CA2884859A1 (en) 2014-03-20
AU2020200453A1 (en) 2020-02-13
EP2895500A1 (en) 2015-07-22
CN104968671A (zh) 2015-10-07
JP6491095B2 (ja) 2019-04-03
WO2014042669A1 (en) 2014-03-20
US10004800B2 (en) 2018-06-26
EP2895500A4 (en) 2016-04-13
US10849970B2 (en) 2020-12-01
AU2013316100B8 (en) 2018-03-08
JP2015529678A (ja) 2015-10-08

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Co-patentee after: THE TRUSTEES OF THE University OF PENNSYLVANIA

Co-patentee after: TRUSTEES OF BOSTON University

Co-patentee after: U.S. Government Office of Health and Utilities

Co-patentee after: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR University

Address before: North Carolina

Co-patentee before: Los Alamos National Security, LLC

Patentee before: DUKE University

Co-patentee before: THE TRUSTEES OF THE University OF PENNSYLVANIA

Co-patentee before: TRUSTEES OF BOSTON University

Co-patentee before: U.S. Government Office of Health and Utilities

Co-patentee before: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR University

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